Michael Seaman, Ph.D.

Principal Investigator
Seaman Laboratory

Associate Professor of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School

mseaman@bidmc.harvard.edu
T: 617-735-4449
F: 617-735-4540

University of Washington, Seattle, WA, B.S., 1992 (Microbiology)
University of Texas Southwestern Medical Center, Dallas, TX, Ph.D., 2000 (Immunology)

Research Fellow, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA, 2004 (Immunology)

1992-1994, Research Assistant I and II, Department of Immunobiology, Immunex Corporation, Seattle, WA
2004-2007, Instructor in Medicine, Harvard Medical School, Boston, MA
2007-2017, Assistant Professor of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
2017- present, Associate Professor of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

1996-1999, NRSA Predoctoral Trainee, NIH #5 T32 CA09082
2000-2002, NRSA Fellow, Postdoctoral Training Program in AIDS Research (Dana-Farber Cancer Institute, NIH #5 T32 AI07386)
2008, Network Citizenship Award, NIH HIV Vaccine Trials Network (HVTN)
2012, Young/Early Career Investigator Award, Collaboration for AIDS Vaccine Development (CAVD)

Walker-Sperling VEK, Nkolola J, Liu J, Aid M, Julg B, Seaman MS, Barouch DH. Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques. Nat Commun. 2025 Dec 18;16(1):11226. doi: 10.1038/s41467-025-66321-7. PMID: 41413011; PMCID: PMC12714793. [Article]

Jons CK, Kasse CM, Mayer BT, Hyrien O, Sen S, Meany EL, d'Aquino AI, Ganesh P, Eckman N, Dong C, Yan J, Nguyen LT, Doulames VM, Song YE, Saouaf OM, Williams CM, Williams SC, Paredes J, Raghavan R, Palomares M, Alpert M, Yates NL, Tomaras GD, Seaman MS, Farzan M, Appel EA. Hydrogel formulations for sustained-release of broadly neutralizing antibodies. J Control Release. 2025 Dec 10;388(Pt 2):114349. doi: 10.1016/j.jconrel.2025.114349. Epub 2025 Oct 31. PMID: 41177463; PMCID: PMC12659352. [Article]

Ryan S. Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell, Mattia Bonsignori, Yicheng Guo, Michael P. Hogarty, Adam S. Olia, Kirsten J. Sowers, Baoshan Zhang, Frederic Bibollet-Ruche, Tatsiana Bylund, Sean Callaghan, John W. Carey, Gabriele Cerutti, Darcy R. Harris, Wanting He, Emily Lewis, Tracy Liu, Rosemarie D. Mason, Yujie Qiao, Younghoon Park, Juliette M. Rando, Ajay Singh, Jeremy J. Wolff, Q. Paula Lei, Mark K. Louder, Raiees Andrabi, Nicole A. Doria-Rose, Kevin O. Saunders, Michael S. Seaman, Barton F. Haynes, Daniel W. Kulp, John R. Mascola, Mario Roederer, Theodore C. Pierson, Zizhang Sheng, Beatrice H. Hahn, George M. Shaw, Peter D. Kwong, Lawrence Shapiro; Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies. J Exp Med 6 October 2025; 222 (10): e20250638. doi: https://doi.org/10.1084/jem.20250638 [Article]

Sajadi, M. M., Abbasi, A., Tehrani, Z. R., Siska, C., Clark, R., Chi, W., Seaman, M. S., Mielke, D., Wagh, K., Liu, Q., Jumpa, T., Ketchem, R. R., Nguyen, D. N., Tolbert, W. D., Pierce, B. G., Atkinson, B., Deming, D., Sprague, M., Asakawa, A., Ferrer, D., … DeVico, A. (2025). A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV. Structure (London, England : 1993), 33(7), 1150–1164.e8. https://doi.org/10.1016/j.str.2025.04.016 [Article]

Morris DJ, Gorman J, Zhou T, Lora J, Connell AJ, Li H, Liu W, Roark RS, Campion MS, Carey JW, Habib R, Li Y, Martella CL, Park Y, Singh A, Sowers KJ, Teng IT, Wang S, Chohan N, Ding W, Lauer C, Lewis E, Mason RD, Rando JM, Peyton L, Schramm CA, Wagh K, Korber B, Seaman MS, Douek DC, Haynes BF, Kulp DW, Roederer M, Hahn BH, Kwong PD, Shaw GM. Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques. Cell Reports. 2025 Jun 24;44(6):115848. doi: 10.1016/j.celrep.2025.115848. Epub 2025 Jun 13. [Article]

Dam, K. A., Gristick, H. B., Li, Y. E., Yang, Z., Gnanapragasam, P. N. P., West, A. P., Jr, Seaman, M. S., & Bjorkman, P. J. (2025). Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design. Cell reports, 44(5), 115713. https://doi.org/10.1016/j.celrep.2025.115713 [Article]

Kim, S., Radford, C. E., Xu, D., Zhong, J., Do, J., Pham, D. M., Travisano, K. A., Filsinger Interrante, M. V., Bruun, T. U. J., Rezek, V., Wilder, B., Palomares, M., Seaman, M. S., Kitchen, S. G., Bloom, J. D., & Kim, P. S. (2025). A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning. Nature communications, 16(1), 4617. https://doi.org/10.1038/s41467-025-60035-6 [Article]

Chaubey, M., Gao, H., Lavine, C. L., Seaman, M. S., Chen, B., & Chou, J. J. (2025). Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR. Journal of the American Chemical Society, 147(21), 17561–17565. https://doi.org/10.1021/jacs.5c04597 [Article]

Youssef N, Gurev S, Ghantous F, Brock KP, Jaimes JA, Thadani NN, Dauphin A, Sherman AC, Yurkovetskiy L, Soto D, Estanboulieh R, Kotzen B, Notin P, Kollasch AW, Cohen AA, Dross SE, Erasmus J, Fuller DH, Bjorkman PJ, Lemieux JE, Luban J, Seaman MS, Marks DS. Computationally designed proteins mimic antibody immune evasion in viral evolution. Immunity. 2025 Jun 10;58(6):1411-1421.e6. doi: 10.1016/j.immuni.2025.04.015. Epub 2025 May 8. [Article]

Holmes S, Li H, Shen X, Martin M, Tuck R, Chen Y, Giorgi EE, Kirshner HF, Berry M, Van Italie E, Venkatayogi S, Martin Beem JS, Edwards RJ, Mansouri K, Singh A, Kuykendall C, Gurley T, Anthony Moody M, DeNayer N, Demarco T, Denny TN, Wang Y, Evangelous TD, Clinton JT, Hora B, Wagh K, Seaman MS, Saunders KO, Solomotis N, Misamore J, Lewis MG, Wiehe K, Montefiori DC, Shaw GM, Williams WB. Neonatal immunity associated with heterologous HIV-1 neutralizing antibody induction in SHIV-infected Rhesus Macaques. Nat Commun. 2024 Nov 27;15(1):10302. doi: 10.1038/s41467-024-54753-6. PMID: 39604409; PMCID: PMC11603298. [Article]