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Journal Club

  • Center for Virology and Vaccine Research 3 Blackfan Circle - 1033 Boston, MA, 02115 United States (map)

Peter Abbink of the Center for Virology and Vaccine Research will be presenting "HIV-1 Therapy with Monoclonal Antibody 3BNC117 Elicits Host Immune Responses Against HIV-1"

ABSTRACT:  3BNC117 is a broad and potent anti-HIV-1 neutralizing antibody that targets the CD4 binding site on the viral envelope spike. When administered passively, this antibody can prevent infection in animal models and suppress viremia in HIV-1-infected individuals. Here we report that HIV-1 immunotherapy with a single injection of 3BNC117 impacts host antibody responses in viremic subjects. In comparison to untreated controls that showed little change in their neutralizing activity over a six-month period, 3BNC117 infusion significantly improved neutralizing responses to heterologous tier 2 viruses in nearly all study participants. We conclude that 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.

Earlier Event: September 29
Seminar Series
Later Event: October 6
Seminar Series