The central role of the Bioinformatics team at CVVR is to apply state-of-the-art computational methods, and machine learning algorithms to analyze and integrate high throughput data sets to provide analytical tools and support in computational biology and bioinformatics to the broad CVVR community. We aim to accelerate genomics research and its applications in clinical practice by analyzing and integrating high throughput data sets such as bulk and single cell RNA-Seq; metabolome, proteome, cytokines and chemokines profiling, flow cytometry, and high-dimensional tissue imaging to generate and validate mechanistic hypotheses using human and animal models for HIV, SIV, TB, ZIKA, Yellow Fever, and COVID-19 studies.
About Academic Web Pages
This author has not written his bio yet.
But we are proud to say that Academic Web Pages contributed 87 entries already.
Entries by Academic Web Pages
One of the areas of research aims to understand how humoral and cellular immunity is altered during pregnancy. We study the maternal immune response to the feto-placental unit using basic science to profile immune responses at the uterus in healthy and complicated pregnancies. We also study how pregnancy physiology alters the response to pathogens and vaccines, and how to optimize neonatal immunity through transplacental transfer of antibodies from mother to fetus.
Understanding how immune cells exert functions in their native context is fundamental towards deciphering engineering better defenses against viral infections or cancer. CVVR investigators collaboratively combine their deep expertise in translational immunology, viral pathogenesis and technological breakthroughs in spatial-omics to tackle intractable questions in infectious diseases.
Key breakthroughs in biological research often results from combining engineering innovative solutions to address fundamental questions. CVVR investigators are developing creative molecular tools to re-interrogate key questions in virus-host interactions and immune responses to diseases, thus enabling new insights into targetable therapeutics.
Dr. Dan Barouch discusses the challenge of Corona virus on WGBH with Liz Neisloss. Read more
We are looking for healthy men and women ages 18-50 years old for a clinical trial of an experimental HIV vaccine given in capsule form. Note: it is impossible to get HIV infection from the study vaccine.
This study assessed two different dosages of an investigational Zika Virus vaccine in healthy adults. The study closed enrollment in September 2018. Data analysis is underway.
This study assessed different vaccine schedules using two experimental HIV vaccines in healthy HIV-negative adults. The study started in March 2016 and was completed in January 2019.
The Boston Red Sox honored Dr.Stephenson on June 7th,2019 as a Medical All-Star for her work in the HIV research field.
Center for Virology and Vaccine Research
3 Blackfan Circle
Boston, MA 02115 – USA
CVVR Clinical Trials Unit