Dan Barouch

Dan H. Barouch, M.D., Ph.D.

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Dan H. Barouch, M.D., Ph.D.

Principal Investigator
Barouch Laboratory

William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC
Member, Ragon Institute of MGH, MIT, and Harvard

dbarouch@bidmc.harvard.edu
T: 617-735-4548
F: 617-735-4566
Profile

Education

  • Harvard College, Cambridge, MA, A.B., 1993 (Biochemistry)
  • Oxford University, Oxford, UK, Ph.D., 1995 (Immunology)
  • Harvard Medical School, Boston, MA, M.D., 1999 (Medicine)

Training

  • 1996-2002 Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center, Boston, MA
  • 1999-2000 Intern in Medicine, Massachusetts General Hospital, Boston, MA
  • 2000-2001 Resident in Medicine, Massachusetts General Hospital, Boston, MA
  • 2001-2004 Clinical Fellow in Infectious Diseases, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA

Appointments

  • 2002-2004, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2004-2006, Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 2004-Present, Associate Physician, Brigham & Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA
  • 2004-Present, Staff Physician, Beth Israel Deaconess Medical Center, Boston, MA
  • 2004-2009, Faculty, Beth Israel Deaconess Medical Center, Boston, MA
  • 2006-2010,  Associate Professor of Medicine, Harvard Medical School, Boston, MA
  • 2009-2012, Chief, Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2009-Present, Faculty and Steering Committee, Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard
  • 2010- Present, Professor of Medicine, Harvard Medical School, Boston, MA
  • 2010-2015, Associate Immunologist, Massachusetts General Hospital
  • 2012-Present, Director, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA
  • 2015-2018, Professor of Microbiology and Immunobiology, Harvard Medical School
  • 2015-Present, Immunologist, Massachusetts General Hospital
  • 2015-Present, Research Associate, CAPRISA, Durban, South Africa
  • 2018-Present, Professor of Immunology, Harvard Medical School
  • 2020-Present,William Bosworth Castle Professor of Medicine, Harvard Medical School

Honors

  • 1991-1993, Barry M. Goldwater Scholarship
  • 1992, Phi Beta Kappa, Harvard College
  • 1993, Lawrence J. Henderson Prize, Department of Biochemistry, Harvard College
  • 1993, Thomas T. Hoopes Prize, Harvard College
  • 1993, A.B. summa cum laude, Harvard College
  • 1993-1995, British Marshall Scholarship, Marshall Commission
  • 1996, Certificate of Distinction in Teaching, Harvard University
  • 1999, Soma Weiss Research Award, Harvard Medical School
  • 1999, Leon Reznick Memorial Prize, Harvard Medical School
  • 1999, M.D. summa cum laude, Harvard Medical School
  • 2002, Partners in Excellence Award, Mass. General Hospital, Brigham & Women’s Hospital, Boston, MA
  • 2004, Maxwell Finland Young Investigator Award, Massachusetts Infectious Diseases Society
  • 2009, American Society for Clinical Investigation (ASCI)
  • 2010, Sir William Osler Young Investigator Award, Interurban Clinical Club
  • 2012, Oswald Avery Award, Infectious Diseases Society of America
  • 2013, Association of American Physicians (AAP)
  • 2015, World’s Most Highly Cited Researchers, Thomson Reuters
  • 2015, Distinguished Speaker, Walter Reed Army Institute of Research
  • 2015-2019, Highly Cited Researcher, Clarivate Analytics
  • 2016, Medical All-Star, Boston Red Sox
  • 2016, Honorary Researcher, Université de Montréal
  • 2016, Bostonian of the Year, Boston Globe Magazine
  • 2017, Cannon Eley Lectureship, Boston Children’s Hospital
  • 2017, Investigator of the Year,Massachusetts Society for Medical Research
  • 2017, Official Citation, Massachusetts House of Representatives, Massachusetts Senate
  • 2017, Drexel Prize in Immunology, Drexel University College of Medicine
  • 2019, Best Academic Research Team,World Vaccine Congress
  • 2020, National Academy of Medicine
  • 2020, Bloomberg 50 Most Influential People
  • 2021, George Ledlie Prize, Harvard University
  • 2021, Heroes Among Us Award, Boston Celtics
  • 2021, Bostonian of the Year, Boston Globe Magazine

Publications

  • Hachmann, N. P., Miller, J., Collier, A. Y., & Barouch, D. H. (2022). Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.4.6. The New England journal of medicine, 387(20), 1904–1906. https://doi.org/10.1056/NEJMc2212117   [Article]

  • Moldt B, Chandrashekar A, Borducchi EN, Nkolola JP, Stephenson H, Nagel M, Hung M, Goldsmith J, Pace CS, Carr B, Thomsen ND, Blair WS, Geleziunas R, Barouch DH. HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys. PLoS Pathog. 2022 Apr 22;18(4):e1010467. doi: 10.1371/journal.ppat.1010467. Epub ahead of print. PMID: 35452496. [Article]

  • Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G. mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Sci Transl Med. 2022 Mar 29:eabm2311. doi: 10.1126/scitranslmed.abm2311. Epub ahead of print. PMID: 35348368; PMCID: PMC8995030. [Article]

  • Chandrashekar A, Yu J, McMahan K, Jacob-Dolan C, Liu J, He X, Hope D, Anioke T, Barrett J, Chung B, Hachmann NP, Lifton M, Miller J, Powers O, Sciacca M, Sellers D, Siamatu M, Surve N, VanWyk H, Wan H, Wu C, Pessaint L, Valentin D, Van Ry A, Muench J, Boursiquot M, Cook A, Velasco J, Teow E, Boon ACM, Suthar MS, Jain N, Martinot AJ, Lewis MG, Andersen H, Barouch DH. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques. Cell. 2022 Mar 17:S0092-8674(22)00334-8. doi: 10.1016/j.cell.2022.03.024. Epub ahead of print. PMID: 35427477; PMCID: PMC8926910. [Article]

  • Yu J, Collier AY, Rowe M, Mardas F, Ventura JD, Wan H, Miller J, Powers O, Chung B, Siamatu M, Hachmann NP, Surve N, Nampanya F, Chandrashekar A, Barouch DH. Comparable Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. medRxiv [Preprint]. 2022 Feb 7:2022.02.06.22270533. doi: 10.1101/2022.02.06.22270533. Update in: N Engl J Med. 2022 Mar 16;: PMID: 35169817; PMCID: PMC8845515. [Article]

  • Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, Bowman L, Naranjo CA, Yun D, Flinchbaugh Z, Pessaint L, Brown R, Velasco J, Teow E, Cook A, Andersen H, Lewis MG, Camp DL, Silverman JM, Nagar GS, Rao HD, Lothe RR, Chandrasekharan R, Rajurkar MP, Shaligram US, Kleanthous H, Joshi SB, Volkin DB, Biswas S, Love JC, Barouch DH. SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques. Sci Adv. 2022 Mar 18;8(11):eabl6015. doi: 10.1126/sciadv.abl6015. Epub 2022 Mar 16. PMID: 35294244; PMCID: PMC8926328. [Article]

  • Liu J, Chandrashekar A, Sellers D, Barrett J, Jacob-Dolan C, Lifton M, McMahan K, Sciacca M, VanWyk H, Wu C, Yu J, Collier AY, Barouch DH. Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron. Nature. 2022 Jan 31. doi: 10.1038/s41586-022-04465-y. Epub ahead of print. PMID: 35102312. [Article]

  • Gebre MS, Rauch S, Roth N, Yu J, Chandrashekar A, Mercado NB, He X, Liu J, McMahan K, Martinot A, Martinez DR, Giffin T, Hope D, Patel S, Sellers D, Sanborn O, Barrett J, Liu X, Cole AC, Pessaint L, Valentin D, Flinchbaugh Z, Yalley-Ogunro J, Muench J, Brown R, Cook A, Teow E, Andersen H, Lewis MG, Boon ACM, Baric RS, Mueller SO, Petsch B, Barouch DH. Optimization of Non-Coding Regions for a Non-Modified mRNA COVID-19 Vaccine. Nature. 2021 Nov 18. doi: 10.1038/s41586-021-04231-6. Epub ahead of print. PMID: 34794169. [Article]

  • Collier AY, Yu J, McMahan K, Liu J, Chandrashekar A, Maron JS, Atyeo C, Martinez DR, Ansel JL, Aguayo R, Rowe M, Jacob-Dolan C, Sellers D, Barrett J, Ahmad K, Anioke T, VanWyk H, Gardner S, Powers O, Bondzie EA, Wan H, Baric RS, Alter G, Hacker MR, Barouch DH. Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines. N Engl J Med. 2021 Oct 15. doi: 10.1056/NEJMc2115596. Epub ahead of print. PMID: 34648703. [Article]

  • Alter G, Yu J, Liu J, Chandrashekar A, Borducchi EN, Tostanoski LH, McMahan K, Jacob-Dolan C, Martinez DR, Chang A, Anioke T, Lifton M, Nkolola J, Stephenson KE, Atyeo C, Shin S, Fields P, Kaplan I, Robins H, Amanat F, Krammer F, Baric RS, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H, Barouch DH. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Nature. 2021 Aug;596(7871):268-272. doi: 10.1038/s41586-021-03681-2. Epub 2021 Jun 9. PMID: 34107529. [Article]