R. Keith Reeves, Ph.D.

Principal Investigator and Adjunct

Professor and Director, Duke University Center for Human Systems Immunology

Adjunct Professor, Center for Virology and Vaccine Research

keith.reeves@duke.edu

2007-2014, Postdoctoral Research Fellow in Medicine, New England Primate Research Center, Harvard Medical School

2011 – 2013, Instructor in Medicine, Harvard Medical School, NEPRC
2013, Instructor in Medicine, Beth Israel Deaconess Medical Center
2013 – present, Adjunct Assistant Professor, Department of Pathology, Emory University
2014 – present, Assistant Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center
2021 – present, Professor of Surgery, Duke University School of Medicine
2021 – present, Professor of Pathology, Duke University School of Medicine
2021 – present, Director, Center for Human Systems Immunology, Duke University School of Medicine
2021 – present, Adjunct Professor, Center for Virology and Vaccine Research

2000, H. H. Harned Memorial Award/Scholarship for Most Outstanding Undergraduate Student in Microbiology, MSU
2002-2003, E. B. Carmichael Scholar – One chosen annually from all University of Alabama at Birmingham graduate students in biomedical disciplines
2003-2007, NIH Predoctoral Fellowship – Basic Mechanisms in Virology
2006, Raymond N. Hiramoto Award in Microbiology, University of Alabama at Birmingham
2008, Early Career Investigator, OCTAVE Mucosal Immunity and Vaccine Design, Cape Town, South Africa
2008, Young Investigator Award, 26th Annual Nonhuman Primate Models for AIDS Symposium, San Juan, Puerto Rico
2009, Early Stage Investigator Award, CHAVI/HVTN
2009, Young Investigator Award, 16th Annual Conference on Retroviruses and Opportunistic Infections, Montreal, Quebec, CAN
2009, Keystone Symposia Scholarship, Prevention of HIV/AIDS, Keystone, Colorado
2010, Young Investigator Award, 17th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, CA
2011, Early Stage Investigator Award, CHAVI/HVTN
2011, Conference Scholarship, AIDS Vaccine, Bangkok, Thailand
2012, Early Career Grant, AAI

Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug;17(4):692-699. doi: 10.1016/j.mucimm.2024.04.003. Epub 2024 Apr 25. PMID: 38677592; PMCID: PMC11323182. [Article]

Balachandran H, Kroll K, Terry K, Manickam C, Jones R, Woolley G, Hayes T, Martinot AJ, Sharma A, Lewis M, Jost S, Reeves RK. NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. PLoS Pathog. 2024 Aug 12;20(8):e1012439. doi: 10.1371/journal.ppat.1012439. PMID: 39133756; PMCID: PMC11341101. [Article]

Balachandran, H., Kroll, K., Terry, K., Manickam, C., Jones, R., Woolley, G., Hayes, T., Martinot, A. J., Sharma, A., Lewis, M., Jost, S., & Reeves, R. K. (2024). NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. PLoS pathogens, 20(8), e1012439. https://doi.org/10.1371/journal.ppat.1012439 [Article]

Sugawara, S., Lee, E., Craemer, M. A., Pruitt, A., Balachandran, H., Gressens, S. B., Kroll, K., Manickam, C., Li, Y., Jost, S., Woolley, G., & Reeves, R. K. (2024). Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1. AIDS research and human retroviruses, 10.1089/AID.2023.0114. Advance online publication. https://doi.org/10.1089/AID.2023.0114 [Article]

Woolley G, Kroll K, Hoffman K, Ward A, Corneli A, Mudrak SV, Qureshi MU, Okeke NL, Chan C, Jones AD, Tomaras GD, Reeves RK. The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk? AIDS Res Hum Retroviruses. 2024 May 27. doi: 10.1089/AID.2024.0050. Epub ahead of print. PMID: 38753709. [Article]

Manickam C, Upadhyay AA, Woolley G, Kroll KW, Terry K, Broedlow CA, Klatt NR, Bosinger SE, Reeves RK. Natural killer like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques. PLoS Pathog. 2024 May 13;20(5):e1012223. doi: 10.1371/journal.ppat.1012223. Epub ahead of print. PMID: 38739675. [Article]

Woolley G, Kroll K, Hoffman K, Ward A, Corneli A, Mudrak SV, Qureshi MU, Okeke NL, Chan C, Jones AD, Tomaras GD, Reeves RK. The Climate Change Burden on Immune Health: Are Persons Living With HIV More at Risk? AIDS Res Hum Retroviruses. 2024 May 16. doi: 10.1089/AID.2024.0050. Epub ahead of print. PMID: 38753709. [Article]

Manickam C, Upadhyay AA, Woolley G, Kroll KW, Terry K, Broedlow CA, Klatt NR, Bosinger SE, Reeves RK. Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques. PLoS Pathog. 2024 May 13;20(5):e1012223. doi: 10.1371/journal.ppat.1012223. PMID: 38739675; PMCID: PMC11115201. [Article]

Wilson SM, Woolley G, Hawn C, Hoffman K, Jones AD, Chan C, Mudrak SV, Qureshi MU, Ward A, Knippler ET, Okeke NL, Corneli A, Tomaras GD, Reeves RK. Intersectional climate justice, health equity, and HIV. Lancet HIV. 2024 May;11(5):e280-e281. doi: 10.1016/S2352-3018(24)00062-6. Epub 2024 Apr 3. PMID: 38582097. [Article]

Jost S, Lucar O, Lee E, Yoder T, Kroll K, Sugawara S, Smith S, Jones R, Tweet G, Werner A, Tomezsko PJ, Dugan HL, Ghofrani J, Rascle P, Altfeld M, Müller-Trutwin M, Goepfert P, Reeves RK. Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis. Sci Immunol. 2023 Dec 8;8(90):eadi3974. doi: 10.1126/sciimmunol.adi3974. Epub 2023 Dec 8. PMID: 38064568. [Article]