James B. Whitney

James B. Whitney, Ph.D.

James B. Whitney, Ph.D.

Principal Investigator
Whitney Laboratory

Assistant Professor of Medicine, Harvard Medical School; Associate Member, Ragon Institute of MGH, MIT, and Harvard

jwhitne2@bidmc.harvard.edu
T: 617-667-2042
F: 617-667-8210

Education

  • University of Manitoba, Winnipeg, Canada, Bsc., 1997 (Microbiology)
  • McGill University, Montreal, Canada, Ph.D., 2004 (Virology)

Training

  • 2004-2006, CIHR Fellow, Division of Cancer Immunology and AIDS, Dana-Farber Cancer Institute
  • 2006-2008, Senior Fellow, Division of Viral Pathogenesis, BIDMC

Appointments

  • 2009-present, Staff Scientist, Center for Virology and Vaccine Research, BIDMC
  • 2011-2014, Instructor in Medicine, Harvard Medical School
  • 2014-present, Assistant Professor of Medicine, Harvard Medical School
  • 2014-present, Associate Member, Ragon Institute of MGH, MIT, and Harvard

Honors

  • 2000, 7th Conference on Retroviruses and Opportunistic Infections Scholarship.
  • 2000, Graduate Student Travel Award, Shire Biochem Pharmaceuticals.
  • 2000, McGill Alma Mater graduate award.
  • 2001, Canadian Institutes of Health Research (CIHR) Doctoral Fellowship (3 yrs).
  • 2001, 8th Conference on Retroviruses and Opportunistic Infections Scholarship.
  • 2001, 1st International AIDS Society Conference on HIV Pathogenesis Scholarship.
  • 2002, 9th Conference on Retroviruses and Opportunistic Infections Scholarship.
  • 2002, McGill Alma Mater graduate award.
  • 2003, 2nd International AIDS Society Conference Scholarship.
  • 2003, 10th Conference on Retroviruses and Opportunistic Infections Scholarship.
  • 2004, Canadian Institutes of Health Research (CIHR) Fellowship (3 yrs).
  • 2011, Nonhuman Primate Models for AIDS, 29th Annual Symposium Young Investigator Award

Publications

  • Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB. Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature. 2018 Sep;561(7723):E20-E28. doi: 10.1038/s41586-018-0495-2. Epub 2018 Sep 19. Erratum in: Nature. 2018 Nov;563(7733):E33. PMID: 30232424; PMCID: PMC6528470. [Article]

  • Li H, Hai Y, Lim SY, Toledo N, Crecente-Campo J, Schalk D, Li L, Omange RW, Dacoba TG, Liu LR, Kashem MA, Wan Y, Liang B, Li Q, Rakasz E, Schultz-Darken N, Alonso MJ, Plummer FA, Whitney JB, Luo M. Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques. PLoS One. 2018 Aug 28;13(8):e0202997. doi: 10.1371/journal.pone.0202997. PMID: 30153293; PMCID: PMC6112674. [Article]

  • Whitney JB, Lim SY, Osuna CE, Kublin JL, Chen E, Yoon G, Liu PT, Abbink P, Borducci EN, Hill A, Lewis MG, Geleziunas R, Robb ML, Michael NL, Barouch DH. Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy. Nat. Commun. 2018; 9:5429. [Article]

  • Bhattacharyya M, Whitney JB, Seaman M, Barouch DH, Penaloza-MacMaster P. T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection. Immunology 2018; 155:458-466. [Article]

  • Gabriela M. Webb, Shengbin Li, Gwantwa Mwakalundwa, Joy M. Folkvord, Justin M. Greene, Jason S. Reed, Jeffery J. Stanton, Alfred W. Legasse, Theodore Hobbs, Lauren D. Martin, Byung S. Park, James B. Whitney, Emily K. Jeng, Hing C. Wong, Douglas F. Nixon, R. Brad Jones, Elizabeth Connick, Pamela J. Skinner, Jonah B. Sacha; The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles. Blood Adv 2018; 2 (2): 76–84. [Article]

  • Lim SY, Osuna CE, Hraber PT, Hesselgesser J, Gerold JM, Barnes TL, Sanisetty S, Seaman MS, Lewis MG, Geleziunas R, Miller MD, Cihlar T, Lee WA, Hill AL, Whitney JB. TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. Sci Transl Med. 2018 May 2;10(439). [Article]

  • Kublin JL, Whitney JB. Zika virus research models. Virus Res. 2018 Aug 2;254:15-20. doi: 10.1016/j.virusres.2017.07.025. Epub 2017 Aug 12. PMID: 28811170; PMCID: PMC5809325. [Article]

  • Li H, Omange RW, Czarnecki C, Correia-Pinto JF, Crecente-Campo J, Richmond M, Li L, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, Luo M. Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection. J Med Primatol. 2017 Aug;46(4):137-143. doi: 10.1111/jmp.12300. PMID: 28748659; PMCID: PMC5560087. [Article]

  • Li H, Nykoluk M, Li L, Liu LR, Omange RW, Soule G, Schroeder LT, Toledo N, Kashem MA, Correia-Pinto JF, Liang B, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, Luo M. Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques. PLoS One. 2017 Oct 5;12(10):e0186079. doi: 10.1371/journal.pone.0186079. PMID: 28982126; PMCID: PMC5628977. [Article]

  • Osuna CE, Whitney JB. Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development. J Infect Dis. 2017 Dec 16;216(suppl_10):S928-S934. doi: 10.1093/infdis/jix540. PMID: 29267926; PMCID: PMC5853426. [Article]