Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.

Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P. Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Sci Adv 2017 Sep 15;3(9):e1701264. doi: 10.1126/sciadv.1701264. eCollection 2017 Sep. PubMed PMID: 28912938; PubMed Central PMCID: PMC5600524.

Capsid-dependent host factors in HIV-1 infection.

Yamashita M, Engelman AN. Capsid-dependent host factors in HIV-1 infection. Trends Microbiol 2017 Sep;25(9):741-55. doi: 10.1016/j.tim.2017.04.004. Epub 2017 May 18. PubMed PMID: 28528781; PubMed Central PMCID: PMC5562514.

A supramolecular assembly mediates lentiviral DNA integration.

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P. A supramolecular assembly mediates lentiviral DNA integration. Science 2017 Jan 6;355(6320):89-92. doi: 10.1126/science.aah7002. PubMed PMID: 28059770. PubMed Central PMCID: PMC5321526.

Structural basis for spumavirus GAG tethering to chromatin.

Lesbats P, Serrao E, Maskell DP, Pye VE, O’Reilly N, Lindemann D, Engelman AN, Cherepanov P. Structural basis for spumavirus GAG tethering to chromatin. Proc Natl Acad Sci U S A 2017 May 23;114(21):5509-14. doi: 10.1073/pnas.1621159114. Epub May10. PubMed PMID: 28490494; PubMed Central PMCID: PMC5448199.

Retroviral integrase protein and intasome nucleoprotein complex structures.

Grawenhoff J, Engelman AN. Retroviral integrase protein and intasome nucleoprotein complex structures. World J Biol Chem 2017 Feb 26;8(1):32-44. doi: http://dx.doi.org/10.4331/wjbc.v8.i1.32. PubMed PMID: 28289517; PubMed Central PMCID: PMC5329712.

Retroviral intasomes arising.

Engelman AN, Cherepanov P. Retroviral intasomes arising. Curr Opin Struct Biol 2017 Dec 27;47:23-29. doi: 10.1016/j.sbi.2017.04.005. Epub 2017 Apr 28. PubMed PMID: 28458055; PubMed Central PMCID: PMC5660667.

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN. Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature 2016 Feb 18;530(7590):358-61. doi: 10.1038/nature16955. PubMed PMID: 26887496; PubMed Central PMCID: PMC4908968.

Engineered murine HSCs reconstitute multi-lineage hematopoiesis and adaptive immunity.

Lu Y-F, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ. Engineered murine HSCs reconstitute multi-lineage hematopoiesis and adaptive immunity. Cell Rep 2016 Dec 20;17(12):3178-92. doi: 10.1016/j.celrep.2016.11.077. PubMed PMID: 28009288. PubMed Central PMCID: PMC5247798.

Establishment and reversal of HIV-1 latency in naïve and central memory CD4+ T cells in vitro.

Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N. Establishment and reversal of HIV-1 latency in naïve and central memory CD4+ T cells in vitro. J Virol 2016 Aug 26;90(18):8059-73. doi: 10.1128/JVI.00553-16. Print 2016 Sep 15. PubMed PMID: 27356901; PubMed Central PMCID: PMC5008097.

Interactions of prototype foamy virus capsids with host polo-like kinases are important for efficient viral DNA integration.

Zurnic I, Hütter S, Rzeha U, Helbig R, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D. Interactions of prototype foamy virus capsids with host polo-like kinases are important for efficient viral DNA integration. PLoS Pathog 2016 Aug 31;12(8):e1005860. doi: 10.1371/journal.ppat.1005860. eCollection 2016 Aug. PubMed PMID: 27579920; PubMed Central PMCID: PMC5006980. Erratum in: PLoS Pathog. 2016 Oct 10;12(10 ):e1005956. doi: 10.1371/journal.ppat.1005956. PubMed PMID: 27723818; PubMed Central PMCID: PMC5056747.