Kathryn Stephenson

Kathryn E. Stephenson, M.D., M.P.H.

Kathryn E. Stephenson, M.D., M.P.H.

Principal Investigator and CTU Principal Investigator
Clinical Trials Unit

Assistant Professor of Medicine- Harvard Medical School; Ragon Institute of MGH, MIT, and Harvard

Director, Clinical Trials Unit, Center for Virology and Vaccine Research- Beth Israel Deaconess Medical Center

kstephen@bidmc.harvard.edu
T: 617-735-4556
F: 617-735-4566

Dr. Stephenson is a physician-scientist in the Center for Virology and Vaccine Research (CVVR) and the Division of Infectious Diseases at Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts. She is also an Assistant Professor of Medicine at Harvard Medical School. She has expertise in conducting phase 1 clinical trials testing novel immunologic interventions for HIV and emerging infectious diseases like SARS-CoV-2 and Zika virus. During the COVID-19 pandemic, she was the site Principal Investigator for the first-in-human trial of the Johnson & Johnson/Janssen Ad26.COV2.S COVID-19 vaccine, as well as for the Phase 3 efficacy trials of remdesivir, Novavax vaccine, and casirivimab and imdevimab monoclonal antibodies. She is currently the protocol co-chair of CoVPN 3006, the largest federally-funded study to test whether the Moderna COVID-19 vaccine can block SARS-CoV-2 transmission. This COVID-19 work complements her previous contributions in testing a mosaic Ad26-based HIV vaccine and broadly neutralizing antibodies for HIV prevention, treatment and remission. In addition, Dr. Stephenson is an outspoken advocate for increasing research equity for Black and Latinx populations in clinical trials, and is committed to ensuring access to promising medicines and vaccines for our most vulnerable communities.

Dr. Stephenson received her medical degree from New York University, and completed her internal medicine training at Columbia NY Presbyterian Hospital, followed by infectious diseases training at Mass General Brigham. She also obtained a Masters in Public Health from Columbia University where she focused on the ethics of clinical trials, isolation and quarantine.

Education

  • Williams College, Williamstown, MA, B.A., 1996 (Anthropology)
  • Joseph L. Mailman School of Public Health, Columbia University, New York, NY, M.P.H., 2001
  • New York University School of Medicine, New York, NY, M.D., 2005

Training

  • Residency, Columbia University Medical Center, 2005-2008 (Internal Medicine)
  • Clinical Fellowship, Massachusetts General Hospital, Brigham and Women’s Hospital, 2008-2009 (Infectious Diseases)
  • Postdoctoral Fellowship, Center for Virology and Vaccine Research, Beth Israel Deaconess Medial Center, 2009-2011 (Immunology)

Appointments

  • 1997-1999, Research Assistant/Associate, HIV/AIDS Division, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA
  • 2000, Intern, Joint United Nations Programme on HIV/AIDS (UNAIDS), Geneva, Switzerland
  • 2007, Jay I. Meltzer Fellow in Medical Ethics, Columbia University, New York
  • 2011-2016, Associate Physician, Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, MA
  • 2011-2015, Instructor in Medicine, Harvard Medical School, Boston, MA
  • 2011-2016, Consulting Staff, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
  • 2014-present, Staff Physician, Division of Infectious Diseases, BIDMC, Boston, MA
  • 2015-present, Assistant Professor of Medicine, Harvard Medical School, 2015-present
  • 2017-present, Associate Member, Ragon Institute of MGH, MIT and Harvard

Honors

  • 1994 Gargoyle Society Alumni Scholarship, Williams College
  • 1995 Ruchman Fellow, Oakley Center for Humanities and Social Sciences, Williams College
  • 1996 Benjamin B. Wainwright 1920 Prize in English, Williams College
  • 2005 Jack and Diana Nelson Award for Scholarship and Professionalism, NYU School of Medicine
  • 2008 13th Annual Joseph N. Muschel Award, Columbia University, New York-Presbyterian Hospital
  • 2011 AIDS Vaccine 2011 Conference Scholarship, Global HIV Vaccine Enterprise
  • 2012 AIDS Vaccine 2012 Conference Scholarship, Global HIV Vaccine Enterprise
  • 2013 Maxwell Finland Award for Research Excellence, Massachusetts Infectious Diseases Society
  • 2014 Center for AIDS Research Scholar Award, Harvard University
  • 2016 103.3 AMP Radio Badass Chick of the Week
  • 2016 The Omololu Falobi Award for Excellence in HIV Prevention Research Community Advocacy, Global HIV Vaccine Enterprise

Publications

  • Barouch DH, Stephenson KE, Sadoff J, Yu J, Chang A, Gebre M, McMahan K, Liu J, Chandrashekar A, Patel S, Le Gars M, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H. Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination. N Engl J Med. 2021 Jul 14:NEJMc2108829. doi: 10.1056/NEJMc2108829. Epub ahead of print. PMID: 34260834; PMCID: PMC8314733. [Article]

  • Stephenson KE, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Truyers C, Atyeo C, Loos C, Chandrashekar A, McMahan K, Tostanoski LH, Yu J, Gebre MS, Jacob-Dolan C, Li Z, Patel S, Peter L, Liu J, Borducchi EN, Nkolola JP, Souza M, Tan CS, Zash R, Julg B, Nathavitharana RR, Shapiro RL, Azim AA, Alonso CD, Jaegle K, Ansel JL, Kanjilal DG, Guiney CJ, Bradshaw C, Tyler A, Makoni T, Yanosick KE, Seaman MS, Lauffenburger DA, Alter G, Struyf F, Douoguih M, Van Hoof J, Schuitemaker H, Barouch DH. Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19. JAMA. 2021 Mar 11:e213645. doi: 10.1001/jama.2021.3645. Epub ahead of print. PMID: 33704352; PMCID: PMC7953339. [Article]

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  • Sadoff, Jerald, Georgi Shukarev, Dirk Heerwegh, Carla Truyers, Anne M. De Groot, Jeroen Stoop, Sarah Tete, Wim VanDamme, Isabel Leroux-Roels, Pieter-Jan Berghmans, Murray Kimmel, Pierre Van Damme, Jan De Hoon, William Smith, Kathryn Stephenson, Stephen De Rosa, Kristen Cohen, Juliana McElrath, Emmanuel Cormier, Gert Scheper, Dan Barouch, Jenny Hendriks, Frank Struyf, Macaya Douoguih, Johan Van Hoof, and Henneke Schuitemaker. "Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine." The New England Journal of Medicine (2021). Print. [Article]

  • Stephenson KE, Wagh K, Korber B, Barouch DH. Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention. Annu Rev Immunol. 2020;38:673‐703. doi:10.1146/annurev-immunol-080219-023629 [Article]

  • Dussupt V, Sankhala RS, Gromowski GD, et al. Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med. 2020;26(2):228‐235. doi:10.1038/s41591-019-0746-2 [Article]

  • Stephenson KE, Wegmann F, Tomaka F, et al. Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010/HPX1002) and a preclinical study in rhesus monkeys (NHP 17-22) [published online ahead of print, 2020 Feb 17] [published correction appears in Lancet HIV. 2020 Feb 28;:]. Lancet HIV. 2020;S2352-3018(20)30001-1. doi:10.1016/S2352-3018(20)30001-1 [Article]

  • Bricault CA, Yusim K, Seaman MS, Yoon H, Theiler J, Giorgi EE, Wagh K, Theiler M, Hraber P, Macke JP, Kreider EF, Learn GH, Hahn BH, Scheid JF, Kovacs JM, Shields JL, Lavine CL, Ghantous F, Rist M, Bayne MG, Neubauer GH, McMahan K, Peng H, Chéneau C, Jones JJ, Zeng J, Ochsenbauer C, Nkolola JP, Stephenson KE, Chen B, Gnanakaran S, Bonsignori M, Williams LD, Haynes BF, Doria-Rose N, Mascola JR, Montefiori DC, Barouch DH*, Korber B*. HIV-1 neutralizing antibody signatures and application to epitope-targeted vaccine design. Cell Host Microbe 2019; 25:59-72. [Article]

  • Barouch DH, Tomaka FL, Wegmann F, Stieh DJ, Alter G, Robb ML, Michael NL, Peter L, Nkolola JP, Borducchi EN, Chandrashekar A, Jetton D, Stephenson KE, Li W, Korber B, Tomaras GD, Montefiori DC, Gray G, Frahm N, McElrath MJ, Baden L, Johnson J, Hutter J, Swann E, Karita E, Kibuuka H, Mpendo J, Garrett N, Mngadi K, Chinyenze K, Priddy F, Lazarus E, Laher F, Nitayapan S, Pitisuttithum P, Bart S, Campbell T, Feldman R, Lucksinger G, Borremans C, Callewaert K, Roten R, Sadoff J, Scheppler L, Weijtens M, Feddes-de Boer K, van Manen D, Vreugdenhil J, Zahn R, Lavreys L, Nijs S, Tolboom J, Hendriks J, Euler Z, Pau MG, Schuitemaker H. Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19). Lancet. 2018 Jul 21;392(10143):232-243. doi: 10.1016/S0140-6736(18)31364-3. Epub 2018 Jul 6. PubMed PMID: 30047376; PubMed Central PMCID: PMC6192527. [Article]