Dan Barouch

Dan H. Barouch, M.D., Ph.D.

Dan H. Barouch, M.D., Ph.D.

Principal Investigator
Barouch Laboratory

William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC
Member, Ragon Institute of MGH, MIT, and Harvard

dbarouch@bidmc.harvard.edu
T: 617-735-4548
F: 617-735-4566

Education

  • Harvard College, Cambridge, MA, A.B., 1993 (Biochemistry)
  • Oxford University, Oxford, UK, Ph.D., 1995 (Immunology)
  • Harvard Medical School, Boston, MA, M.D., 1999 (Medicine)

Training

  • 1996-2002 Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center, Boston, MA
  • 1999-2000 Intern in Medicine, Massachusetts General Hospital, Boston, MA
  • 2000-2001 Resident in Medicine, Massachusetts General Hospital, Boston, MA
  • 2001-2004 Clinical Fellow in Infectious Diseases, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA

Appointments

  • 2002-2004, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2004-2006, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 2004-Present, Associate Physician, Brigham & Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA
  • 2004-Present, Staff Physician, Beth Israel Deaconess Medical Center, Boston, MA
  • 2004-2009, Faculty, Beth Israel Deaconess Medical Center, Boston, MA
  • 2006-2010,  Associate Professor of Medicine, Harvard Medical School, Boston, MA
  • 2009-2012, Chief, Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2009-Present, Faculty and Steering Committee, Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard
  • 2010- Present, Professor of Medicine, Harvard Medical School, Boston, MA
  • 2010-2015, Associate Immunologist, Massachusetts General Hospital
  • 2012-Present, Director, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-2018, Professor of Microbiology and Immunobiology, Harvard Medical School
  • 2015-Present, Immunologist, Massachusetts General Hospital
  • 2015-Present, Research Associate, CAPRISA, Durban, South Africa
  • 2018-Present, Professor of Immunology, Harvard Medical School
  • 2020-Present,William Bosworth Castle Professor of Medicine, Harvard Medical School

Honors

  • 1991-1993, Barry M. Goldwater Scholarship
  • 1992, Phi Beta Kappa, Harvard College
  • 1993, Lawrence J. Henderson Prize, Department of Biochemistry, Harvard College
  • 1993, Thomas T. Hoopes Prize, Harvard College
  • 1993, A.B. summa cum laude, Harvard College
  • 1993-1995, British Marshall Scholarship, Marshall Commission
  • 1996, Certificate of Distinction in Teaching, Harvard University
  • 1999, Soma Weiss Research Award, Harvard Medical School
  • 1999, Leon Reznick Memorial Prize, Harvard Medical School
  • 1999, M.D. summa cum laude, Harvard Medical School
  • 2002, Partners in Excellence Award, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA
  • 2004, Maxwell Finland Young Investigator Award, Massachusetts Infectious Diseases Society
  • 2009, American Society for Clinical Investigation (ASCI)
  • 2010, Sir William Osler Young Investigator Award, Interurban Clinical Club
  • 2012, Oswald Avery Award, Infectious Diseases Society of America
  • 2013, Association of American Physicians (AAP)
  • 2015, World’s Most Highly Cited Researchers, Thomson Reuters
  • 2015, Distinguished Speaker, Walter Reed Army Institute of Research
  • 2015-2019, Highly Cited Researcher, Clarivate Analytics
  • 2016, Medical All-Star, Boston Red Sox
  • 2016, Honorary Researcher, Université de Montréal
  • 2016, Bostonian of the Year, Boston Globe Magazine
  • 2017, Cannon Eley Lectureship, Boston Children’s Hospital
  • 2017, Investigator of the Year,Massachusetts Society for Medical Research
  • 2017, Official Citation, Massachusetts House of Representatives, Massachusetts Senate
  • 2017, Drexel Prize in Immunology, Drexel University College of Medicine
  • 2019, Best Academic Research Team,World Vaccine Congress

Publications

  • Abbink P, Mercado NB, Nkolola JP, Peterson RL, Tuyishime H, McMahan K, Moseley ET, Borducchi EN, Chandrashekar A, Bondzie EA, Agarwal A, Belli AJ, Reimann KA, Keele BF, Geleziunas R, Lewis MG, Barouch DH. Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques. Science 2019; 365:1029-1033. [Article]

  • Borducchi EN, Liu J, Nkolola JP, Cadena AM, Yu WH, Fischinger S, Broge T, Abbink P, Mercado NB, Chandrashekar A, Jetton D, Peter L, McMahan K, Moseley ET, Bekerman E, Hesselgesser J, Li W, Lewis MG, Alter G, Geleziunas R, Barouch DH. Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys. Nature 2018; 563:360-364. [Article]

  • Barouch DH, Tomaka FL, Wegmann F, Stieh DJ, Alter G, Robb ML, Michael NL, Peter L, Nkolola JP, Borducchi EN, Chandrashekar A, Jetton D, Stephenson KE, Li W, Korber B, Tomaras GD, Montefiori DC, Gray G, Frahm N, McElrath MJ, Baden L, Johnson J, Hutter J, Swann E, Karita E, Kibuuka H, Mpendo J, Garrett N, Mngadi K, Chinyenze K, Priddy F, Lazarus E, Laher F, Nitayapan S, Pitisuttithum P, Bart S, Campbell T, Feldman R, Lucksinger G, Borremans C, Callewaert K, Roten R, Sadoff J, Scheppler L, Weijtens M, Feddes-de Boer K, van Manen D, Vreugdenhil J, Zahn R, Lavreys L, Nijs S, Tolboom J, Hendriks J, Euler Z, Pau MG, Schuitemaker H. Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19). Lancet. 2018 Jul 21;392(10143):232-243. doi: 10.1016/S0140-6736(18)31364-3. Epub 2018 Jul 6. PubMed PMID: 30047376; PubMed Central PMCID: PMC6192527. [Article]

  • Martinot AJ, Abbink P, Afacan O, Prohl AK, Bronson R, Hecht JL, Borducchi EN, Larocca RA, Peterson RL, Rinaldi W, Ferguson M, Didier PJ, Weiss D, Lewis MG, De La Barrera RA, Yang E, Warfield SK, Barouch DH. Fetal neuropathology in Zika virus-infected pregnant female rhesus monkeys. Cell 2018; 173:1111-1122. [Article]

  • Aid M, Abbink P, Larocca RA, Boyd M, Nityanandam R, Nanayakkara O, Martinot AJ, Moseley ET, Blass E, Borducchi EN, Chandrashekar A, Brinkman AL, Molloy K, Jetton D, Tartaglia LJ, Liu J, Best K, Perelson AS, De La Barrera RA, Lewis MG, Barouch DH. Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys. Cell 2017; 169:610-620. [Article]

  • Borducchi EN, Cabral C, Stephenson KE, Liu J, Abbink P, Ng'ang'a D, Nkolola JP, Brinkman AL, Peter L, Lee BC, Jimenez J, Jetton D, Mondesir J, Mojta S, Chandrashekar A, Molloy K, Alter G, Gerold JM, Hill AL, Lewis MG, Pau MG, Schuitemaker H, Hesselgesser J, Geleziunas R, Kim JH, Robb ML, Michael NL, Barouch DH. Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys. Nature 2016; 540:284-287. [Article]

  • Liu J, Ghneim K, Sok D, Bosche WJ, Li Y, Chipriano E, Berkemeier B, Oswald K, Borducchi E, Cabral C, Peter L, Brinkman A, Shetty M, Jimenez J, Mondesir J, Lee B, Giglio P, Chandrashekar A, Abbink P, Colantonio A, Gittens C, Baker C, Wagner W, Lewis MG, Li W, Sekaly RP, Lifson JD, Burton DR, Barouch DH. Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus. Science 2016; 353:1045-1049. [Article]

  • Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng'ang'a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science 2016; 353:1129-1132. [Article]

  • Larocca RA, Abbink P, Peron JP, Zanotto PM, Iampietro MJ, Badamchi-Zadeh A, Boyd M, Ng'ang'a D, Kirilova M, Nityanandam R, Mercado NB, Li Z, Moseley ET, Bricault CA, Borducchi EN, Giglio PB, Jetton D, Neubauer G, Nkolola JP, Maxfield LF, De La Barrera RA, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Vaccine protection against Zika virus from Brazil. Nature 2016; 536:474-478. [Article]

  • Barouch DH, Ghneim K, Bosche WJ, Li Y, Berkemeier B, Hull M, Bhattacharyya S, Cameron M, Liu J, Smith K, Borducchi E, Cabral C, Peter L, Brinkman A, Shetty M, Li H, Gittens C, Baker C, Wagner W, Lewis MG, Colantonio A, Kang HJ, Li W, Lifson JD, Piatak M, Sekaly RP. Rapid inflammasome activation following mucosal SIV infection of rhesus monkeys. Cell 2016; 165:656-667. [Article]