Publications - R. Keith Reeves, Ph.D.

NK Cells

Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Connole, M., and Johnson, R. P.  2010. CD16— natural killer cells: Enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.  Blood. 115(22):4439-4446.

Reeves, R. K., Evans, T. I., Gillis, J., and Johnson, R. P.  2010. SIV infection induces an expansion of α4β7+ and cytotoxic CD56+ NK cells.  J. Virol. 84(17):8959-8963.

Schafer, J. L., Li, H., Evans, T. I., Estes, J. D., and Reeves, R. K.  2015. Accumulation of cytotoxic CD16+ NK cells in SIV-infected lymph nodes associated with in situ differentiation and functional anergy. Journal of Virology. doi:10.1128/JVI.00660-15.

Reeves, R. K., Li, H., Jost, S., Blass, E., Li, H., Eslamizar, L., Altfeld, M., von Andrian, U. H., and Barouch, D. H. 2015. Antigen-specific NK cell memory in rhesus macaques.  In press at Nature Immunology.

 

Innate Lymphoid Cells

Reeves, R. K., Rajakumar, P., Evans, T. I., Connole, M., Gillis, J., Wong, F. E., Kuzmichev, Y. V., Carville, A. and Johnson, R. P.  2011. Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection. Blood. 118(12): 3321-3330.

Li, H. and Reeves, R. K. 2013. Functional perturbation of classical natural killer and innate lymphoid cells in the oral mucosa during SIV infection. Front. Immunol. 3:417. doi: 10.3389/fimmu.2012.00417

Reeves, R. K., Kang, G., Li, H., and Li, Q. 2014. Depletion of lamina propria innate lymphoid cells in SIV infection.  AIDS Res. Hum. Retroviruses. 30(12):1160-1161.

Li, H., Evans, T. I., Gillis, J., Estes, J.D., Keele, B.F., Klatt, N.R., and Reeves, R. K. 2014. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Path. 10(12):e1004551. 

 

Mucosal Homing of pDCs and Immune Activation in HIV/SIV Disease

Reeves, R. K., Evans, T. I., Gillis, J., Wong, F. E., Kang, G., Li, Q., and Johnson, R. P.  2012.  SIV infection induces increased trafficking of plasmacytoid dendritic cells to the gut mucosa. Journal of Infect. Dis. 206(9):1462-1468. 

Li, H., Gillis, J., and Reeves, R. K. 2013. Multifunctional plasmacytoid dendritic cells redistribute to gut tissues during SIV infection. Immunology. 140(2):244-249.

Li, H., Evans, T. I., Gillis, J., Connole, M., and Reeves, R. K. 2014. Bone marrow-imprinted gut-homing of pDCs in acute SIV infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae.  In press at Journal of Infectious Diseases. doi: 10.1093/infdis/jiu671

Li, H., Goepfert, P., and Reeves, R. K. 2014. pDCs from HIV-1 Elite Controllers maintain a gut-homing phenotype associated with immune activation.  AIDS Res. Hum. Retroviruses. 30(12):1213-1315.

 

Development of a Novel HCV Animal Model in Common Marmosets

Reeves, R. K., Evans, T. I., Fultz, P.N., and Johnson, R. P.  2011. Potential confusion of contaminating CD16+ mDCs with anergic CD16+ NK cells in chimpanzees. Eur. J. Immunol. 41(4):1070-1074.

Carville, A., Evans, T. I., and Reeves, R. K. 2013. Characterization of circulating natural killer cells in neotropical primates. PLoS One. 8(11):e78793 

Manickam, C. and Reeves, R. K. 2014. Modeling HCV disease in animals: Virology, immunology, and pathogenesis of HCV and GBV-B infections.  Front. Microbiol. 5:690. doi: 10.3389/fmicb.2014.00690

 

Immune Correlates of Protection in Live Attenuated SIV

Alpert, M. D., Harvey, J. D., Lauer, W. A., MacKenzie, E., Reeves, R. K., Piatak, M., Carville, Mansfield, K. G., Lifson, J. D., Li, W., Desrosiers, R. C., Johnson, R. P., and Evans, D. T. 2012. Antibody-dependent cell-mediated cytotoxicity develops over time during persistent infection with live-attenuated SIV and correlates with protection against pathogenic SIV infection. PLoS Path. 8(8): e1002890.

Li, Q., Duan, S., Zeng, M., Shang, L., Smith, A., Wietgrefe, S., Southern, P. J., Reilly, C. S., Pambuccian, S., Skinner, P. J., Zupancic, M., Piatak, M., Waterman, D., Reeves, R. K., Lifson, J. D., Johnson, R. P., and Haase, A. T. 2014. Vaccine-induced antibody concentrated at the mucosal border correlates with limited local and systemic SIV infection. J. Immunol193(6):3113-25

Adnan, S., Colantonio, A. D., Yu, Y., Gillis, J., Wong, F. E., Becker, E. A., Piatak, M., Reeves, R. K., Lifson, J. D., O’Connor, S. L., and R. P. Johnson.  2015. CD8+ T cell response maturation defined by anentropic specificity and repertoire depth correlates with protection in SIVDnef-vaccinated animals.  PLoS Path. 11(2):e1004633

Billingsley, J. M., Rajakumar, P. A., Connole, M. A., Salisch, N. C., Kuzmichev, Y. V., Hong, H. S., Reeves, R. K., Kang, H.-J, Li, W., Haase, A. T., and Johnson, R. P. 2015. Characterization of CD8+ T cell differentiation following SIVDnef vaccination by transcription factor expression profiling. PLoS Path. 11(2):e1004740