Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

Singh PK, Bedwell GJ, Engelman AN. Spatial and Genomic Correlates of HIV-1 Integration Site Targeting. Cells. 2022 Feb 14;11(4):655. doi: 10.3390/cells11040655. PMID: 35203306; PMCID: PMC8869898.

 

rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo

Bedwell GJ, Jang S, Li W, Singh PK, Engelman AN. rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo. Nucleic Acids Res. 2021 Jul 21;49(13):7330-7346. doi: 10.1093/nar/gkab514. PMID: 34165568; PMCID: PMC8287940.

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Jul 14;11(1):3505. doi: 10.1038/s41467-020-17256-8. Erratum in: Nat Commun. 2020 Nov 26;11(1):6165. PMID: 32665593; PMCID: PMC7360574.

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. PMID: 33060363; PMCID: PMC7831379.

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. mBio. 2020 Sep 29;11(5):e02254-20. doi: 10.1128/mBio.02254-20. PMID: 32994325; PMCID: PMC7527728.

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Nov 26;11(1):6165. doi: 10.1038/s41467-020-20152-w. Erratum for: Nat Commun. 2020 Jul 14;11(1):3505. PMID: 33244008; PMCID: PMC7692523.

A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies

Li M, Chen X, Wang H, Jurado KA, Engelman AN, Craigie R. A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies. J Mol Biol 2020 Feb 13. pii: S0022-2836(20)30106-6. doi: 10.1016/j.jmb.2020.01.040. [Epub ahead of print]. PubMed PMID: 32061936.

Structural basis of second-generation inhibitor action and viral resistance

Cook NJ, Li W, Berta D, Badaoui D, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Structural basis of second-generation inhibitor action and viral resistance. Science 2020 Feb 14;367(6479):806-10. doi: 10.1126/science.aay4919. Epub 2020 Jan 30. PubMed PMID: 32001525.

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res. 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206. PMID: 30916345; PMCID: PMC6511849.

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.

Engelman, AN. Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition. J Biol Chem 2019 Oct 11;294(41):15137-57. doi: 10.1074/jbc.REV119.006901. Epub 2019 Aug 29. PubMed PMID: 31467082; PubMed Central PMCID: PMC6791320.