Pablo Penaloza-MacMaster, Ph.D.


1. Penaloza-MacMaster P, Masopust D, Ahmed R. T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction. Immunology 2009;128:164-171.

2. Penaloza-MacMaster P, Ur Rasheed A, Iyer SS, Yagita H, Blazar BR, Ahmed R. Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice. J Virol. 2011 85:6168-6174

3. Pillai VK, Kannanganat S, Penaloza-MacMaster P, Chennareddi L, Robinson HL, Blackwell J, Amara RR. Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines. Vaccine 2011 29:5399-5406.

4. Vezys V*, Penaloza-MacMaster P*, Barber DL, Ha SJ, Konieczny B, Freeman GJ, Mittler RS, Ahmed R. 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. J Immunol. 2011;187:1634-1642. *EQUAL CONTRIBUTION

5. Penaloza-MacMaster P, Provine NM, Ra J, Borducchi EN, McNally A, Simmons NL, Iampietro MJ, Barouch DH. Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors. J Virol. 2013 ;87:1373-1384.

6. Tan WG, Jin HT, West EE, Penaloza-MacMaster, Wieland A, Zilliox MJ, McElrath MJ, Barouch DH, Ahmed R. Comparative analysis of simian immunodeficiency virus gag-specific effector and memory CD8+ T cells induced by different adenovirus vectors. J Virol. 2013; 87:1359-1372

7. West EE, Jin HT, Rasheed AU, Penaloza-MacMaster P, Ha SJ, Tan WG, Youngblood B, Freeman GJ, Smith KA, Ahmed R. PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J Clin Invest. 2013; 123:2604-2615.

8. Iyer SS, Latner DR, Zilliox MJ, McCausland M, Akondy RS, Penaloza-MacMaster P, Hale JS, Ye L, Mohammed AU, Yamaguchi T, Sakaguchi S, Amara RR, Ahmed R. Identification of novel markers for mouse CD4(+) T follicular helper cells. Eur J Immunol. 2013 12:3219-3232.

9. Penaloza-MacMaster P, Teigler JE, Obeng RC, Kang ZH, Provine NM, Parenteau L, Blackmore S, Ra J, Borducchi EN, Barouch DH. Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens. J. Virol. 2014; 88:6243-6254.

10. Provine NM, Larocca RA, Penaloza-MacMaster P, Borducchi EN, McNally A, Parenteau LR, Kaufman DR, Barouch DH. Longitudinal requirement for CD4+ T cell help for adenovirus vector-elicited CD8+ T cell responses. J. Immunol. 2014; 192:5214-5225.

11. Teigler JE*, Penaloza-MacMaster P*, Obeng R, Provine NM, Larocca RA, Borducchi EN, Barouch DH. Hexon hypervariable region-modified adenovirus 5 vectors display reduced hepatotoxicity but induce T lymphocyte phenotypes similar to Ad5 vectors. Clin. Vaccine Immunol. 2014; 21:1137-1144. *EQUAL CONTRIBUTION

12. Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DIS, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 2014; 512:74-77.

13. Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K , Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of Experimental Medicine 2014; 211:1905-1918.

14. Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates K, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, Barouch DH. Immunopathology of vaccine-elicited CD4 T cells following chronic LCMV infection. Science 2015; 6219:278-282.

15. Noe Rodriguez-Rodriguez, Sokratis A. Apostolidis, Pablo Penaloza-MacMaster, Jose Manuel Martin Villa, Dan H. Barouch, George C. Tsokos, and Jose C. Crispin. Programmed Cell Death 1 and Helios Distinguish TCR-ab+ Double-Negative (CD4- CD8-) T Cells That Derive from Self- Reactive CD8 T Cells. J. Immunol. 2015; 194: 4207-4214.

16. Pablo Penaloza-MacMaster, Nicholas M. Provine, Eryn Blass, Dan H. Barouch. CD4 T cell depletion substantially augments the rescue potential of PD-L1 blockade for deeply exhausted CD8 T cells. J. Immunol. 2015; 195:1054-63.