Dan H. Barouch, M.D., Ph.D.

Dan Barouch received his Ph.D. in immunology from Oxford University and his M.D. from Harvard Medical School. He is currently the William Bosworth Castle Professor of Medicine at Harvard Medical School, Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, and a member of the Ragon Institute of MGH, MIT, and Harvard.  His laboratory focuses on studying the immunology and pathogenesis of viral infections and developing novel vaccine and treatment strategies.  His group has led the development of vaccine candidates for HIV-1, Zika, SARS-CoV-2, tuberculosis, and influenza.  His work contributed to the development of the Johnson & Johnson COVID-19 vaccine and the evaluation of multiple COVID-19 vaccines and therapeutics.  He was elected to the American Society for Clinical Investigation (2009), Association of American Physicians (2013), and National Academy of Medicine (2020), and he received the King Faisal Prize in Medicine (2023).

Education

• Harvard College, Cambridge, MA, A.B., 1993 (Biochemistry)
• Oxford University, Oxford, UK, Ph.D., 1995 (Immunology)
• Harvard Medical School, Boston, MA, M.D., 1999 (Medicine)

Training

• 1996-2002 Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center, Boston, MA
• 1999-2000 Intern in Medicine, Massachusetts General Hospital, Boston, MA
• 2000-2001 Resident in Medicine, Massachusetts General Hospital, Boston, MA
• 2001-2004 Clinical Fellow in Infectious Diseases, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA

Appointments

• 2002-2004, Instructor in Medicine, Harvard Medical School, Boston, MA
• 2004-2006, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
• 2004-Present, Associate Physician, Brigham & Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA
• 2004-Present, Staff Physician, Beth Israel Deaconess Medical Center, Boston, MA
• 2004-2009, Faculty, Beth Israel Deaconess Medical Center, Boston, MA
• 2006-2010,  Associate Professor of Medicine, Harvard Medical School, Boston, MA
• 2009-2012, Chief, Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
• 2009-Present, Faculty and Steering Committee, Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard
• 2010- Present, Professor of Medicine, Harvard Medical School, Boston, MA
• 2010-2015, Associate Immunologist, Massachusetts General Hospital
• 2012-Present, Director, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
• 2015-2018, Professor of Microbiology and Immunobiology, Harvard Medical School
• 2015-Present, Immunologist, Massachusetts General Hospital
• 2015-Present, Research Associate, CAPRISA, Durban, South Africa
• 2018-Present, Professor of Immunology, Harvard Medical School
• 2020-Present,William Bosworth Castle Professor of Medicine, Harvard Medical School
• 2026, Conference Co-Chair, Keystone Symposium on Immuno-Vaccinology: A New Era in Vaccine Design, Killarney, Ireland

Honors

• 1991-1993, Barry M. Goldwater Scholarship
• 1992, Phi Beta Kappa, Harvard College
• 1993, Lawrence J. Henderson Prize, Department of Biochemistry, Harvard College
• 1993, Thomas T. Hoopes Prize, Harvard College
• 1993, A.B. summa cum laude, Harvard College
• 1993-1995, British Marshall Scholarship, Marshall Commission
• 1996, Certificate of Distinction in Teaching, Harvard University
• 1999, Soma Weiss Research Award, Harvard Medical School
• 1999, Leon Reznick Memorial Prize, Harvard Medical School
• 1999, M.D. summa cum laude, Harvard Medical School
• 2002, Partners in Excellence Award, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA
• 2004, Maxwell Finland Young Investigator Award, Massachusetts Infectious Diseases Society
• 2009, American Society for Clinical Investigation (ASCI)
• 2010, Sir William Osler Young Investigator Award, Interurban Clinical Club
• 2012, Oswald Avery Award, Infectious Diseases Society of America
• 2013, Association of American Physicians (AAP)
• 2015, World’s Most Highly Cited Researchers, Thomson Reuters
• 2015, Distinguished Speaker, Walter Reed Army Institute of Research
• 2015-2024, Highly Cited Researcher, Clarivate Analytics
• 2016, Medical All-Star, Boston Red Sox
• 2016, Honorary Researcher, Université de Montréal
• 2016, Bostonian of the Year, Boston Globe Magazine
• 2017, Cannon Eley Lectureship, Boston Children’s Hospital
• 2017, Investigator of the Year,Massachusetts Society for Medical Research
• 2017, Official Citation, Massachusetts House of Representatives, Massachusetts Senate
• 2017, Drexel Prize in Immunology, Drexel University College of Medicine
• 2019, Best Academic Research Team,World Vaccine Congress
• 2020, National Academy of Medicine
• 2020, Bloomberg 50 Most Influential People
• 2021, George Ledlie Prize, Harvard University
• 2021, Heroes Among Us Award, Boston Celtics
• 2021, Bostonian of the Year, Boston Globe Magazine
• 2022, Franklin Epstein Lectureship, Beth Israel Deaconess Medical Center, New England Journal of Medicine
• 2022, Bernard Fields Lectureship, CROI
• 2022, Stanley Plotkin Lectureship, Fondation Merieux, Annecy, France
• 2022, Daniel Jick Excellence in Leadership Award, Beth Israel Deaconess Medical Center
• 2023, King Faisal Prize in Medicine, King Faisal Foundation
• 2023, Tim Gill Lectureship, University of Colorado, Aurora, CO
• 2023, Paragon Prize  for Research Excellence, Doris Duke Foundation, New York, NY
• 2024, Kenner Lectureship, Albright Institute, Wellesley College, Wellesley, MA
• 2024, Highly Ranked Scholar (Top 0.05%), ScholarGPS
• 2024, Best Medicine Scientists, Research.com
• 2024, Top 100 Sustainability Researchers, Cell Research
• 2024, World’s Top 2% Scientists (#4 in virology), Stanford University

Publications

• Aid M, Boero-Teyssier V, McMahan K, Dang R, Doyle M, Belabbaci N, Borducchi E, Collier AY, Mullington J, Barouch DH. Long COVID involves activation of proinflammatory and immune exhaustion pathways. Nat Immunol. 2026 Jan;27(1):61-71. doi: 10.1038/s41590-025-02353-x. Epub 2025 Dec 12. Erratum in: Nat Immunol. 2026 Jan 23. doi: 10.1038/s41590-026-02438-1. PMID: 41388153; PMCID: PMC12764429. [Article]


• Ram DR, Gopalakrishnan RM, Aid M, Kroll K, Miftahof J, Aristizabal O, Gikundiro EK, Davis C, Hefti MM, Fiock KL, Tilahun B, Umutoniwase Y, Loidolt K, Fennessey CM, Mercado NB, Harper-Alexander V, Jones R, Woolley G, Varner V, Lifton M, Bosinger SE, Barouch DH, Keele BF, Reeves RK, Tan CS. Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain. Cell Rep Med. 2026 Jan 20;7(1):102567. doi: 10.1016/j.xcrm.2025.102567 [Article]


• Li Y, Stieh DJ, Droit L, Kim AH, Rodgers R, Mihindukulasuriya KA, Wang L, Pau MG, Yuan O, Virgin HW, Barouch DH, Baldridge MT, Handley SA. Associations between the microbiome and immune responses to an adenovirus-based HIV-1 candidate vaccine are distinct between African and US cohorts. mSystems. 2026 Jan 15:e0143525. doi: 10.1128/msystems.01435-25. Epub ahead of print. PMID: 41537600. [Article]


• Lasrado N, Rössler A, McConnell I, Molloy K, Bhowmik R, Happle C, Guan R, McMahan K, Pereira J, Liu J, Borducchi E, Wang L, Shah K, Wixted B, Stankov MV, Dopfer-Jablonka A, Collier AY, Behrens GMN, Barouch DH. Immunogenicity of JN.1 and KP.2 COVID-19 mRNA vaccines against emerging SARS-CoV-2 variants. Vaccine. 2026 Jan 1;69:127997. doi: 10.1016/j.vaccine.2025.127997. Epub 2025 Nov 19. PMID: 41265004; PMCID: PMC12643176. [Article]


• Walker-Sperling VEK, Nkolola J, Liu J, Aid M, Julg B, Seaman MS, Barouch DH. Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques. Nat Commun. 2025 Dec 18;16(1):11226. doi: 10.1038/s41467-025-66321-7. PMID: 41413011; PMCID: PMC12714793. [Article]


• Vidal SJ, Lasrado N, Tostanoski LH, Chaudhari J, Mbiwan ER, Neka GD, Strutton EA, Espinosa Perez AA, Sellers D, Barrett J, Lifton M, Wakabayashi S, Eshaghi B, Borducchi EN, Aid M, Li W, Scriba TJ, Jaklenec A, Langer R, Barouch DH. Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines. Cell. 2025 Nov 26;188(24):6791-6803.e13. doi: 10.1016/j.cell.2025.08.027. Epub 2025 Sep 15. PMID: 40957415; PMCID: PMC12445596. [Article]


• Andersen H, Aid M, Stone JJ, Lyons CE, Berlied A, Nkolola J, Lasrado N, Peterson M, Pessaint L, Kitajewski C, Yalley-Ogunro J, Porto M, Stone R, Cabus M, Valentin D, Van Ry A, Narvaez B, Orekov T, Kar S, Teow E, Kouneski K, Ferreira A, Velasco J, Campbell R, Henderson C, Beah W, Patel G, Finneyfrock B, Cook A, Paul S, Haasnoot J, Ramirez-Carvajal L, Koldijk MH, Arias Rivas S, Koch CM, Goudsmit J, Lewis MG, Martinot AJ, Barouch DH. Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaques. Immunity. 2025 Sep 9;58(9):2157-2165.e5. doi: 10.1016/j.immuni.2025.07.020. Epub 2025 Aug 18. PMID: 40829590. [Article]


• Vidal SJ, Barouch DH. A Novel Approach for Preventing Respiratory Virus Infections. JAMA Intern Med. 2025;185(11):1317–1318. doi:10.1001/jamainternmed.2025.4297 [Article]


• Kenny A, van Duijn J, Dintwe O, Heptinstall J, Burnham R, Sawant S, Zhang L, Mielke D, Khuzwayo S, Omar FL, Stanfield-Oakley S, Keyes T, Dunn B, Goodman D, Fong Y, Benkeser D, Zou R, Hural J, Hyrien O, Juraska M, Luedtke A, van der Laan L, Giorgi EE, Magaret C, Carpp LN, Pattacini L, van de Kerkhof T, Korber B, Willems W, Fisher LH, Schuitemaker H, Swann E, Kublin JG, Pau MG, Buchbinder S, Tomaka F, Nijs S, Lavreys L, Gelderblom HC, Corey L, Mngadi K, Gray GE, Borducchi E, Hendriks J, Seaton KE, Zolla-Pazner S, Barouch DH, Ferrari G, De Rosa SC, McElrath MJ, Andersen-Nissen E, Stieh DJ, Tomaras GD, Gilbert PB; Imbokodo Study and Correlates Group. Corrigendum to 'Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study'. EBioMedicine 2024;108: 105320. EBioMedicine. 2025 Sep;119:105874. doi: 10.1016/j.ebiom.2025.105874. Epub 2025 Aug 23. Erratum for: EBioMedicine. 2024 Oct;108:105320. doi: 10.1016/j.ebiom.2024.105320. PMID: 40850015; PMCID: PMC12789700. [Article]


• Schroeder TA, Manuzak JA, Miller CJ, Gustin AT, Basting CM, Cheu RK, Velez A, Driscoll CB, Tisoncik-Go J, Schifanella L, Hensley-McBain T, Evandy CA, Smith EA, Bratt D, Shields-Cutler R, Smedley J, Fuller DH, Barouch DH, O'Connor MA, Gale M, Klatt NR.2025.Elevated peripheral and nervous system inflammation is associated with decreased short-chain fatty acid levels in Zika virus-infected macaques. J Virol99:e01003-25.https://doi.org/10.1128/jvi.01003-25 [Article]