Alan Engelman

Alan N. Engelman, Ph.D.

Alan N. Engelman, Ph.D.

Principal Investigator
Engelman Laboratory

Professor of Medicine, Harvard Medical School

alan_engelman@dfci.harvard.edu
T: 617-632-4361
F: 617-632-4338

Education

  • Tufts University, Medford, MA, B.S.Ch.E., 1981 (Chemical Engineering)
  • Tufts University, Medford, MA, M.S., 1985 (Life Science Engineering)
  • Tufts University School of Medicine, Boston, MA, Ph.D., 1990 (Molecular Biology)

Training

  • NIDDK/National Institutes of Health, Bethesda, MD, 1995 (HIV-1 Integration)

Appointments

  • 1995-2001, Assistant Professor, Department of Pathology, Harvard Medical School, Boston, MA
  • 2001-2009, Associate Professor, Department of Pathology, Harvard Medical School, Boston, MA
  • 2009-2012, Associate Professor, Department of Medicine, Harvard Medical School, Boston, MA
  • 2012-present, Professor, Department of Medicine, Harvard Medical School, Boston, MA
  • 2016-2018, Affiliated Faculty, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA
  • 2018-present, Affiliated Faculty, Department of Microbiology, Harvard Medical School, Boston, MA

Hospital Appointments

  • 1995-1996, Assistant Professor of Pathology, Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA
  • 1997-2001, Assistant Professor of Pathology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2001-2009, Associate Professor of Pathology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2009-2012, Associate Professor of Medicine, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2009-2012, Associate Professor of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2012-2015, Professor of Medicine, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA
  • 2012, Professor of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2013-present, Professor of Medicine, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-present, Professor of Medicine, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA

Honors

  • 1995, R-AXIS Golden Crystal Award, 2nd place, Molecular Structure Corporation, The Woodlands, TX
  • 2010, MERIT Award, NIAID/NIH
  • 2012, Master of Arts, Honoris Causa, Harvard University
  • 2014, Keynote Speaker, 5th International Conference on Retroviral Integration, Asilomar, California
  • 2014, Elected Fellow, American Association for the Advancement of Science
  • 2016, Elected Fellow, American Academy of Microbiology

Publications

  • Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Viral and host mediators of non-suppressible HIV-1 viremia. Nat Med. 2023 Dec;29(12):3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. PMID: 37957382; PMCID: PMC10719098. [Article]

  • Irie WC, Chitneni P, Glynn TR, Allen W, Chai PR, Engelman AN, Hurtado R, Li JZ, Li P, Lockman S, Marcus JL, Ogunshola FJ, Rönn MM, Haberer J, Ghebremichael M, Ciaranello A; Harvard University Center for AIDS Research Diversity, Equity, and Inclusion Working Group. Pathways and Intersections: Multifaceted Approaches to Engage Individuals From Underrepresented and Marginalized Communities in HIV Research and Career Development. J Acquir Immune Defic Syndr. 2023 Oct 1;94(2S):S116-S121. doi: 10.1097/QAI.0000000000003265. PMID: 37707858; PMCID: PMC10503030. [Article]

  • Jang S, Engelman AN. Capsid-host interactions for HIV-1 ingress. Microbiol Mol Biol Rev. 2023 Dec 20;87(4):e0004822. doi: 10.1128/mmbr.00048-22. Epub 2023 Sep 26. PMID: 37750702; PMCID: PMC10732038. [Article]

  • Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2202815120. doi: 10.1073/pnas.2202815120. Epub 2023 Mar 21. PMID: 36943880; PMCID: PMC10068764. [Article]

  • Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nat Struct Mol Biol. 2023 Apr;30(4):425-435. doi: 10.1038/s41594-023-00925-9. Epub 2023 Feb 20. PMID: 36807645; PMCID: PMC10121901. [Article]

  • Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio. 2023 Feb 28;14(1):e0356022. doi: 10.1128/mbio.03560-22. Epub 2023 Feb 6. PMID: 36744954; PMCID: PMC9973045. [Article]

  • Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman AN. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022; 14(9):1883. https://doi.org/10.3390/v14091883 [Article]

  • Singh PK, Bedwell GJ, Engelman AN. Spatial and Genomic Correlates of HIV-1 Integration Site Targeting. Cells. 2022 Feb 14;11(4):655. doi: 10.3390/cells11040655. PMID: 35203306; PMCID: PMC8869898.   [Article]

  • Bedwell GJ, Jang S, Li W, Singh PK, Engelman AN. rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo. Nucleic Acids Res. 2021 Jul 21;49(13):7330-7346. doi: 10.1093/nar/gkab514. PMID: 34165568; PMCID: PMC8287940. [Article]

  • Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Jul 14;11(1):3505. doi: 10.1038/s41467-020-17256-8. Erratum in: Nat Commun. 2020 Nov 26;11(1):6165. PMID: 32665593; PMCID: PMC7360574. [Article]