World's Second Man Cleared of AIDS Virus Invigorates Quest for Cure

Say No to AIDS.jpg

“Dan Barouch, a vaccine researcher at the Harvard-affiliated Beth Israel Deaconess Medical Center in Boston, is working with Gilead to develop what's known as a "kick and kill" treatment.

The idea is to use an initial drug to flush out HIV that is hiding from the immune system and then use standard antiretrovirals to kill the newly-exposed virus. Animal studies have shown hope, but it has not yet been proven in people.

"All HIV cure approaches in general are in their infancy," he said in a telephone interview.

Rare cases of remission, such as the London and Berlin patients "provide a lot of enthusiasm and motivation" for research teams and show that a cure can be achieved, he said, "but we still have a long way to go".

To Read More, Click here.

NIH Statement on World AIDS Day

ribbon hiv.jpg

“We are optimistic that an end to the HIV pandemic is feasible. However, to reach this goal, we must apply the tools and advances already at hand as we continue to follow the science in laboratories and clinics around the world. Today we honor the achievements of dedicated researchers, health care professionals, clinical trial participants and members of the global community, and we reaffirm our commitment to work together to fill the remaining gaps.”

To Read More: Click Here

HIV vaccine on horizon as jab triggers immunity in humans and stops monkeys being infected


“We eagerly await the results of the phase 2b Imbokodo’, which will determine whether or not this vaccine will protect humans against acquiring HIV.”

To Read More: Click Here

"Scientists cautiously optimistic about HIV vaccine candidate"


"I would say that we are pleased with these data so far, but we have to interpret the data cautiously," said study co-author Dr. Dan H. Barouch, a principal investigator on the study, a professor of medicine at Harvard Medical School and the director of the Center for Virology and Vaccine Research. "We have to acknowledge that developing an HIV vaccine is an unprecedented challenge, and we will not know for sure whether this vaccine will protect humans."

To Read More: Click here

"There is no cure for HIV—but scientists may be getting closer"

"But in the latest report presented this month at the Conference on Retroviruses and Opportunistic Infections in Boston, researchers revealed the strongest evidence yet that these latent viruses can be activated and eliminated, at least in animals. In a study involving a form of HIV that infects monkeys, Dr. Dan Barouch and his colleagues at Beth Israel Deaconess Medical Center and Harvard Medical School showed that a drug that stimulates the immune system and activates the dormant HIV, combined with a powerful antibody that can neutralize the HIV-infected cells, prevented HIV from surging back in five of 11 animals, six months after they stopped taking ARVs. In the monkeys whose HIV did return, the virus levels were 100 times lower than they were in animals that were not treated at all.

I think our data raises the possibility that an intervention achieving a functional cure is possible,” says Barouch. “It shows a level of potential efficacy, at least in animals, that to the best of my knowledge hasn’t been seen before.”

To Read More Click Here