Elephant in the room: natural killer cells don’t forget HIV either

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Jost S, Reeves RK. Elephant in the room: natural killer cells don’t forget HIV either. Curr Opin HIV AIDS. 2025 Mar 1;20(2):109-116. doi: 10.1097/COH.0000000000000909. Epub 2025 Jan 17. PMID: 39773904; PMCID: PMC11802307.

Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity

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Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, Reeves RK, Wiehe KJ, Pollara J, Tomaras GD, Bradley T, Ferrari G. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity. Pathog Immun. 2025 Jan 23;10(1):49-79. doi: 10.20411/pai.v10i1.734. PMID: 39911143; PMCID: PMC11792536.

In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions

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Semmes, E. C., Nettere, D. R., Nelson, A. N., Hurst, J. H., Cain, D. W., Burt, T. D., Kurtzberg, J., Reeves, R. K., Coyne, C. B., Fouda, G. G., Pollara, J., Permar, S. R., & Walsh, K. M. (2024). In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions. The Journal of clinical investigation, 135(1), e181342. https://doi.org/10.1172/JCI181342

Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1

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Sugawara, S., Lee, E., Craemer, M. A., Pruitt, A., Balachandran, H., Gressens, S. B., Kroll, K., Manickam, C., Li, Y., Jost, S., Woolley, G., & Reeves, R. K. (2024). Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1. AIDS research and human retroviruses, 40(11), 631–636. https://doi.org/10.1089/AID.2023.0114

The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?

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Woolley, G., Kroll, K., Hoffman, K., Ward, A., Corneli, A., Mudrak, S. V., Qureshi, M. U., Okeke, N. L., Chan, C., Jones, A. D., Tomaras, G. D., & Reeves, R. K. (2024). The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?. AIDS research and human retroviruses, 40(10), 549–554. https://doi.org/10.1089/AID.2024.0050

FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions

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Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug;17(4):692-699. doi: 10.1016/j.mucimm.2024.04.003. Epub 2024 Apr 25. PMID: 38677592; PMCID: PMC11323182.

NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage

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Balachandran H, Kroll K, Terry K, Manickam C, Jones R, Woolley G, Hayes T, Martinot AJ, Sharma A, Lewis M, Jost S, Reeves RK. NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. PLoS Pathog. 2024 Aug 12;20(8):e1012439. doi: 10.1371/journal.ppat.1012439. PMID: 39133756; PMCID: PMC11341101.

NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage

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Balachandran, H., Kroll, K., Terry, K., Manickam, C., Jones, R., Woolley, G., Hayes, T., Martinot, A. J., Sharma, A., Lewis, M., Jost, S., & Reeves, R. K. (2024). NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. PLoS pathogens, 20(8), e1012439. https://doi.org/10.1371/journal.ppat.1012439

Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1

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Sugawara, S., Lee, E., Craemer, M. A., Pruitt, A., Balachandran, H., Gressens, S. B., Kroll, K., Manickam, C., Li, Y., Jost, S., Woolley, G., & Reeves, R. K. (2024). Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1. AIDS research and human retroviruses, 10.1089/AID.2023.0114. Advance online publication. https://doi.org/10.1089/AID.2023.0114

The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?

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Woolley G, Kroll K, Hoffman K, Ward A, Corneli A, Mudrak SV, Qureshi MU, Okeke NL, Chan C, Jones AD, Tomaras GD, Reeves RK. The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk? AIDS Res Hum Retroviruses. 2024 May 27. doi: 10.1089/AID.2024.0050. Epub ahead of print. PMID: 38753709.