Dan Barouch

Dan H. Barouch, M.D., Ph.D.

Dan H. Barouch, M.D., Ph.D.

Principal Investigator
Barouch Laboratory

William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC
Member, Ragon Institute of MGH, MIT, and Harvard

dbarouch@bidmc.harvard.edu
T: 617-735-4548
F: 617-735-4566

Education

  • Harvard College, Cambridge, MA, A.B., 1993 (Biochemistry)
  • Oxford University, Oxford, UK, Ph.D., 1995 (Immunology)
  • Harvard Medical School, Boston, MA, M.D., 1999 (Medicine)

Training

  • 1996-2002 Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center, Boston, MA
  • 1999-2000 Intern in Medicine, Massachusetts General Hospital, Boston, MA
  • 2000-2001 Resident in Medicine, Massachusetts General Hospital, Boston, MA
  • 2001-2004 Clinical Fellow in Infectious Diseases, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA

Appointments

  • 2002-2004, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2004-2006, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 2004-Present, Associate Physician, Brigham & Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA
  • 2004-Present, Staff Physician, Beth Israel Deaconess Medical Center, Boston, MA
  • 2004-2009, Faculty, Beth Israel Deaconess Medical Center, Boston, MA
  • 2006-2010,  Associate Professor of Medicine, Harvard Medical School, Boston, MA
  • 2009-2012, Chief, Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2009-Present, Faculty and Steering Committee, Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard
  • 2010- Present, Professor of Medicine, Harvard Medical School, Boston, MA
  • 2010-2015, Associate Immunologist, Massachusetts General Hospital
  • 2012-Present, Director, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-2018, Professor of Microbiology and Immunobiology, Harvard Medical School
  • 2015-Present, Immunologist, Massachusetts General Hospital
  • 2015-Present, Research Associate, CAPRISA, Durban, South Africa
  • 2018-Present, Professor of Immunology, Harvard Medical School
  • 2020-Present,William Bosworth Castle Professor of Medicine, Harvard Medical School

Honors

  • 1991-1993, Barry M. Goldwater Scholarship
  • 1992, Phi Beta Kappa, Harvard College
  • 1993, Lawrence J. Henderson Prize, Department of Biochemistry, Harvard College
  • 1993, Thomas T. Hoopes Prize, Harvard College
  • 1993, A.B. summa cum laude, Harvard College
  • 1993-1995, British Marshall Scholarship, Marshall Commission
  • 1996, Certificate of Distinction in Teaching, Harvard University
  • 1999, Soma Weiss Research Award, Harvard Medical School
  • 1999, Leon Reznick Memorial Prize, Harvard Medical School
  • 1999, M.D. summa cum laude, Harvard Medical School
  • 2002, Partners in Excellence Award, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA
  • 2004, Maxwell Finland Young Investigator Award, Massachusetts Infectious Diseases Society
  • 2009, American Society for Clinical Investigation (ASCI)
  • 2010, Sir William Osler Young Investigator Award, Interurban Clinical Club
  • 2012, Oswald Avery Award, Infectious Diseases Society of America
  • 2013, Association of American Physicians (AAP)
  • 2015, World’s Most Highly Cited Researchers, Thomson Reuters
  • 2015, Distinguished Speaker, Walter Reed Army Institute of Research
  • 2015-2019, Highly Cited Researcher, Clarivate Analytics
  • 2016, Medical All-Star, Boston Red Sox
  • 2016, Honorary Researcher, Université de Montréal
  • 2016, Bostonian of the Year, Boston Globe Magazine
  • 2017, Cannon Eley Lectureship, Boston Children’s Hospital
  • 2017, Investigator of the Year,Massachusetts Society for Medical Research
  • 2017, Official Citation, Massachusetts House of Representatives, Massachusetts Senate
  • 2017, Drexel Prize in Immunology, Drexel University College of Medicine
  • 2019, Best Academic Research Team,World Vaccine Congress

Publications

  • Alter G, Yu J, Liu J, Chandrashekar A, Borducchi EN, Tostanoski LH, McMahan K, Jacob-Dolan C, Martinez DR, Chang A, Anioke T, Lifton M, Nkolola J, Stephenson KE, Atyeo C, Shin S, Fields P, Kaplan I, Robins H, Amanat F, Krammer F, Baric RS, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H, Barouch DH. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Nature. 2021 Aug;596(7871):268-272. doi: 10.1038/s41586-021-03681-2. Epub 2021 Jun 9. PMID: 34107529. [Article]

  • O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Hou P, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; Covid-19 Phase 3 Prevention Trial Team. Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med. 2021 Aug 4:NEJMoa2109682. doi: 10.1056/NEJMoa2109682. Epub ahead of print. PMID: 34347950; PMCID: PMC8362593. [Article]

  • Barouch DH, Stephenson KE, Sadoff J, Yu J, Chang A, Gebre M, McMahan K, Liu J, Chandrashekar A, Patel S, Le Gars M, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H. Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination. N Engl J Med. 2021 Jul 14:NEJMc2108829. doi: 10.1056/NEJMc2108829. Epub ahead of print. PMID: 34260834; PMCID: PMC8314733. [Article]

  • Sadoff J, Gray G, Vandebosch A, Cárdenas V, Shukarev G, Grinsztejn B, Goepfert PA, Truyers C, Fennema H, Spiessens B, Offergeld K, Scheper G, Taylor KL, Robb ML, Treanor J, Barouch DH, Stoddard J, Ryser MF, Marovich MA, Neuzil KM, Corey L, Cauwenberghs N, Tanner T, Hardt K, Ruiz-Guiñazú J, Le Gars M, Schuitemaker H, Van Hoof J, Struyf F, Douoguih M; ENSEMBLE Study Group. Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. N Engl J Med. 2021 Jun 10;384(23):2187-2201. doi: 10.1056/NEJMoa2101544. Epub 2021 Apr 21. PMID: 33882225. [Article]

  • Sadoff, Jerald, Georgi Shukarev, Dirk Heerwegh, Carla Truyers, Anne M. De Groot, Jeroen Stoop, Sarah Tete, Wim VanDamme, Isabel Leroux-Roels, Pieter-Jan Berghmans, Murray Kimmel, Pierre Van Damme, Jan De Hoon, William Smith, Kathryn Stephenson, Stephen De Rosa, Kristen Cohen, Juliana McElrath, Emmanuel Cormier, Gert Scheper, Dan Barouch, Jenny Hendriks, Frank Struyf, Macaya Douoguih, Johan Van Hoof, and Henneke Schuitemaker. "Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine." The New England Journal of Medicine (2021). Print. [Article]

  • Tostanoski, L.H., Wegmann, F., Martinot, A.J. et al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nat Med (2020). https://doi.org/10.1038/s41591-020-1070-6 [Article]

  • Mercado, N.B., Zahn, R., Wegmann, F. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature (2020). https://doi.org/10.1038/s41586-020-2607-z [Article]

  • Chandrashekar A, Liu J, Martinot AJ, McMahan K, Mercado NB, peter L, Tostanoski LH, Yu J, Maliga Z, Nekorchuk M, Busman-Sahay K, Terry M, Wrijil LM, Ducat S, Martinez DR, Atyeo C, Fischinger S, Burke JS, Slein MD, Pessaint L, Ry AV, Greenhouse J, Taylor T, Blade K, Cook A, Finneyfrock B, Brown R, Teow E, Velasco J, Zahn R, Wegmann F, Abbink P, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kordana N, Li Z, Lifton MA, Mahrokhian SH, Maxfield LF, Nityanandam R, Nkolola JP, Schmidt AG, Miller AD, Baric RS, Alter G, Sorger PK, Estes JD, Andersen H, Lewis MG, Barouch DH. SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Science. May 2020. doi:10.1126/science.abc4776. [Article]

  • Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, Nkolola JP, Liu J, Li Z, Chandrashekar A, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, Lelis FJ, Travers M, Habibi S, Pessaint L, Ry AV, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. May 2020. doi:10.1126/science.abc6284. [Article]

  • Abbink P, Mercado NB, Nkolola JP, Peterson RL, Tuyishime H, McMahan K, Moseley ET, Borducchi EN, Chandrashekar A, Bondzie EA, Agarwal A, Belli AJ, Reimann KA, Keele BF, Geleziunas R, Lewis MG, Barouch DH. Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques. Science 2019; 365:1029-1033. [Article]