Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.

Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SFJ, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem 2012 May 11;287(20):16801-11. doi: 10.1074/jbc.M112.354373. Epub 2012 Mar 21. PubMed PMID: 22437836; PubMed Central PMCID: PMC3351293.

Retroviral integrase proteins and HIV-1 DNA integration

Krishnan L, Engelman A. Retroviral integrase proteins and HIV-1 DNA integration. J Biol Chem 2012 Nov 30;287(49):40858-66. doi: 10.1074/jbc.R112.397760. Epub 2012 Oct 5. PubMed PMID: 23043109; PubMed Central PMCID: PMC3510789.

The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.

Shah V, Shi J, Hout D, Oztop I, Krishnan L, Ahn J, Shotwell M, Engelman A, Aiken C. The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J Virol 2013 Jan;87(1):422-32. doi: 10.1128/JVI.07177-11. Epub 2012 Oct 24. PubMed PMID: 23097435; PubMed Central PMCID: PMC3536424.

The structural biology of HIV-1: mechanistic and therapeutic insights.

Engelman A, Cherepanov P. The structural biology of HIV-1: mechanistic and therapeutic insights. Nat Rev Microbiol 2012 Mar 16;10(4):279-90. doi: 10.1038/nrmicro2747. PubMed PMID: 22421880; PubMed Central PMCID: PMC3588166.