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X-WR-CALNAME:Center for Virology and Vaccine Research (CVVR)
X-ORIGINAL-URL:https://cvvr.hms.harvard.edu
X-WR-CALDESC:Events for Center for Virology and Vaccine Research (CVVR)
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DTSTART:20200308T070000
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200807T133000
DTEND;TZID=America/New_York:20200807T143000
DTSTAMP:20200804T190426Z
CREATED:20200804T190426Z
LAST-MODIFIED:20200804T190426Z
UID:6201-1596807000-1596810600@cvvr.hms.harvard.edu
SUMMARY:SARS-CoV2 infection\, recovery and mortality: Insights from multiplexed imaging\, proteomics and transcript profiling
DESCRIPTION:Zoltan Maliga\, Ph.D.\,  Laboratory of Systems Pharmacology- Harvard Medical School
URL:https://cvvr.hms.harvard.edu/event/sars-cov2-infection-recovery-and-mortality-insights-from-multiplexed-imaging-proteomics-and-transcript-profiling/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200731T133000
DTEND;TZID=America/New_York:20200731T143000
DTSTAMP:20200727T191740Z
CREATED:20200620T175510Z
LAST-MODIFIED:20200727T191740Z
UID:5902-1596202200-1596205800@cvvr.hms.harvard.edu
SUMMARY:Immune Evasion and Vaccine Design for HIV-1 Env Trimer and SARS-CoV-2 Spike
DESCRIPTION:Peter D. Kwong\, Ph.D.\, Chief\, Structural Biology Section\, Vaccine Research Center\, NIAID\, NIH
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-series-5/
LOCATION:Zoom Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200724T133000
DTEND;TZID=America/New_York:20200724T143000
DTSTAMP:20200721T130857Z
CREATED:20200123T203640Z
LAST-MODIFIED:20200721T130857Z
UID:3894-1595597400-1595601000@cvvr.hms.harvard.edu
SUMMARY:Sounding the Alarm and Putting Out the Fire: New Mechanistic Insights into Inflammatory Cell Death
DESCRIPTION:Judy Lieberman\, M.D.\, Ph.D.\, Professor\, Pediatrics\, Harvard Medical School Chair\, PCMM\, Boston Children’s Hospital
URL:https://cvvr.hms.harvard.edu/event/seminar-18/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200717T133000
DTEND;TZID=America/New_York:20200717T143000
DTSTAMP:20200714T143423Z
CREATED:20200620T175408Z
LAST-MODIFIED:20200714T143423Z
UID:5898-1594992600-1594996200@cvvr.hms.harvard.edu
SUMMARY:The transcriptional response to SARS-CoV-2 and its contribution to the development of COVID-19
DESCRIPTION:Benjamin tenOever\, Ph.D.\, Fishberg Professor of Medicine\, Icahn Scholar and Professor of Microbiology. Director\, Virus Engineering Center for Therapeutics and Research (VECToR)-Icahn School of Medicine at Mount Sinai
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-series-4/
LOCATION:Zoom Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200710T133000
DTEND;TZID=America/New_York:20200710T143000
DTSTAMP:20200707T160517Z
CREATED:20200618T201326Z
LAST-MODIFIED:20200707T160517Z
UID:5895-1594387800-1594391400@cvvr.hms.harvard.edu
SUMMARY:Recognizing the problem: the problem of recognition. T cells and immunity to infection
DESCRIPTION:Samuel Behar\, MD\, Ph.D.\, Professor\, Microbiology and Physiological Systems- University of Massachusetts Medical School
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-series-3/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200701T180000
DTEND;TZID=America/New_York:20200701T190000
DTSTAMP:20200701T130254Z
CREATED:20200701T130112Z
LAST-MODIFIED:20200701T130254Z
UID:5949-1593626400-1593630000@cvvr.hms.harvard.edu
SUMMARY:Equity and COVID-19 Research 101
DESCRIPTION:Dr. Stephenson will part of this webinar’s panelist discussing COVID-19 treatment and vaccine research studies and\, the challenges to the engagement of Black and Latinx research participants. Register here
URL:https://cvvr.hms.harvard.edu/event/equity-and-covid-19-research-101/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/png:https://cvvr.hms.harvard.edu/wp-content/uploads/2020/07/COVID-Webinar-Equity-July-1_2020.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200626T133000
DTEND;TZID=America/New_York:20200626T143000
DTSTAMP:20200622T135052Z
CREATED:20200618T150139Z
LAST-MODIFIED:20200622T135052Z
UID:5888-1593178200-1593181800@cvvr.hms.harvard.edu
SUMMARY:Computational Systems Modeling Approach to Enhancing Translation from Animal to Human
DESCRIPTION:Douglas Lauffenburger\, Ph.D.\, Ford Professor of Bioengineering\, Departments of Biological Engineering\, Chemical Engineering\, and Biology- MIT\, Associate Member\, Ragon Institute of MGH / MIT / Harvard.
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-series-2/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200619T133000
DTEND;TZID=America/New_York:20200619T143000
DTSTAMP:20200615T132325Z
CREATED:20200423T181616Z
LAST-MODIFIED:20200615T132325Z
UID:5556-1592573400-1592577000@cvvr.hms.harvard.edu
SUMMARY:Uncovering correlates of vaccine-induced immunity using latent models
DESCRIPTION:Jishnu Das\, Ph.D.\, Assistant Professor\, Departments of Immunology and Computational & Systems Biology Core Faculty Member\, Center for Systems Immunology\, University of Pittsburgh School of Medicine
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-5/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200616T200000
DTEND;TZID=America/New_York:20200616T213000
DTSTAMP:20200616T133913Z
CREATED:20200616T133913Z
LAST-MODIFIED:20200616T133913Z
UID:5876-1592337600-1592343000@cvvr.hms.harvard.edu
SUMMARY:The Search for a Vaccine in the Age of COVID-19
DESCRIPTION:Hollywood\, Health & Society\, in partnership with the WGAE and WGAW\, continues its series of discussions via Zoom on a variety of topics affected by the pandemic. Dr. Barouch will be part of a discussion that focuses on the search for a vaccine for the coronavirus. Register here
URL:https://cvvr.hms.harvard.edu/event/the-search-for-a-vaccine-in-the-age-of-covid-19/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://cvvr.hms.harvard.edu/wp-content/uploads/2020/06/db.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200612T133000
DTEND;TZID=America/New_York:20200612T143000
DTSTAMP:20200609T000250Z
CREATED:20200423T181201Z
LAST-MODIFIED:20200609T000250Z
UID:5553-1591968600-1591972200@cvvr.hms.harvard.edu
SUMMARY:A rhesus macaque model of Hepatitis B virus infection
DESCRIPTION:Benjamin Burwitz\, Ph.D.\, Research Assistant Professor\, Oregon Health & Science University
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-4/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200605T133000
DTEND;TZID=America/New_York:20200605T143000
DTSTAMP:20200604T214039Z
CREATED:20200513T140724Z
LAST-MODIFIED:20200604T214039Z
UID:5643-1591363800-1591367400@cvvr.hms.harvard.edu
SUMMARY:Immune Complex Biology is Complex Immune Biology
DESCRIPTION:George K. Lewis\, Ph.D.\, Director\, Division of Vaccine Research\, University of Maryland School of Medicine- (IHV)
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-series/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200529T120000
DTEND;TZID=America/New_York:20200529T130000
DTSTAMP:20200525T154803Z
CREATED:20200423T180839Z
LAST-MODIFIED:20200525T154803Z
UID:5542-1590753600-1590757200@cvvr.hms.harvard.edu
SUMMARY:Epidemiology of COVID 19
DESCRIPTION:Marc Lipsitch\, D.Phil\, Professor of Epidemiology\, Dept of Epidemiology. Director\, Center for Communicable Disease Dynamics- Harvard T.H. Chan School of Public Health
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-3/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200527T120000
DTEND;TZID=America/New_York:20200527T130000
DTSTAMP:20200525T134223Z
CREATED:20200513T135107Z
LAST-MODIFIED:20200525T134223Z
UID:5637-1590580800-1590584400@cvvr.hms.harvard.edu
SUMMARY:Natural and Vaccine-Induced Immunity to COVID-19 in Rhesus Macaques
DESCRIPTION:Dr. Barouch will be part of Oxford University COVID-19 virtual lecture series
URL:https://cvvr.hms.harvard.edu/event/oxford-university-covid-19-lecture-series/
LOCATION:Oxford University Webinar
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://cvvr.hms.harvard.edu/wp-content/uploads/2020/05/oxford-university.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200522T133000
DTEND;TZID=America/New_York:20200522T143000
DTSTAMP:20200518T145815Z
CREATED:20200423T180353Z
LAST-MODIFIED:20200518T145815Z
UID:5538-1590154200-1590157800@cvvr.hms.harvard.edu
SUMMARY:"Preventing Tuberculosis in SIV+ macaques with IV BCG" and "All We Need is a Miracle"
DESCRIPTION:Shelby O’Connor\, Ph.D.\, Associate Professor\, University of Wisconsin School of Medicine and Public Health \nDavid O’Connor\,Ph.D.\, Professor\, University of Wisconsin School of Medicine and Public Health
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar-2/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200515T133000
DTEND;TZID=America/New_York:20200515T143000
DTSTAMP:20200512T224144Z
CREATED:20200423T180004Z
LAST-MODIFIED:20200512T224144Z
UID:5530-1589549400-1589553000@cvvr.hms.harvard.edu
SUMMARY:Mapping Dynamic Multicellular Transcriptional Responses during Acute HIV-1 Infection
DESCRIPTION:Samuel Kazer\, Ph.D.\,Ragon Institute\, Institute for Medical Engineering and Science\, MIT
URL:https://cvvr.hms.harvard.edu/event/zoom-seminar/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200513T210000
DTEND;TZID=America/New_York:20200513T220000
DTSTAMP:20200506T144903Z
CREATED:20200506T144733Z
LAST-MODIFIED:20200506T144903Z
UID:5605-1589403600-1589407200@cvvr.hms.harvard.edu
SUMMARY:Decoding COVID-19
DESCRIPTION:Scientists race to understand and defeat the coronavirus behind the COVID-19 pandemic. Premieres  May 13th 2020
URL:https://cvvr.hms.harvard.edu/event/decoding-covid-19/
LOCATION:PBS NOVA
CATEGORIES:Television
ATTACH;FMTTYPE=image/jpeg:https://cvvr.hms.harvard.edu/wp-content/uploads/2020/05/nova.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200508T133000
DTEND;TZID=America/New_York:20200508T143000
DTSTAMP:20200506T145332Z
CREATED:20200123T204328Z
LAST-MODIFIED:20200506T145332Z
UID:3897-1588944600-1588948200@cvvr.hms.harvard.edu
SUMMARY:From Genes to Mechanisms to Medicines: the Arc of Discovery
DESCRIPTION: Anna Greka\, MD\, Ph.D.\, Associate Professor of Medicine at Harvard Medical School\, Broad Institute of MIT and Harvard Brigham and Women’s Hospital
URL:https://cvvr.hms.harvard.edu/event/seminar-19/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200501T133000
DTEND;TZID=America/New_York:20200501T143000
DTSTAMP:20200430T142707Z
CREATED:20200430T142707Z
LAST-MODIFIED:20200430T142707Z
UID:5597-1588339800-1588343400@cvvr.hms.harvard.edu
SUMMARY:Protective Efficacy of SARS-CoV-2 Infection Against Re-Challenge
DESCRIPTION:Dan Barouch\, M.D.\,Ph.D.\, William Bosworth Castle Professor of Medicine\, Harvard Medical School Ragon Institute of MGH\, MIT\, and Harvard. Director\, Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center
URL:https://cvvr.hms.harvard.edu/event/protective-efficacy-of-sars-cov-2-infection-against-re-challenge/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200424T133000
DTEND;TZID=America/New_York:20200424T143000
DTSTAMP:20200423T180126Z
CREATED:20200219T195840Z
LAST-MODIFIED:20200423T180126Z
UID:4558-1587735000-1587738600@cvvr.hms.harvard.edu
SUMMARY:IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence
DESCRIPTION:Susan Pereira Ribeiro\, Ph.D.\, Case Western Reserve University
URL:https://cvvr.hms.harvard.edu/event/seminar-25/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200417T133000
DTEND;TZID=America/New_York:20200417T143000
DTSTAMP:20200413T161038Z
CREATED:20200401T185417Z
LAST-MODIFIED:20200413T161038Z
UID:4555-1587130200-1587133800@cvvr.hms.harvard.edu
SUMMARY:The Story of HIV: From ER to Designated Survivor (1994-Present)
DESCRIPTION:Neal Baer\, M.D.
URL:https://cvvr.hms.harvard.edu/event/seminar-24/
LOCATION:Zoom Seminar Series
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200410T133000
DTEND;TZID=America/New_York:20200410T143000
DTSTAMP:20200320T162014Z
CREATED:20200123T203153Z
LAST-MODIFIED:20200320T162014Z
UID:3891-1586525400-1586529000@cvvr.hms.harvard.edu
SUMMARY:Seminar Cancelled
DESCRIPTION:James Munro\, Ph.D\, Associate Professor of Microbiology and Physiological Systems\, UMASS Medical School
URL:https://cvvr.hms.harvard.edu/event/seminar-17/
LOCATION:Beth Israel Deaconess Medical Center\, Leventhal Conference Room\, 330 Brookline Avenue\, Boston\, MA\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200403T133000
DTEND;TZID=America/New_York:20200403T143000
DTSTAMP:20200320T161956Z
CREATED:20200219T195211Z
LAST-MODIFIED:20200320T161956Z
UID:4550-1585920600-1585924200@cvvr.hms.harvard.edu
SUMMARY:Seminar Cancelled
DESCRIPTION:Sarah Fortune\, M.D.\, professor of  Immunology and Infectious Diseases Chair\, HSPH
URL:https://cvvr.hms.harvard.edu/event/seminar-23/
LOCATION:Beth Israel Deaconess Medical Center\, Leventhal Conference Room\, 330 Brookline Avenue\, Boston\, MA\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200327T133000
DTEND;TZID=America/New_York:20200327T143000
DTSTAMP:20200320T161507Z
CREATED:20200123T203031Z
LAST-MODIFIED:20200320T161507Z
UID:3888-1585315800-1585319400@cvvr.hms.harvard.edu
SUMMARY:Seminar Cancelled
DESCRIPTION:Caroline Junqueira\, Ph.D. Research Associates at Lieberman Lab\, Harvard Medical School \n  \n 
URL:https://cvvr.hms.harvard.edu/event/seminar-16/
LOCATION:Beth Israel Deaconess Medical Center\, Leventhal Conference Room\, 330 Brookline Avenue\, Boston\, MA\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200313T150000
DTEND;TZID=America/New_York:20200313T160000
DTSTAMP:20200320T162212Z
CREATED:20200303T160218Z
LAST-MODIFIED:20200320T162212Z
UID:4670-1584111600-1584115200@cvvr.hms.harvard.edu
SUMMARY:Cancelled: Integration of high dimensional flow cytometry\, transcriptomics and metabolomics to define the innate and adaptive immune response to chronic HIV infection\, HIV reservoir and cancers
DESCRIPTION:Susan Ribeiro\, Ph.D.\, Case Western Reserve University
URL:https://cvvr.hms.harvard.edu/event/integration-of-high-dimensional-flow-cytometry-transcriptomics-and-metabolomics-to-define-the-innate-and-adaptive-immune-response-to-chronic-hiv-infection-hiv-reservoir-and-cancers/
LOCATION:Center for Life Sciences\, Room 1021\, 330 Brookline Avenue\, Boston\, MA\, United States
CATEGORIES:YIC Meeting
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200313T133000
DTEND;TZID=America/New_York:20200313T143000
DTSTAMP:20200303T160353Z
CREATED:20200205T171643Z
LAST-MODIFIED:20200303T160353Z
UID:4090-1584106200-1584109800@cvvr.hms.harvard.edu
SUMMARY:Seminar
DESCRIPTION:Susan Ribeiro\, Ph.D.\, Case Western Reserve University
URL:https://cvvr.hms.harvard.edu/event/seminar-22/
LOCATION:Beth Israel Deaconess Medical Center\, Leventhal Conference Room\, 330 Brookline Avenue\, Boston\, MA\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200311T103000
DTEND;TZID=America/New_York:20200311T110000
DTSTAMP:20200311T221010Z
CREATED:20200228T184037Z
LAST-MODIFIED:20200311T221010Z
UID:4653-1583922600-1583924400@cvvr.hms.harvard.edu
SUMMARY:CROI 2020: HUMAN NK CELLS DEVELOP ANTIGEN-SPECIFIC IMMUNOLOGICAL MEMORY OF HIV
DESCRIPTION:Stephanie Jost\, Ph.D\, Principal Investigator at CVVR
URL:https://cvvr.hms.harvard.edu/event/croi-2020-human-nk-cells-develop-antigen-specific-immunological-memory-of-hiv/
LOCATION:Hynes Convention Center\, 900 Boylston Street\, Boston\, MA\, 02115
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200310T143000
DTEND;TZID=America/New_York:20200310T160000
DTSTAMP:20200228T161209Z
CREATED:20200228T161152Z
LAST-MODIFIED:20200228T161209Z
UID:4648-1583850600-1583856000@cvvr.hms.harvard.edu
SUMMARY:CROI 2020: PGT121 AND VESATOLIMOD IN CHRONICALLY TREATED SHIV-INFECTED RHESUS MONKEYS
DESCRIPTION:Joseph Nkolola\, Ph.D. \, Staff Sciencist at CVVR
URL:https://cvvr.hms.harvard.edu/event/croi2020-pgt121-and-vesatolimod-in-chronically-treated-shiv-infected-rhesus-monkeys/
LOCATION:Hynes Convention Center\, 900 Boylston Street\, Boston\, MA\, 02115
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200309T133000
DTEND;TZID=America/New_York:20200309T143000
DTSTAMP:20200225T192322Z
CREATED:20200213T202858Z
LAST-MODIFIED:20200225T192322Z
UID:4436-1583760600-1583764200@cvvr.hms.harvard.edu
SUMMARY:CROI 2020: Sharpening the Cutting Edge: Additions to the Molecular Virology Toolkit
DESCRIPTION:Alan N. Engelman\, Ph.D.\, Professor of Medicine\, Harvard Medical School
URL:https://cvvr.hms.harvard.edu/event/sharpening-the-cutting-edge-additions-to-the-molecular-virology-toolkit/
LOCATION:Hynes Convention Center\, 900 Boylston Street\, Boston\, MA\, 02115
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200306T133000
DTEND;TZID=America/New_York:20200306T143000
DTSTAMP:20200302T140640Z
CREATED:20200302T140540Z
LAST-MODIFIED:20200302T140640Z
UID:4666-1583501400-1583505000@cvvr.hms.harvard.edu
SUMMARY:The Immunogenicity of mRNA Vaccines for HIV-1
DESCRIPTION:Makda Gebre\, Ph.D. Candidate\, Virology Ph.D. Program\, HMS\, CVVR\, BIDMC
URL:https://cvvr.hms.harvard.edu/event/the-immunogenicity-of-mrna-vaccines-for-hiv-1/
LOCATION:Beth Israel Deaconess Medical Center\, Leventhal Conference Room\, 330 Brookline Avenue\, Boston\, MA\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200228T133000
DTEND;TZID=America/New_York:20200228T143000
DTSTAMP:20200224T202059Z
CREATED:20200115T190613Z
LAST-MODIFIED:20200224T202059Z
UID:3440-1582896600-1582900200@cvvr.hms.harvard.edu
SUMMARY:“HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells”
DESCRIPTION:Jeremy Luban\, M.D.\, Professor at UMASS Medical School
URL:https://cvvr.hms.harvard.edu/event/seminar-14/
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR