Malika Aid-Boudries, Ph.D.

Dr. Aid-Boudries is an Assistant professor of Medicine at the Center for Virology and Vaccine Research (CVVR). She received her Ph.D. in Computational Biology and Bioinformatics from the Center for Immunology and Cancer at the University of Montreal, Quebec, Canada. At CVVR, her research focuses on developing computational pipelines and machine learning-based approaches (ML/AI) to investigate OMICS signatures associated with disease pathogenesis, baseline and post-vaccination predictor biomarkers of vaccines immunogenicity, and durability. Dr. Boudries is also exploring disease pathogenesis through epigenetics profiling, with a keen interest in decoding the epigenetics determinant of HIV integration and the latent HIV reservoir maintenance and persistence.

Education

B.Sc., Computer Science engineering, 1995. UMMTO, Algeria

M.Sc., Biology, 2007. Department of Biochemistry, University of Montreal, Montreal, Canada

Ph.D., Computational Biology and Bioinformatics, 2014. Institute for Research in Immunology and cancer, University of Montreal, Montreal, Canada

Training

02/2014 – 12/2014   Research Fellow, Vaccine and Gene Therapy Institute of Florida/Case Western Reserve University, Cleveland, Ohio

2015 – 2018 Research Fellow, Harvard Medical School, Center for Virology and Vaccine Research, BIDMC, Boston, MA

2019 – 2022, Instructor in Medicine, Harvard Medical School, Center for Virology and Vaccine Research, BIDMC, Boston, MA

Appointments

2014-2015, Research Associate, CASE Western Reserve University School of Medicine, Cleveland, Ohio

2016-2019, Staff Scientist, Harvard Medical School, Center for Virology and Vaccine Research, BIDMC, Boston, MA

2019- 2022, Instructor in Medicine, Harvard Medical School, Center for Virology and Vaccine Research, BIDMC, Boston, MA

Honors

2010 – 2011, Biochemistry Department Excellence Scholarship, University of Montreal, Quebec, Canada

2007 – 2010, Excellence Scholarship for Ph.D. student, University of Montreal, Canada

2006 – 2007, Excellence Scholarship for Master’s Student, University of Montreal, Canada

2023-2025, Diversity Inclusion and Community Partnership (DICP) Faculty Fellowship Award

Publications

• Aid M, Boero-Teyssier V, McMahan K, Dang R, Doyle M, Belabbaci N, Borducchi E, Collier AY, Mullington J, Barouch DH. Long COVID involves activation of proinflammatory and immune exhaustion pathways. Nat Immunol. 2026 Jan;27(1):61-71. doi: 10.1038/s41590-025-02353-x. Epub 2025 Dec 12. Erratum in: Nat Immunol. 2026 Jan 23. doi: 10.1038/s41590-026-02438-1. PMID: 41388153; PMCID: PMC12764429. [Article]


• Ram DR, Gopalakrishnan RM, Aid M, Kroll K, Miftahof J, Aristizabal O, Gikundiro EK, Davis C, Hefti MM, Fiock KL, Tilahun B, Umutoniwase Y, Loidolt K, Fennessey CM, Mercado NB, Harper-Alexander V, Jones R, Woolley G, Varner V, Lifton M, Bosinger SE, Barouch DH, Keele BF, Reeves RK, Tan CS. Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain. Cell Rep Med. 2026 Jan 20;7(1):102567. doi: 10.1016/j.xcrm.2025.102567 [Article]


• Andersen H, Aid M, Stone JJ, Lyons CE, Berlied A, Nkolola J, Lasrado N, Peterson M, Pessaint L, Kitajewski C, Yalley-Ogunro J, Porto M, Stone R, Cabus M, Valentin D, Van Ry A, Narvaez B, Orekov T, Kar S, Teow E, Kouneski K, Ferreira A, Velasco J, Campbell R, Henderson C, Beah W, Patel G, Finneyfrock B, Cook A, Paul S, Haasnoot J, Ramirez-Carvajal L, Koldijk MH, Arias Rivas S, Koch CM, Goudsmit J, Lewis MG, Martinot AJ, Barouch DH. Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaques. Immunity. 2025 Sep 9;58(9):2157-2165.e5. doi: 10.1016/j.immuni.2025.07.020. Epub 2025 Aug 18. PMID: 40829590. [Article]


• Blass, E., Colarusso, A., Aid, M., Larocca, R. A., Reeves, R. K., & Barouch, D. H. (2025). Early spatiotemporal evolution of the immune response elicited by adenovirus serotype 26 vector vaccination in mice. Journal of virology, 99(5), e0024725. https://doi.org/10.1128/jvi.00247-25 [Article]


• Aid M, Stephenson KE, Collier AY, Nkolola JP, Michael JV, McKenzie SE, Barouch DH. Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination. Nat Commun. 2023 Oct 23;14(1):6703. doi: 10.1038/s41467-023-42559-x. PMID: 37872311; PMCID: PMC10593859. [Article]


• Aid M, Sciacca M, McMahan K, Hope D, Liu J, Jacob-Dolan C, Powers O, Barrett J, Wu C, Mutoni A, Murdza T, Richter H, Velasco J, Teow E, Boursiquot M, Cook A, Orekov T, Hamilton M, Pessaint L, Ryan A, Hayes T, Martinot AJ, Seaman MS, Lewis MG, Andersen H, Barouch DH. Mpox infection protects against re-challenge in rhesus macaques. Cell. 2023 Oct 12;186(21):4652-4661.e13. doi: 10.1016/j.cell.2023.08.023. Epub 2023 Sep 20. PMID: 37734373; PMCID: PMC10591870. [Article]


• Vidal SJ, Sellers D, Yu J, Wakabayashi S, Sixsmith J, Aid M, Barrett J, Stevens SF, Liu X, Li W, Plumlee CR, Urdahl KB, Martinot AJ, Barouch DH. Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model. iScience. 2023 May 28;26(6):106963. doi: 10.1016/j.isci.2023.106963. PMID: 37378347; PMCID: PMC10291467. [Article]