Alan Engelman

Alan N. Engelman, Ph.D.

Alan N. Engelman, Ph.D.

Principal Investigator
Engelman Laboratory

Professor of Medicine, Harvard Medical School

alan_engelman@dfci.harvard.edu
T: 617-632-4361
F: 617-632-4338

Education

  • Tufts University, Medford, MA, B.S.Ch.E., 1981 (Chemical Engineering)
  • Tufts University, Medford, MA, M.S., 1985 (Life Science Engineering)
  • Tufts University School of Medicine, Boston, MA, Ph.D., 1990 (Molecular Biology)

Training

  • NIDDK/National Institutes of Health, Bethesda, MD, 1995 (HIV-1 Integration)

Appointments

  • 1995-2001, Assistant Professor, Department of Pathology, Harvard Medical School, Boston, MA
  • 2001-2009, Associate Professor, Department of Pathology, Harvard Medical School, Boston, MA
  • 2009-2012, Associate Professor, Department of Medicine, Harvard Medical School, Boston, MA
  • 2012-present, Professor, Department of Medicine, Harvard Medical School, Boston, MA
  • 2016-2018, Affiliated Faculty, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA
  • 2018-present, Affiliated Faculty, Department of Microbiology, Harvard Medical School, Boston, MA

Hospital Appointments

  • 1995-1996, Assistant Professor of Pathology, Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA
  • 1997-2001, Assistant Professor of Pathology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2001-2009, Associate Professor of Pathology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2009-2012, Associate Professor of Medicine, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2009-2012, Associate Professor of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2012-2015, Professor of Medicine, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2012, Professor of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2013-present, Professor of Medicine, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-present, Professor of Medicine, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA

Honors

  • 1995, R-AXIS Golden Crystal Award, 2nd place, Molecular Structure Corporation, The Woodlands, TX
  • 2010, MERIT Award, NIAID/NIH
  • 2012, Master of Arts, Honoris Causa, Harvard University
  • 2014, Keynote Speaker, 5th International Conference on Retroviral Integration, Asilomar, California
  • 2014, Elected Fellow, American Association for the Advancement of Science
  • 2016, Elected Fellow, American Academy of Microbiology

Publications

  • Singh PK, Bedwell GJ, Engelman AN. Spatial and Genomic Correlates of HIV-1 Integration Site Targeting. Cells. 2022 Feb 14;11(4):655. doi: 10.3390/cells11040655. PMID: 35203306; PMCID: PMC8869898.   [Article]

  • Bedwell GJ, Jang S, Li W, Singh PK, Engelman AN. rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo. Nucleic Acids Res. 2021 Jul 21;49(13):7330-7346. doi: 10.1093/nar/gkab514. PMID: 34165568; PMCID: PMC8287940. [Article]

  • Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Jul 14;11(1):3505. doi: 10.1038/s41467-020-17256-8. Erratum in: Nat Commun. 2020 Nov 26;11(1):6165. PMID: 32665593; PMCID: PMC7360574. [Article]

  • Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. PMID: 33060363; PMCID: PMC7831379. [Article]

  • Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. mBio. 2020 Sep 29;11(5):e02254-20. doi: 10.1128/mBio.02254-20. PMID: 32994325; PMCID: PMC7527728. [Article]

  • Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Nov 26;11(1):6165. doi: 10.1038/s41467-020-20152-w. Erratum for: Nat Commun. 2020 Jul 14;11(1):3505. PMID: 33244008; PMCID: PMC7692523. [Article]

  • Li M, Chen X, Wang H, Jurado KA, Engelman AN, Craigie R. A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies. J Mol Biol 2020 Feb 13. pii: S0022-2836(20)30106-6. doi: 10.1016/j.jmb.2020.01.040. [Epub ahead of print]. PubMed PMID: 32061936. [Article]

  • Cook NJ, Li W, Berta D, Badaoui D, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Structural basis of second-generation inhibitor action and viral resistance. Science 2020 Feb 14;367(6479):806-10. doi: 10.1126/science.aay4919. Epub 2020 Jan 30. PubMed PMID: 32001525. [Article]

  • Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res. 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206. PMID: 30916345; PMCID: PMC6511849. [Article]

  • Zhang DW, Luo RH, Xu L, Yang L-M, Xu X-S, Bedwell GJ, Engelman AN, Zheng Y-T, Chang S. A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-terminal domain of capsid. Antiviral Res 2019 Sep;169:104544. doi: 10.1016/j.antiviral.2019.104544. Epub 2019 Jun 27. PubMed PMID: 31254557. [Article]