Zika virus research models

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Kublin JL, Whitney JB. Zika virus research models. Virus Res. 2018 Aug 2;254:15-20. doi: 10.1016/j.virusres.2017.07.025. Epub 2017 Aug 12. PMID: 28811170; PMCID: PMC5809325.

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy.

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Lim SY, Osuna CE, Hraber PT, Hesselgesser J, Gerold JM, Barnes TL, Sanisetty S, Seaman MS, Lewis MG, Geleziunas R, Miller MD, Cihlar T, Lee WA, Hill AL, Whitney JB. TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. Sci Transl Med. 2018 May 2;10(439).

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.

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Gabriela M. Webb, Shengbin Li, Gwantwa Mwakalundwa, Joy M. Folkvord, Justin M. Greene, Jason S. Reed, Jeffery J. Stanton, Alfred W. Legasse, Theodore Hobbs, Lauren D. Martin, Byung S. Park, James B. Whitney, Emily K. Jeng, Hing C. Wong, Douglas F. Nixon, R. Brad Jones, Elizabeth Connick, Pamela J. Skinner, Jonah B. Sacha; The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles. Blood Adv 2018; 2 (2): 76–84.

T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection.

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Bhattacharyya M, Whitney JB, Seaman M, Barouch DH, Penaloza-MacMaster P. T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection. Immunology 2018; 155:458-466.

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy.

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Whitney JB, Lim SY, Osuna CE, Kublin JL, Chen E, Yoon G, Liu PT, Abbink P, Borducci EN, Hill A, Lewis MG, Geleziunas R, Robb ML, Michael NL, Barouch DH. Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy. Nat. Commun. 2018; 9:5429.

Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques.

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Li H, Hai Y, Lim SY, Toledo N, Crecente-Campo J, Schalk D, Li L, Omange RW, Dacoba TG, Liu LR, Kashem MA, Wan Y, Liang B, Li Q, Rakasz E, Schultz-Darken N, Alonso MJ, Plummer FA, Whitney JB, Luo M. Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques. PLoS One. 2018 Aug 28;13(8):e0202997. doi: 10.1371/journal.pone.0202997. PMID: 30153293; PMCID: PMC6112674.

Evidence that CD32a does not mark the HIV-1 latent reservoir.

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Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB. Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature. 2018 Sep;561(7723):E20-E28. doi: 10.1038/s41586-018-0495-2. Epub 2018 Sep 19. Erratum in: Nature. 2018 Nov;563(7733):E33. PMID: 30232424; PMCID: PMC6528470.

Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies.

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Best K, Guedj J, Madelain V, de Lamballerie X, Lim SY, Osuna CE, Whitney JB, Perelson AS. Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8847-8852. doi: 10.1073/pnas.1704011114. Epub 2017 Aug 1. PMID: 28765371; PMCID: PMC5565429.

Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.

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Julg B, Liu PT, Wagh K, Fischer WM, Abbink P, Mercado NB, Whitney JB, Nkolola JP, McMahan K, Tartaglia LJ, Borducchi EN, Khatiwada S, Kamath M, LeSuer JA, Seaman MS, Schmidt SD, Mascola JR, Burton DR, Korber BT, Barouch DH. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail. Sci. Transl. Med. 2017; 9:eaao4235.

Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development.

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Osuna CE, Whitney JB. Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development. J Infect Dis. 2017 Dec 16;216(suppl_10):S928-S934. doi: 10.1093/infdis/jix540. PMID: 29267926; PMCID: PMC5853426.