Publications

2025

Terry K, Kroll KW, Jones RA, Reeves RK. Application of a novel branched-DNA assay to quantify killer immunoglobulin-like receptor (KIR) mRNA expression identifies tissue compartmentalization in naïve and SIV-infected rhesus macaques. J Immunol Methods. 2026 Jan;546:114022. doi: 10.1016/j.jim.2025.114022. Epub 2025 Dec 20. PMID: 41429386; PMCID: PMC12840321. [Article]

Walker-Sperling VEK, Nkolola J, Liu J, Aid M, Julg B, Seaman MS, Barouch DH. Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques. Nat Commun. 2025 Dec 18;16(1):11226. doi: 10.1038/s41467-025-66321-7. PMID: 41413011; PMCID: PMC12714793. [Article]

Jons CK, Kasse CM, Mayer BT, Hyrien O, Sen S, Meany EL, d'Aquino AI, Ganesh P, Eckman N, Dong C, Yan J, Nguyen LT, Doulames VM, Song YE, Saouaf OM, Williams CM, Williams SC, Paredes J, Raghavan R, Palomares M, Alpert M, Yates NL, Tomaras GD, Seaman MS, Farzan M, Appel EA. Hydrogel formulations for sustained-release of broadly neutralizing antibodies. J Control Release. 2025 Dec 10;388(Pt 2):114349. doi: 10.1016/j.jconrel.2025.114349. Epub 2025 Oct 31. PMID: 41177463; PMCID: PMC12659352. [Article]

Siddiqi HK, Bhatt K, Gopal DM, Siddiqi OK. Stabilizers, Silencers, and Disease Stage: Lessons From Recent Trials of ATTR Cardiac Amyloidosis. J Am Coll Cardiol. 2025 Dec 3:S0735-1097(25)09918-8. doi: 10.1016/j.jacc.2025.10.019. Epub ahead of print. PMID: 41335083. [Article]

Bernard E, Cortés-Ciriano I, Gaiti F, Gan S, Jiang S, Kovatcheva M, Meisel M, Reticker-Flynn NE, Schram AM, Shoshani O, Silverbush D, Venkataramani V, Weeden CE, Zhou X. Reflections on Advances in Cancer Research in 2025. Cancer Discov. 2025 Dec 2;15(12):2422-2430. doi: 10.1158/2159-8290.CD-25-1833. PMID: 41327969. [Article]

Vidal SJ, Lasrado N, Tostanoski LH, Chaudhari J, Mbiwan ER, Neka GD, Strutton EA, Espinosa Perez AA, Sellers D, Barrett J, Lifton M, Wakabayashi S, Eshaghi B, Borducchi EN, Aid M, Li W, Scriba TJ, Jaklenec A, Langer R, Barouch DH. Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines. Cell. 2025 Nov 26;188(24):6791-6803.e13. doi: 10.1016/j.cell.2025.08.027. Epub 2025 Sep 15. PMID: 40957415; PMCID: PMC12445596. [Article]

Manickam C, Jones R, Deb Adhikary NR, Kroll KW, Terry K, Balachandran H, Woolley G, Tomaras GD, Villinger FJ, Reeves RK. Myeloid cell recruitment and activation through systemic and mucosae-directed cytokine therapy. Immunol Cell Biol. 2025 Nov-Dec;103(10):945-956. doi: 10.1111/imcb.70061. Epub 2025 Oct 7. PMID: 41054306; PMCID: PMC12667110. [Article]

Kroll KW, Woolley G, Reeves RK. Building a better natural killer (NK) cell: Fc receptor engineering strategies for NK cell therapeutics. Future Virol. 2025 Oct;20(10):369-371. doi: 10.1080/17460794.2025.2580187. Epub 2025 Oct 29. PMID: 41409329; PMCID: PMC12707376. [Article]

Wang H, Mou Z, Yeo YY, Ge Q, Liu X, Narita Y, Li Z, Wang C, Li W, Zhao KR, Li J, Bu W, Gewurz B, Cohen JI, Teng M, Dai X, Liu X, Jiang S, Zhao B. Epstein-Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor. Nat Microbiol. 2025 Nov;10(11):2781-2796. doi: 10.1038/s41564-025-02126-0. Epub 2025 Sep 26. PMID: 41006833. [Article]

Andersen H, Aid M, Stone JJ, Lyons CE, Berlied A, Nkolola J, Lasrado N, Peterson M, Pessaint L, Kitajewski C, Yalley-Ogunro J, Porto M, Stone R, Cabus M, Valentin D, Van Ry A, Narvaez B, Orekov T, Kar S, Teow E, Kouneski K, Ferreira A, Velasco J, Campbell R, Henderson C, Beah W, Patel G, Finneyfrock B, Cook A, Paul S, Haasnoot J, Ramirez-Carvajal L, Koldijk MH, Arias Rivas S, Koch CM, Goudsmit J, Lewis MG, Martinot AJ, Barouch DH. Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaques. Immunity. 2025 Sep 9;58(9):2157-2165.e5. doi: 10.1016/j.immuni.2025.07.020. Epub 2025 Aug 18. PMID: 40829590. [Article]

Vidal SJ, Barouch DH. A Novel Approach for Preventing Respiratory Virus Infections. JAMA Intern Med. 2025;185(11):1317–1318. doi:10.1001/jamainternmed.2025.4297 [Article]

Lu Y, Dai H, Tang H, Donahoo WT, George TJ, Sun RC, Jiang S, Tan AC, Guo Y, Licht JD, Allen JM, Lee KP, Guo J, Bian J. Association of Glucagon-Like Peptide-1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes. Obesity (Silver Spring). 2025 Aug 21. doi: 10.1002/oby.24366. [Article]

Kenny A, van Duijn J, Dintwe O, Heptinstall J, Burnham R, Sawant S, Zhang L, Mielke D, Khuzwayo S, Omar FL, Stanfield-Oakley S, Keyes T, Dunn B, Goodman D, Fong Y, Benkeser D, Zou R, Hural J, Hyrien O, Juraska M, Luedtke A, van der Laan L, Giorgi EE, Magaret C, Carpp LN, Pattacini L, van de Kerkhof T, Korber B, Willems W, Fisher LH, Schuitemaker H, Swann E, Kublin JG, Pau MG, Buchbinder S, Tomaka F, Nijs S, Lavreys L, Gelderblom HC, Corey L, Mngadi K, Gray GE, Borducchi E, Hendriks J, Seaton KE, Zolla-Pazner S, Barouch DH, Ferrari G, De Rosa SC, McElrath MJ, Andersen-Nissen E, Stieh DJ, Tomaras GD, Gilbert PB; Imbokodo Study and Correlates Group. Corrigendum to 'Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study'. EBioMedicine 2024;108: 105320. EBioMedicine. 2025 Sep;119:105874. doi: 10.1016/j.ebiom.2025.105874. Epub 2025 Aug 23. Erratum for: EBioMedicine. 2024 Oct;108:105320. doi: 10.1016/j.ebiom.2024.105320. PMID: 40850015; PMCID: PMC12789700. [Article]

Schroeder TA, Manuzak JA, Miller CJ, Gustin AT, Basting CM, Cheu RK, Velez A, Driscoll CB, Tisoncik-Go J, Schifanella L, Hensley-McBain T, Evandy CA, Smith EA, Bratt D, Shields-Cutler R, Smedley J, Fuller DH, Barouch DH, O'Connor MA, Gale M, Klatt NR.2025.Elevated peripheral and nervous system inflammation is associated with decreased short-chain fatty acid levels in Zika virus-infected macaques. J Virol99:e01003-25.https://doi.org/10.1128/jvi.01003-25 [Article]

Ryan S. Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell, Mattia Bonsignori, Yicheng Guo, Michael P. Hogarty, Adam S. Olia, Kirsten J. Sowers, Baoshan Zhang, Frederic Bibollet-Ruche, Tatsiana Bylund, Sean Callaghan, John W. Carey, Gabriele Cerutti, Darcy R. Harris, Wanting He, Emily Lewis, Tracy Liu, Rosemarie D. Mason, Yujie Qiao, Younghoon Park, Juliette M. Rando, Ajay Singh, Jeremy J. Wolff, Q. Paula Lei, Mark K. Louder, Raiees Andrabi, Nicole A. Doria-Rose, Kevin O. Saunders, Michael S. Seaman, Barton F. Haynes, Daniel W. Kulp, John R. Mascola, Mario Roederer, Theodore C. Pierson, Zizhang Sheng, Beatrice H. Hahn, George M. Shaw, Peter D. Kwong, Lawrence Shapiro; Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies. J Exp Med 6 October 2025; 222 (10): e20250638. doi: https://doi.org/10.1084/jem.20250638 [Article]

Parks KR, Moodie Z, Allen MA, Yen C, Furch BD, MacPhee KJ, Ozorowski G, Heptinstall J, Hahn WO, Zheng Z, Lu H, Grant S, Domin E, Duff MO, Seese A, Marini-Macouzet C, Ballweber-Fleming L, Lee WH, Cottrell CA, Liguori A, Georgeson E, Alavi N, Kubitz M, Phelps N, Seaton KE, Cohen KW, Anderson MA, Mondal K, Laufer DS, Kublin JG, Ward AB, Hyrien O, De Rosa SC, Himansu S, Leav B, Reuter C, Tomaras GD, Montefiori D, Walsh SR, Frank I, Sobieszczyk ME, Goepfert PA, Stephenson KE, Baden LR, Van Tieu H, Keefer MC, Clark J, Riddler SA, Schief WR, McElrath MJ. Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial. Science Translational Medicine. 2025 Jul 30;17(809):eady6831. doi: 10.1126/scitranslmed.ady6831. [Article]

Riddler SA, Moodie Z, Clark J, Yen C, Allen M, Furch BD, Lu H, Grant S, Mondal K, Anderson M, Maenza J, Lemos MP, Woodward Davis AS, Walsh SR, Sobieszczyk ME, Frank I, Goepfert P, Stephenson KE, Baden LR, Tieu HV, Keefer MC, McElrath MJ, Kublin JG, Corey L. High Frequency of Chronic Urticaria Following an Investigational HIV-1 BG505 MD39.3 Trimer mRNA Vaccine in a Phase 1, Randomized, Open-Label Clinical Trial (HVTN 302). Annals to Internal Medicine. 2025 Jul;178(7):963-974. doi: 10.7326/ANNALS-24-02701. [Article]

Jones R, Afifi A, Reeves RK, Manickam C. Functional Reprogramming of Peripheral Eosinophils in Lentivirus-Infected Rhesus Macaques. AIDS Research and Human Retroviruses. 2025 Aug;41(8):411-413. doi: 10.1089/aid.2024.0105. Epub 2025 Jun 10. [Article]

Liu SX, Wu TW, Luo DH, Zhang LL, Zhou L, Luo YL, Du WT, Huang TT, Jiang S, Zhang Z, Han P, Zeng MS, Zhong Q. Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma. Cell Reports Medicine. 2025 Jul 15;6(7):102200. doi: 10.1016/j.xcrm.2025.102200. Epub 2025 Jun 20. [Article]

Jacob-Dolan C, Hope D, Liu J, Waller-Pulido A, Verrette B, Cabrera-Barragan DN, Nangle SJ, Wang Q, Blanc R, Fisher J, Lasrado N, Wang L, Cook A, Pessiant L, Lewis M, Andersen H, Hopps M, Scully IL, Allen PS, McNamara RP, Anderson AS, Barouch DH. Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques. Sci Transl Med. 2025 Jul 9;17(806):eadu7646. doi: 10.1126/scitranslmed.adu7646. Epub 2025 Jul 9. [Article]

Hou Z, Shen Y, Fronik S, Shen J, Shi J, Xu J, Chen L, Hardenbrook N, Engelman AN, Aiken C, Zhang P. HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability. Nature Microbiology. 2025 Aug;10(8):1868-1885. doi: 10.1038/s41564-025-02054-z. Epub 2025 Jul 7. [Article]

Sajadi, M. M., Abbasi, A., Tehrani, Z. R., Siska, C., Clark, R., Chi, W., Seaman, M. S., Mielke, D., Wagh, K., Liu, Q., Jumpa, T., Ketchem, R. R., Nguyen, D. N., Tolbert, W. D., Pierce, B. G., Atkinson, B., Deming, D., Sprague, M., Asakawa, A., Ferrer, D., … DeVico, A. (2025). A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV. Structure (London, England : 1993), 33(7), 1150–1164.e8. https://doi.org/10.1016/j.str.2025.04.016 [Article]

Morris DJ, Gorman J, Zhou T, Lora J, Connell AJ, Li H, Liu W, Roark RS, Campion MS, Carey JW, Habib R, Li Y, Martella CL, Park Y, Singh A, Sowers KJ, Teng IT, Wang S, Chohan N, Ding W, Lauer C, Lewis E, Mason RD, Rando JM, Peyton L, Schramm CA, Wagh K, Korber B, Seaman MS, Douek DC, Haynes BF, Kulp DW, Roederer M, Hahn BH, Kwong PD, Shaw GM. Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques. Cell Reports. 2025 Jun 24;44(6):115848. doi: 10.1016/j.celrep.2025.115848. Epub 2025 Jun 13. [Article]

Chapman A, Barouch DH, Lip GYH, Pliakas T, Polverino E, Sourij H, Abduljawad S. Risk of severe outcomes from COVID-19 in comorbid populations in the Omicron era: A systematic review and meta-analysis. International Journal of Infectious Diseases. 2025 Sep;158:107958. doi: 10.1016/j.ijid.2025.107958. Epub 2025 Jun 24. [Article]

Engelman AN, Grandgenett DP, Maertens GN, Yoder KE, Kvaratskhelia M. Retrointegration2023-Papers from the 7th International Conference on Retroviral Integration. Viruses. 2025 Jun 23;17(7):879. doi: 10.3390/v17070879. [Article]

Wang L, Chan CN, Chaudhari J, Hope D, Espinosa Perez AA, Lasrado N, Li Z, Waller-Pulido A, Cabrera-Barragan DN, Verrette B, Nangle SJ, Ayala-Bernot J, Jacob-Dolan C, Lifton M, Strutton E, Fisher J, Mbiwan E, Rossler A, Schrag S, Barouch DH. Mucosal boosting increases protective efficacy of an influenza vaccine in mice. iScience. 2025 May 21;28(6):112721. doi: 10.1016/j.isci.2025.112721. [Article]

Huang Y, Zhang L, Gelderblom H, Seaton KE, Yates NL, Paez CA, Karuna ST, Andrew P, Gamble T, Robinson ST, Ledgerwood JE, Hyrien O, Walsh SR, Gay CL, Gwira JA, Spiegel HML, Sobieszczyk ME, Mannheimer SB, Edupuganti S, Hurt CB, Stephenson KE, Yu C, Kelley CF, Mahomed S, Siegel M, Yacovone M, Pensiero MN, Donnell D, Cohen MS, Corey L, Gilbert PB, Koup RA, Tomaras GD; VRC 605, HVTN 127/HPTN 087, HVTN 130/HPTN 089, HVTN 136/HPTN 092, and HVTN 140/HPTN 101 study teams. Fixed dosing versus weight-based dosing of HIV-1 prophylactic monoclonal antibodies in adults: a post-hoc, cross-protocol pharmacokinetics modelling study. EBioMedicine. 2025 Jul;117:105804. doi: 10.1016/j.ebiom.2025.105804. Epub 2025 Jun 13. [Article]

Aliazis K, Christofides A, Shah R, Yeo YY, Jiang S, Charest A, Boussiotis VA. The tumor microenvironment's role in the response to immune checkpoint blockade. Nature Cancer. 2025 Jun;6(6):924-937. doi: 10.1038/s43018-025-00986-3. Epub 2025 Jun 13. [Article]

Malewana RD, Stalls V, May A, Lu X, Martinez DR, Schäfer A, Li D, Barr M, Sutherland LL, Lee E, Parks R, Beck WE, Newman A, Bock KW, Minai M, Nagata BM, DeMarco CT, Denny TN, Oguin TH 3rd, Rountree W, Wang Y, Mansouri K, Edwards RJ, Smith L, Sempowski GD, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain DW, Santra S, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Montefiori DC, Pardi N, Weissman D, Baric RS, Acharya P, Haynes BF, Saunders KO. Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates. Science Translation Medicine. 2025 Jun 11;17(802):eadn5651. doi: 10.1126/scitranslmed.adn5651. Epub 2025 Jun 11. [Article]

Lagadec F, Singh PK, Calmels C, Lapaillerie D, Lindemann D, Parissi V, Cherepanov P, Engelman AN, Lesbats P. Timed chromatin invasion during mitosis governs prototype foamy virus integration site selection and infectivity. Nucleic Acids Res. 2025 May 22;53(10):gkaf449. doi: 10.1093/nar/gkaf449. [Article]

Seaton KE, Paez CA, Yu C, Karuna ST, Gamble T, Miner MD, Heptinstall J, Zhang L, Gao F, Yacovone M, Spiegel H, Dumond JB, Anderson M, Piwowar-Manning E, Dye B, Tindale I, Proulx-Burns L, Trahey M, Takuva S, Takalani A, Bailey VC, Kalams SA, Scott H, Mkhize NN, Weiner JA, Ackerman ME, McElrath MJ, Pensiero M, Barouch DH, Montefiori D, Tomaras GD, Corey L, Cohen MS, Huang Y, Mahomed S, Siegel M, Kelley CF; HVTN 140/HPTN 101 study team. Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, a V2 specific HIV-1 broadly neutralising antibody, infused intravenously or subcutaneously in people without HIV-1 in the USA (HVTN 140/HPTN 101 part A): a first-in-human, phase 1 randomised trial. Lancet HIV. 2025 Jun;12(6):e405-e415. doi: 10.1016/S2352-3018(25)00012-8. [Article]

Andrews LIB, Halloran ME, Neuzil KM, van der Laan L, Huang Y, Andriesen J, Patel M, Fisher LH, Janes H, Rouphael N, Walsh SR, Theodore DA, Tieu HV, Sobieszczyk M, El Sahly HM, Baden LR, Falsey AR, Campbell TB, Kelley CF, Healy CM, Immergluck L, Luft B, Hirsch I, de Bruyn G, Truyers C, Priddy F, Sumner KM, Flannery B, Follmann D, Gilbert PB; COVID-19 Prevention Network (CoVPN). Evaluating the Test-Negative Design for COVID-19 Vaccine Effectiveness Using Randomized Trial Data: A Secondary Cross-Protocol Analysis of 5 Randomized Clinical Trials. JAMA Netw Open. 2025 May 1;8(5):e2512763. doi: 10.1001/jamanetworkopen.2025.12763

Dam, K. A., Gristick, H. B., Li, Y. E., Yang, Z., Gnanapragasam, P. N. P., West, A. P., Jr, Seaman, M. S., & Bjorkman, P. J. (2025). Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design. Cell reports, 44(5), 115713. https://doi.org/10.1016/j.celrep.2025.115713 [Article]

Sambaturu N, Fray EJ, Hariharan V, Wu F, Zitzmann C, Simonetti FR, Barouch DH, Siliciano JD, Siliciano RF, Ribeiro RM, Perelson AS, Molina-París C, Leitner T. SIV proviruses seeded later in infection are harbored in short-lived CD4⁺ T cells. Cell Reports. 2025 May 27;44(5):115663. doi: 10.1016/j.celrep.2025.115663. Epub 2025 May 5. [Article]

Zhang L, Cagle C, Nguyen DH, Gomes GS, Gromova B, Csizmadia E, Karimitar A, Lee GR, Chen G, Kokkotou E, Grossberg L, Jiang S, Cheifetz AS, Kota SK, Longhi MS. Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease. Cellular Molecular Immunology. 2025 Jul;22(7):730-742. doi: 10.1038/s41423-025-01295-6. Epub 2025 May 26. [Article]

Zhu B, Gao S, Chen S, Wang Y, Yeung J, Bai Y, Huang AY, Yeo YY, Liao G, Mao S, Jiang ZG, Rodig SJ, Wong KC, Shalek AK, Nolan GP, Jiang S, Ma Z. CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data. Nature Immunology. 2025 Jun;26(6):963-974. doi: 10.1038/s41590-025-02163-1. Epub 2025 May 22. [Article]

Kim, S., Radford, C. E., Xu, D., Zhong, J., Do, J., Pham, D. M., Travisano, K. A., Filsinger Interrante, M. V., Bruun, T. U. J., Rezek, V., Wilder, B., Palomares, M., Seaman, M. S., Kitchen, S. G., Bloom, J. D., & Kim, P. S. (2025). A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning. Nature communications, 16(1), 4617. https://doi.org/10.1038/s41467-025-60035-6 [Article]

Chaubey, M., Gao, H., Lavine, C. L., Seaman, M. S., Chen, B., & Chou, J. J. (2025). Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR. Journal of the American Chemical Society, 147(21), 17561–17565. https://doi.org/10.1021/jacs.5c04597 [Article]

Mahyari, E., Boggy, G. J., McElfresh, G. W., Kaza, M., Benjamin, S., Varco-Merth, B., Ojha, S., Feltham, S., Goodwin, W., Nkoy, C., Duell, D., Selseth, A., Bennett, T., Barber-Axthelm, A., Smedley, J. V., Labriola, C. S., Axthelm, M. K., Reeves, R. K., Okoye, A. A., Hansen, S. G., … Bimber, B. N. (2025). Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas. Cell genomics, 5(5), 100849. https://doi.org/10.1016/j.xgen.2025.100849 [Article]

Youssef N, Gurev S, Ghantous F, Brock KP, Jaimes JA, Thadani NN, Dauphin A, Sherman AC, Yurkovetskiy L, Soto D, Estanboulieh R, Kotzen B, Notin P, Kollasch AW, Cohen AA, Dross SE, Erasmus J, Fuller DH, Bjorkman PJ, Lemieux JE, Luban J, Seaman MS, Marks DS. Computationally designed proteins mimic antibody immune evasion in viral evolution. Immunity. 2025 Jun 10;58(6):1411-1421.e6. doi: 10.1016/j.immuni.2025.04.015. Epub 2025 May 8. [Article]

Stephenson K. E. (2025). Next-Generation Coronavirus Disease 2019 Vaccines: Clinical Data and Future Directions. Infectious disease clinics of North America, 39(2), 253–274. https://doi.org/10.1016/j.idc.2025.02.003 [Article]

Jiang, K., Gootenberg, J. S., & Abudayyeh, O. O. (2025). Fanzors, a family of eukaryotic RNA-guided DNA endonucleases. FEBS letters, 599(8), 1089–1093. https://doi.org/10.1002/1873-3468.70038 [Article]

Briganti, L., Annamalai, A. S., Bester, S. M., Wei, G., Andino-Moncada, J. R., Singh, S. P., Kleinpeter, A. B., Tripathi, M., Nguyen, B., Radhakrishnan, R., Singh, P. K., Greenwood, J., Schope, L. I., Haney, R., Huang, S.-W., Freed, E. O., Engelman, A. N., Francis, A. C., & Kvaratskhelia, M. (2025). Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir. mBio, 16(5), e0361324. https://doi.org/10.1128/mbio.03613-24 [Article]

Fell CW, Villiger L, Lim J, Hiraizumi M, Tagliaferri D, Yarnall MTN, Lee A, Jiang K, Kayabolen A, Krajeski RN, Schmitt-Ulms C, Ramani H, Yousef SM, Roberts N, Vakulskas CA, Nishimasu H, Abudayyeh OO, Gootenberg JS. Reprogramming site-specific retrotransposon activity to new DNA sites. Nature. 2025 Jun;642(8069):1080-1089. doi: 10.1038/s41586-025-08877-4. Epub 2025 Apr 9. [Article]

Chaudhuri, E., Jang, S., Chakraborty, R., Radhakrishnan, R., Arnarson, B., Prakash, P., Cornish, D., Rohlfes, N., Singh, P. K., Shi, J., Aiken, C., Campbell, E., Hultquist, J., Balsubramaniam, M., Engelman, A. N., & Dash, C. (2025). CPSF6 promotes HIV-1 preintegration complex function. Journal of virology, 99(5), e0049025. https://doi.org/10.1128/jvi.00490-25 [Article]

Blass, E., Colarusso, A., Aid, M., Larocca, R. A., Reeves, R. K., & Barouch, D. H. (2025). Early spatiotemporal evolution of the immune response elicited by adenovirus serotype 26 vector vaccination in mice. Journal of virology, 99(5), e0024725. https://doi.org/10.1128/jvi.00247-25 [Article]

Ingram, Z., Kline, C., Hughson, A. K., Singh, P. K., Fischer, H. L., Radhakrishnan, R., Sowd, G. A., Dos Santos, N. F. B., Ganser-Pornillos, B. K., Watkins, S. C., Kane, M., Engelman, A. N., & Ambrose, Z. (2025). Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration. mBio, 16(4), e0016925. https://doi.org/10.1128/mbio.00169-25 [Article]

Han, J., Kanelli, M., Liu, Y., Daristotle, J. L., Pardeshi, A., Forster, T. A., Karchin, A., Folk, B., Murmann, L., Tostanoski, L. H., Carrasco, S. E., Alsaiari, S. K., Wang, E. Y., Tran, K., Zhang, L., Eshaghi, B., Levy, L., Pyon, S., Sloane, C., Lin, S. Q., … Jaklenec, A. (2025). On-patient medical record and mRNA therapeutics using intradermal microneedles. Nature materials, 24(5), 794–803. https://doi.org/10.1038/s41563-024-02115-4 [Article]

Chawana, T. D., Walsh, S. R., Stranix-Chibanda, L., Chirenje, Z. M., Yu, C., Zhang, L., Seaton, K. E., Heptinstall, J., Zhang, L., Paez, C. A., Gamble, T., Karuna, S. T., Andrew, P., Hanscom, B., Sobieszczyk, M. E., Edupuganti, S., Gay, C. L., Mannheimer, S. B., Hurt, C. B., Stephenson, K. E., … HVTN 127/HPTN 087, HVTN 130/HPTN 089 and HVTN 136/HPTN 092 Study Teams (2025). Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV. BMC immunology, 26(1), 8. https://doi.org/10.1186/s12865-025-00687-7 [Article]

Mielke, D., Tuyishime, M., Kelkar, N. S., Wang, Y., Parks, R., Santra, S., Rountree, W., Williams, L. D., Peters, T., Eisel, N., Sawant, S., Zhang, L., Goodman, D., Jha, S., Zalaquett, A., Ramasubramanian, P., Stanfield-Oakley, S., Matyas, G., Beck, Z., ... Ferrari, G. (2025). Computationally Selected Multivalent HIV-1 Subtype C Vaccine Protects Against Heterologous SHIV Challenge. Vaccines, 13(3), 231. https://doi.org/10.3390/vaccines13030231 [Article]

Hudson, A., Wu, P., Kroll, K. W., Hueber, B., Woolley, G., Shi, P., & Reeves, R. K. (2025). Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes. Journal of virology, 99(3), e0163424. https://doi.org/10.1128/jvi.01634-24 [Article]

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Kahan, R. H., Abraham, N., Lee, H. J., Ettenger, R. B., Grimm, P. C., Reed, E. F., Reeves, R. K., Sarwal, M. M., Stempora, L. L., Warshaw, B. L., Kirk, A. D., Martinez, O. M., & Chambers, E. T. (2024). Natural Killer Cell Phenotypes and Clinical Outcomes in Pediatric Kidney Transplantation. Pediatric transplantation, 28(8), e14877. https://doi.org/10.1111/petr.14877 [Article]

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Govindan, R., & Stephenson, K. E. (2024). HIV Vaccine Development at a Crossroads: New B and T Cell Approaches. Vaccines, 12(9), 1043. https://doi.org/10.3390/vaccines12091043 [Article]

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Chang, Y., Liu, J., Jiang, Y., Ma, A., Yeo, Y. Y., Guo, Q., McNutt, M., Krull, J. E., Rodig, S. J., Barouch, D. H., Nolan, G. P., Xu, D., Jiang, S., Li, Z., Liu, B., & Ma, Q. (2024). Graph Fourier transform for spatial omics representation and analyses of complex organs. Nature communications, 15(1), 7467. https://doi.org/10.1038/s41467-024-51590-5 [Article]

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Gelderblom, H.C., Corey, L. and Barouch, D.H. (2024), The potential of broadly neutralizing antibodies for HIV prevention. J Int AIDS Soc., 27: e26257. https://doi.org/10.1002/jia2.26257 [Article]

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Gelderblom HC, Corey L, Barouch DH. The potential of broadly neutralizing antibodies for HIV prevention. J Int AIDS Soc. 2024 May;27(5):e26257. doi: 10.1002/jia2.26257. PMID: 38757844; PMCID: PMC11100278. [Article]

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Woolley G, Kroll K, Hoffman K, Ward A, Corneli A, Mudrak SV, Qureshi MU, Okeke NL, Chan C, Jones AD, Tomaras GD, Reeves RK. The Climate Change Burden on Immune Health: Are Persons Living With HIV More at Risk? AIDS Res Hum Retroviruses. 2024 May 16. doi: 10.1089/AID.2024.0050. Epub ahead of print. PMID: 38753709. [Article]

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Wilson SM, Woolley G, Hawn C, Hoffman K, Jones AD, Chan C, Mudrak SV, Qureshi MU, Ward A, Knippler ET, Okeke NL, Corneli A, Tomaras GD, Reeves RK. Intersectional climate justice, health equity, and HIV. Lancet HIV. 2024 May;11(5):e280-e281. doi: 10.1016/S2352-3018(24)00062-6. Epub 2024 Apr 3. PMID: 38582097. [Article]

Mahrokhian, S. H., Tostanoski, L. H., Vidal, S. J., & Barouch, D. H. (2024). COVID-19 vaccines: Immune correlates and clinical outcomes. Human Vaccines & Immunotherapeutics, 20(1). https://doi.org/10.1080/21645515.2024.2324549 [Article]

Pinski AN, Gan T, Lin S, Droit L, Diamond M, Barouch DH, Wang D.2024.Isolation of a recombinant simian adenovirus encoding the human adenovirus G52 hexon suggests a simian origin for human adenovirus G52. J Virol98:e00043-24.https://doi.org/10.1128/jvi.00043-24 [Article]

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Vander Straeten A, Sarmadi M, Daristotle JL, Kanelli M, Tostanoski LH, Collins J, Pardeshi A, Han J, Varshney D, Eshaghi B, Garcia J, Forster TA, Li G, Menon N, Pyon SL, Zhang L, Jacob-Dolan C, Powers OC, Hall K, Alsaiari SK, Wolf M, Tibbitt MW, Farra R, Barouch DH, Langer R, Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nat Biotechnol. 2024 Mar;42(3):510-517. doi: 10.1038/s41587-023-01774-z. Epub 2023 Apr 24. PMID: 37095347; PMCID: PMC10593912. [Article]

Lasrado N, Rössler A, Rowe M, Collier AY, Barouch DH. Neutralization of SARS-CoV-2 Omicron subvariant BA.2.87.1. Vaccine. 2024 Apr 2;42(9):2117-2121. doi: 10.1016/j.vaccine.2024.03.007. Epub 2024 Mar 7. PMID: 38458874. [Article]

Alsaiari SK, Nadeef S, Daristotle JL, Rothwell W, Du B, Garcia J, Zhang L, Sarmadi M, Forster TA, Menon N, Lin SQ, Tostanoski LH, Hachmann N, Wang EY, Ventura JD, Barouch DH, Langer R, Jaklenec A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Sci Adv. 2024 Mar 8;10(10):eadj6380. doi: 10.1126/sciadv.adj6380. Epub 2024 Mar 6. PMID: 38446889; PMCID: PMC10917347. [Article]

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Mayer BT, Zhang L, deCamp AC, Yu C, Sato A, Angier H, Seaton KE, Yates N, Ledgerwood JE, Mayer K, et al. Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV. Pharmaceutics. 2024; 16(5):594. https://doi.org/10.3390/pharmaceutics16050594 [Article]

Joseph P Nkolola, Jinyan Liu, Ai-ris Y Collier, Catherine Jacob-Dolan, Yasmeen Senussi, Ella Borberg, Zoe Swank, David R Walt, Dan H Barouch, High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays, The Journal of Infectious Diseases, 2024;, jiae174, https://doi.org/10.1093/infdis/jiae174 [Article]

Cassidy T, Stephenson KE, Barouch DH, Perelson AS (2024) Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1. PLOS Computational Biology 20(3): e1011518. https://doi.org/10.1371/journal.pcbi.1011518

Jiang, S. PANINI: Combined protein and nucleic acid imaging in tissues. Nat Rev Immunol (2024). https://doi.org/10.1038/s41577-024-01028-2 [Article]

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Gao L, Zhang W, Zhang L, Gromova B, Chen G, Csizmadia E, Cagle C, Nastasio S, Ma Y, Bonder A, Patwardhan V, Robson SC, Jiang S, Longhi MS. Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis. J Autoimmun. 2024 Feb;143:103162. doi: 10.1016/j.jaut.2023.103162. Epub 2023 Dec 23. PMID: 38142533; PMCID: PMC10981568. [Article]

Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency. Sci Transl Med. 2024 Jan 24;16(731):eadk1599. doi: 10.1126/scitranslmed.adk1599. Epub 2024 Jan 24. PMID: 38266109. [Article]

Song NJ, Chakravarthy KB, Jeon H, Bolyard C, Reynolds K, Weller KP, Reisinger S, Wang Y, Li A, Jiang S, Ma Q, Barouch DH, Rubinstein MP, Shields PG, Oltz EM, Chung D, Li Z. mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer. J Immunother Cancer. 2024 Jan 4;12(1):e007922. doi: 10.1136/jitc-2023-007922. PMID: 38177076; PMCID: PMC10773442.

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Shaban M, Bai Y, Qiu H, Mao S, Yeung J, Yeo YY, Shanmugam V, Chen H, Zhu B, Weirather JL, Nolan GP, Shipp MA, Rodig SJ, Jiang S, Mahmood F. MAPS: pathologist-level cell type annotation from tissue images through machine learning. Nat Commun. 2024 Jan 2;15(1):28. doi: 10.1038/s41467-023-44188-w. PMID: 38167832; PMCID: PMC10761896. [Article]

Patel AG, Ashenberg O, Collins NB, Segerstolpe Å, Jiang S, Slyper M, Huang X, Caraccio C, Jin H, Sheppard H, Xu K, Chang TC, Orr BA, Shirinifard A, Chapple RH, Shen A, Clay MR, Tatevossian RG, Reilly C, Patel J, Lupo M, Cline C, Dionne D, Porter CBM, Waldman J, Bai Y, Zhu B, Barrera I, Murray E, Vigneau S, Napolitano S, Wakiro I, Wu J, Grimaldi G, Dellostritto L, Helvie K, Rotem A, Lako A, Cullen N, Pfaff KL, Karlström Å, Jané-Valbuena J, Todres E, Thorner A, Geeleher P, Rodig SJ, Zhou X, Stewart E, Johnson BE, Wu G, Chen F, Yu J, Goltsev Y, Nolan GP, Rozenblatt-Rosen O, Regev A, Dyer MA. A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity. bioRxiv [Preprint]. 2024 Jan 16:2024.01.07.574538. doi: 10.1101/2024.01.07.574538. PMID: 38260392; PMCID: PMC10802404. [Article]

Conley HE, He MM, Easterhoff D, Kirshner HF, Cocklin SL, Meyer J, Hoxie T, Berry M, Bradley T, Tolbert WD, Pazgier M, Tomaras GD, Schmitz JE, Moody MA, Wiehe K, Pollara J. Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing. Front Immunol. 2024 Jan 9;14:1306292. doi: 10.3389/fimmu.2023.1306292. PMID: 38264644; PMCID: PMC10803544. [Article]

2023

Nkolola JP, Barouch DH. Prophylactic HIV-1 vaccine trials: past, present, and future. Lancet HIV. 2023 Dec 20:S2352-3018(23)00264-3. doi: 10.1016/S2352-3018(23)00264-3. Epub ahead of print. PMID: 38141639. [Article]

McMahan K, Wegmann F, Aid M, Sciacca M, Liu J, Hachmann NP, Miller J, Jacob-Dolan C, Powers O, Hope D, Wu C, Pereira J, Murdza T, Mazurek CR, Hoyt A, Boon ACM, Davis-Gardner M, Suthar MS, Martinot AJ, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Tolboom J, Serroyen J, Solforosi L, Costes LMM, Zahn RC, Barouch DH. Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques. Nature. 2023 Dec 14. doi: 10.1038/s41586-023-06951-3. Epub ahead of print. PMID: 38096903. [Article]

Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, Cui Z, Zhao D, Barouch DH, Yu J. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses. 2023 Dec 9;15(12):2401. doi: 10.3390/v15122401. PMID: 38140642; PMCID: PMC10747620. [Article]

Jost S, Lucar O, Lee E, Yoder T, Kroll K, Sugawara S, Smith S, Jones R, Tweet G, Werner A, Tomezsko PJ, Dugan HL, Ghofrani J, Rascle P, Altfeld M, Müller-Trutwin M, Goepfert P, Reeves RK. Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis. Sci Immunol. 2023 Dec 8;8(90):eadi3974. doi: 10.1126/sciimmunol.adi3974. Epub 2023 Dec 8. PMID: 38064568. [Article]

Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Viral and host mediators of non-suppressible HIV-1 viremia. Nat Med. 2023 Dec;29(12):3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. PMID: 37957382; PMCID: PMC10719098. [Article]

Lasrado N, Collier AY, Hachmann NP, Miller J, Rowe M, Schonberg ED, Rodrigues SL, LaPiana A, Patio RC, Anand T, Fisher J, Mazurek CR, Guan R, Wagh K, Theiler J, Korber BT, Barouch DH. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023 Nov 13;41(47):6904-6909. doi: 10.1016/j.vaccine.2023.10.051. Epub 2023 Oct 21. PMID: 37872011. [Article]

Lasrado N, Barouch DH. SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds. J Infect Dis. 2023 Nov 11;228(10):1311-1313. doi: 10.1093/infdis/jiad353. PMID: 37592872. [Article]

Huot N, Planchais C, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Rosenbaum P, Rey F, Reeves RK, Grand RL, Mouquet H, Müller-Trutwin M. Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection. Nat Immunol 24, 2068–2079 (2023). https://doi.org/10.1038/s41590-023-01661-4 [Article]

Huot N, Planchais C, Rosenbaum P, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Beaumont E, Orta-Resendiz A, Rey FA, Reeves RK, Le Grand R, Mouquet H, Müller-Trutwin M. SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells. Nat Immunol. 2023 Dec;24(12):2068-2079. doi: 10.1038/s41590-023-01661-4. Epub 2023 Nov 2. PMID: 37919524; PMCID: PMC10681903. [Article]

Stephenson KE, Marcelin JR, Pettifor AE, Janes H, Brown E, Neradilek M, Yen C, Andriesen J, Grunenberg N, Espy N, Trahey M, Fischer RSB, DeSouza CA, Shisler JL, Connick E, Houpt ER, Chu HY, McCulloh RJ, Becker-Dreps S, Vielot NA, Kalbaugh CA, Cherabuddi K, Krueger KM, Rosenberg M, Greenberg RN, Joaquin A, Immergluck LC, Corey L, Kublin JG. Efficacy of Messenger RNA-1273 Against Severe Acute Respiratory Syndrome Coronavirus 2 Acquisition in Young Adults From March to December 2021. Open Forum Infect Dis. 2023 Nov 2;10(11):ofad511. doi: 10.1093/ofid/ofad511. PMID: 38023544; PMCID: PMC10655942. [Article]

van Duijn J, Stieh D, Fernandez N, King D, Gilmour J, Tolboom J, Callewaert K, Willems W, Pau MG, De Rosa SC, McElrath MJ, Barouch DH, Hayes P. Mosaic HIV-1 vaccination induces anti-viral CD8⁺ T cell functionality in the phase 1/2a clinical trial APPROACH. J Virol. 2023 Oct 31;97(10):e0112623. doi: 10.1128/jvi.01126-23. Epub 2023 Oct 9. PMID: 37811993; PMCID: PMC10617392. [Article]

Mabrouk MT, Zidan AA, Aly N, Mohammed MT, Ghantous F, Seaman MS, Lovell JF, Nasr ML. Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens. Vaccines (Basel). 2023 Oct 28;11(11):1655. doi: 10.3390/vaccines11111655. PMID: 38005987; PMCID: PMC10675430. [Article]

Kumar MR, Fray EJ, Bender AM, Zitzmann C, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2313209120. doi: 10.1073/pnas.2313209120. Epub 2023 Oct 16. PMID: 37844236; PMCID: PMC10614214. [Article]

Aid M, Stephenson KE, Collier AY, Nkolola JP, Michael JV, McKenzie SE, Barouch DH. Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination. Nat Commun. 2023 Oct 23;14(1):6703. doi: 10.1038/s41467-023-42559-x. PMID: 37872311; PMCID: PMC10593859. [Article]

Aid M, Sciacca M, McMahan K, Hope D, Liu J, Jacob-Dolan C, Powers O, Barrett J, Wu C, Mutoni A, Murdza T, Richter H, Velasco J, Teow E, Boursiquot M, Cook A, Orekov T, Hamilton M, Pessaint L, Ryan A, Hayes T, Martinot AJ, Seaman MS, Lewis MG, Andersen H, Barouch DH. Mpox infection protects against re-challenge in rhesus macaques. Cell. 2023 Oct 12;186(21):4652-4661.e13. doi: 10.1016/j.cell.2023.08.023. Epub 2023 Sep 20. PMID: 37734373; PMCID: PMC10591870. [Article]

Sobieszczyk ME, Mannheimer S, Paez CA, Yu C, Gamble T, Theodore DA, Chege W, Yacovone M, Hanscom B, Heptinstall J, Seaton KE, Zhang L, Miner MD, Eaton A, Weiner JA, Mayer K, Kalams S, Stephenson K, Julg B, Caskey M, Nussenzweig M, Gama L, Barouch DH, Ackerman ME, Tomaras GD, Huang Y, Montefiori D; HVTN 130/HPTN 089 Study Team. Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial. Lancet HIV. 2023 Oct;10(10):e653-e662. doi: 10.1016/S2352-3018(23)00140-6. PMID: 37802566; PMCID: PMC10629933.https://www.sciencedirect.com/science/article/abs/pii/S2352301823001406?via%3Dihub [Article]

Irie WC, Chitneni P, Glynn TR, Allen W, Chai PR, Engelman AN, Hurtado R, Li JZ, Li P, Lockman S, Marcus JL, Ogunshola FJ, Rönn MM, Haberer J, Ghebremichael M, Ciaranello A; Harvard University Center for AIDS Research Diversity, Equity, and Inclusion Working Group. Pathways and Intersections: Multifaceted Approaches to Engage Individuals From Underrepresented and Marginalized Communities in HIV Research and Career Development. J Acquir Immune Defic Syndr. 2023 Oct 1;94(2S):S116-S121. doi: 10.1097/QAI.0000000000003265. PMID: 37707858; PMCID: PMC10503030. [Article]

Collier AY, Modest AM, Aguayo RA, Bondzie EA, Patel S, Hacker MR, Barouch DH. Altered Cytokine Production in Human Intervillous Blood T Cells in Preeclampsia. Reprod Sci. 2023 Sep;30(9):2655-2664. doi: 10.1007/s43032-023-01165-4. Epub 2023 Feb 7. PMID: 36749459; PMCID: PMC10404629. [Article]

Jang S, Engelman AN. Capsid-host interactions for HIV-1 ingress. Microbiol Mol Biol Rev. 2023 Dec 20;87(4):e0004822. doi: 10.1128/mmbr.00048-22. Epub 2023 Sep 26. PMID: 37750702; PMCID: PMC10732038. [Article]

Sankhala RS, Dussupt V, Donofrio G, Gromowski GD, De La Barrera RA, Larocca RA, Mendez-Rivera L, Lee A, Choe M, Zaky W, Mantus G, Jensen JL, Chen WH, Gohain N, Bai H, McCracken MK, Mason RD, Leggat D, Slike BM, Tran U, Jian N, Abbink P, Peterson R, Mendes EA, Freitas de Oliveira Franca R, Calvet GA, Bispo de Filippis AM, McDermott A, Roederer M, Hernandez M, Albertus A, Davidson E, Doranz BJ, Rolland M, Robb ML, Lynch RM, Barouch DH, Jarman RG, Thomas SJ, Modjarrad K, Michael NL, Krebs SJ, Joyce MG. Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 2023 Aug 29;42(8):112942. doi: 10.1016/j.celrep.2023.112942. Epub 2023 Aug 9. PMID: 37561630; PMCID: PMC10775418. [Article]

Liew MY, Mathews JI, Li A, Singh R, Jaramillo SA, Weiss ZF, Bowman K, Ankomah PO, Ghantous F, Lewis GD, Neuringer I, Bitar N, Lipiner T, Dighe AS, Kotton CN, Seaman MS, Lemieux JE, Goldberg MB. Delayed and Attenuated Antibody Responses to Coronavirus Disease 2019 Vaccination With Poor Cross-Variant Neutralization in Solid-Organ Transplant Recipients-A Prospective Longitudinal Study. Open Forum Infect Dis. 2023 Aug 10;10(8):ofad369. doi: 10.1093/ofid/ofad369. PMID: 37577118; PMCID: PMC10414143. [Article]

Aid M, Colarusso A, Walker-Sperling V, Barouch DH. Peripheral blood biomarkers predict viral rebound following antiretroviral therapy discontinuation in SIV-infected, early ART-treated rhesus macaques. Cell Rep Med. 2023 Jul 18;4(7):101122. doi: 10.1016/j.xcrm.2023.101122. PMID: 37467721; PMCID: PMC10394255. [Article]

Redhunt AM, Ledyard R, Collier AY, Hacker MR, Burris HH. Resilience as a potential modifier of racial inequities in preterm birth. Ann Epidemiol. 2023 Jul;83:54-59.e1. doi: 10.1016/j.annepidem.2023.04.010. Epub 2023 Apr 22. PMID: 37088321; PMCID: PMC10330189. [Article]

Wagh K, Seaman MS. Divide and conquer: broadly neutralizing antibody combinations for improved HIV-1 viral coverage. Curr Opin HIV AIDS. 2023 Jul 1;18(4):164-170. doi: 10.1097/COH.0000000000000800. Epub 2023 May 19. PMID: 37249911; PMCID: PMC10256304. [Article]

Vidal SJ, Sellers D, Yu J, Wakabayashi S, Sixsmith J, Aid M, Barrett J, Stevens SF, Liu X, Li W, Plumlee CR, Urdahl KB, Martinot AJ, Barouch DH. Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model. iScience. 2023 May 28;26(6):106963. doi: 10.1016/j.isci.2023.106963. PMID: 37378347; PMCID: PMC10291467. [Article]

Bartsch YC, Cizmeci D, Kang J, Gao H, Shi W, Chandrashekar A, Collier AY, Chen B, Barouch DH, Alter G. Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions. iScience. 2023 May 19;26(5):106582. doi: 10.1016/j.isci.2023.106582. Epub 2023 Apr 7. PMID: 37082529; PMCID: PMC10079316. [Article]

Gan T, Droit L, Vernon S, Barouch DH, Wang D. Isolation of a rhesus calicivirus that can replicate in human cells. Virology. 2023 May;582:83-89. doi: 10.1016/j.virol.2023.03.012. Epub 2023 Apr 2. PMID: 37031656; PMCID: PMC10264158. [Article]

Vander Straeten A, Sarmadi M, Daristotle JL, Kanelli M, Tostanoski LH, Collins J, Pardeshi A, Han J, Varshney D, Eshaghi B, Garcia J, Forster TA, Li G, Menon N, Pyon SL, Zhang L, Jacob-Dolan C, Powers OC, Hall K, Alsaiari SK, Wolf M, Tibbitt MW, Farra R, Barouch DH, Langer R, Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nat Biotechnol. 2023 Apr 24:10.1038/s41587-023-01774-z. doi: 10.1038/s41587-023-01774-z. Epub ahead of print. PMID: 37095347; PMCID: PMC10593912. [Article]

Yu J, Thomas PV, Sciacca M, Wu C, Liu J, He X, Miller J, Hachmann NP, Surve N, McMahan K, Jacob-Dolan C, Powers O, Hall K, Barrett J, Hope D, Mazurek CR, Murdza T, Chang WC, Golub E, Rees PA, Peterson CE, Hajduczki A, Chen WH, Martinez EJ, Hussin E, Lange C, Gong H, Matyas GR, Rao M, Suthar M, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Bolton DL, Michael NL, Joyce MG, Modjarrad K, Barouch DH. Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques. Cell Rep Med. 2023 Apr 18;4(4):101018. doi: 10.1016/j.xcrm.2023.101018. Epub 2023 Mar 27. PMID: 37023746; PMCID: PMC10040355. [Article]

Daniel J Stieh, Dan H Barouch, Christy Comeaux, Michal Sarnecki, Kathryn E Stephenson, Stephen R Walsh, Sheetal Sawant, Jack Heptinstall, Georgia D Tomaras, James G Kublin, M Juliana McElrath, Kristen W Cohen, Stephen C De Rosa, Galit Alter, Guido Ferrari, David Montefiori, Philipp Mann, Steven Nijs, Katleen Callewaert, Paul A Goepfert, Srilatha Edupuganti, Etienne Karita, Michael S Seaman, Lawrence Corey, Lindsey R Baden, Maria G Pau, Hanneke Schuitemaker, Frank Tomaka, the ASCENT/HVTN118/HPX2003 Study Team , Safety and Immunogenicity of Ad26-Vectored HIV Vaccine With Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-Uninfected Adults: A Phase 1/2a Study, The Journal of Infectious Diseases, Volume 227, Issue 8, 15 April 2023, Pages 939–950, https://doi.org/10.1093/infdis/jiac445 [Article]

Solforosi, L., Costes, L.M.M., Tolboom, J.T.B.M. et al. Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques. Nat Commun 14, 1944 (2023). https://doi.org/10.1038/s41467-023-37715-2 [Article]

Cable J, Graham BS, Koup RA, Seder RA, Karikó K, Pardi N, Barouch DH, Sharma B, Rauch S, Nachbagauer R, Forsell MNE, Schotsaert M, Ellebedy AH, Loré K, Irvine DJ, Pilkington E, Tahtinen S, Thompson EA, Feraoun Y, King NP, Saunders K, Alter G, Moin SM, Sliepen K, Karlsson Hedestam GB, Wardemann H, Pulendran B, Doria-Rose NA, He WT, Juno JA, Ataca S, Wheatley AK, McLellan JS, Walker LM, Lederhofer J, Lindesmith LC, Wille H, Hotez PJ, Bekker LG. Progress in vaccine development for infectious diseases-a Keystone Symposia report. Ann N Y Acad Sci. 2023 Jun;1524(1):65-86. doi: 10.1111/nyas.14975. Epub 2023 Apr 5. PMID: 37020354. [Article]

Garber, David A.a; Guenthner, Patriciaa; Zhao, Chunxiaa; Mitchell, Jamesa; Ellis, Shanona; Jia, Hongweia; Manganare, Marcosa; Gazumyan, Annab; Seaman, Michael S.c; Vishwanathan, Sundaram Ajaya; Heneine, Walida; McNicholl, Janet M.a. Broadly neutralizing antibody-mediated protection against simian-HIV infection among macaques with vaginal sexually transmitted infections. AIDS 37(5):p 723-731, April 1, 2023. | DOI: 10.1097/QAD.0000000000003472 [Article]

Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2202815120. doi: 10.1073/pnas.2202815120. Epub 2023 Mar 21. PMID: 36943880; PMCID: PMC10068764. [Article]

Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Mar 3;8(1):30. doi: 10.1038/s41541-023-00634-w. Erratum for: NPJ Vaccines. 2023 Feb 14;8(1):18. PMID: 36869134; PMCID: PMC9982769. [Article]

Joseph NT, Collier AY. COVID-19 Therapeutics and Considerations for Pregnancy. Obstet Gynecol Clin North Am. 2023 Mar;50(1):163-182. doi: 10.1016/j.ogc.2022.10.018. Epub 2022 Oct 21. PMID: 36822701; PMCID: PMC9584862. [Article]

Jacob-Dolan, C., Yu, J., McMahan, K. et al. Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques. npj Vaccines 8, 23 (2023). https://doi.org/10.1038/s41541-023-00622-0 [Article]

Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nat Struct Mol Biol. 2023 Apr;30(4):425-435. doi: 10.1038/s41594-023-00925-9. Epub 2023 Feb 20. PMID: 36807645; PMCID: PMC10121901. [Article]

Fray EJ, Wu F, Simonetti FR, Zitzmann C, Sambaturu N, Molina-Paris C, Bender AM, Liu PT, Ventura JD, Wiseman RW, O'Connor DH, Geleziunas R, Leitner T, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants. Cell Host Microbe. 2023 Mar 8;31(3):356-372.e5. doi: 10.1016/j.chom.2023.01.016. Epub 2023 Feb 20. PMID: 36809762; PMCID: PMC10583177. [Article]

Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Feb 14;8(1):18. doi: 10.1038/s41541-023-00610-4. Erratum in: NPJ Vaccines. 2023 Mar 3;8(1):30. PMID: 36788219; PMCID: PMC9927065. [Article]

Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio. 2023 Feb 28;14(1):e0356022. doi: 10.1128/mbio.03560-22. Epub 2023 Feb 6. PMID: 36744954; PMCID: PMC9973045. [Article]

Woolley G, Mosher M, Kroll K, Jones R, Hueber B, Sugawara S, Manickam C, Terry K, Varner V, Lifton M, Ram D, Fennessey CM, Keele BF, Reeves RK. Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events. J Virol. 2023 Jan 31;97(1):e0151922. doi: 10.1128/jvi.01519-22. Epub 2022 Dec 13. PMID: 36511699; PMCID: PMC9888193

Rascle P, Woolley G, Jost S, Manickam C, Reeves RK. NK cell education: Physiological and pathological influences. Front Immunol. 2023 Jan 20;14:1087155. doi: 10.3389/fimmu.2023.1087155. PMID: 36742337; PMCID: PMC9896005.

Kroll K, Reeves RK. Protocol for identification and computational analysis of human natural killer cells using flow cytometry and R. STAR Protoc. 2023 Jan 19;4(1):102044. doi: 10.1016/j.xpro.2023.102044. Epub ahead of print. PMID: 36853664; PMCID: PMC9871333.

Miller, J., Hachmann, N. P., Collier, A. Y., Lasrado, N., Mazurek, C. R., Patio, R. C., Powers, O., Surve, N., Theiler, J., Korber, B., & Barouch, D. H. (2023). Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1. The New England journal of medicine, 10.1056/NEJMc2214314. Advance online publication. https://doi.org/10.1056/NEJMc2214314 [Article]

Collier, A. Y., Miller, J., Hachmann, N. P., McMahan, K., Liu, J., Bondzie, E. A., Gallup, L., Rowe, M., Schonberg, E., Thai, S., Barrett, J., Borducchi, E. N., Bouffard, E., Jacob-Dolan, C., Mazurek, C. R., Mutoni, A., Powers, O., Sciacca, M., Surve, N., VanWyk, H., … Barouch, D. H. (2023). Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters. The New England journal of medicine, 10.1056/NEJMc2213948. Advance online publication. https://doi.org/10.1056/NEJMc2213948 [Article]

2022

Cooper, A., Sidaway, A., Chandrashekar, A., Latta, E., Chakraborty, K., Yu, J., McMahan, K., Giffin, V., Manickam, C., Kroll, K., Mosher, M., Reeves, R. K., Gam, R., Arthofer, E., Choudhry, M., Henley, T., & Barouch, D. H. (2022). A genetically engineered, stem-cell-derived cellular vaccine. Cell reports. Medicine, 3(12), 100843. https://doi.org/10.1016/j.xcrm.2022.100843 [Article]

Cooper A, Sidaway A, Chandrashekar A, Latta E, Chakraborty K, Yu J, McMahan K, Giffin V, Manickam C, Kroll K, Mosher M, Reeves RK, Gam R, Arthofer E, Choudhry M, Henley T, Barouch DH. A genetically engineered, stem-cell-derived cellular vaccine. Cell Rep Med. 2022 Dec 20;3(12):100843. doi: 10.1016/j.xcrm.2022.100843. Epub 2022 Dec 7. PMID: 36480934; PMCID: PMC9727836.

Yu, J., Thomas, P. V., McMahan, K., Jacob-Dolan, C., Liu, J., He, X., Hope, D., Martinez, E. J., Chen, W. H., Sciacca, M., Hachmann, N. P., Lifton, M., Miller, J., Powers, O. C., Hall, K., Wu, C., Barrett, J., Swafford, I., Currier, J. R., King, J., … Barouch, D. H. (2022). Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN. Science advances, 8(47), eade4433. https://doi.org/10.1126/sciadv.ade4433 [Article]

Stieh, D. J., Barouch, D. H., Comeaux, C., Sarnecki, M., Stephenson, K. E., Walsh, S. R., Sawant, S., Heptinstall, J., Tomaras, G. D., Kublin, J. G., McElrath, M. J., Cohen, K. W., De Rosa, S. C., Alter, G., Ferrari, G., Montefiori, D., Mann, P., Nijs, S., Callewaert, K., Goepfert, P. A., … Tomaka, F. (2022). Safety and Immunogenicity of Ad26-vectored HIV Vaccine with Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-uninfected Adults: A Phase 1/2a Study. The Journal of infectious diseases, jiac445. Advance online publication. https://doi.org/10.1093/infdis/jiac445 [Article]

Dagotto, G., Ventura, J. D., Martinez, D. R., Anioke, T., Chung, B. S., Siamatu, M., Barrett, J., Miller, J., Schäfer, A., Yu, J., Tostanoski, L. H., Wagh, K., Baric, R. S., Korber, B., & Barouch, D. H. (2022). Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex. NPJ vaccines, 7(1), 125. https://doi.org/10.1038/s41541-022-00553-2 [Article]

Gopalakrishnan RM, Aid M, Mercado NB, Davis C, Malik S, Geiger E, Varner V, Jones R, Bosinger SE, Piedra-Mora C, Martinot AJ, Barouch DH, Reeves RK, Tan CS. Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection. JCI Insight. 2021 Oct 22;6(20):e152013. doi: 10.1172/jci.insight.152013. PMID: 34676832; PMCID: PMC8564899.

Hachmann, N. P., Miller, J., Collier, A. Y., & Barouch, D. H. (2022). Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.4.6. The New England journal of medicine, 387(20), 1904–1906. https://doi.org/10.1056/NEJMc2212117 [Article]

Kroll KW, Shah SV, Lucar OA, Premeaux TA, Shikuma CM, Corley MJ, Mosher M, Woolley G, Bowler S, Ndhlovu LC, Reeves RK. Mucosal-homing natural killer cells are associated with aging in persons living with HIV. Cell Rep Med. 2022 Oct 18;3(10):100773. doi: 10.1016/j.xcrm.2022.100773. Epub 2022 Oct 7. PMID: 36208628; PMCID: PMC9589002.

Le T, Reeves RK, McKinnon LR. The functional diversity of tissue-resident natural killer cells against infection. Immunology. 2022 Sep;167(1):28-39. doi: 10.1111/imm.13523. Epub 2022 Jul 12. PMID: 35751452. [Article]

Barouch D. H. (2022). Covid-19 Vaccines - Immunity, Variants, Boosters. The New England journal of medicine, 387(11), 1011–1020. https://doi.org/10.1056/NEJMra2206573 [Article]

Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman AN. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022; 14(9):1883. https://doi.org/10.3390/v14091883 [Article]

Liu J, Yu J, McMahan K, Jacob-Dolan C, He X, Giffin V, Wu C, Sciacca M, Powers O, Nampanya F, Miller J, Lifton M, Hope D, Hall K, Hachmann NP, Chung B, Anioke T, Li W, Muench J, Gamblin A, Boursiquot M, Cook A, Lewis MG, Andersen H, Barouch DH. CD8 T Cells Contribute to Vaccine Protection Against SARS-CoV-2 in Macaques. Sci Immunol. 2022 Aug 9:eabq7647. doi: 10.1126/sciimmunol.abq7647. Epub ahead of print. PMID: 35943359. [Article]

Cheu RK, Mohammadi A, Schifanella L, Broedlow C, Driscoll CB, Miller CJ, Reeves RK, Yudin MH, Hensley-McBain T, Kaul R, Klatt NR. Altered Innate Immunity and Damaged Epithelial Integrity in Vaginal Microbial Dysbiosis. Front Reprod Health. 2022 Jul 13;4:876729. doi: 10.3389/frph.2022.876729. PMID: 36303633; PMCID: PMC9580658.

Valsecchio C, Winterton D, Fakhr BS, Collier AY, Nozari A, Ortoleva J, Mukerji S, Gibson LE, Carroll RW, Shaefi S, Pinciroli R, La Vita C, Ackman JB, Hohmann E, Arora P, Barth WH, Kaimal A, Ichinose F, Berra L;DELivery oF iNO (DELFINO) Network Collaborators. High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 Pneumonia. Obstet Gynecol. April 2022. Accepted

Tan CS, Collier AY,Yu J, Liu J, Chandrashekar A, McMahan KA, Jacob-Dolan C, He X, Roy V, Hauser BM, Munt JE, Mallory ML, Mattocks M, Powers JM, Meganck RM, Rowe M, Hemond R, Bondzie EA, Jaegle KH, Baric RS, Schmidt AG, Alter G, Le Gars M, Sadoff J, Barouch DH. Durability of Heterologous and Homologous COVID-19 Vaccine Boost Regimens. JAMA Network Open. June 2022. Accepted.

Hachmann NP, Miller J, Collier AY, Ventura JD, Yu J, Rowe M, Bondzie EA, Powers O, Surve N, Hall K, Barouch DH. Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5. N Engl J Med. 2022 Jun 22. doi: 10.1056/NEJMc2206576. Epub ahead of print. PMID: 35731894. [Article]

Sugawara S, Reeves RK, Jost S. Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression. Front Immunol. 2022 Apr 27;13:858383. doi: 10.3389/fimmu.2022.858383. PMID: 35572502; PMCID: PMC9094575 [Article]

Moldt B, Chandrashekar A, Borducchi EN, Nkolola JP, Stephenson H, Nagel M, Hung M, Goldsmith J, Pace CS, Carr B, Thomsen ND, Blair WS, Geleziunas R, Barouch DH. HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys. PLoS Pathog. 2022 Apr 22;18(4):e1010467. doi: 10.1371/journal.ppat.1010467. Epub ahead of print. PMID: 35452496. [Article]

Collier AY, Brown CM, McMahan KA, Yu J, Liu J, Jacob-Dolan C, Chandrashekar A, Tierney D, Ansel JL, Rowe M, Sellers D, Ahmad K, Aguayo R, Anioke T, Gardner S, Siamatu M, Bermudez-Rivera L, Hacker MR, Madoff LC, Barouch DH. Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant. Sci Transl Med. 2022 Apr 20;14(641):eabn6150. doi: 10.1126/scitranslmed.abn6150. Epub 2022 Apr 20. PMID: 35258323; PMCID: PMC8995036. [Article]

DeGrace MM, Ghedin E, Frieman MB, Krammer F, Grifoni A, Alisoltani A, Alter G, Amara RR, Baric RS, Barouch DH, Bloom JD, Bloyet LM, Bonenfant G, Boon ACM, Boritz EA, Bratt DL, Bricker TL, Brown L, Buchser WJ, Carreño JM, Cohen-Lavi L, Darling TL, Davis-Gardner ME, Dearlove BL, Di H, Dittmann M, Doria-Rose NA, Douek DC, Drosten C, Edara VV, Ellebedy A, Fabrizio TP, Ferrari G, Florence WC, Fouchier RAM, Franks J, García-Sastre A, Godzik A, Gonzalez-Reiche AS, Gordon A, Haagmans BL, Halfmann PJ, Ho DD, Holbrook MR, Huang Y, James SL, Jaroszewski L, Jeevan T, Johnson RM, Jones TC, Joshi A, Kawaoka Y, Kercher L, Koopmans MPG, Korber B, Koren E, Koup RA, LeGresley EB, Lemieux JE, Liebeskind MJ, Liu Z, Livingston B, Logue JP, Luo Y, McDermott AB, McElrath MJ, Meliopoulos VA, Menachery VD, Montefiori DC, Mühlemann B, Munster VJ, Munt JE, Nair MS, Netzl A, Niewiadomska AM, O'Dell S, Pekosz A, Perlman S, Pontelli MC, Rockx B, Rolland M, Rothlauf PW, Sacharen S, Scheuermann RH, Schmidt SD, Schotsaert M, Schultz-Cherry S, Seder RA, Sedova M, Sette A, Shabman RS, Shen X, Shi PY, Shukla M, Simon V, Stumpf S, Sullivan NJ, Thackray LB, Theiler J, Thomas PG, Trifkovic S, Türeli S, Turner SA, Vakaki MA, van Bakel H, VanBlargan LA, Vincent LR, Wallace ZS, Wang L, Wang M, Wang P, Wang W, Weaver SC, Webby RJ, Weiss CD, Wentworth DE, Weston SM, Whelan SPJ, Whitener BM, Wilks SH, Xie X, Ying B, Yoon H, Zhou B, Hertz T, Smith DJ, Diamond MS, Post DJ, Suthar MS. Defining the risk of SARS-CoV-2 variants on immune protection. Nature. 2022 Mar 31. doi: 10.1038/s41586-022-04690-5. Epub ahead of print. PMID: 35361968. [Article]

Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G. mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Sci Transl Med. 2022 Mar 29:eabm2311. doi: 10.1126/scitranslmed.abm2311. Epub ahead of print. PMID: 35348368; PMCID: PMC8995030. [Article]

Chandrashekar A, Yu J, McMahan K, Jacob-Dolan C, Liu J, He X, Hope D, Anioke T, Barrett J, Chung B, Hachmann NP, Lifton M, Miller J, Powers O, Sciacca M, Sellers D, Siamatu M, Surve N, VanWyk H, Wan H, Wu C, Pessaint L, Valentin D, Van Ry A, Muench J, Boursiquot M, Cook A, Velasco J, Teow E, Boon ACM, Suthar MS, Jain N, Martinot AJ, Lewis MG, Andersen H, Barouch DH. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques. Cell. 2022 Mar 17:S0092-8674(22)00334-8. doi: 10.1016/j.cell.2022.03.024. Epub ahead of print. PMID: 35427477; PMCID: PMC8926910. [Article]

Yu J, Collier AY, Rowe M, Mardas F, Ventura JD, Wan H, Miller J, Powers O, Chung B, Siamatu M, Hachmann NP, Surve N, Nampanya F, Chandrashekar A, Barouch DH. Comparable Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. medRxiv [Preprint]. 2022 Feb 7:2022.02.06.22270533. doi: 10.1101/2022.02.06.22270533. Update in: N Engl J Med. 2022 Mar 16;: PMID: 35169817; PMCID: PMC8845515. [Article]

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Petrus MLC, Kiefer LA, Puri P, Heemskerk E, Seaman MS, Barouch DH, Arias S, van Wezel GP, Havenga M. A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli. Appl. Microbiol. Biotechnol. 2019; in press. [Article]

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Mahomed S, Garrett N, Capparelli E, Baxter C, Zuma NY, Gengiah T, Archary D, Moore P, Samsunder N, Barouch DH, Mascola J, Ledgerwood J, Morris L, Abdool Karim S. Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial. BMJ Open 2019; 9:e030283. [Article]

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Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C. Dominant negative MA-CA fusion protein is incorporated into HIV-1 cores and inhibits nuclear entry of viral preintegration complexes. J Virol 2019 Oct 15;93(21). pii: e01118-19. doi: 10.1128/JVI.01118-19. Print 2019 Nov 1. Epub 2019 Aug 14. PubMed PMID: 31413124; PubMed Central PMCID: _.

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Truitt, L. L., Yang, D., Espinoza, D. A., Fan, X., Ram, D. R., Moström, M. J., … Wu, C. (2019). Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques. Frontiers in immunology, 10, 2381. doi:10.3389/fimmu.2019.02381 [Article]

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Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B. Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques. JCI Insight 2019; 4:126047. [Article]

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2018

Borducchi EN, Liu J, Nkolola JP, Cadena AM, Yu WH, Fischinger S, Broge T, Abbink P, Mercado NB, Chandrashekar A, Jetton D, Peter L, McMahan K, Moseley ET, Bekerman E, Hesselgesser J, Li W, Lewis MG, Alter G, Geleziunas R, Barouch DH. Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys. Nature 2018; 563:360-364. [Article]

Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J. A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge. 2018; Nat Commun; 9(1):2363. [Article]

Gautam R, Nishimura Y, Gaughan N, Gazumyan A, Schoofs T, Buckler-White A, Seaman MS, Swihart BJ, Follmann DA, Nussenzweig MC, Martin MA. A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection. Nat Med. 2018 May;24(5):610-616. [Article]

Cox F, van der Fits L, Abbink P, Larocca RA, van Huizen E, Saeland E, Verhagen J, Peterson R, Tolboom J, Kaufmann B, Schuitemaker H, Barouch DH, Zahn R. Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge. PLoS One 2018; 13:e0202820. [Article]

Blass E, Aid M, Martinot AJ, Larocca RA, Kang ZH, Badamchi-Zadeh A, Penaloza-MacMaster P, Reeves RK, Barouch DH. Adenovirus vector vaccination impacts NK cell rheostat function following lymphocytic choriomeningitis virus infection. J. Virol. 2018; 92:e02103-17. [Article]

Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, Walker BD, Diamond MS, Alter G. Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Sci. Immunol. 2018; 3: eaat7796. [Article]

Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 interaction licenses nuclear HIV-1 trafficking to sites of viral DNA integration. Cell Host Microbe 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30. PubMed PMID: 30173955; PubMed Central PMCID: PMC6368089. [Article]

Engelman AN, Singh PK. Cellular and molecular mechanisms of HIV-1 integration targeting. Cell Mol Life Sci 2018 July;75(14):2491-507. doi: 10.1007/s00018-018-2772-5. Epub 2018 Feb 7. PubMed PMID: 29417178; PubMed Central PMCID: PMC6004233. [Article]

Shah SV, Manickam C, Ram DR, Kroll K, Itell H, Permar SR, Barouch DH, Klatt NR, Reeves RK. CMV primes functional alternative signaling in adaptive Δg NK cells but is subverted by lentivirus infection in rhesus macaques. Cell Rep. 2018; 25:2766-2774. [Article]

Patel A, Gupta V, Hickey J, Nightlinger NS, Rogers RS, Siska C, Joshi SB, Seaman MS, Volkin DB, Kerwin BA. Co-formulation of broadly neutralizing antibodies 3BNC117 and PGT121: Analytical challenges during pre-formulation characterization and storage stability studies.J Pharm Sci. 2018 Aug 31. pii: S0022-3549(18)30513-6. [Epub ahead of print]. [Article]

Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP Jr, Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M, Nussenzweig MC. Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature. 2018 Sep;561(7724):479-484. [Article]

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Penaloza-MacMaster P, Abbink P, Blass E, Tregoning JS, Irvine DJ, Barouch DH. Combined HDAC and BET inhibition enhances melanoma vaccine immunogenicity and efficacy. J. Immunol. 2018; 201:2744-2752. [Article]

Wagh K, Kreider EF, Li Y, Barbian HJ, Learn GH, Giorgi E, Hraber PT, Decker TG, Smith AG, Gondim MV, Gillis L, Wandzilak J, Chuang GY, Rawi R, Cai F, Pellegrino P, Williams I, Overbaugh J, Gao F, Kwong PD, Haynes BF, Shaw GM, Borrow P, Seaman MS, Hahn BH, Korber B. Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth. Cell Rep. 2018 Oct 23;25(4):893-908.e7. [Article]

Prigent J, Jarossay A, Planchais C, Eden C, Dufloo J, Kök A, Lorin V, Vratskikh O, Couderc T, Bruel T, Schwartz O, Seaman MS, Ohlenschläger O, Dimitrov JD, Mouquet H. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep. 2018 May 29;23(9):2568-2581. [Article]

Manickam, C., Shah, S., Ram, D.R., Lucar, O., and Reeves, R.K. 2018 Cytokine-mediated tissue injury in non-human primate models of viral infections. Front. Immunol. 9:2862. PMID: 30568659. PMCID: PMC6290327. [Article]

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP. Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques. PLoS Pathog. 2018; 14:e1006913. [Article]

Barouch DH, Tomaka FL, Wegmann F, Stieh DJ, Alter G, Robb ML, Michael NL, Peter L, Nkolola JP, Borducchi EN, Chandrashekar A, Jetton D, Stephenson KE, Li W, Korber B, Tomaras GD, Montefiori DC, Gray G, Frahm N, McElrath MJ, Baden L, Johnson J, Hutter J, Swann E, Karita E, Kibuuka H, Mpendo J, Garrett N, Mngadi K, Chinyenze K, Priddy F, Lazarus E, Laher F, Nitayapan S, Pitisuttithum P, Bart S, Campbell T, Feldman R, Lucksinger G, Borremans C, Callewaert K, Roten R, Sadoff J, Scheppler L, Weijtens M, Feddes-de Boer K, van Manen D, Vreugdenhil J, Zahn R, Lavreys L, Nijs S, Tolboom J, Hendriks J, Euler Z, Pau MG, Schuitemaker H. Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19). Lancet. 2018 Jul 21;392(10143):232-243. doi: 10.1016/S0140-6736(18)31364-3. Epub 2018 Jul 6. PubMed PMID: 30047376; PubMed Central PMCID: PMC6192527. [Article]

Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB. Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature. 2018 Sep;561(7723):E20-E28. doi: 10.1038/s41586-018-0495-2. Epub 2018 Sep 19. Erratum in: Nature. 2018 Nov;563(7733):E33. PMID: 30232424; PMCID: PMC6528470. [Article]

Chettimada, S., Lorenz, D.R., Misra, V., Dillon, S.T., Reeves, R.K., Manickam, C., Morgello, S., Kirk, G.D., Mehta, S.H., and Gabuzda, D. Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy. 2018. Sci Rep. 8(1):7227. PMID: 29740045. PMCID: PMC5940833 [Article]

Yu W H, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G. Exploiting glycan topography for computational design of Env glycoprotein antigenicity. PLoS Comput Biol. 2018 Apr 20;14(4):e1006093. [Article]

Martinot AJ, Abbink P, Afacan O, Prohl AK, Bronson R, Hecht JL, Borducchi EN, Larocca RA, Peterson RL, Rinaldi W, Ferguson M, Didier PJ, Weiss D, Lewis MG, De La Barrera RA, Yang E, Warfield SK, Barouch DH. Fetal neuropathology in Zika virus-infected pregnant female rhesus monkeys. Cell 2018; 173:1111-1122. [Article]

Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Karlsson Hedestam GB, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, Alter G, Burton DR, Robb ML, Krebs SJ, Seaman MS, Bailey-Kellogg C, Ackerman ME. Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. JCI Insight. 2018 Mar 8;3(5). [Article]

Stephenson KE, Keefer MC, Bunce CA, Frances D, Abbink P, Maxfield LF, Neubauer GH, Nkolola J, Peter L, Lane C, Park H, Verlinde C, Lombardo A, Yallop C, Havenga M, Fast P, Treanor J, Barouch DH. First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1. PLoS One 2018; 13:e0205139. [Article]

Baden LR, Walsh SR, Seaman MS, Cohen YZ, Johnson JA, Licona JH, Filter RD, Kleinjan JA, Gothing JA, Jennings J, Peter L, Nkolola J, Abbink P, Borducchi EN, Kirilova M, Stephenson KE, Pegu P, Eller MA, Trinh HV, Rao M, Ake JA, Sarnecki M, Nijs S, Callewaert K, Schuitemaker H, Hendriks J, Pau MG, Tomaka F, Korber BT, Alter G, Dolin R, Earl PL, Moss B, Michael NL, Robb ML, Barouch DH; IPCAVD006/RV380/HIV-V-A002 Study Group. First-in-human randomized, controlled trial of mosaic HIV-1 immunogens delivered via a modified vaccinia Ankara vector. J. Infect. Dis. 2018; 218:633-644. [Article]

Mudd, J.C., DiNapoli, S. R., Lai, S., Sheik, V., Lisco, A., Deleage, C., Richardson, B., Cameron, M., Sereti, I., Reeves, R.K., Estes, J.D., and Brenchley, J. M. Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells. 2018. Nat Comm. 9(1):3967. PMID: 30262807. PMCID: PMC6160474

Hogan LE, Hanhauser E, Hobbs KS, Palmer CD, Robles Y, Jost S, LaCasce AS, Abramson J, Hamdan A, Marty FM, Kuritzkes DR, Henrich TJ. Human Herpes Virus 8 in HIV-1 infected individuals receiving cancer chemotherapy and stem cell transplantation. (2018) PLoS One. 13(5):e0197298. [Article]

Sajadi MM, Dashti A, Rikhtegaran Tehrani Z, Tolbert WD, Seaman MS, Ouyang X, Gohain N, Pazgier M, Kim D, Cavet G, Yared J, Redfield RR, Lewis GK, DeVico AL. Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses. Cell. 2018 Jun 14;173(7):1783-1795. [Article]

Blasi M, Negri D, LaBranche C, Alam SM, Baker EJ, Brunner EC, Gladden MA, Michelini Z, Vandergrift NA, Wiehe KJ, Parks R, Shen X, Bonsignori M, Tomaras GD, Ferrari G, Montefiori DC, Santra S, Haynes BF, Moody MA, Cara A, Klotman ME. IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells. 2018. Commun Biol. 1:134. [Article]

Iampietro MJ, Larocca RA, Provine NM, Abbink P, Kang ZH, Bricault CA, Barouch DH. Immunogenicity and cross-reactivity of rhesus adenoviral vectors. J. Virol. 2018; 92:e00159-18. [Article]

Saunders KO, Santra S, Parks R, Yates NL, Sutherland LL, Scearce RM, Balachandran H, Bradley T, Goodman D, Eaton A, Stanfield-Oakley SA, Tartaglia J, Phogat S, Pantaleo G, Esteban M, Gomez CE, Perdiguero B, Jacobs B, Kibler K, Korber B, Montefiori DC, Ferrari G, Vandergrift N, Liao HX, Tomaras GD, Haynes BF. Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates. 2018; J. Virol. 92(8). [Article]

Ram, D.R., Kroll, K. and Reeves, R.K. Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal-draining lymph nodes. 2018. J. Med. Primatol. 47(5):302-304. PMID: 30256418. PMCID: PMC6161495 [Article]

Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nair U, Ghneim K, Fallon PG, Sekaly RP, Barouch DH, Shalek AK, Bruckbauer A, Strid J, Batista FD. Initiation of antiviral B cell immunity relies on innate signals from spatially positioned NKT cells. Cell 2018; 172:1-17. [Article]

Hensley-McBain, T., Berard, A., Miller, C., Manuzak, J., Zevin, A.S., Firpo, P., Gile, J., Agricola, B., Cameron, M., Hu, S-L., Reeves, R.K., Smedley, J., Keel, B.F., Burgener, A, and Klatt, N.R. Intestinal damage precedes mucosal immune dysfunction in SIV infection. 2018. Mucosal Immunol. doi: 10.1038/s41385-018-0032-5. PMID: 29907866 [Article]

El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juege S, Boeckx N, Engelman A, Debyser Z, De Rijck J. LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. Blood 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30. PubMed PMID: 29084744; PubMed Central PMCID: PMC5755044. [Article]

Huot, N., Bosinger, S., Paiardini, M., Reeves, R.K., and Muller-Trutwin, M. 2018 Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV cure Strategies. Front. Immunol. 9:780. PMID: 29725327. PMCID: PMC5916971. [Article]

Li H, Hai Y, Lim SY, Toledo N, Crecente-Campo J, Schalk D, Li L, Omange RW, Dacoba TG, Liu LR, Kashem MA, Wan Y, Liang B, Li Q, Rakasz E, Schultz-Darken N, Alonso MJ, Plummer FA, Whitney JB, Luo M. Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques. PLoS One. 2018 Aug 28;13(8):e0202997. doi: 10.1371/journal.pone.0202997. PMID: 30153293; PMCID: PMC6112674. [Article]

Montefiori DC, Roederer M, Morris L, Seaman MS. Neutralization tiers of HIV-1. Curr Opin HIV AIDS. 2018 Mar;13(2):128-136. [Article]

Cohen YZ, Lorenzi JCC, Seaman MS, Nogueira L, Schoofs T, Krassnig L, Butler A, Millard K, Fitzsimons T, Daniell X, Dizon JP, Shimeliovich I, Montefiori DC, Caskey M, Nussenzweig MC. Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells. J Virol. 2018 Feb 12;92(5). [Article]

Bricault CA, Kovacs JM, Badamchi-Zadeh A, McKee K, Shields JL, Gunn BM, Neubauer GH, Ghantous F, Jennings J, Gillis L, Perry J, Nkolola JP, Alter G, Chen B, Stephenson KE, Doria-Rose N, Mascola JR, Seaman MS, Barouch DH. Neutralizing antibody responses following long-term vaccination with HIV-1 Env gp140 in guinea pigs. J. Virol. 2018; 92:e00369-18. [Article]

Hogan LE, Körner C, Hobbs K, Simoneau CR, Thanh C, Gibson EA, Palmer CD, Pandit A, Marty FM, Kuritzkes DR, Jost S, Ritz J, Henrich TJ. NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation. (2018) Blood Advances. 2(12):1412-1416. [Article]

Modjarrad K, Lin L, George SL, Stephenson KE, Eckels KH, De La Barrera RA, Jarman RG, Sondergaard E, Tennant J, Ansel JL, Mills K, Koren M, Robb ML, Barrett J, Thompson J, Kosel AE, Dawson P, Hale A, Tan CS, Walsh SR, Meyer KE, Brien J, Crowell TA, Blazevic A, Mosby K, Larocca RA, Abbink P, Boyd M, Bricault CA, Seaman MS, Basil A, Walsh M, Tonwe V, Hoft DF, Thomas SJ, Barouch DH, Michael NL. Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials. Lancet. 2018 Feb 10;391(10120):563-571. doi: 10.1016/S0140-6736(17)33106-9. Epub 2017 Dec 5. PubMed PMID: 29217375; PubMed Central PMCID: PMC5884730. [Article]

Brown EP, Weiner JA, Lin S, Natarajan H, Normandin E, Barouch DH, Alter G, Sarzotti-Kelsoe M, Ackerman ME. Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. J. Immunol. Methods 2018; 455:24-33. [Article]

Bendapudi PK, Robbins A, LeBoeuf N, Pozdnyakova O, Bhatt A, Duke F, Sells R, McQuiston J, Humrighouse B, Rouaisnel B, Colling M, Stephenson KE, Saavedra A, Losman JA. Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate. Blood Adv. 2018 Nov 13;2(21):2917-2921. doi: 10.1182/bloodadvances.2018024430. PubMed PMID: 30396911; PubMed Central PMCID: PMC6234356. [Article]

Wagh K, Seaman MS, Zingg M, Fitzsimons T, Barouch DH, Burton DR, Connors M, Ho DD, Mascola JR, Nussenzweig MC, Ravetch J, Gautam R, Martin MA, Montefiori DC, Korber B. Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections. PLoS Pathog. 2018; 14:e1006860. [Article]

Modjarrad K, Lin L, George SL, Stephenson KE, Eckels KH, De La Barrera RA, Jarman RG, Sondergaard E, Tennant J, Ansel JL, Mills K, Koren M, Robb ML, Barrett J, Thompson J, Kosel AE, Dawson P, Hale A, Tan CS, Walsh SR, Meyer KE, Brien J, Crowell TA, Blazevic A, Mosby K, Larocca RA, Abbink P, Boyd M, Bricault CA, Seaman MS, Basil A, Walsh M, Tonwe V, Hoft DF, Thomas SJ, Barouch DH*, Michael NL*. Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials. Lancet 2018; 391:563-571. [Article]

Whitney JB, Lim SY, Osuna CE, Kublin JL, Chen E, Yoon G, Liu PT, Abbink P, Borducci EN, Hill A, Lewis MG, Geleziunas R, Robb ML, Michael NL, Barouch DH. Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy. Nat. Commun. 2018; 9:5429. [Article]

Manickam C, Nwanze C, Ram DR, Shah SV, Smith S, Jones R, Hueber B, Kroll K, Varner V, Goepfert P, Jost S, Reeves RK. Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract. (2018) AIDS. 32(12):1571-1578. [Article]

Abbink P, Kirilova M, Boyd M, Mercado N, Li Z, Nityanandam R, Nanayakkara O, Peterson R, Larocca RA, Aid M, Tartaglia L, Mutetwa T, Blass E, Jetton D, Maxfield LF, Borducchi EN, Badamchi-Zadeh A, Handley S, Zhao G, Virgin HW, Havenga MJ, Barouch DH. Rapid cloning of novel rhesus adenoviral vaccine vectors. J. Virol. 2018; 92:e01924-17. [Article]

López-Camacho C, Abbink P, Larocca RA, Dejnirattisai W, Boyd M, Badamchi-Zadeh A, Wallace ZR, Doig J, Velazquez RS, Neto RDL, Coelho DF, Kim YC, Donald CL, Owsianka A, De Lorenzo G, Kohl A, Gilbert SC, Dorrell L, Mongkolsapaya J, Patel AH, Screaton GR, Barouch DH, Hill AVS, Reyes-Sandoval A. Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nat. Commun. 2018; 9:2441. [Article]

Cohen YZ, Lorenzi JCC, Krassnig L, Barton JP, Burke L, Pai J, Lu CL, Mendoza P, Oliveira TY, Sleckman C, Millard K, Butler AL, Dizon JP, Belblidia SA, Witmer-Pack M, Shimeliovich I, Gulick RM, Seaman MS, Jankovic M, Caskey M, Nussenzweig MC. Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117. J Exp Med. 2018 Sep 3;215(9):2311-2324. [Article]

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Autissier, E., Li, H., Goepfert, P., and Reeves, R.K. Short Communication: Apoptotic Membrane Microparticles Quantified by Fluorescent Bead-Based Assay Are Elevated in HIV and SIV Infections. 2018. AIDS Res. Hum. Retroviruses. 34(5):446-448. PMID: 29486582. PMCID: PMC5934972 [Article]

Kang ZH, Bricault CA, Borducchi EN, Stephenson KE, Seaman MS, Pau M, Schuitemaker H, van Manen D, Wegmann F, Barouch DH. Similar epitope specificities of IgG and IgA antibodies elicited by Ad26 vector prime, Env protein boost immunizations in rhesus monkeys. J. Virol. 2018; 92:e00537-18. [Article]

Fu Q, Shaik MM, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC, Seaman MS, Chen B, Chou JJ. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8892-E8899. [Article]

Bhattacharyya M, Whitney JB, Seaman M, Barouch DH, Penaloza-MacMaster P. T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection. Immunology 2018; 155:458-466. [Article]

Gabriela M. Webb, Shengbin Li, Gwantwa Mwakalundwa, Joy M. Folkvord, Justin M. Greene, Jason S. Reed, Jeffery J. Stanton, Alfred W. Legasse, Theodore Hobbs, Lauren D. Martin, Byung S. Park, James B. Whitney, Emily K. Jeng, Hing C. Wong, Douglas F. Nixon, R. Brad Jones, Elizabeth Connick, Pamela J. Skinner, Jonah B. Sacha; The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles. Blood Adv 2018; 2 (2): 76–84. [Article]

Abbink P, Larocca RA, Dejnirattisai W, Peterson R, Nkolola JP, Borducchi EN, Supasa P, Mongkolsapaya J, Screaton GR, Barouch DH. Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys. Nat. Med. 2018; 24:721-723. [Article]

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Stephenson KE. Therapeutic vaccination for HIV: hopes and challenges. Curr Opin HIV AIDS. 2018 Sep;13(5):408-415. doi: 10.1097/COH.0000000000000491. Review. PubMed PMID: 29957615.

Lim SY, Osuna CE, Hraber PT, Hesselgesser J, Gerold JM, Barnes TL, Sanisetty S, Seaman MS, Lewis MG, Geleziunas R, Miller MD, Cihlar T, Lee WA, Hill AL, Whitney JB. TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. Sci Transl Med. 2018 May 2;10(439). [Article]

Ram, D.R., Manickam, C., Hueber, B., Permar, S.R., Varner, V., and Reeves, R.K. Tracking KLRC2(NKG2C)+ memory and memory-like NK cells in rhCMV+ and SIV+ rhesus macaques. 2018. PLoS Pathog. 14(5):e1007104. PMID: 29851983. PMCID: PMC5997355 [Article]

Kublin JL, Whitney JB. Zika virus research models. Virus Res. 2018 Aug 2;254:15-20. doi: 10.1016/j.virusres.2017.07.025. Epub 2017 Aug 12. PMID: 28811170; PMCID: PMC5809325. [Article]

Abbink P, Stephenson KE, Barouch DH. Zika virus vaccines. Nat Rev Microbiol. 2018 Oct;16(10):594-600. doi: 10.1038/s41579-018-0039-7. Review. PubMed PMID: 29921914; PubMed Central PMCID: PMC6162149.

[Article]

2017

Aid M, Abbink P, Larocca RA, Boyd M, Nityanandam R, Nanayakkara O, Martinot AJ, Moseley ET, Blass E, Borducchi EN, Chandrashekar A, Brinkman AL, Molloy K, Jetton D, Tartaglia LJ, Liu J, Best K, Perelson AS, De La Barrera RA, Lewis MG, Barouch DH. Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys. Cell 2017; 169:610-620. [Article]

Manickam, C. and Reeves, R. K. 2017. A Mouse Model for HCV Infection: Are We There Yet? Annals of Infection. 8:5 doi: 10.21037/aoi.2017.11.01. PMID: 30123888. PMCID: PMC6095674 [Article]

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P. A supramolecular assembly mediates lentiviral DNA integration. Science 2017 Jan 6;355(6320):89-92. doi: 10.1126/science.aah7002. PubMed PMID: 28059770. PubMed Central PMCID: PMC5321526. [Article]

Keele BF, Li W, Borducchi EN, Nkolola JP, Abbink P, Chen B, Seaman MS, Barouch DH. Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys. Nat. Commun. 2017; 8:15740. [Article]

Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature 2017; 547:217-221.

Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F. Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nat Med. 2017 Feb;23(2):185-191. [Article]

Cai Y, , Karaca-Griffin S, Chen J, Tian S, Fredette N, Linton CE, Rits-Volloch S, Lu J, Wagh K, Theiler J, Korber B, Seaman MS, Harrison SC, Carfi A, Chen B. Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4477-4482. [Article]

Wang H, Gristick HB, Scharf L, West AP, Galimidi RP, Seaman MS, Freund NT, Nussenzweig MC, Bjorkman PJ. Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies. Elife. 2017 May 26;6. [Article]

Easterhoff D, Moody MA, Fera D, Cheng H, Ackerman M, Wiehe K, Saunders KO, Pollara J, Vandergrift N, Parks R, Kim J, Michael NL, O'Connell RJ, Excler JL, Robb ML, Vasan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Kepler TB, Alam SM, Liao HX, Ferrari G, Seaman MS, Montefiori DC, Tomaras GD, Harrison SC, Haynes BF. Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementary determining region in the randomized double blind RV305 HIV-1 vaccine trial. PLoS Pathog. 2017 Feb 24;13(2):e1006182. [Article]

Lorin V, Malbec M, Eden C, Bruel T, Porrot F, Seaman MS, Schwartz O, Mouquet H. Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity. Mucosal Immunol. 2017 May; 10(3):814-826. [Article]

Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, Abbink P, Schmidt SD, Wang K, Chen X, Joyce MG, Georgiev IS, Choe M, Kwong PD, Doria-Rose NA, Le K, Louder MK, Bailer RT, Moore PL, Korber B, Seaman MS, Abdool Karim SS, Morris L, Koup RA, Mascola JR, Burton DR, Barouch DH. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge. Sci. Transl. Med. 2017; 9:eaal1321. [Article]

Yamashita M, Engelman AN. Capsid-dependent host factors in HIV-1 infection. Trends Microbiol 2017 Sep;25(9):741-55. doi: 10.1016/j.tim.2017.04.004. Epub 2017 May 18. PubMed PMID: 28528781; PubMed Central PMCID: PMC5562514. [Article]

Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, van Gils MJ, Sanders RW, Wang LX, Seaman MS, Burton DR, Gazumyan A, Walker BD, West AP Jr, Bjorkman PJ, Nussenzweig MC. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med. 2017 Jan 18;9(373). [Article]

Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P. Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Sci Adv 2017 Sep 15;3(9):e1701264. doi: 10.1126/sciadv.1701264. eCollection 2017 Sep. PubMed PMID: 28912938; PubMed Central PMCID: PMC5600524. [Article]

Penaloza MacMaster P, Shields JL, Alayo QA, Cabral C, Jimenez J, Mondesir J, Chandrashekar A, Cabral JM, Lim M, Iampietro MJ, Provine NM, Bricault CA, Seaman M, Orlinger K, Aspoeck A, Fuhrmann G, Lilja AE, Monath T, Mangeat B, Pinschewer DD, Barouch DH. Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine 2017; 35:1-9. [Article]

Abbink P, Larocca RA, Visitsunthorn K, Boyd M, De La Barrera RA, Gromowski GD, Kirilova M, Peterson R, Li Z, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Chandrashekar A, Jetton D, Mojta S, Gandhi P, LeSuer J, Khatiwada S, Lewis MG, Modjarrad K, Jarman RG, Eckels KH, Thomas SJ, Michael NL, Barouch DH. Durability and correlates of vaccine protection against Zika virus in rhesus monkeys. Sci. Transl. Med. 2017; 9:eaao4163. [Article]

Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foulds KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA. Early antibody therapy can induce long-lasting immunity to SHIV. Nature. 2017 Mar 23; 543 (7646):559-563. [Article]

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches. Immunity 2017; 46:1073-1088. [Article]

Sugimura R, Jha DK, Han A, Soria-Valles C, Lummertz da Rocha E, Lu Y-F, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Hematopoietic stem and progenitor cells from human pluripotent stem cells. Nature 2017 May 25;545(7655):432-8. doi: 10.1038/nature22370. Epub May 17. PubMed PMID: 28514439; PubMed Central PMCID: PMC5872146. [Article]

Manickam, C., Varner, V., Martinot, A.J., and Reeves, R.K. 2017. Hepatic immunopathology during occult Hepacivirus re-infection. Virology. 512:48-55. PMID: 28915405. PMCID: PMC5653381 [Article]

Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon DS, Scully EP, Jost S, Kirchhoff F, Carrington M, Altfeld M. HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. (2017) Cell Host & Microbe. 22(1):111-119.e4.

Garcia-Arriaza J, Perdiguero B, Heeney JL, Seaman MS, Montefiori DC, Yates NL, Tomaras GD, Ferrari G, Foulds KE, Roederer M, Self SG, Borate B, Gottardo R, Phogat S, Tartaglia J, Barnett SW, Burke B, Cristillo AD, Weiss DE, Lee C, Kibler KV, Jacobs BL, Wagner R, Ding S, Pantaleo G, Esteban M. HIV/AIDS vaccine candidates based on replication-competent recombinant poxvirus NYVAC-C-KC expressing trimeric gp140 and Gag-derived VLPs or lacking the viral molecule B19 that inhibits type I interferon activate relevant HIV-1-specific B and T cell immune functions in non-human primates. J Virol. 2017 Apr 13; 91(9). [Article]

Henrich TJ, Hobbs KS, Hanhauser E, Scully E, Hogan LE, Robles YP, Leadabrand KS, Marty FM, Palmer CD, Jost S, Korner C, Li JZ, Ghandi RT, Hamdan A, Abramson J, LaCasce AS, Kuritzkes DR. Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy. (2017) The Journal of infectious diseases. 216(2):254-262. [Article]

McCracken MK, Gromowski GD, Friberg HL, Lin X, Abbink P, De La Barrera R, Eckles KH, Garver LS, Boyd M, Jetton D, Barouch DH, Wise MC, Lewis BS, Currier JR, Modjarrad K, Milazzo M, Liu M, Mullins AB, Putnak JR, Michael NL, Jarman RG, Thomas SJ. Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques. PLoS Pathog. 2017; 13:e1006487.

Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C. Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein. J Virol 2017 April 13;91(9). pii: e02155-16. doi: 10.1128/JVI.02155-16. Print 2017 May 1. PubMed PMID: 28202766; PubMed Central PMCID: PMC5391466. [Article]

Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L. Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. 2017. Nat Commun. 8(1):1732. [Article]

Shah, S., Manickam, C., Ram, D., and Reeves, R.K. 2017. Innate Lymphoid Cells in HIV/SIV Infections. Front. Immunol. 8:1818. PMID: 29326704. PMCID: PMC5733347 [Article]

Li H, Omange RW, Czarnecki C, Correia-Pinto JF, Crecente-Campo J, Richmond M, Li L, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, Luo M. Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection. J Med Primatol. 2017 Aug;46(4):137-143. doi: 10.1111/jmp.12300. PMID: 28748659; PMCID: PMC5560087. [Article]

Manickam, C., Martinot, A.J., Rajakumar, P., Wachtman, L., and Reeves, R.K. 2017. Metabolic dysregulation in hepacivirus infection of common marmosets (Callithrix jacchus). PLoS One. 12(1):e0170240. PMID: 28085952. PMCID: PMC5234844 [Article]

Zhu Y, Wand X, Fouromand E, Jeong J, Qiao F, Sowd G, Engelman AN, Xie X, Hertel K, Shi Y. Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation. Mol Cell 2018 Jan 4;69(1):62-74.e4. doi: 10.1016/j.molcel.2017.11.031. Epub 2017 Dec 21. PubMed PMID: 29276085; PubMed Central PMCID: PMC5756121. [Article]

Puray-Chavez M, Tedbury PR, Huber AD, Ukah OB, Yapo V, Liu D, Ji J, Wolf JJ, Engelman AN, Sarafianos SG. Multiplex single-cell visualization of nucleic acids and protein during HIV infection. Nat Commun 2017 Dec 1;8(1):1882. doi: 10.1038/s41467-017-01693-z. PubMed PMID: 29192235; PubMed Central PMCID: PMC5709414. [Article]

Brown EP, Dowell KG, Boesch AW, Normandin E, Mahan AE, Chu T, Barouch DH, Bailey-Kellogg C, Alter G, Ackerman ME. Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles. J. Immunol. Methods 2017; 443:33-44. [Article]

Li H, Nykoluk M, Li L, Liu LR, Omange RW, Soule G, Schroeder LT, Toledo N, Kashem MA, Correia-Pinto JF, Liang B, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, Luo M. Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques. PLoS One. 2017 Oct 5;12(10):e0186079. doi: 10.1371/journal.pone.0186079. PMID: 28982126; PMCID: PMC5628977. [Article]

Huot, N., Jacquelin, B., Garcia-Tellez, T., Rascle, P., Ploquin, M.J., Reeves, R.K., Derreudre-Bosquet, N., and Muller-Trutwin, M. 2017. Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys. Nat. Med. 23(11):1277-1286. PMID: 29035370. PMCID: PMC6362838 [Article]

Horwitz JA, Bar-On Y, Lu CL, Fera D, Lockhart AAK, Lorenzi JCC, Nogueira L, Golijanin J, Scheid JF, Seaman MS, Gazumyan A, Zolla-Pazner S, Nussenzweig MC. Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo. Cell. 2017 Aug 10;170(4):637-648 [Article]

Osuna CE, Whitney JB. Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development. J Infect Dis. 2017 Dec 16;216(suppl_10):S928-S934. doi: 10.1093/infdis/jix540. PMID: 29267926; PMCID: PMC5853426. [Article]

Hraber P, Rademeyer C, Williamson C, Seaman MS, Gottardo R, Tang H, Greene K, Gao H, LaBranche C, Mascola JR, Morris L, Montefiori DC, Korber B. Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments. J Virol. 2017 Sep 12;91(19).

Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF. Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. Sci Immunol. 2017 Jan 27;2(7). [Article]

DeWolfe D, Gandhi J, Mackenzie MR, Broge TA Jr, Bord E, Babwah A, Mandelbrot DA, Pavlakis M, Cardarelli F, Viscidi R, Chandraker A, Tan CS. Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients. PLoS One. 2017;12(5):e0177339. doi: 10.1371/journal.pone.0177339. eCollection 2017. PubMed PMID: 28562595; PubMed Central PMCID: PMC5451008. [Article]

Julg B, Liu PT, Wagh K, Fischer WM, Abbink P, Mercado NB, Whitney JB, Nkolola JP, McMahan K, Tartaglia LJ, Borducchi EN, Khatiwada S, Kamath M, LeSuer JA, Seaman MS, Schmidt SD, Mascola JR, Burton DR, Korber BT, Barouch DH. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail. Sci. Transl. Med. 2017; 9:eaao4235. [Article]

Julg B, Sok D, Schmidt SD, Abbink P, Newman RM, Broge T, Linde C, Nkolola J, Le K, Su D, Torabi J, Pack M, Pegu A, Allen TM, Mascola JR, Burton DR, Barouch DH. Protective efficacy of broadly neutralizing antibodies with incomplete neutralization activity against SHIV in rhesus monkeys. J. Virol. 2017; 91:e01187-17. [Article]

Tan CS. Reactivation of Multiple Infectious Pathogens after Hematopoietic Stem Cell Transplantation. Acta Haematol 2017; 138(1): 1-2.

Paust, S., Blish, C.A., and Reeves, R.K. 2017. Redefining Memory: Building the Case for Adaptive NK Cells. J. Virol. 91(20):e00169-17. PMID: 28794018. PMCID: PMC5625515 [Article]

Bhattacharyya M, Madden P, Henning N, Gregory S, Aid M, Martinot AJ, Barouch DH, Penaloza-MacMaster P. Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection. Immunology 2017; 152:328-343. [Article]

Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing. J Biol Chem 2017 Dec 1;292(48):19814-25. doi:10.1074/jbc.M117.816645. Epub 2017 Sep 28. PubMed PMID: 28972144; PubMed Central PMCID: PMC5712621. [Article]

Engelman AN, Cherepanov P. Retroviral intasomes arising. Curr Opin Struct Biol 2017 Dec 27;47:23-29. doi: 10.1016/j.sbi.2017.04.005. Epub 2017 Apr 28. PubMed PMID: 28458055; PubMed Central PMCID: PMC5660667. [Article]

Grawenhoff J, Engelman AN. Retroviral integrase protein and intasome nucleoprotein complex structures. World J Biol Chem 2017 Feb 26;8(1):32-44. doi: http://dx.doi.org/10.4331/wjbc.v8.i1.32. PubMed PMID: 28289517; PubMed Central PMCID: PMC5329712. [Article]

Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D. Statoviruses, a novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology 2017; 504:36-44. [Article]

Lesbats P, Serrao E, Maskell DP, Pye VE, O’Reilly N, Lindemann D, Engelman AN, Cherepanov P. Structural basis for spumavirus GAG tethering to chromatin. Proc Natl Acad Sci U S A 2017 May 23;114(21):5509-14. doi: 10.1073/pnas.1621159114. Epub May10. PubMed PMID: 28490494; PubMed Central PMCID: PMC5448199. [Article]

Xu L, Pegu A, Rao E, Doria-Rose N, Beninga J, McKee K, Lord DM, Wei RR, Deng G, Louder M, Schmidt SD, Mankoff Z, Wu L, Asokan M, Beil C, Lange C, Leuschner WD, Kruip J, Sendak R, Do Kwon Y, Zhou T, Chen X, Bailer RT, Wang K, Choe M, Tartaglia LJ, Barouch DH, O'Dell S, Todd JP, Burton DR, Roederer M, Connors M, Koup RA, Kwong PD, Yang ZY, Mascola JR, Nabel GJ. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Science 2017; 358:85-90. [Article]

Saunders KO, Nicely NI, Wiehe K, Bonsignori M, Meyerhoff RR, Parks R, Walkowicz WE, Aussedat B, Wu NR, Cai F, Vohra Y, Park PK, Eaton A, Go EP, Sutherland LL, Scearce RM, Barouch DH, Zhang R, Von Holle T, Overman RG, Anasti K, Sanders RW, Moody MA, Kepler TB, Korber B, Desaire H, Santra S, Letvin NL, Nabel GJ, Montefiori DC, Tomaras GD, Liao HX, Alam SM, Danishefsky SJ, Haynes BF. Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates. Cell Rep. 2017; 18:2175-2188. [Article]

Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, Georgiev IS, Joyce MG, Tomaras GD, Bonsignori M, Reed SG, Salazar A, Mascola JR, Moody MA, Cain DW, Centlivre M, Zurawski S, Zurawski G, Erickson HP, Kwong PD, Alam SM, Levy Y, Montefiori DC, Haynes BF. Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. 2017; Cell Rep. 21(13):3681-3690. [Article]

Julg B, Pegu A, Abbink P, Liu J, Brinkman A, Molloy K, Mojta S, Chandrashekar A, Callow K, Wang K, Chen X, Schmidt SD, Huang J, Koup RA, Seaman MS, Keele BF, Mascola JR, Connors M, Barouch DH. Virological control by the CD4-binding site antibody N6 in simian-human immunodeficiency virus-infected rhesus monkeys. J. Virol. 2017; 91:e00498-17. [Article]

Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich T, Pereyra F, Walker BD, Lauffenburger D, Kwon D, Keele BF, Alter G. Virus driven inflammation is associated with the development of bnAbs in spontaneous controllers of HIV. Clin Infect Dis. 2017 Apr 15; 64(8): 1098-1104. [Article]

Zhao G, Wu G, Lim ES, Droit L, Krishnamurthy S, Barouch DH, Virgin HW, Wang D. VirusSeeker, a computational pipeline for virus discovery and virome composition analysis. Virology 2017; 503:21-30. [Article]

Best K, Guedj J, Madelain V, de Lamballerie X, Lim SY, Osuna CE, Whitney JB, Perelson AS. Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8847-8852. doi: 10.1073/pnas.1704011114. Epub 2017 Aug 1. PMID: 28765371; PMCID: PMC5565429. [Article]

Publications

Center for Virology and Vaccine Research

CVVR Clinical Trials Unit

Affiliates