Keith Reeves

R. Keith Reeves, Ph.D.

R. Keith Reeves, Ph.D.

Principal Investigator and Adjunct

Professor and Director, Duke University Center for Human Systems Immunology

Adjunct Professor, Center for Virology and Vaccine Research


  • MS State University, Starkville, MS, B.S., 2002 (Microbiology)
  • University of Alabama Medical School, Birmingham, AL, Ph.D., 2007 (Virology)


  • 2007-2014, Postdoctoral Research Fellow in Medicine, New England Primate Research Center, Harvard Medical School


  • 2011 – 2013, Instructor in Medicine, Harvard Medical School, NEPRC
  • 2013, Instructor in Medicine, Beth Israel Deaconess Medical Center
  • 2013 –  present, Adjunct Assistant Professor, Department of Pathology, Emory University
  • 2014 – present, Assistant Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center
  • 2021 – present, Professor of Surgery, Duke University School of Medicine
  • 2021 – present, Professor of Pathology, Duke University School of Medicine
  • 2021 – present, Director, Center for Human Systems Immunology, Duke University School of Medicine
  • 2021 – present, Adjunct Professor, Center for Virology and Vaccine Research


  • 2000, H. H. Harned Memorial Award/Scholarship for Most Outstanding Undergraduate Student in Microbiology, MSU
  • 2002-2003, E. B. Carmichael Scholar – One chosen annually from all University of Alabama at Birmingham graduate students in biomedical disciplines
  • 2003-2007, NIH Predoctoral Fellowship – Basic Mechanisms in Virology
  • 2006, Raymond N. Hiramoto Award in Microbiology, University of Alabama at Birmingham
  • 2008, Early Career Investigator, OCTAVE Mucosal Immunity and Vaccine Design, Cape Town, South Africa
  • 2008, Young Investigator Award, 26th Annual Nonhuman Primate Models for AIDS Symposium, San Juan, Puerto Rico
  • 2009, Early Stage Investigator Award, CHAVI/HVTN
  • 2009, Young Investigator Award, 16th Annual Conference on Retroviruses and Opportunistic Infections, Montreal, Quebec, CAN
  • 2009, Keystone Symposia Scholarship, Prevention of HIV/AIDS, Keystone, Colorado
  • 2010, Young Investigator Award, 17th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, CA
  • 2011, Early Stage Investigator Award, CHAVI/HVTN
  • 2011, Conference Scholarship, AIDS Vaccine, Bangkok, Thailand
  • 2012, Early Career Grant, AAI


  • Wilson SM, Woolley G, Hawn C, Hoffman K, Jones AD, Chan C, Mudrak SV, Qureshi MU, Ward A, Knippler ET, Okeke NL, Corneli A, Tomaras GD, Reeves RK. Intersectional climate justice, health equity, and HIV. Lancet HIV. 2024 May;11(5):e280-e281. doi: 10.1016/S2352-3018(24)00062-6. Epub 2024 Apr 3. PMID: 38582097. [Article]

  • Jost S, Lucar O, Lee E, Yoder T, Kroll K, Sugawara S, Smith S, Jones R, Tweet G, Werner A, Tomezsko PJ, Dugan HL, Ghofrani J, Rascle P, Altfeld M, Müller-Trutwin M, Goepfert P, Reeves RK. Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis. Sci Immunol. 2023 Dec 8;8(90):eadi3974. doi: 10.1126/sciimmunol.adi3974. Epub 2023 Dec 8. PMID: 38064568. [Article]

  • Huot N, Planchais C, Rosenbaum P, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Beaumont E, Orta-Resendiz A, Rey FA, Reeves RK, Le Grand R, Mouquet H, Müller-Trutwin M. SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells. Nat Immunol. 2023 Dec;24(12):2068-2079. doi: 10.1038/s41590-023-01661-4. Epub 2023 Nov 2. PMID: 37919524; PMCID: PMC10681903. [Article]

  • Cooper, A., Sidaway, A., Chandrashekar, A., Latta, E., Chakraborty, K., Yu, J., McMahan, K., Giffin, V., Manickam, C., Kroll, K., Mosher, M., Reeves, R. K., Gam, R., Arthofer, E., Choudhry, M., Henley, T., & Barouch, D. H. (2022). A genetically engineered, stem-cell-derived cellular vaccine. Cell reports. Medicine3(12), 100843.   [Article]

  • Jones R, Kroll K, Broedlow C, Schifanella L, Smith S, Hueber B, Shah SV, Ram DR, Manickam C, Varner V, Klatt NR, Reeves RK. Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection. Sci Rep. 2021 Jul 15;11(1):14507. doi: 10.1038/s41598-021-93918-x. PMID: 34267278; PMCID: PMC8282626.

  • [Article]

  • Aid, M., Ram, D. R., Bosinger, S. E., Barouch, D. H., & Reeves, R. K. (2020). Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections. Frontiers in Cellular and Infection Microbiology10. doi: 10.3389/fcimb.2020.00194 [Article]

  • Hueber, B., Curtis, A. D., Kroll, K., Varner, V., Jones, R., Pathak, S., … Reeves, R. K. (2020). Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques. Journal of Virology94(5). doi: 10.1128/jvi.01644-19 [Article]

  • Manickam C, Reeves RK. Silent damage? Occult HCV replication and histological disease may occur following apparent HCV clearance. EBioMedicine. 2019;47:12-13. doi:10.1016/j.ebiom.2019.08.029. [Article]

  • Lucar, O., Reeves, R.K., and Jost, S. 2019 A natural impact: NK cells at the intersection of cancer and HIV disease. Front. Immunol. 10:1850. PMID: 31474977. PMCID: PMC6705184