Publications
2025
Jost S, Reeves RK. Elephant in the room: natural killer cells don't forget HIV either. Curr Opin HIV AIDS. 2025 Mar 1;20(2):109-116. doi: 10.1097/COH.0000000000000909. Epub 2025 Jan 17. PMID: 39773904; PMCID: PMC11802307.
[Article]
Zhu B, Bai Y, Yeo YY, Lu X, Rovira-Clavé X, Chen H, Yeung J, Nkosi D, Glickman J, Delgado-Gonzalez A, Gerber GK, Angelo M, Shalek AK, Nolan GP, Jiang S. A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment. Nat Commun. 2025 Jan 31;16(1):1230. doi: 10.1038/s41467-025-56237-7. PMID: 39890778; PMCID: PMC11785740.
[Article]
Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, Reeves RK, Wiehe KJ, Pollara J, Tomaras GD, Bradley T, Ferrari G. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity. Pathog Immun. 2025 Jan 23;10(1):49-79. doi: 10.20411/pai.v10i1.734. PMID: 39911143; PMCID: PMC11792536.
[Article]
Shah DP, Thaweethai T, Karlson EW, Bonilla H, Horne BD, Mullington JM, Wisnivesky JP, Hornig M, Shinnick DJ, Klein JD, Erdmann NB, Brosnahan SB, Lee-Iannotti JK, Metz TD, Maughan C, Ofotokun I, Reeder HT, Stiles LE, Shaukat A, Hess R, Ashktorab H, Bartram L, Bassett IV, Becker JH, Brim H, Charney AW, Chopra T, Clifton RG, Deeks SG, Erlandson KM, Fierer DS, Flaherman VJ, Fonseca V, Gander JC, Hodder SL, Jacoby VL, Kotini-Shah P, Krishnan JA, Kumar A, Levy BD, Lieberman D, Lin JJ, Martin JN, McComsey GA, Moukabary T, Okumura MJ, Peluso MJ, Rosen CJ, Saade G, Shah PK, Sherif ZA, Taylor BS, Tuttle KR, Urdaneta AE, Wallick JA, Wiley Z, Zhang D, Horwitz LI, Foulkes AS, Singer NG; RECOVER Consortium. Sex Differences in Long COVID. JAMA Netw Open. 2025 Jan 2;8(1):e2455430. doi: 10.1001/jamanetworkopen.2024.55430. PMID: 39841477; PMCID: PMC11755195.
[Article]
Rössler A, Netzl A, Lasrado N, Chaudhari J, Mühlemann B, Wilks SH, Kimpel J, Smith DJ, Barouch DH. Nonhuman primate antigenic cartography of SARS-CoV-2. Cell Rep. 2025 Jan 28;44(1):115140. doi: 10.1016/j.celrep.2024.115140. Epub 2025 Jan 3. PMID: 39754717; PMCID: PMC11781863.
[Article]
Edupuganti S, Hurt CB, Stephenson KE, Huang Y, Paez CA, Yu C, Yen C, Hanscom B, He Z, Miner MD, Gamble T, Heptinstall J, Seaton KE, Domin E, Lin BC, McKee K, Doria-Rose N, Regenold S, Spiegel H, Anderson M, McClosky N, Zhang L, Piwowar-Manning E, Ackerman ME, Pensiero M, Dye BJ, Landovitz RJ, Mayer K, Siegel M, Sobieszczyk M, Walsh SR, Gama L, Barouch DH, Montefiori DC, Tomaras GD; HVTN 136/HPTN 092 Study Team. Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial. Lancet HIV. 2025 Jan;12(1):e13-e25. doi: 10.1016/S2352-3018(24)00247-9. Epub 2024 Dec 10. PMID: 39667379; PMCID: PMC11795396.
[Article]
2024
Dagotto, G., Fisher, J. L., Li, D., Li, Z., Jenni, S., Li, Z., Tartaglia, L. J., Abbink, P., & Barouch, D. H. (2024). Identification of a novel neutralization epitope in rhesus AAVs. Molecular therapy. Methods & clinical development, 32(4), 101350. https://doi.org/10.1016/j.omtm.2024.101350
[Article]
Swank, Z., Borberg, E., Chen, Y., Senussi, Y., Chalise, S., Manickas-Hill, Z., Yu, X. G., Li, J. Z., Alter, G., Henrich, T. J., Kelly, J. D., Hoh, R., Goldberg, S. A., Deeks, S. G., Martin, J. N., Peluso, M. J., Talla, A., Li, X., Skene, P., Bumol, T. F., … RECOVER consortium authors (2024). Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 30(12), 1599–1605. https://doi.org/10.1016/j.cmi.2024.09.001
[Article]
Swank, Z., Borberg, E., Chen, Y., Senussi, Y., Chalise, S., Manickas-Hill, Z., Yu, X. G., Li, J. Z., Alter, G., Henrich, T. J., Kelly, J. D., Hoh, R., Goldberg, S. A., Deeks, S. G., Martin, J. N., Peluso, M. J., Talla, A., Li, X., Skene, P., Bumol, T. F., … RECOVER consortium authors (2024). Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 30(12), 1599–1605. https://doi.org/10.1016/j.cmi.2024.09.001
[Article]
Gray, G. E., Mngadi, K., Lavreys, L., Nijs, S., Gilbert, P. B., Hural, J., Hyrien, O., Juraska, M., Luedtke, A., Mann, P., McElrath, M. J., Odhiambo, J. A., Stieh, D. J., van Duijn, J., Takalani, A. N., Willems, W., Tapley, A., Tomaras, G. D., Van Hoof, J., Schuitemaker, H., … Imbokodo/HVTN 705/HPX2008 Study Group (2024). Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial. The Lancet. Infectious diseases, 24(11), 1201–1212. https://doi.org/10.1016/S1473-3099(24)00358-X
[Article]
Holmes S, Li H, Shen X, Martin M, Tuck R, Chen Y, Giorgi EE, Kirshner HF, Berry M, Van Italie E, Venkatayogi S, Martin Beem JS, Edwards RJ, Mansouri K, Singh A, Kuykendall C, Gurley T, Anthony Moody M, DeNayer N, Demarco T, Denny TN, Wang Y, Evangelous TD, Clinton JT, Hora B, Wagh K, Seaman MS, Saunders KO, Solomotis N, Misamore J, Lewis MG, Wiehe K, Montefiori DC, Shaw GM, Williams WB. Neonatal immunity associated with heterologous HIV-1 neutralizing antibody induction in SHIV-infected Rhesus Macaques. Nat Commun. 2024 Nov 27;15(1):10302. doi: 10.1038/s41467-024-54753-6. PMID: 39604409; PMCID: PMC11603298.
[Article]
Nkolola JP, Hope D, Guan R, Colarusso A, Aid M, Weiss D, Misamore J, Andersen H, Lewis MG, Williamson L, Carnahan RH, Crowe JE, Barouch DH.2024.Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques. J Virol98:e01429-24.https://doi.org/10.1128/jvi.01429-24
[Article]
Vijayan, A., Vogels, R., Groppo, R., Jin, Y., Khan, S., Van Kampen, M., Jorritsma, S., Boedhoe, S., Baert, M., van Diepen, H., Kuipers, H., Serroyen, J., Del Valle, J. R., Broman, A., Nguyen, L., Ray, S., Jarai, B., Arora, J., Lifton, M., Mildenberg, B., … Zahn, R. (2024). A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates. Nature communications, 15(1), 9884. https://doi.org/10.1038/s41467-024-54289-9
[Article]
Semmes, E. C., Nettere, D. R., Nelson, A. N., Hurst, J. H., Cain, D. W., Burt, T. D., Kurtzberg, J., Reeves, R. K., Coyne, C. B., Fouda, G. G., Pollara, J., Permar, S. R., & Walsh, K. M. (2024). In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions. The Journal of clinical investigation, 135(1), e181342. https://doi.org/10.1172/JCI181342
[Article]
Kahan, R. H., Abraham, N., Lee, H. J., Ettenger, R. B., Grimm, P. C., Reed, E. F., Reeves, R. K., Sarwal, M. M., Stempora, L. L., Warshaw, B. L., Kirk, A. D., Martinez, O. M., & Chambers, E. T. (2024). Natural Killer Cell Phenotypes and Clinical Outcomes in Pediatric Kidney Transplantation. Pediatric transplantation, 28(8), e14877. https://doi.org/10.1111/petr.14877
[Article]
Sugawara, S., Lee, E., Craemer, M. A., Pruitt, A., Balachandran, H., Gressens, S. B., Kroll, K., Manickam, C., Li, Y., Jost, S., Woolley, G., & Reeves, R. K. (2024). Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1. AIDS research and human retroviruses, 40(11), 631–636. https://doi.org/10.1089/AID.2023.0114
[Article]
Banga, J., Brock-Fisher, T., Petros, B. A., Dai, E. Y., Leonelli, A. T., Dobbins, S. T., Messer, K. S., Nathanson, A. B., Capone, A., Littlehale, N., Appiah-Danquah, V., Dim, S., Moreno, G. K., Crowther, M., DeRuff, K. C., MacInnis, B. L., Springer, M., Sabeti, P. C., & Stephenson, K. E. (2024). Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission During the Omicron Era in Massachusetts: A Prospective, Case-Ascertained Study Using Genomic Epidemiology. Open forum infectious diseases, 11(11), ofae591. https://doi.org/10.1093/ofid/ofae591
[Article]
Lasrado, N., Rowe, M., McMahan, K., Hachmann, N. P., Miller, J., Jacob-Dolan, C., Liu, J., Verrette, B., Gotthardt, K. A., Ty, D. M., Pereira, J., Mazurek, C. R., Hoyt, A., Collier, A. Y., & Barouch, D. H. (2024). SARS-CoV-2 XBB.1.5 mRNA booster vaccination elicits limited mucosal immunity. Science translational medicine, 16(770), eadp8920. https://doi.org/10.1126/scitranslmed.adp8920
[Article]
Woolley, G., Kroll, K., Hoffman, K., Ward, A., Corneli, A., Mudrak, S. V., Qureshi, M. U., Okeke, N. L., Chan, C., Jones, A. D., Tomaras, G. D., & Reeves, R. K. (2024). The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?. AIDS research and human retroviruses, 40(10), 549–554. https://doi.org/10.1089/AID.2024.0050
[Article]
Collier, A. Y., McMahan, K., Jacob-Dolan, C., Liu, J., Borducchi, E. N., Moss, B., & Barouch, D. H. (2024). Decline of Mpox Antibody Responses After Modified Vaccinia Ankara-Bavarian Nordic Vaccination. JAMA, 332(19), 1669–1672. https://doi.org/10.1001/jama.2024.20951
[Article]
Kenny, A., van Duijn, J., Dintwe, O., Heptinstall, J., Burnham, R., Sawant, S., Zhang, L., Mielke, D., Khuzwayo, S., Omar, F. L., Stanfield-Oakley, S., Keyes, T., Dunn, B., Goodman, D., Fong, Y., Benkeser, D., Zou, R., Hural, J., Hyrien, O., Juraska, M., … Imbokodo Study and Correlates Group (2024). Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study. EBioMedicine, 108, 105320. https://doi.org/10.1016/j.ebiom.2024.105320
[Article]
Vanshylla, K., Tolboom, J., Stephenson, K. E., Feddes-de Boer, K., Verwilligen, A., Rosendahl Huber, S. K., Rutten, L., Schuitemaker, H., Zahn, R. C., Barouch, D. H., & Wegmann, F. (2024). Mosaic HIV-1 vaccine and SHIV challenge strain V2 loop sequence identity and protection in primates. NPJ vaccines, 9(1), 179. https://doi.org/10.1038/s41541-024-00974-1
[Article]
Tong X, Wang Q, Jung W, Chicz TM, Blanc R, Parker LJ, Barouch DH, McNamara RP. Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques. iScience. 2024 Jun 4;27(9):110174. doi: 10.1016/j.isci.2024.110174. PMID: 39224511; PMCID: PMC11367469.
[Article]
Hall, J. M., Lyons, C. E., Li, J., Martinez-Romero, G., Hayes, T., Cook, A., Barouch, D. H., & Martinot, A. J. (2024). Mpox infection of stromal cells and macrophages of macaque with endometriosis. Scientific reports, 14(1), 21947. https://doi.org/10.1038/s41598-024-73012-8
[Article]
Joseph P Nkolola, Jinyan Liu, Ai-ris Y Collier, Catherine Jacob-Dolan, Yasmeen Senussi, Ella Borberg, Zoe Swank, David R Walt, Dan H Barouch, High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays, The Journal of Infectious Diseases, Volume 230, Issue 3, 15 September 2024, Pages e601–e604, https://doi.org/10.1093/infdis/jiae174
[Article]
Govindan, R., & Stephenson, K. E. (2024). HIV Vaccine Development at a Crossroads: New B and T Cell Approaches. Vaccines, 12(9), 1043. https://doi.org/10.3390/vaccines12091043
[Article]
Julg B, Walker-Sperling VEK, Wagh K, Aid M, Stephenson KE, Zash R, Liu J, Nkolola JP, Hoyt A, Castro M, Serebryannyy L, Yanosick K, Speidel T, Borducchi EN, Murzda T, Maxfield L, Arduino R, McDermott AB, Gama L, Giorgi EE, Koup RA, Seaman MS, Rolle CP, DeJesus E, Li W, Korber B, Barouch DH. Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial. Nat Med. 2024 Sep 12. doi: 10.1038/s41591-024-03247-5. Epub ahead of print. PMID: 39266747.
[Article]
Sooin Jang, Gregory J Bedwell, Satya P Singh, Hyun Jae Yu, Bjarki Arnarson, Parmit K Singh, Rajalingam Radhakrishnan, AidanDarian W Douglas, Zachary M Ingram, Christian Freniere, Onno Akkermans, Stefan G Sarafianos, Zandrea Ambrose, Yong Xiong, Praju V Anekal, Paula Montero Llopis, Vineet N KewalRamani, Ashwanth C Francis, Alan N Engelman, HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration, Nucleic Acids Research, 2024;, gkae769, https://doi.org/10.1093/nar/gkae769
[Article]
Rowe M, Collier AY, Barouch DH. Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience. Vaccine. 2024 Oct 24;42(24):126306. doi: 10.1016/j.vaccine.2024.126306. Epub 2024 Sep 5. PMID: 39241351; PMCID: PMC11401756.
[Article]
Kenny A, van Duijn J, Dintwe O, Heptinstall J, Burnham R, Sawant S, Zhang L, Mielke D, Khuzwayo S, Omar FL, Stanfield-Oakley S, Keyes T, Dunn B, Goodman D, Fong Y, Benkeser D, Zou R, Hural J, Hyrien O, Juraska M, Luedtke A, van der Laan L, Giorgi EE, Magaret C, Carpp LN, Pattacini L, van de Kerkhof T, Korber B, Willems W, Fisher LH, Schuitemaker H, Swann E, Kublin JG, Pau MG, Buchbinder S, Tomaka F, Nijs S, Lavreys L, Gelderblom HC, Corey L, Mngadi K, Gray GE, Borducchi E, Hendriks J, Seaton KE, Zolla-Pazner S, Barouch DH, Ferrari G, De Rosa SC, McElrath MJ, Andersen-Nissen E, Stieh DJ, Tomaras GD, Gilbert PB; Imbokodo Study and Correlates Group. Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study. EBioMedicine. 2024 Sep 4;108:105320. doi: 10.1016/j.ebiom.2024.105320. Epub ahead of print. PMID: 39236556.
[Article]
Erlandson, K. M., Geng, L. N., Selvaggi, C. A., Thaweethai, T., Chen, P., Erdmann, N. B., Goldman, J. D., Henrich, T. J., Hornig, M., Karlson, E. W., Katz, S. D., Kim, C., Cribbs, S. K., Laiyemo, A. O., Letts, R., Lin, J. Y., Marathe, J., Parthasarathy, S., Patterson, T. F., Taylor, B. D., … RECOVER-Adult Cohort (2024). Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort. Annals of internal medicine, 177(9), 1209–1221. https://doi.org/10.7326/M24-0737
[Article]
Caniels TG, Medina-Ramìrez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sánchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Sci Immunol. 2024 Aug 30;9(98):eadk9550. doi: 10.1126/sciimmunol.adk9550. Epub 2024 Aug 30. PMID: 39213338.
[Article]
Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug;17(4):692-699. doi: 10.1016/j.mucimm.2024.04.003. Epub 2024 Apr 25. PMID: 38677592; PMCID: PMC11323182.
[Article]
Chang, Y., Liu, J., Jiang, Y., Ma, A., Yeo, Y. Y., Guo, Q., McNutt, M., Krull, J. E., Rodig, S. J., Barouch, D. H., Nolan, G. P., Xu, D., Jiang, S., Li, Z., Liu, B., & Ma, Q. (2024). Graph Fourier transform for spatial omics representation and analyses of complex organs. Nature communications, 15(1), 7467. https://doi.org/10.1038/s41467-024-51590-5
[Article]
Martinot, A. J., Cox, F., Abbink, P., Hecht, J. L., Bronson, R., Borducchi, E. N., Rinaldi, W. J., Ferguson, M. J., De La Barrera, R. A., Zahn, R., van der Fits, L., & Barouch, D. H. (2024). Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection. NPJ vaccines, 9(1), 157. https://doi.org/10.1038/s41541-024-00927-8
[Article]
Vielot, N. A., Kelly, N. K., Ludema, C., Rosenberg, M., Brown, E. R., Janes, H. E., Kublin, J. G., Stephenson, K. E., Marcelin, J. R., & Pettifor, A. (2024). Patterns and predictors of COVID-19 vaccination among young adults at 44 US sites: Secondary analysis of a randomized, controlled, open-label trial, March - December 2021. Vaccine, 42(23), 126237. https://doi.org/10.1016/j.vaccine.2024.126237
[Article]
Balachandran H, Kroll K, Terry K, Manickam C, Jones R, Woolley G, Hayes T, Martinot AJ, Sharma A, Lewis M, Jost S, Reeves RK. NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. PLoS Pathog. 2024 Aug 12;20(8):e1012439. doi: 10.1371/journal.ppat.1012439. PMID: 39133756; PMCID: PMC11341101.
[Article]
Balachandran, H., Kroll, K., Terry, K., Manickam, C., Jones, R., Woolley, G., Hayes, T., Martinot, A. J., Sharma, A., Lewis, M., Jost, S., & Reeves, R. K. (2024). NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. PLoS pathogens, 20(8), e1012439. https://doi.org/10.1371/journal.ppat.1012439
[Article]
Sugawara, S., Lee, E., Craemer, M. A., Pruitt, A., Balachandran, H., Gressens, S. B., Kroll, K., Manickam, C., Li, Y., Jost, S., Woolley, G., & Reeves, R. K. (2024). Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1. AIDS research and human retroviruses, 10.1089/AID.2023.0114. Advance online publication. https://doi.org/10.1089/AID.2023.0114
[Article]
Nelson GW, van Duijn J, Yuki Y, Pau MG, Tomaka F, Lavreys L, DeRosa SC, McElrath MJ, Kirk GD, Michael NL, Haas DW, Deeks SG, Wolinsky S, Walker B, Barouch DH, Stieh D, Carrington M.2024.Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles. J Virol98:e00281-24.https://doi.org/10.1128/jvi.00281-24
[Article]
Nelson GW, van Duijn J, Yuki Y, Pau MG, Tomaka F, Lavreys L, DeRosa SC, McElrath MJ, Kirk GD, Michael NL, Haas DW, Deeks SG, Wolinsky S, Walker B, Barouch DH, Stieh D, Carrington M.2024.Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles. J Virol98:e00281-24.https://doi.org/10.1128/jvi.00281-24
[Article]
Li M, Li Z, Chen X, Cui Y, Engelman AN, Craigie R. HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration. Viruses. 2024; 16(7):1166. https://doi.org/10.3390/v16071166
[Article]
Gray GE, Mngadi K, Lavreys L, Nijs S, Gilbert PB, Hural J, Hyrien O, Juraska M, Luedtke A, Mann P, McElrath MJ, Odhiambo JA, Stieh DJ, van Duijn J, Takalani AN, Willems W, Tapley A, Tomaras GD, Van Hoof J, Schuitemaker H, Swann E, Barouch DH, Kublin JG, Corey L, Pau MG, Buchbinder S, Tomaka F; Imbokodo/HVTN 705/HPX2008 Study Group. Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Infect Dis. 2024 Jul 19:S1473-3099(24)00358-X. doi: 10.1016/S1473-3099(24)00358-X. Epub ahead of print. PMID: 39038477.
[Article]
Williams WB, Alam SM, Ofek G, Erdmann N, Montefiori DC, Seaman MS, Wagh K, Korber B, Edwards RJ, Mansouri K, Eaton A, Cain DW, Martin M, Hwang J, Arus-Altuz A, Lu X, Cai F, Jamieson N, Parks R, Barr M, Foulger A, Anasti K, Patel P, Sammour S, Parsons RJ, Huang X, Lindenberger J, Fetics S, Janowska K, Niyongabo A, Janus BM, Astavans A, Fox CB, Mohanty I, Evangelous T, Chen Y, Berry M, Kirshner H, Van Itallie E, Saunders KO, Wiehe K, Cohen KW, McElrath MJ, Corey L, Acharya P, Walsh SR, Baden LR, Haynes BF. Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans. Cell. 2024 Jun 6;187(12):2919-2934.e20. doi: 10.1016/j.cell.2024.04.033. Epub 2024 May 17. PMID: 38761800.
[Article]
Woolley G, Kroll K, Hoffman K, Ward A, Corneli A, Mudrak SV, Qureshi MU, Okeke NL, Chan C, Jones AD, Tomaras GD, Reeves RK. The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk? AIDS Res Hum Retroviruses. 2024 May 27. doi: 10.1089/AID.2024.0050. Epub ahead of print. PMID: 38753709.
[Article]
Gelderblom, H.C., Corey, L. and Barouch, D.H. (2024), The potential of broadly neutralizing antibodies for HIV prevention. J Int AIDS Soc., 27: e26257. https://doi.org/10.1002/jia2.26257
[Article]
Fisher LH, Kee JJ, Liu A, et al. SARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated Individuals: A Secondary Cross-Protocol Analysis of 4 Randomized Trials. JAMA Netw Open. 2024;7(5):e2412835. doi:10.1001/jamanetworkopen.2024.12835
[Article]
Williams WB, Alam SM, Ofek G, Erdmann N, Montefiori DC, Seaman MS, Wagh K, Korber B, Edwards RJ, Mansouri K, Eaton A, Cain DW, Martin M, Hwang J, Arus-Altuz A, Lu X, Cai F, Jamieson N, Parks R, Barr M, Foulger A, Anasti K, Patel P, Sammour S, Parsons RJ, Huang X, Lindenberger J, Fetics S, Janowska K, Niyongabo A, Janus BM, Astavans A, Fox CB, Mohanty I, Evangelous T, Chen Y, Berry M, Kirshner H, Van Itallie E, Saunders KO, Wiehe K, Cohen KW, McElrath MJ, Corey L, Acharya P, Walsh SR, Baden LR, Haynes BF. Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans. Cell. 2024 May 14:S0092-8674(24)00459-8. doi: 10.1016/j.cell.2024.04.033. Epub ahead of print. PMID: 38761800.
[Article]
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Redhunt AM, Ledyard R, Collier AY, Hacker MR, Burris HH. Resilience as a potential modifier of racial inequities in preterm birth. Ann Epidemiol. 2023 Jul;83:54-59.e1. doi: 10.1016/j.annepidem.2023.04.010. Epub 2023 Apr 22. PMID: 37088321; PMCID: PMC10330189.
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Wagh K, Seaman MS. Divide and conquer: broadly neutralizing antibody combinations for improved HIV-1 viral coverage. Curr Opin HIV AIDS. 2023 Jul 1;18(4):164-170. doi: 10.1097/COH.0000000000000800. Epub 2023 May 19. PMID: 37249911; PMCID: PMC10256304.
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Vidal SJ, Sellers D, Yu J, Wakabayashi S, Sixsmith J, Aid M, Barrett J, Stevens SF, Liu X, Li W, Plumlee CR, Urdahl KB, Martinot AJ, Barouch DH. Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model. iScience. 2023 May 28;26(6):106963. doi: 10.1016/j.isci.2023.106963. PMID: 37378347; PMCID: PMC10291467.
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Bartsch YC, Cizmeci D, Kang J, Gao H, Shi W, Chandrashekar A, Collier AY, Chen B, Barouch DH, Alter G. Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions. iScience. 2023 May 19;26(5):106582. doi: 10.1016/j.isci.2023.106582. Epub 2023 Apr 7. PMID: 37082529; PMCID: PMC10079316.
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Gan T, Droit L, Vernon S, Barouch DH, Wang D. Isolation of a rhesus calicivirus that can replicate in human cells. Virology. 2023 May;582:83-89. doi: 10.1016/j.virol.2023.03.012. Epub 2023 Apr 2. PMID: 37031656; PMCID: PMC10264158.
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Vander Straeten A, Sarmadi M, Daristotle JL, Kanelli M, Tostanoski LH, Collins J, Pardeshi A, Han J, Varshney D, Eshaghi B, Garcia J, Forster TA, Li G, Menon N, Pyon SL, Zhang L, Jacob-Dolan C, Powers OC, Hall K, Alsaiari SK, Wolf M, Tibbitt MW, Farra R, Barouch DH, Langer R, Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nat Biotechnol. 2023 Apr 24:10.1038/s41587-023-01774-z. doi: 10.1038/s41587-023-01774-z. Epub ahead of print. PMID: 37095347; PMCID: PMC10593912.
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Yu J, Thomas PV, Sciacca M, Wu C, Liu J, He X, Miller J, Hachmann NP, Surve N, McMahan K, Jacob-Dolan C, Powers O, Hall K, Barrett J, Hope D, Mazurek CR, Murdza T, Chang WC, Golub E, Rees PA, Peterson CE, Hajduczki A, Chen WH, Martinez EJ, Hussin E, Lange C, Gong H, Matyas GR, Rao M, Suthar M, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Bolton DL, Michael NL, Joyce MG, Modjarrad K, Barouch DH. Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques. Cell Rep Med. 2023 Apr 18;4(4):101018. doi: 10.1016/j.xcrm.2023.101018. Epub 2023 Mar 27. PMID: 37023746; PMCID: PMC10040355.
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Daniel J Stieh, Dan H Barouch, Christy Comeaux, Michal Sarnecki, Kathryn E Stephenson, Stephen R Walsh, Sheetal Sawant, Jack Heptinstall, Georgia D Tomaras, James G Kublin, M Juliana McElrath, Kristen W Cohen, Stephen C De Rosa, Galit Alter, Guido Ferrari, David Montefiori, Philipp Mann, Steven Nijs, Katleen Callewaert, Paul A Goepfert, Srilatha Edupuganti, Etienne Karita, Michael S Seaman, Lawrence Corey, Lindsey R Baden, Maria G Pau, Hanneke Schuitemaker, Frank Tomaka, the ASCENT/HVTN118/HPX2003 Study Team , Safety and Immunogenicity of Ad26-Vectored HIV Vaccine With Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-Uninfected Adults: A Phase 1/2a Study, The Journal of Infectious Diseases, Volume 227, Issue 8, 15 April 2023, Pages 939–950, https://doi.org/10.1093/infdis/jiac445
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Solforosi, L., Costes, L.M.M., Tolboom, J.T.B.M. et al. Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques. Nat Commun 14, 1944 (2023). https://doi.org/10.1038/s41467-023-37715-2
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Cable J, Graham BS, Koup RA, Seder RA, Karikó K, Pardi N, Barouch DH, Sharma B, Rauch S, Nachbagauer R, Forsell MNE, Schotsaert M, Ellebedy AH, Loré K, Irvine DJ, Pilkington E, Tahtinen S, Thompson EA, Feraoun Y, King NP, Saunders K, Alter G, Moin SM, Sliepen K, Karlsson Hedestam GB, Wardemann H, Pulendran B, Doria-Rose NA, He WT, Juno JA, Ataca S, Wheatley AK, McLellan JS, Walker LM, Lederhofer J, Lindesmith LC, Wille H, Hotez PJ, Bekker LG. Progress in vaccine development for infectious diseases-a Keystone Symposia report. Ann N Y Acad Sci. 2023 Jun;1524(1):65-86. doi: 10.1111/nyas.14975. Epub 2023 Apr 5. PMID: 37020354.
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Garber, David A.a; Guenthner, Patriciaa; Zhao, Chunxiaa; Mitchell, Jamesa; Ellis, Shanona; Jia, Hongweia; Manganare, Marcosa; Gazumyan, Annab; Seaman, Michael S.c; Vishwanathan, Sundaram Ajaya; Heneine, Walida; McNicholl, Janet M.a. Broadly neutralizing antibody-mediated protection against simian-HIV infection among macaques with vaginal sexually transmitted infections. AIDS 37(5):p 723-731, April 1, 2023. | DOI: 10.1097/QAD.0000000000003472
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Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2202815120. doi: 10.1073/pnas.2202815120. Epub 2023 Mar 21. PMID: 36943880; PMCID: PMC10068764.
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Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Mar 3;8(1):30. doi: 10.1038/s41541-023-00634-w. Erratum for: NPJ Vaccines. 2023 Feb 14;8(1):18. PMID: 36869134; PMCID: PMC9982769.
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Joseph NT, Collier AY. COVID-19 Therapeutics and Considerations for Pregnancy. Obstet Gynecol Clin North Am. 2023 Mar;50(1):163-182. doi: 10.1016/j.ogc.2022.10.018. Epub 2022 Oct 21. PMID: 36822701; PMCID: PMC9584862.
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Jacob-Dolan, C., Yu, J., McMahan, K. et al. Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques. npj Vaccines 8, 23 (2023). https://doi.org/10.1038/s41541-023-00622-0
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Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nat Struct Mol Biol. 2023 Apr;30(4):425-435. doi: 10.1038/s41594-023-00925-9. Epub 2023 Feb 20. PMID: 36807645; PMCID: PMC10121901.
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Fray EJ, Wu F, Simonetti FR, Zitzmann C, Sambaturu N, Molina-Paris C, Bender AM, Liu PT, Ventura JD, Wiseman RW, O'Connor DH, Geleziunas R, Leitner T, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants. Cell Host Microbe. 2023 Mar 8;31(3):356-372.e5. doi: 10.1016/j.chom.2023.01.016. Epub 2023 Feb 20. PMID: 36809762; PMCID: PMC10583177.
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Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Feb 14;8(1):18. doi: 10.1038/s41541-023-00610-4. Erratum in: NPJ Vaccines. 2023 Mar 3;8(1):30. PMID: 36788219; PMCID: PMC9927065.
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Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio. 2023 Feb 28;14(1):e0356022. doi: 10.1128/mbio.03560-22. Epub 2023 Feb 6. PMID: 36744954; PMCID: PMC9973045.
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Miller, J., Hachmann, N. P., Collier, A. Y., Lasrado, N., Mazurek, C. R., Patio, R. C., Powers, O., Surve, N., Theiler, J., Korber, B., & Barouch, D. H. (2023). Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1. The New England journal of medicine, 10.1056/NEJMc2214314. Advance online publication. https://doi.org/10.1056/NEJMc2214314
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Collier, A. Y., Miller, J., Hachmann, N. P., McMahan, K., Liu, J., Bondzie, E. A., Gallup, L., Rowe, M., Schonberg, E., Thai, S., Barrett, J., Borducchi, E. N., Bouffard, E., Jacob-Dolan, C., Mazurek, C. R., Mutoni, A., Powers, O., Sciacca, M., Surve, N., VanWyk, H., … Barouch, D. H. (2023). Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters. The New England journal of medicine, 10.1056/NEJMc2213948. Advance online publication. https://doi.org/10.1056/NEJMc2213948
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2022
Cooper, A., Sidaway, A., Chandrashekar, A., Latta, E., Chakraborty, K., Yu, J., McMahan, K., Giffin, V., Manickam, C., Kroll, K., Mosher, M., Reeves, R. K., Gam, R., Arthofer, E., Choudhry, M., Henley, T., & Barouch, D. H. (2022). A genetically engineered, stem-cell-derived cellular vaccine. Cell reports. Medicine, 3(12), 100843. https://doi.org/10.1016/j.xcrm.2022.100843
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Yu, J., Thomas, P. V., McMahan, K., Jacob-Dolan, C., Liu, J., He, X., Hope, D., Martinez, E. J., Chen, W. H., Sciacca, M., Hachmann, N. P., Lifton, M., Miller, J., Powers, O. C., Hall, K., Wu, C., Barrett, J., Swafford, I., Currier, J. R., King, J., … Barouch, D. H. (2022). Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN. Science advances, 8(47), eade4433. https://doi.org/10.1126/sciadv.ade4433
[Article]
Stieh, D. J., Barouch, D. H., Comeaux, C., Sarnecki, M., Stephenson, K. E., Walsh, S. R., Sawant, S., Heptinstall, J., Tomaras, G. D., Kublin, J. G., McElrath, M. J., Cohen, K. W., De Rosa, S. C., Alter, G., Ferrari, G., Montefiori, D., Mann, P., Nijs, S., Callewaert, K., Goepfert, P. A., … Tomaka, F. (2022). Safety and Immunogenicity of Ad26-vectored HIV Vaccine with Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-uninfected Adults: A Phase 1/2a Study. The Journal of infectious diseases, jiac445. Advance online publication. https://doi.org/10.1093/infdis/jiac445
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Dagotto, G., Ventura, J. D., Martinez, D. R., Anioke, T., Chung, B. S., Siamatu, M., Barrett, J., Miller, J., Schäfer, A., Yu, J., Tostanoski, L. H., Wagh, K., Baric, R. S., Korber, B., & Barouch, D. H. (2022). Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex. NPJ vaccines, 7(1), 125. https://doi.org/10.1038/s41541-022-00553-2
[Article]
Hachmann, N. P., Miller, J., Collier, A. Y., & Barouch, D. H. (2022). Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.4.6. The New England journal of medicine, 387(20), 1904–1906. https://doi.org/10.1056/NEJMc2212117
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Barouch D. H. (2022). Covid-19 Vaccines - Immunity, Variants, Boosters. The New England journal of medicine, 387(11), 1011–1020. https://doi.org/10.1056/NEJMra2206573
[Article]
Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman AN. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022; 14(9):1883. https://doi.org/10.3390/v14091883
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Liu J, Yu J, McMahan K, Jacob-Dolan C, He X, Giffin V, Wu C, Sciacca M, Powers O, Nampanya F, Miller J, Lifton M, Hope D, Hall K, Hachmann NP, Chung B, Anioke T, Li W, Muench J, Gamblin A, Boursiquot M, Cook A, Lewis MG, Andersen H, Barouch DH. CD8 T Cells Contribute to Vaccine Protection Against SARS-CoV-2 in Macaques. Sci Immunol. 2022 Aug 9:eabq7647. doi: 10.1126/sciimmunol.abq7647. Epub ahead of print. PMID: 35943359.
[Article]
Valsecchio C, Winterton D, Fakhr BS, Collier AY, Nozari A, Ortoleva J, Mukerji S, Gibson LE, Carroll RW, Shaefi S, Pinciroli R, La Vita C, Ackman JB, Hohmann E, Arora P, Barth WH, Kaimal A, Ichinose F, Berra L;DELivery oF iNO (DELFINO) Network Collaborators. High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 Pneumonia. Obstet Gynecol. April 2022. Accepted
Tan CS, Collier AY,Yu J, Liu J, Chandrashekar A, McMahan KA, Jacob-Dolan C, He X, Roy V, Hauser BM, Munt JE, Mallory ML, Mattocks M, Powers JM, Meganck RM, Rowe M, Hemond R, Bondzie EA, Jaegle KH, Baric RS, Schmidt AG, Alter G, Le Gars M, Sadoff J, Barouch DH. Durability of Heterologous and Homologous COVID-19 Vaccine Boost Regimens. JAMA Network Open. June 2022. Accepted.
Hachmann NP, Miller J, Collier AY, Ventura JD, Yu J, Rowe M, Bondzie EA, Powers O, Surve N, Hall K, Barouch DH. Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5. N Engl J Med. 2022 Jun 22. doi: 10.1056/NEJMc2206576. Epub ahead of print. PMID: 35731894.
[Article]
Moldt B, Chandrashekar A, Borducchi EN, Nkolola JP, Stephenson H, Nagel M, Hung M, Goldsmith J, Pace CS, Carr B, Thomsen ND, Blair WS, Geleziunas R, Barouch DH. HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys. PLoS Pathog. 2022 Apr 22;18(4):e1010467. doi: 10.1371/journal.ppat.1010467. Epub ahead of print. PMID: 35452496.
[Article]
Collier AY, Brown CM, McMahan KA, Yu J, Liu J, Jacob-Dolan C, Chandrashekar A, Tierney D, Ansel JL, Rowe M, Sellers D, Ahmad K, Aguayo R, Anioke T, Gardner S, Siamatu M, Bermudez-Rivera L, Hacker MR, Madoff LC, Barouch DH. Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant. Sci Transl Med. 2022 Apr 20;14(641):eabn6150. doi: 10.1126/scitranslmed.abn6150. Epub 2022 Apr 20. PMID: 35258323; PMCID: PMC8995036.
[Article]
DeGrace MM, Ghedin E, Frieman MB, Krammer F, Grifoni A, Alisoltani A, Alter G, Amara RR, Baric RS, Barouch DH, Bloom JD, Bloyet LM, Bonenfant G, Boon ACM, Boritz EA, Bratt DL, Bricker TL, Brown L, Buchser WJ, Carreño JM, Cohen-Lavi L, Darling TL, Davis-Gardner ME, Dearlove BL, Di H, Dittmann M, Doria-Rose NA, Douek DC, Drosten C, Edara VV, Ellebedy A, Fabrizio TP, Ferrari G, Florence WC, Fouchier RAM, Franks J, García-Sastre A, Godzik A, Gonzalez-Reiche AS, Gordon A, Haagmans BL, Halfmann PJ, Ho DD, Holbrook MR, Huang Y, James SL, Jaroszewski L, Jeevan T, Johnson RM, Jones TC, Joshi A, Kawaoka Y, Kercher L, Koopmans MPG, Korber B, Koren E, Koup RA, LeGresley EB, Lemieux JE, Liebeskind MJ, Liu Z, Livingston B, Logue JP, Luo Y, McDermott AB, McElrath MJ, Meliopoulos VA, Menachery VD, Montefiori DC, Mühlemann B, Munster VJ, Munt JE, Nair MS, Netzl A, Niewiadomska AM, O'Dell S, Pekosz A, Perlman S, Pontelli MC, Rockx B, Rolland M, Rothlauf PW, Sacharen S, Scheuermann RH, Schmidt SD, Schotsaert M, Schultz-Cherry S, Seder RA, Sedova M, Sette A, Shabman RS, Shen X, Shi PY, Shukla M, Simon V, Stumpf S, Sullivan NJ, Thackray LB, Theiler J, Thomas PG, Trifkovic S, Türeli S, Turner SA, Vakaki MA, van Bakel H, VanBlargan LA, Vincent LR, Wallace ZS, Wang L, Wang M, Wang P, Wang W, Weaver SC, Webby RJ, Weiss CD, Wentworth DE, Weston SM, Whelan SPJ, Whitener BM, Wilks SH, Xie X, Ying B, Yoon H, Zhou B, Hertz T, Smith DJ, Diamond MS, Post DJ, Suthar MS. Defining the risk of SARS-CoV-2 variants on immune protection. Nature. 2022 Mar 31. doi: 10.1038/s41586-022-04690-5. Epub ahead of print. PMID: 35361968.
[Article]
Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G. mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Sci Transl Med. 2022 Mar 29:eabm2311. doi: 10.1126/scitranslmed.abm2311. Epub ahead of print. PMID: 35348368; PMCID: PMC8995030.
[Article]
Chandrashekar A, Yu J, McMahan K, Jacob-Dolan C, Liu J, He X, Hope D, Anioke T, Barrett J, Chung B, Hachmann NP, Lifton M, Miller J, Powers O, Sciacca M, Sellers D, Siamatu M, Surve N, VanWyk H, Wan H, Wu C, Pessaint L, Valentin D, Van Ry A, Muench J, Boursiquot M, Cook A, Velasco J, Teow E, Boon ACM, Suthar MS, Jain N, Martinot AJ, Lewis MG, Andersen H, Barouch DH. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques. Cell. 2022 Mar 17:S0092-8674(22)00334-8. doi: 10.1016/j.cell.2022.03.024. Epub ahead of print. PMID: 35427477; PMCID: PMC8926910.
[Article]
Yu J, Collier AY, Rowe M, Mardas F, Ventura JD, Wan H, Miller J, Powers O, Chung B, Siamatu M, Hachmann NP, Surve N, Nampanya F, Chandrashekar A, Barouch DH. Comparable Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. medRxiv [Preprint]. 2022 Feb 7:2022.02.06.22270533. doi: 10.1101/2022.02.06.22270533. Update in: N Engl J Med. 2022 Mar 16;: PMID: 35169817; PMCID: PMC8845515.
[Article]
Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, Bowman L, Naranjo CA, Yun D, Flinchbaugh Z, Pessaint L, Brown R, Velasco J, Teow E, Cook A, Andersen H, Lewis MG, Camp DL, Silverman JM, Nagar GS, Rao HD, Lothe RR, Chandrasekharan R, Rajurkar MP, Shaligram US, Kleanthous H, Joshi SB, Volkin DB, Biswas S, Love JC, Barouch DH. SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques. Sci Adv. 2022 Mar 18;8(11):eabl6015. doi: 10.1126/sciadv.abl6015. Epub 2022 Mar 16. PMID: 35294244; PMCID: PMC8926328.
[Article]
Singh PK, Bedwell GJ, Engelman AN. Spatial and Genomic Correlates of HIV-1 Integration Site Targeting. Cells. 2022 Feb 14;11(4):655. doi: 10.3390/cells11040655. PMID: 35203306; PMCID: PMC8869898.
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Sadoff J, Gray G, Vandebosch A, Cárdenas V, Shukarev G, Grinsztejn B, Goepfert PA, Truyers C, Van Dromme I, Spiessens B, Vingerhoets J, Custers J, Scheper G, Robb ML, Treanor J, Ryser MF, Barouch DH, Swann E, Marovich MA, Neuzil KM, Corey L, Stoddard J, Hardt K, Ruiz-Guiñazú J, Le Gars M, Schuitemaker H, Van Hoof J, Struyf F, Douoguih M; ENSEMBLE Study Group. Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S. N Engl J Med. 2022 Feb 9. doi: 10.1056/NEJMoa2117608. Epub ahead of print. PMID: 35139271.
[Article]
Cobb RR, Nkolola J, Gilchuk P, Chandrashekar A, Yu J, House RV, Earnhart CG, Dorsey NM, Hopkins SA, Snow DM, Chen RE, VanBlargan LA, Hechenblaickner M, Hoppe B, Collins L, Tomic MT, Nonet GH, Hackett K, Slaughter JC, Lewis M, Andersen H, Cook A, Diamond MS, Carnahan RH, Barouch DH, Crowe JE Jr. A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques. Med (N Y). 2022 Feb 3. doi: 10.1016/j.medj.2022.01.004. Epub ahead of print. PMID: 35132398; PMCID: PMC8810411.
[Article]
Liu J, Chandrashekar A, Sellers D, Barrett J, Jacob-Dolan C, Lifton M, McMahan K, Sciacca M, VanWyk H, Wu C, Yu J, Collier AY, Barouch DH. Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron. Nature. 2022 Jan 31. doi: 10.1038/s41586-022-04465-y. Epub ahead of print. PMID: 35102312.
[Article]
Jacob-Dolan C, Barouch DH. COVID-19 Vaccines: Adenoviral Vectors. Annu Rev Med. 2022 Jan 27;73:41-54. doi: 10.1146/annurev-med-012621-102252. Epub 2021 Oct 5. PMID: 34609905; PMCID: PMC8795482.
[Article]
Yu J, Collins ND, Mercado NB, McMahan K, Chandrashekar A, Liu J, Anioke T, Chang A, Giffin VM, Hope DL, Sellers D, Nampanya F, Gardner S, Barrett J, Wan H, Velasco J, Teow E, Cook A, Van Ry A, Pessaint L, Andersen H, Lewis MG, Hofer C, Burke DS, Barkei EK, King HAD, Subra C, Bolton D, Modjarrad K, Michael NL, Barouch DH. Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques. J Virol. 2022 Jan 26;96(2):e0159921. doi: 10.1128/JVI.01599-21. Epub 2021 Oct 27. PMID: 34705557; PMCID: PMC8791250.
[Article]
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