Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques

Tong X, Wang Q, Jung W, Chicz TM, Blanc R, Parker LJ, Barouch DH, McNamara RP. Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques. iScience. 2024 Jun 4;27(9):110174. doi: 10.1016/j.isci.2024.110174. PMID: 39224511; PMCID: PMC11367469.

Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial

Julg B, Walker-Sperling VEK, Wagh K, Aid M, Stephenson KE, Zash R, Liu J, Nkolola JP, Hoyt A, Castro M, Serebryannyy L, Yanosick K, Speidel T, Borducchi EN, Murzda T, Maxfield L, Arduino R, McDermott AB, Gama L, Giorgi EE, Koup RA, Seaman MS, Rolle CP, DeJesus E, Li W, Korber B, Barouch DH. Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial. Nat Med. 2024 Sep 12. doi: 10.1038/s41591-024-03247-5. Epub ahead of print. PMID: 39266747.

Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience

Rowe M, Collier AY, Barouch DH. Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience. Vaccine. 2024 Oct 24;42(24):126306. doi: 10.1016/j.vaccine.2024.126306. Epub 2024 Sep 5. PMID: 39241351; PMCID: PMC11401756.

Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study

Kenny A, van Duijn J, Dintwe O, Heptinstall J, Burnham R, Sawant S, Zhang L, Mielke D, Khuzwayo S, Omar FL, Stanfield-Oakley S, Keyes T, Dunn B, Goodman D, Fong Y, Benkeser D, Zou R, Hural J, Hyrien O, Juraska M, Luedtke A, van der Laan L, Giorgi EE, Magaret C, Carpp LN, Pattacini L, van de Kerkhof T, Korber B, Willems W, Fisher LH, Schuitemaker H, Swann E, Kublin JG, Pau MG, Buchbinder S, Tomaka F, Nijs S, Lavreys L, Gelderblom HC, Corey L, Mngadi K, Gray GE, Borducchi E, Hendriks J, Seaton KE, Zolla-Pazner S, Barouch DH, Ferrari G, De Rosa SC, McElrath MJ, Andersen-Nissen E, Stieh DJ, Tomaras GD, Gilbert PB; Imbokodo Study and Correlates Group. Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study. EBioMedicine. 2024 Sep 4;108:105320. doi: 10.1016/j.ebiom.2024.105320. Epub ahead of print. PMID: 39236556.

Graph Fourier transform for spatial omics representation and analyses of complex organs

Chang, Y., Liu, J., Jiang, Y., Ma, A., Yeo, Y. Y., Guo, Q., McNutt, M., Krull, J. E., Rodig, S. J., Barouch, D. H., Nolan, G. P., Xu, D., Jiang, S., Li, Z., Liu, B., & Ma, Q. (2024). Graph Fourier transform for spatial omics representation and analyses of complex organs. Nature communications15(1), 7467. https://doi.org/10.1038/s41467-024-51590-5

Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection

Martinot, A. J., Cox, F., Abbink, P., Hecht, J. L., Bronson, R., Borducchi, E. N., Rinaldi, W. J., Ferguson, M. J., De La Barrera, R. A., Zahn, R., van der Fits, L., & Barouch, D. H. (2024). Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection. NPJ vaccines9(1), 157. https://doi.org/10.1038/s41541-024-00927-8

Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles

Nelson GW, van Duijn J, Yuki Y, Pau MG, Tomaka F, Lavreys L, DeRosa SC, McElrath MJ, Kirk GD, Michael NL, Haas DW, Deeks SG, Wolinsky S, Walker B, Barouch DH, Stieh D, Carrington M.2024.Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles. J Virol98:e00281-24.https://doi.org/10.1128/jvi.00281-24

Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles

Nelson GW, van Duijn J, Yuki Y, Pau MG, Tomaka F, Lavreys L, DeRosa SC, McElrath MJ, Kirk GD, Michael NL, Haas DW, Deeks SG, Wolinsky S, Walker B, Barouch DH, Stieh D, Carrington M.2024.Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles. J Virol98:e00281-24.https://doi.org/10.1128/jvi.00281-24

Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial

Gray GE, Mngadi K, Lavreys L, Nijs S, Gilbert PB, Hural J, Hyrien O, Juraska M, Luedtke A, Mann P, McElrath MJ, Odhiambo JA, Stieh DJ, van Duijn J, Takalani AN, Willems W, Tapley A, Tomaras GD, Van Hoof J, Schuitemaker H, Swann E, Barouch DH, Kublin JG, Corey L, Pau MG, Buchbinder S, Tomaka F; Imbokodo/HVTN 705/HPX2008 Study Group. Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Infect Dis. 2024 Jul 19:S1473-3099(24)00358-X. doi: 10.1016/S1473-3099(24)00358-X. Epub ahead of print. PMID: 39038477.

Covid on The Rise Again in Dozens of States

Health authorities say Covid cases are on the rise around the nation, with 15 states reporting high levels of the virus in wastewater. While the severity of the disease is lessening overall, the elderly and immunocompromised are still at higher risk. NBC News’ Erin McLaughlin reports.