Dan Barouch

Dan H. Barouch, M.D., Ph.D.

Dan H. Barouch, M.D., Ph.D.

Principal Investigator
Barouch Laboratory

William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC
Member, Ragon Institute of MGH, MIT, and Harvard

dbarouch@bidmc.harvard.edu
T: 617-735-4548
F: 617-735-4566
Profile

Education

  • Harvard College, Cambridge, MA, A.B., 1993 (Biochemistry)
  • Oxford University, Oxford, UK, Ph.D., 1995 (Immunology)
  • Harvard Medical School, Boston, MA, M.D., 1999 (Medicine)

Training

  • 1996-2002 Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center, Boston, MA
  • 1999-2000 Intern in Medicine, Massachusetts General Hospital, Boston, MA
  • 2000-2001 Resident in Medicine, Massachusetts General Hospital, Boston, MA
  • 2001-2004 Clinical Fellow in Infectious Diseases, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA

Appointments

  • 2002-2004, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2004-2006, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 2004-Present, Associate Physician, Brigham & Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA
  • 2004-Present, Staff Physician, Beth Israel Deaconess Medical Center, Boston, MA
  • 2004-2009, Faculty, Beth Israel Deaconess Medical Center, Boston, MA
  • 2006-2010,  Associate Professor of Medicine, Harvard Medical School, Boston, MA
  • 2009-2012, Chief, Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2009-Present, Faculty and Steering Committee, Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard
  • 2010- Present, Professor of Medicine, Harvard Medical School, Boston, MA
  • 2010-2015, Associate Immunologist, Massachusetts General Hospital
  • 2012-Present, Director, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-2018, Professor of Microbiology and Immunobiology, Harvard Medical School
  • 2015-Present, Immunologist, Massachusetts General Hospital
  • 2015-Present, Research Associate, CAPRISA, Durban, South Africa
  • 2018-Present, Professor of Immunology, Harvard Medical School
  • 2020-Present,William Bosworth Castle Professor of Medicine, Harvard Medical School

Honors

  • 1991-1993, Barry M. Goldwater Scholarship
  • 1992, Phi Beta Kappa, Harvard College
  • 1993, Lawrence J. Henderson Prize, Department of Biochemistry, Harvard College
  • 1993, Thomas T. Hoopes Prize, Harvard College
  • 1993, A.B. summa cum laude, Harvard College
  • 1993-1995, British Marshall Scholarship, Marshall Commission
  • 1996, Certificate of Distinction in Teaching, Harvard University
  • 1999, Soma Weiss Research Award, Harvard Medical School
  • 1999, Leon Reznick Memorial Prize, Harvard Medical School
  • 1999, M.D. summa cum laude, Harvard Medical School
  • 2002, Partners in Excellence Award, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA
  • 2004, Maxwell Finland Young Investigator Award, Massachusetts Infectious Diseases Society
  • 2009, American Society for Clinical Investigation (ASCI)
  • 2010, Sir William Osler Young Investigator Award, Interurban Clinical Club
  • 2012, Oswald Avery Award, Infectious Diseases Society of America
  • 2013, Association of American Physicians (AAP)
  • 2015, World’s Most Highly Cited Researchers, Thomson Reuters
  • 2015, Distinguished Speaker, Walter Reed Army Institute of Research
  • 2015-2019, Highly Cited Researcher, Clarivate Analytics
  • 2016, Medical All-Star, Boston Red Sox
  • 2016, Honorary Researcher, Université de Montréal
  • 2016, Bostonian of the Year, Boston Globe Magazine
  • 2017, Cannon Eley Lectureship, Boston Children’s Hospital
  • 2017, Investigator of the Year,Massachusetts Society for Medical Research
  • 2017, Official Citation, Massachusetts House of Representatives, Massachusetts Senate
  • 2017, Drexel Prize in Immunology, Drexel University College of Medicine
  • 2019, Best Academic Research Team,World Vaccine Congress
  • 2020, National Academy of Medicine
  • 2020, Bloomberg 50 Most Influential People
  • 2021, George Ledlie Prize, Harvard University
  • 2021, Heroes Among Us Award, Boston Celtics
  • 2021, Bostonian of the Year, Boston Globe Magazine

Publications

  • Gelderblom HC, Corey L, Barouch DH. The potential of broadly neutralizing antibodies for HIV prevention. J Int AIDS Soc. 2024 May;27(5):e26257. doi: 10.1002/jia2.26257. PMID: 38757844; PMCID: PMC11100278. [Article]

  • Jacob-Dolan C, Lifton M, Powers OC, Miller J, Hachmann NP, Vu M, Surve N, Mazurek CR, Fisher JL, Rodrigues S, Patio RC, Anand T, Le Gars M, Sadoff J, Schmidt AG, Barouch DH. B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S. iScience. 2024 Apr 9;27(5):109716. doi: 10.1016/j.isci.2024.109716. PMID: 38655202; PMCID: PMC11035370. [Article]

  • Mahrokhian, S. H., Tostanoski, L. H., Vidal, S. J., & Barouch, D. H. (2024). COVID-19 vaccines: Immune correlates and clinical outcomes. Human Vaccines & Immunotherapeutics20(1). https://doi.org/10.1080/21645515.2024.2324549 [Article]

  • Pinski AN, Gan T, Lin S, Droit L, Diamond M, Barouch DH, Wang D.2024.Isolation of a recombinant simian adenovirus encoding the human adenovirus G52 hexon suggests a simian origin for human adenovirus G52. J Virol98:e00043-24.https://doi.org/10.1128/jvi.00043-24 [Article]

  • Vander Straeten A, Sarmadi M, Daristotle JL, Kanelli M, Tostanoski LH, Collins J, Pardeshi A, Han J, Varshney D, Eshaghi B, Garcia J, Forster TA, Li G, Menon N, Pyon SL, Zhang L, Jacob-Dolan C, Powers OC, Hall K, Alsaiari SK, Wolf M, Tibbitt MW, Farra R, Barouch DH, Langer R, Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nat Biotechnol. 2024 Mar;42(3):510-517. doi: 10.1038/s41587-023-01774-z. Epub 2023 Apr 24. PMID: 37095347; PMCID: PMC10593912. [Article]

  • Lasrado N, Rössler A, Rowe M, Collier AY, Barouch DH. Neutralization of SARS-CoV-2 Omicron subvariant BA.2.87.1. Vaccine. 2024 Apr 2;42(9):2117-2121. doi: 10.1016/j.vaccine.2024.03.007. Epub 2024 Mar 7. PMID: 38458874. [Article]

  • Alsaiari SK, Nadeef S, Daristotle JL, Rothwell W, Du B, Garcia J, Zhang L, Sarmadi M, Forster TA, Menon N, Lin SQ, Tostanoski LH, Hachmann N, Wang EY, Ventura JD, Barouch DH, Langer R, Jaklenec A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Sci Adv. 2024 Mar 8;10(10):eadj6380. doi: 10.1126/sciadv.adj6380. Epub 2024 Mar 6. PMID: 38446889; PMCID: PMC10917347. [Article]

  • Joseph P Nkolola, Jinyan Liu, Ai-ris Y Collier, Catherine Jacob-Dolan, Yasmeen Senussi, Ella Borberg, Zoe Swank, David R Walt, Dan H Barouch, High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays, The Journal of Infectious Diseases, 2024;, jiae174, https://doi.org/10.1093/infdis/jiae174 [Article]

  • Lasrado N, Rössler A, Rowe M, Collier AY, Barouch DH. Neutralization of SARS-CoV-2 Omicron subvariant BA.2.87.1. Vaccine. 2024 Apr 2;42(9):2117-2121. doi: 10.1016/j.vaccine.2024.03.007. Epub 2024 Mar 7. PMID: 38458874. [Article]

  • Cassidy T, Stephenson KE, Barouch DH, Perelson AS (2024) Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1. PLOS Computational Biology 20(3): e1011518. https://doi.org/10.1371/journal.pcbi.1011518