Reflections on Advances in Cancer Research in 2025

Bernard E, Cortés-Ciriano I, Gaiti F, Gan S, Jiang S, Kovatcheva M, Meisel M, Reticker-Flynn NE, Schram AM, Shoshani O, Silverbush D, Venkataramani V, Weeden CE, Zhou X. Reflections on Advances in Cancer Research in 2025. Cancer Discov. 2025 Dec 2;15(12):2422-2430. doi: 10.1158/2159-8290.CD-25-1833. PMID: 41327969.

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor

Wang H, Mou Z, Yeo YY, Ge Q, Liu X, Narita Y, Li Z, Wang C, Li W, Zhao KR, Li J, Bu W, Gewurz B, Cohen JI, Teng M, Dai X, Liu X, Jiang S, Zhao B. Epstein-Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor. Nat Microbiol. 2025 Nov;10(11):2781-2796. doi: 10.1038/s41564-025-02126-0. Epub 2025 Sep 26. PMID: 41006833.

Association of Glucagon-Like Peptide-1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Lu Y, Dai H, Tang H, Donahoo WT, George TJ, Sun RC, Jiang S, Tan AC, Guo Y, Licht JD, Allen JM, Lee KP, Guo J, Bian J. Association of Glucagon-Like Peptide-1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes. Obesity (Silver Spring). 2025 Aug 21. doi: 10.1002/oby.24366.

Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma

Liu SX, Wu TW, Luo DH, Zhang LL, Zhou L, Luo YL, Du WT, Huang TT, Jiang S, Zhang Z, Han P, Zeng MS, Zhong Q. Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma. Cell Reports Medicine. 2025 Jul 15;6(7):102200. doi: 10.1016/j.xcrm.2025.102200. Epub 2025 Jun 20.

The tumor microenvironment’s role in the response to immune checkpoint blockade

Aliazis K, Christofides A, Shah R, Yeo YY, Jiang S, Charest A, Boussiotis VA. The tumor microenvironment’s role in the response to immune checkpoint blockade. Nature Cancer. 2025 Jun;6(6):924-937. doi: 10.1038/s43018-025-00986-3. Epub 2025 Jun 13.

Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease

Zhang L, Cagle C, Nguyen DH, Gomes GS, Gromova B, Csizmadia E, Karimitar A, Lee GR, Chen G, Kokkotou E, Grossberg L, Jiang S, Cheifetz AS, Kota SK, Longhi MS. Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease. Cellular Molecular Immunology. 2025 Jul;22(7):730-742. doi: 10.1038/s41423-025-01295-6. Epub 2025 May 26.

CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data

Zhu B, Gao S, Chen S, Wang Y, Yeung J, Bai Y, Huang AY, Yeo YY, Liao G, Mao S, Jiang ZG, Rodig SJ, Wong KC, Shalek AK, Nolan GP, Jiang S, Ma Z. CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data. Nature Immunology. 2025 Jun;26(6):963-974. doi: 10.1038/s41590-025-02163-1. Epub 2025 May 22.

Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development

Hahn, K., Amberg, B., Monné Rodriguez, J. M., Verslegers, M., Kang, B., Wils, H., Saravanan, C., Bangari, D. S., Long, S. Y., Youssef, S. A., Pesti, B., Schaffenrath, J., Valdeolivas, A., Kumpesa, N., Galván, J. A., Richardson, M., Giroud, N., Kunz, L., Veiga, I. B., Bscheider, M., … Jacobsen, B. (2025). Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development. Toxicologic pathology53(1), 107–129. doi: 10.1177/01926233241311258

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment

Zhu B, Bai Y, Yeo YY, Lu X, Rovira-Clavé X, Chen H, Yeung J, Nkosi D, Glickman J, Delgado-Gonzalez A, Gerber GK, Angelo M, Shalek AK, Nolan GP, Jiang S. A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment. Nat Commun. 2025 Jan 31;16(1):1230. doi: 10.1038/s41467-025-56237-7. PMID: 39890778; PMCID: PMC11785740.

Graph Fourier transform for spatial omics representation and analyses of complex organs

Chang, Y., Liu, J., Jiang, Y., Ma, A., Yeo, Y. Y., Guo, Q., McNutt, M., Krull, J. E., Rodig, S. J., Barouch, D. H., Nolan, G. P., Xu, D., Jiang, S., Li, Z., Liu, B., & Ma, Q. (2024). Graph Fourier transform for spatial omics representation and analyses of complex organs. Nature communications15(1), 7467. https://doi.org/10.1038/s41467-024-51590-5