Dr. Michael Seaman is an Assistant Professor in Medicine at Beth Israel Deaconess Medical Center, Harvard Medical School. He obtained his Ph.D. in Immunology from the University of Texas Southwestern Medical Center in 2000, and did his post-doctoral research training with Dr. Norman Letvin at Harvard Medical School where he studied the use of cytokine adjuvants for augmenting HIV vaccine-elicited T cell responses in non-human primates. Since 2006, Dr. Seaman has directed the CAVD Pre-Clinical Neutralizing Antibody Core Laboratory as part of the Comprehensive Antibody Vaccine Immune Monitoring Consortium (CA-VIMC), under the direction of Dr. David Montefiori. His laboratory collaborates with numerous CAVD investigators by providing standardized assessments of neutralizing antibody responses to HIV-1, SIV, and SHIV viruses. These include, in part, the assessment of antibody responses elicited by candidate HIV-1 vaccines in small animal or non-human primate models, the screening of HIV+ patient cohorts to identify potent neutralizers, and the phenotypic assessment of novel monoclonal antibodies being developed by VDC investigators for their breadth and potency of neutralizing activity. To date, Dr. Seaman’s laboratory has conducted approximately 80,000 neutralizing antibody assays for 71 registered CAVD studies. Within the CA-VIMC, Dr. Seaman’s laboratory has also been extensively involved in the Standard Virus Panel Consortium, which has developed >500 novel HIV-1 Env pseudovirus strains from diverse genetic subtypes for use in standardized neutralization assays. In addition his lab participates in CA-VIMC Research and Development Program projects, the Specimen Acquisition Laboratory, and the Neutralization Serotype Discovery Project.
Principal Investigator: Michael Seaman, Ph.D.
Position: Assistant Professor of Medicine, Harvard Medical School
Office/Location: Beth Israel Deaconess Medical Center, 3 Blackfan Circle, E/CLS-1001, Boston, MA 02115
Staff Scientist: Christy Lavine
Research Assistants/Associates: Katie Yanosick, Alessandra Setaro Fadi Ghantous, Eric Muller; Marshall Zingg, Tom Fitzsimons, Shana Hardy, Anna Tse, Katie Henrikson, Kevin McManus, Sadli Beriane and Joseph Sapiente