Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein.

/in

Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C. Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein. J Virol 2017 April 13;91(9). pii: e02155-16. doi: 10.1128/JVI.02155-16. Print 2017 May 1. PubMed PMID: 28202766; PubMed Central PMCID: PMC5391466.

Hematopoietic stem and progenitor cells from human pluripotent stem cells.

/in

Sugimura R, Jha DK, Han A, Soria-Valles C, Lummertz da Rocha E, Lu Y-F, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Hematopoietic stem and progenitor cells from human pluripotent stem cells. Nature 2017 May 25;545(7655):432-8. doi: 10.1038/nature22370. Epub May 17. PubMed PMID: 28514439; PubMed Central PMCID: PMC5872146.

Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.

/in

Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P. Cryo-EM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Sci Adv 2017 Sep 15;3(9):e1701264. doi: 10.1126/sciadv.1701264. eCollection 2017 Sep. PubMed PMID: 28912938; PubMed Central PMCID: PMC5600524.

Capsid-dependent host factors in HIV-1 infection.

/in

Yamashita M, Engelman AN. Capsid-dependent host factors in HIV-1 infection. Trends Microbiol 2017 Sep;25(9):741-55. doi: 10.1016/j.tim.2017.04.004. Epub 2017 May 18. PubMed PMID: 28528781; PubMed Central PMCID: PMC5562514.

A supramolecular assembly mediates lentiviral DNA integration.

/in

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P. A supramolecular assembly mediates lentiviral DNA integration. Science 2017 Jan 6;355(6320):89-92. doi: 10.1126/science.aah7002. PubMed PMID: 28059770. PubMed Central PMCID: PMC5321526.

Structural basis for spumavirus GAG tethering to chromatin.

/in

Lesbats P, Serrao E, Maskell DP, Pye VE, O’Reilly N, Lindemann D, Engelman AN, Cherepanov P. Structural basis for spumavirus GAG tethering to chromatin. Proc Natl Acad Sci U S A 2017 May 23;114(21):5509-14. doi: 10.1073/pnas.1621159114. Epub May10. PubMed PMID: 28490494; PubMed Central PMCID: PMC5448199.

Retroviral integrase protein and intasome nucleoprotein complex structures.

/in

Grawenhoff J, Engelman AN. Retroviral integrase protein and intasome nucleoprotein complex structures. World J Biol Chem 2017 Feb 26;8(1):32-44. doi: http://dx.doi.org/10.4331/wjbc.v8.i1.32. PubMed PMID: 28289517; PubMed Central PMCID: PMC5329712.

Retroviral intasomes arising.

/in

Engelman AN, Cherepanov P. Retroviral intasomes arising. Curr Opin Struct Biol 2017 Dec 27;47:23-29. doi: 10.1016/j.sbi.2017.04.005. Epub 2017 Apr 28. PubMed PMID: 28458055; PubMed Central PMCID: PMC5660667.

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

/in

Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN. Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature 2016 Feb 18;530(7590):358-61. doi: 10.1038/nature16955. PubMed PMID: 26887496; PubMed Central PMCID: PMC4908968.

Engineered murine HSCs reconstitute multi-lineage hematopoiesis and adaptive immunity.

/in

Lu Y-F, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ. Engineered murine HSCs reconstitute multi-lineage hematopoiesis and adaptive immunity. Cell Rep 2016 Dec 20;17(12):3178-92. doi: 10.1016/j.celrep.2016.11.077. PubMed PMID: 28009288. PubMed Central PMCID: PMC5247798.