2019 CVVR Visiting Professor
We were honored to have Dr. Robert Siliciano, MD, PhD. join us for our annual visiting professor this year.
Entries by Academic Web Pages
Z001
This study evaluated different vaccine schedules using an investigational Zika Virus vaccine in healthy adults. The study started in October 2016 and was completed in June 2018.
T001
This study assessed different dosages of a monoclonal antibody in healthy HIV-negative and healthy HIV-positive adults. The study closed enrollment in October 2018.
T002
This study evaluated different dosages of a monoclonal antibody given in healthy HIV-negative and healthy HIV-positive adults. The study closed enrollment in October 2018.
T003
This study is assessing the use of an infusion of three antibodies as an alternative treatment for people living with HIV.
Early-Phase Clinical Trials
Investigators at the Center for Virology and Vaccine Research are involved in a wide range of clinical research activities, including prospective clinical trials of novel HIV vaccine candidates, detailed immunological and virologic studies of HIV pathogenesis, and clinical trials of novel antiviral compounds in immunocompromised subjects.
Neuro-Virology/Immunology
Several researchers at CVVR focus their work on the study of viruses that cause neurologic diseases, particularly JC and BK viruses. JC virus causes a devastating neurologic disease called progressive multifocal leukoencephalopathy (PML) that can arise in people who are immunocompromised, such as people with AIDS or patients treated with monoclonal antibodies to suppress the immune system. CVVR faculty are researching new methods to diagnose and treat these neurologic disorders, as well as to better understand the basic science behind the pathology of these neuro-viruses. Additional work is done at CVVR to investigate other pathogens that affect the central nervous system, such as tuberculosis.
Viral Pathogenesis
Understanding how viruses like HIV cause disease in humans is critical to better targeting new treatments and designing new vaccines. CVVR investigators explore viral pathogenesis in animal models and clinical studies to better understand how viral reservoirs are established, the kinetics of viral replication, and the impact that chronic infection has on the immune system.
Translational Immunology
One of the core areas of research at CVVR is the investigation of the immune system, with an emphasis on using basic science to leverage new concepts in vaccine design and anti-viral therapy. Many of our graduate students and postdoctoral fellows explore the fundamental mechanisms of innate and adaptive immunity, including the interplay between CD4+ and CD8+ T cell development, the role of NK cell memory in adaptive immunity, and the evolution of antibody responses following vaccination.
