Dan Barouch

Dan H. Barouch, M.D., Ph.D.

Dan H. Barouch, M.D., Ph.D.

Principal Investigator
Barouch Laboratory

William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC
Member, Ragon Institute of MGH, MIT, and Harvard

dbarouch@bidmc.harvard.edu
T: 617-735-4548
F: 617-735-4566
Profile

Education

  • Harvard College, Cambridge, MA, A.B., 1993 (Biochemistry)
  • Oxford University, Oxford, UK, Ph.D., 1995 (Immunology)
  • Harvard Medical School, Boston, MA, M.D., 1999 (Medicine)

Training

  • 1996-2002 Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center, Boston, MA
  • 1999-2000 Intern in Medicine, Massachusetts General Hospital, Boston, MA
  • 2000-2001 Resident in Medicine, Massachusetts General Hospital, Boston, MA
  • 2001-2004 Clinical Fellow in Infectious Diseases, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA

Appointments

  • 2002-2004, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2004-2006, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 2004-Present, Associate Physician, Brigham & Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA
  • 2004-Present, Staff Physician, Beth Israel Deaconess Medical Center, Boston, MA
  • 2004-2009, Faculty, Beth Israel Deaconess Medical Center, Boston, MA
  • 2006-2010,  Associate Professor of Medicine, Harvard Medical School, Boston, MA
  • 2009-2012, Chief, Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2009-Present, Faculty and Steering Committee, Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard
  • 2010- Present, Professor of Medicine, Harvard Medical School, Boston, MA
  • 2010-2015, Associate Immunologist, Massachusetts General Hospital
  • 2012-Present, Director, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-2018, Professor of Microbiology and Immunobiology, Harvard Medical School
  • 2015-Present, Immunologist, Massachusetts General Hospital
  • 2015-Present, Research Associate, CAPRISA, Durban, South Africa
  • 2018-Present, Professor of Immunology, Harvard Medical School
  • 2020-Present,William Bosworth Castle Professor of Medicine, Harvard Medical School

Honors

  • 1991-1993, Barry M. Goldwater Scholarship
  • 1992, Phi Beta Kappa, Harvard College
  • 1993, Lawrence J. Henderson Prize, Department of Biochemistry, Harvard College
  • 1993, Thomas T. Hoopes Prize, Harvard College
  • 1993, A.B. summa cum laude, Harvard College
  • 1993-1995, British Marshall Scholarship, Marshall Commission
  • 1996, Certificate of Distinction in Teaching, Harvard University
  • 1999, Soma Weiss Research Award, Harvard Medical School
  • 1999, Leon Reznick Memorial Prize, Harvard Medical School
  • 1999, M.D. summa cum laude, Harvard Medical School
  • 2002, Partners in Excellence Award, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA
  • 2004, Maxwell Finland Young Investigator Award, Massachusetts Infectious Diseases Society
  • 2009, American Society for Clinical Investigation (ASCI)
  • 2010, Sir William Osler Young Investigator Award, Interurban Clinical Club
  • 2012, Oswald Avery Award, Infectious Diseases Society of America
  • 2013, Association of American Physicians (AAP)
  • 2015, World’s Most Highly Cited Researchers, Thomson Reuters
  • 2015, Distinguished Speaker, Walter Reed Army Institute of Research
  • 2015-2019, Highly Cited Researcher, Clarivate Analytics
  • 2016, Medical All-Star, Boston Red Sox
  • 2016, Honorary Researcher, Université de Montréal
  • 2016, Bostonian of the Year, Boston Globe Magazine
  • 2017, Cannon Eley Lectureship, Boston Children’s Hospital
  • 2017, Investigator of the Year,Massachusetts Society for Medical Research
  • 2017, Official Citation, Massachusetts House of Representatives, Massachusetts Senate
  • 2017, Drexel Prize in Immunology, Drexel University College of Medicine
  • 2019, Best Academic Research Team,World Vaccine Congress
  • 2020, National Academy of Medicine
  • 2020, Bloomberg 50 Most Influential People
  • 2021, George Ledlie Prize, Harvard University
  • 2021, Heroes Among Us Award, Boston Celtics
  • 2021, Bostonian of the Year, Boston Globe Magazine

Publications

  • Lasrado N, Collier AY, Miller J, Hachmann NP, Liu J, Anand T, A Bondzie E, Fisher JL, Mazurek CR, Patio RC, Rodrigues SL, Rowe M, Surve N, Ty DM, Wu C, Chicz TM, Tong X, Korber B, McNamara RP, Barouch DH. Waning immunity and IgG4 responses following bivalent mRNA boosting. Sci Adv. 2024 Feb 23;10(8):eadj9945. doi: 10.1126/sciadv.adj9945. Epub 2024 Feb 23. PMID: 38394195; PMCID: PMC10889350. [Article]

  • Song NJ, Chakravarthy KB, Jeon H, Bolyard C, Reynolds K, Weller KP, Reisinger S, Wang Y, Li A, Jiang S, Ma Q, Barouch DH, Rubinstein MP, Shields PG, Oltz EM, Chung D, Li Z. mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer. J Immunother Cancer. 2024 Jan 4;12(1):e007922. doi: 10.1136/jitc-2023-007922. PMID: 38177076; PMCID: PMC10773442.
    [Article]

  • Nkolola JP, Barouch DH. Prophylactic HIV-1 vaccine trials: past, present, and future. Lancet HIV. 2023 Dec 20:S2352-3018(23)00264-3. doi: 10.1016/S2352-3018(23)00264-3. Epub ahead of print. PMID: 38141639. [Article]

  • McMahan K, Wegmann F, Aid M, Sciacca M, Liu J, Hachmann NP, Miller J, Jacob-Dolan C, Powers O, Hope D, Wu C, Pereira J, Murdza T, Mazurek CR, Hoyt A, Boon ACM, Davis-Gardner M, Suthar MS, Martinot AJ, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Tolboom J, Serroyen J, Solforosi L, Costes LMM, Zahn RC, Barouch DH. Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques. Nature. 2023 Dec 14. doi: 10.1038/s41586-023-06951-3. Epub ahead of print. PMID: 38096903. [Article]

  • Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, Cui Z, Zhao D, Barouch DH, Yu J. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses. 2023 Dec 9;15(12):2401. doi: 10.3390/v15122401. PMID: 38140642; PMCID: PMC10747620. [Article]

  • Lasrado N, Collier AY, Hachmann NP, Miller J, Rowe M, Schonberg ED, Rodrigues SL, LaPiana A, Patio RC, Anand T, Fisher J, Mazurek CR, Guan R, Wagh K, Theiler J, Korber BT, Barouch DH. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023 Nov 13;41(47):6904-6909. doi: 10.1016/j.vaccine.2023.10.051. Epub 2023 Oct 21. PMID: 37872011. [Article]

  • Lasrado N, Barouch DH. SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds. J Infect Dis. 2023 Nov 11;228(10):1311-1313. doi: 10.1093/infdis/jiad353. PMID: 37592872. [Article]

  • van Duijn J, Stieh D, Fernandez N, King D, Gilmour J, Tolboom J, Callewaert K, Willems W, Pau MG, De Rosa SC, McElrath MJ, Barouch DH, Hayes P. Mosaic HIV-1 vaccination induces anti-viral CD8+ T cell functionality in the phase 1/2a clinical trial APPROACH. J Virol. 2023 Oct 31;97(10):e0112623. doi: 10.1128/jvi.01126-23. Epub 2023 Oct 9. PMID: 37811993; PMCID: PMC10617392. [Article]

  • Kumar MR, Fray EJ, Bender AM, Zitzmann C, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2313209120. doi: 10.1073/pnas.2313209120. Epub 2023 Oct 16. PMID: 37844236; PMCID: PMC10614214. [Article]

  • Aid M, Stephenson KE, Collier AY, Nkolola JP, Michael JV, McKenzie SE, Barouch DH. Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination. Nat Commun. 2023 Oct 23;14(1):6703. doi: 10.1038/s41467-023-42559-x. PMID: 37872311; PMCID: PMC10593859. [Article]