LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juege S, Boeckx N, Engelman A, Debyser Z, De Rijck J. LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. Blood 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30. PubMed PMID: 29084744; PubMed Central PMCID: PMC5755044.

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing.

Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing. J Biol Chem 2017 Dec 1;292(48):19814-25. doi:10.1074/jbc.M117.816645. Epub 2017 Sep 28. PubMed PMID: 28972144; PubMed Central PMCID: PMC5712621.

Multiplex single-cell visualization of nucleic acids and protein during HIV infection.

Puray-Chavez M, Tedbury PR, Huber AD, Ukah OB, Yapo V, Liu D, Ji J, Wolf JJ, Engelman AN, Sarafianos SG. Multiplex single-cell visualization of nucleic acids and protein during HIV infection. Nat Commun 2017 Dec 1;8(1):1882. doi: 10.1038/s41467-017-01693-z. PubMed PMID: 29192235; PubMed Central PMCID: PMC5709414.

Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation.

Zhu Y, Wand X, Fouromand E, Jeong J, Qiao F, Sowd G, Engelman AN, Xie X, Hertel K, Shi Y. Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation. Mol Cell 2018 Jan 4;69(1):62-74.e4. doi: 10.1016/j.molcel.2017.11.031. Epub 2017 Dec 21. PubMed PMID: 29276085; PubMed Central PMCID: PMC5756121.

Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein.

Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C. Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein. J Virol 2017 April 13;91(9). pii: e02155-16. doi: 10.1128/JVI.02155-16. Print 2017 May 1. PubMed PMID: 28202766; PubMed Central PMCID: PMC5391466.

Hematopoietic stem and progenitor cells from human pluripotent stem cells.

Sugimura R, Jha DK, Han A, Soria-Valles C, Lummertz da Rocha E, Lu Y-F, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Hematopoietic stem and progenitor cells from human pluripotent stem cells. Nature 2017 May 25;545(7655):432-8. doi: 10.1038/nature22370. Epub May 17. PubMed PMID: 28514439; PubMed Central PMCID: PMC5872146.

Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.

Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P. Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Sci Adv 2017 Sep 15;3(9):e1701264. doi: 10.1126/sciadv.1701264. eCollection 2017 Sep. PubMed PMID: 28912938; PubMed Central PMCID: PMC5600524.

Capsid-dependent host factors in HIV-1 infection.

Yamashita M, Engelman AN. Capsid-dependent host factors in HIV-1 infection. Trends Microbiol 2017 Sep;25(9):741-55. doi: 10.1016/j.tim.2017.04.004. Epub 2017 May 18. PubMed PMID: 28528781; PubMed Central PMCID: PMC5562514.

A supramolecular assembly mediates lentiviral DNA integration.

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P. A supramolecular assembly mediates lentiviral DNA integration. Science 2017 Jan 6;355(6320):89-92. doi: 10.1126/science.aah7002. PubMed PMID: 28059770. PubMed Central PMCID: PMC5321526.

Structural basis for spumavirus GAG tethering to chromatin.

Lesbats P, Serrao E, Maskell DP, Pye VE, O’Reilly N, Lindemann D, Engelman AN, Cherepanov P. Structural basis for spumavirus GAG tethering to chromatin. Proc Natl Acad Sci U S A 2017 May 23;114(21):5509-14. doi: 10.1073/pnas.1621159114. Epub May10. PubMed PMID: 28490494; PubMed Central PMCID: PMC5448199.