Waning immunity and IgG4 responses following bivalent mRNA boosting

Lasrado N, Collier AY, Miller J, Hachmann NP, Liu J, Anand T, A Bondzie E, Fisher JL, Mazurek CR, Patio RC, Rodrigues SL, Rowe M, Surve N, Ty DM, Wu C, Chicz TM, Tong X, Korber B, McNamara RP, Barouch DH. Waning immunity and IgG4 responses following bivalent mRNA boosting. Sci Adv. 2024 Feb 23;10(8):eadj9945. doi: 10.1126/sciadv.adj9945. Epub 2024 Feb 23. PMID: 38394195; PMCID: PMC10889350.

mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer

Song NJ, Chakravarthy KB, Jeon H, Bolyard C, Reynolds K, Weller KP, Reisinger S, Wang Y, Li A, Jiang S, Ma Q, Barouch DH, Rubinstein MP, Shields PG, Oltz EM, Chung D, Li Z. mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer. J Immunother Cancer. 2024 Jan 4;12(1):e007922. doi: 10.1136/jitc-2023-007922. PMID: 38177076; PMCID: PMC10773442.

Prophylactic HIV-1 vaccine trials: past, present, and future

Nkolola JP, Barouch DH. Prophylactic HIV-1 vaccine trials: past, present, and future. Lancet HIV. 2023 Dec 20:S2352-3018(23)00264-3. doi: 10.1016/S2352-3018(23)00264-3. Epub ahead of print. PMID: 38141639.

Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

McMahan K, Wegmann F, Aid M, Sciacca M, Liu J, Hachmann NP, Miller J, Jacob-Dolan C, Powers O, Hope D, Wu C, Pereira J, Murdza T, Mazurek CR, Hoyt A, Boon ACM, Davis-Gardner M, Suthar MS, Martinot AJ, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Tolboom J, Serroyen J, Solforosi L, Costes LMM, Zahn RC, Barouch DH. Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques. Nature. 2023 Dec 14. doi: 10.1038/s41586-023-06951-3. Epub ahead of print. PMID: 38096903.

Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses

Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, Cui Z, Zhao D, Barouch DH, Yu J. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses. 2023 Dec 9;15(12):2401. doi: 10.3390/v15122401. PMID: 38140642; PMCID: PMC10747620.

Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86

Lasrado N, Collier AY, Hachmann NP, Miller J, Rowe M, Schonberg ED, Rodrigues SL, LaPiana A, Patio RC, Anand T, Fisher J, Mazurek CR, Guan R, Wagh K, Theiler J, Korber BT, Barouch DH. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023 Nov 13;41(47):6904-6909. doi: 10.1016/j.vaccine.2023.10.051. Epub 2023 Oct 21. PMID: 37872011.

SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds

Lasrado N, Barouch DH. SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds. J Infect Dis. 2023 Nov 11;228(10):1311-1313. doi: 10.1093/infdis/jiad353. PMID: 37592872.

Mosaic HIV-1 vaccination induces anti-viral CD8+ T cell functionality in the phase 1/2a clinical trial APPROACH

van Duijn J, Stieh D, Fernandez N, King D, Gilmour J, Tolboom J, Callewaert K, Willems W, Pau MG, De Rosa SC, McElrath MJ, Barouch DH, Hayes P. Mosaic HIV-1 vaccination induces anti-viral CD8+ T cell functionality in the phase 1/2a clinical trial APPROACH. J Virol. 2023 Oct 31;97(10):e0112623. doi: 10.1128/jvi.01126-23. Epub 2023 Oct 9. PMID: 37811993; PMCID: PMC10617392.

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir

Kumar MR, Fray EJ, Bender AM, Zitzmann C, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2313209120. doi: 10.1073/pnas.2313209120. Epub 2023 Oct 16. PMID: 37844236; PMCID: PMC10614214.

Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination

Aid M, Stephenson KE, Collier AY, Nkolola JP, Michael JV, McKenzie SE, Barouch DH. Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination. Nat Commun. 2023 Oct 23;14(1):6703. doi: 10.1038/s41467-023-42559-x. PMID: 37872311; PMCID: PMC10593859.