Future COVID vaccines should be inhaled, suggests new study by Boston scientists

“When we gave the vaccine directly to the lung, we saw a dramatic improvement in … immunity and protection in the lung itself and in the nose, leading to near complete protection against infection,” said Dr. Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center and the senior author on the paper. Current vaccines raise antibodies in the blood, he said, but have a minimal effect in raising antibody and T-cell responses in the nose and the lungs — “where it really matters if you want to block infection.”

The results, Barouch argues, provide a powerful “proof of concept” for the idea that future boosters should be delivered using a device similar to an asthma inhaler. Read Full Article…