The effects of somatic hypermutation on neutralizing and binding in the PGT121 family of broadly neutralizing antibodies.

Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, Simen BB, St John EP, Chan-Hui PY, Swiderek K, Kleinstein SH, Alter G, Seaman MS, Chakraborty AK, Koller D, Wilson IA, Church GM, Burton DR, Poignard P. The effects of somatic hypermutation on neutralizing and binding in the PGT121 family of broadly neutralizing antibodies. PLoS Pathog. 2013, 9(11):e1003754. [Article]