Sampa Santra

Sampa Santra, Ph.D.

Sampa Santra, Ph.D.

Principal Investigator
Santra Laboratory

Associate Professor of Medicine, Harvard Medical School

ssantra@bidmc.harvard.edu
T: 617-735-4508
F: 617-735-4527

Education

  • 1984, University of Calcutta, Calcutta, India, B.Sc., Zoology
  • 1986, University of Calcutta, Calcutta, India, M.Sc., Zoology
  • 1998, University of Calcutta, Calcutta, India, B. Education, Education
  • 1996, Indiana State University, Terre Haute, Indiana, Ph.D., Microbiology

Training

  • 1997-2000, Beth Israel Deaconess Medical Center, Postdoctoral Fellowship, Division of Viral Pathogenesis

Appointments

  • 1997 – 2000, Research Fellow, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2000 – present, Staff PhD, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA
  • 2000 – 2007, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2007 – 2015, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 2015 – present, Associate Professor of Medicine, Harvard Medical School, Boston, MA

Honors

  • 1980, National Merit Scholarship, Government of India
  • 1985, Merit Scholarship, University of Calcutta, India
  • 1994, Academic Excellence Scholarship, Altrusa, Terre Haute, IN Chapter
  • 1995, Academic Excellence Scholarship, Altrusa, Terre Haute, IN Chapter
  • 1996, Educational Excellence Award for Graduate Teaching, Indiana State University

Publications

  • Chamcha V, Reddy PBJ, Kannanganat S, Wilkins C, Gangadhara S, Velu V, Green R, Law GL, Chang J, Bowen JR, Kozlowski PA, Lifton M, Santra S, Legere T, Chea LS, Chennareddi L, Yu T, Suthar MS, Silvestri G, Derdeyn CA, Gale M Jr, Villinger F, Hunter E, Amara RR. Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy. 2019. Sci Trans Med. 11:519.

  • Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J. A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge. 2018; Nat Commun; 9(1):2363. [Article]

  • Blasi M, Negri D, LaBranche C, Alam SM, Baker EJ, Brunner EC, Gladden MA, Michelini Z, Vandergrift NA, Wiehe KJ, Parks R, Shen X, Bonsignori M, Tomaras GD, Ferrari G, Montefiori DC, Santra S, Haynes BF, Moody MA, Cara A, Klotman ME. IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells. 2018. Commun Biol. 1:134. [Article]

  • Saunders KO, Santra S, Parks R, Yates NL, Sutherland LL, Scearce RM, Balachandran H, Bradley T, Goodman D, Eaton A, Stanfield-Oakley SA, Tartaglia J, Phogat S, Pantaleo G, Esteban M, Gomez CE, Perdiguero B, Jacobs B, Kibler K, Korber B, Montefiori DC, Ferrari G, Vandergrift N, Liao HX, Tomaras GD, Haynes BF. Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates. 2018; J. Virol. 92(8). [Article]

  • Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L. Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. 2017. Nat Commun. 8(1):1732. [Article]

  • Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, Georgiev IS, Joyce MG, Tomaras GD, Bonsignori M, Reed SG, Salazar A, Mascola JR, Moody MA, Cain DW, Centlivre M, Zurawski S, Zurawski G, Erickson HP, Kwong PD, Alam SM, Levy Y, Montefiori DC, Haynes BF. Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. 2017; Cell Rep. 21(13):3681-3690. [Article]

  • Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski J. Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J Virol. 2016 May 15; 90(10):5031-46. [Article]

  • Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM. Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. 2016. Proc. Natl. Acad. Sci. USA. 113(24):E3413-3422. [Article]

  • Chamcha V, Kannanganat S, Gangadhara S, Nabi R, Kozlowski PA, Montefiori DC, LaBranche CC, Wrammert J, Keele BF, Balachandran H, Sahu S, Lifton M, Santra S, Basu R, Moss B, Robinson HL, Amara RR. Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine. Open Forum Infect Dis. 2016 Jan; 3(1):ofw034. [Article]

  • Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Parks R, Eaton A, Foulger A, Nie X, Karim SS, Barnett S, Kelsoe G, Kepler TB, Alam SM, Montefiori DC, Moody MA, Liao HX, Morris L, Santra S, Harrison SC, Haynes BF. Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep. 2016 Jan 5; 14(1):43-54. PMID: 26725118. [Article]