Alan Engelman

Alan N. Engelman, Ph.D.

Alan N. Engelman, Ph.D.

Principal Investigator
Engelman Laboratory

Professor of Medicine, Harvard Medical School

alan_engelman@dfci.harvard.edu
T: 617-632-4361
F: 617-632-4338

Education

  • Tufts University, Medford, MA, B.S.Ch.E., 1981 (Chemical Engineering)
  • Tufts University, Medford, MA, M.S., 1985 (Life Science Engineering)
  • Tufts University School of Medicine, Boston, MA, Ph.D., 1990 (Molecular Biology)

Training

  • NIDDK/National Institutes of Health, Bethesda, MD, 1995 (HIV-1 Integration)

Appointments

  • 1995-2001, Assistant Professor, Department of Pathology, Harvard Medical School, Boston, MA
  • 2001-2009, Associate Professor, Department of Pathology, Harvard Medical School, Boston, MA
  • 2009-2012, Associate Professor, Department of Medicine, Harvard Medical School, Boston, MA
  • 2012-present, Professor, Department of Medicine, Harvard Medical School, Boston, MA
  • 2016-2018, Affiliated Faculty, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA
  • 2018-present, Affiliated Faculty, Department of Microbiology, Harvard Medical School, Boston, MA

Hospital Appointments

  • 1995-1996, Assistant Professor of Pathology, Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA
  • 1997-2001, Assistant Professor of Pathology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2001-2009, Associate Professor of Pathology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2009-2012, Associate Professor of Medicine, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2009-2012, Associate Professor of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2012-2015, Professor of Medicine, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2012, Professor of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2013-present, Professor of Medicine, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-present, Professor of Medicine, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA

Honors

  • 1995, R-AXIS Golden Crystal Award, 2nd place, Molecular Structure Corporation, The Woodlands, TX
  • 2010, MERIT Award, NIAID/NIH
  • 2012, Master of Arts, Honoris Causa, Harvard University
  • 2014, Keynote Speaker, 5th International Conference on Retroviral Integration, Asilomar, California
  • 2014, Elected Fellow, American Association for the Advancement of Science
  • 2016, Elected Fellow, American Academy of Microbiology

Publications

  • Li M, Chen X, Wang H, Jurado KA, Engelman AN, Craigie R. A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies. J Mol Biol 2020 Feb 13. pii: S0022-2836(20)30106-6. doi: 10.1016/j.jmb.2020.01.040. [Epub ahead of print]. PubMed PMID: 32061936. [Article]

  • Cook NJ, Li W, Berta D, Badaoui D, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Structural basis of second-generation inhibitor action and viral resistance. Science 2020 Feb 14;367(6479):806-10. doi: 10.1126/science.aay4919. Epub 2020 Jan 30. PubMed PMID: 32001525. [Article]

  • Zhang DW, Luo RH, Xu L, Yang L-M, Xu X-S, Bedwell GJ, Engelman AN, Zheng Y-T, Chang S. A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-terminal domain of capsid. Antiviral Res 2019 Sep;169:104544. doi: 10.1016/j.antiviral.2019.104544. Epub 2019 Jun 27. PubMed PMID: 31254557. [Article]

  • Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206. Epub 2019 Mar 27. PubMed PMID: 30916345; PubMed Central PMCID: PMC6511849. [Article]

  • Loyola L, Achuthan V, Gilroy K, Borland G, Kilbey A, Mackay N, Bell M, Hay J, Aiyer S, Fingerman D, Villanueva RA, Cameron E, Kozak CA, Engelman AN, Neil J, Roth MJ. Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathog 2019 Dec 9;15(12):e1008154. doi: 10.1371/journal.ppat.1008154. eCollection 2019 Dec. PubMed PMID: 31815961. PubMed Central PMCID: 6974304.

  • Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C. Dominant negative MA-CA fusion protein is incorporated into HIV-1 cores and inhibits nuclear entry of viral preintegration complexes. J Virol 2019 Oct 15;93(21). pii: e01118-19. doi: 10.1128/JVI.01118-19. Print 2019 Nov 1. Epub 2019 Aug 14. PubMed PMID: 31413124; PubMed Central PMCID: _.

  • Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344. PubMed PMID: 31120420; PubMed Central PMCID: PMC6581505. [Article]

  • Engelman, AN. Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition. J Biol Chem 2019 Oct 11;294(41):15137-57. doi: 10.1074/jbc.REV119.006901. Epub 2019 Aug 29. PubMed PMID: 31467082; PubMed Central PMCID: PMC6791320. [Article]

  • Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 interaction licenses nuclear HIV-1 trafficking to sites of viral DNA integration. Cell Host Microbe 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30. PubMed PMID: 30173955; PubMed Central PMCID: PMC6368089. [Article]

  • Engelman AN, Singh PK. Cellular and molecular mechanisms of HIV-1 integration targeting. Cell Mol Life Sci 2018 July;75(14):2491-507. doi: 10.1007/s00018-018-2772-5. Epub 2018 Feb 7. PubMed PMID: 29417178; PubMed Central PMCID: PMC6004233. [Article]