A new class of allosteric HIV-1 integrase inhibitors identified by crystallographic fragment screening of the catalytic core domain.

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Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A new class of allosteric HIV-1 integrase inhibitors identified by crystallographic fragment screening of the catalytic core domain. J Biol Chem 2016 Nov 4;291(45):23569-77. doi: 10.1074/jbc.M116.753384. Epub 2016 Sep 19. PubMed PMID: 27645997. PubMed Central PMCID: PMC5095411. [Article]