Long-term outcomes after new onset seizure in children living with HIV: A cohort study

Birbeck GLMwenechanya MUme-Ezeoke IMathews MBositis CMKalungwana L, et al. Long-term outcomes after new onset seizure in children living with HIV: A cohort studyEpilepsia Open20249750757https://doi.org/10.1002/epi4.12921


The central role of the Bioinformatics team at CVVR is to apply state-of-the-art computational methods, and machine learning algorithms to analyze and integrate high throughput data sets to provide analytical tools and support in computational biology and bioinformatics to the broad CVVR community. We aim to accelerate genomics research and its applications in clinical practice by analyzing and integrating high throughput data sets such as bulk and single cell RNA-Seq; metabolome, proteome, cytokines and chemokines profiling, flow cytometry, and high-dimensional tissue imaging to generate and validate mechanistic hypotheses using human and animal models for HIV, SIV, TB, ZIKA, Yellow Fever, and COVID-19 studies.

Reproductive Immunology and Virology

One of the areas of research aims to understand how humoral and cellular immunity is altered during pregnancy. We study the maternal immune response to the feto-placental unit using basic science to profile immune responses at the uterus in healthy and complicated pregnancies. We also study how pregnancy physiology alters the response to pathogens and vaccines, and how to optimize neonatal immunity through transplacental transfer of antibodies from mother to fetus.

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Tissue Biology

Understanding how immune cells exert functions in their native context is fundamental towards deciphering engineering better defenses against viral infections or cancer. CVVR investigators collaboratively combine their deep expertise in translational immunology, viral pathogenesis and technological breakthroughs in spatial-omics to tackle intractable questions in infectious diseases.

Medical Bioengineer Working On Development Vaccines 2019-ncov Coronavirus In Pharmacy Laboratory. Bl

Technology Development and Applications

Key breakthroughs in biological research often results from combining engineering innovative solutions to address fundamental questions. CVVR investigators are developing creative molecular tools to re-interrogate key questions in virus-host interactions and immune responses to diseases, thus enabling new insights into targetable therapeutics.

Omar Siddiqi

Omar K. Siddiqi, M.D., M.P.H.

Boris Juelg

Boris Juelg, M.D., Ph.D.

Group of hands holding red ribbon stop drugs and HIV/AIDS awareness

Early-Phase Clinical Trials

Investigators at the Center for Virology and Vaccine Research are involved in a wide range of clinical research activities, including prospective clinical trials of novel HIV vaccine candidates, detailed immunological and virologic studies of HIV pathogenesis, and clinical trials of novel antiviral compounds in immunocompromised subjects.