Understanding how viruses like HIV cause disease in humans is critical to better targeting new treatments and designing new vaccines. CVVR investigators explore viral pathogenesis in animal models and clinical studies to better understand how viral reservoirs are established, the kinetics of viral replication, and the impact that chronic infection has on the immune system. Together with our partners, we belong to one of the leading research consortiums in the world dedicated to groundbreaking research into HIV/SIV, Influenza, and Flavivirus virology and viral pathogenesis. The CVVR is  strongly committed to basic scientific research, and our investigators are uniquely positioned to extend this basic research directly into vaccine design.