R. Keith Reeves, Ph.D.

Principal Investigator and Adjunct

Professor and Director, Duke University Center for Human Systems Immunology

Adjunct Professor, Center for Virology and Vaccine Research

keith.reeves@duke.edu

2007-2014, Postdoctoral Research Fellow in Medicine, New England Primate Research Center, Harvard Medical School

2011 – 2013, Instructor in Medicine, Harvard Medical School, NEPRC
2013, Instructor in Medicine, Beth Israel Deaconess Medical Center
2013 – present, Adjunct Assistant Professor, Department of Pathology, Emory University
2014 – 2021, Assistant Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center
2021 – present, Professor of Surgery, Duke University School of Medicine
2021 – present, Professor of Pathology, Duke University School of Medicine
2021 – present, Director, Center for Human Systems Immunology, Duke University School of Medicine
2021 – present, Adjunct Professor, Center for Virology and Vaccine Research

2000, H. H. Harned Memorial Award/Scholarship for Most Outstanding Undergraduate Student in Microbiology, MSU
2002-2003, E. B. Carmichael Scholar – One chosen annually from all University of Alabama at Birmingham graduate students in biomedical disciplines
2003-2007, NIH Predoctoral Fellowship – Basic Mechanisms in Virology
2006, Raymond N. Hiramoto Award in Microbiology, University of Alabama at Birmingham
2008, Early Career Investigator, OCTAVE Mucosal Immunity and Vaccine Design, Cape Town, South Africa
2008, Young Investigator Award, 26th Annual Nonhuman Primate Models for AIDS Symposium, San Juan, Puerto Rico
2009, Early Stage Investigator Award, CHAVI/HVTN
2009, Young Investigator Award, 16th Annual Conference on Retroviruses and Opportunistic Infections, Montreal, Quebec, CAN
2009, Keystone Symposia Scholarship, Prevention of HIV/AIDS, Keystone, Colorado
2010, Young Investigator Award, 17th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, CA
2011, Early Stage Investigator Award, CHAVI/HVTN
2011, Conference Scholarship, AIDS Vaccine, Bangkok, Thailand
2012, Early Career Grant, AAI

Ram DR, Gopalakrishnan RM, Aid M, Kroll K, Miftahof J, Aristizabal O, Gikundiro EK, Davis C, Hefti MM, Fiock KL, Tilahun B, Umutoniwase Y, Loidolt K, Fennessey CM, Mercado NB, Harper-Alexander V, Jones R, Woolley G, Varner V, Lifton M, Bosinger SE, Barouch DH, Keele BF, Reeves RK, Tan CS. Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain. Cell Rep Med. 2026 Jan 20;7(1):102567. doi: 10.1016/j.xcrm.2025.102567 [Article]

Terry K, Kroll KW, Jones RA, Reeves RK. Application of a novel branched-DNA assay to quantify killer immunoglobulin-like receptor (KIR) mRNA expression identifies tissue compartmentalization in naïve and SIV-infected rhesus macaques. J Immunol Methods. 2026 Jan;546:114022. doi: 10.1016/j.jim.2025.114022. Epub 2025 Dec 20. PMID: 41429386; PMCID: PMC12840321. [Article]

Manickam C, Jones R, Deb Adhikary NR, Kroll KW, Terry K, Balachandran H, Woolley G, Tomaras GD, Villinger FJ, Reeves RK. Myeloid cell recruitment and activation through systemic and mucosae-directed cytokine therapy. Immunol Cell Biol. 2025 Nov-Dec;103(10):945-956. doi: 10.1111/imcb.70061. Epub 2025 Oct 7. PMID: 41054306; PMCID: PMC12667110. [Article]

Kroll KW, Woolley G, Reeves RK. Building a better natural killer (NK) cell: Fc receptor engineering strategies for NK cell therapeutics. Future Virol. 2025 Oct;20(10):369-371. doi: 10.1080/17460794.2025.2580187. Epub 2025 Oct 29. PMID: 41409329; PMCID: PMC12707376. [Article]

Jones R, Afifi A, Reeves RK, Manickam C. Functional Reprogramming of Peripheral Eosinophils in Lentivirus-Infected Rhesus Macaques. AIDS Research and Human Retroviruses. 2025 Aug;41(8):411-413. doi: 10.1089/aid.2024.0105. Epub 2025 Jun 10. [Article]

Mahyari, E., Boggy, G. J., McElfresh, G. W., Kaza, M., Benjamin, S., Varco-Merth, B., Ojha, S., Feltham, S., Goodwin, W., Nkoy, C., Duell, D., Selseth, A., Bennett, T., Barber-Axthelm, A., Smedley, J. V., Labriola, C. S., Axthelm, M. K., Reeves, R. K., Okoye, A. A., Hansen, S. G., … Bimber, B. N. (2025). Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas. Cell genomics, 5(5), 100849. https://doi.org/10.1016/j.xgen.2025.100849 [Article]

Blass, E., Colarusso, A., Aid, M., Larocca, R. A., Reeves, R. K., & Barouch, D. H. (2025). Early spatiotemporal evolution of the immune response elicited by adenovirus serotype 26 vector vaccination in mice. Journal of virology, 99(5), e0024725. https://doi.org/10.1128/jvi.00247-25 [Article]

Hudson, A., Wu, P., Kroll, K. W., Hueber, B., Woolley, G., Shi, P., & Reeves, R. K. (2025). Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes. Journal of virology, 99(3), e0163424. https://doi.org/10.1128/jvi.01634-24 [Article]

Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, Reeves RK, Wiehe KJ, Pollara J, Tomaras GD, Bradley T, Ferrari G. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity. Pathog Immun. 2025 Jan 23;10(1):49-79. doi: 10.20411/pai.v10i1.734. [Article]

Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, Reeves RK, Wiehe KJ, Pollara J, Tomaras GD, Bradley T, Ferrari G. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity. Pathog Immun. 2025 Jan 23;10(1):49-79. doi: 10.20411/pai.v10i1.734. PMID: 39911143; PMCID: PMC11792536. [Article]