Allosteric integrase potency is determined through the inhibition of HIV-1 particle maturation.

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Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A 2013 May 21;110(21):8690-5. doi: 10.1073/pnas.1300703110. Epub 2013 Apr 22. PubMed PMID: 23610442; PubMed Central PMCID: PMC3666754.

Biochemical characterization of novel retroviral integrase proteins.

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Ballandras-Colas A, Naraharisetty H, Li X, Serrao E, Engelman A. Biochemical characterization of novel retroviral integrase proteins. PLoS One 2013 Oct 4;8(10):e76638. doi: 10.1371/journal.pone.0076638. eCollection 2013. PubMed PMID: 24124581; PubMed Central PMCID: PMC3790719.

Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.

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Jurado KA, Engelman A. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors. Expert Rev Mol Med 2013 Nov 26;15:e14. doi: 10.1017/erm.2013.15. PubMed PMID: 24274067; PubMed Central PMCID: PMC3919682.

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.

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Matreyek KA, Yücel SS, Li X, Engelman A. Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog 2013;9(10):e1003693. doi: 10.1371/journal.ppat.1003693. Epub 2013 Oct 10. PubMed PMID: 24130490; PubMed Central PMCID: PMC3795039.

Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.

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Koh Y, Ballana E, Este J, Engelman A. Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo. AIDS 2013 Feb 20;27(4):655-7. doi: 10.1097/QAD.0b013e32835af34c. PubMed PMID: 23364444; PubMed Central PMCID: PMC3856184.

The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

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Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai, Larue RC, Patel PA, Mitsuya M, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem 2013 May 31;288(22:15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. PubMed PMID: 23615903; PubMed Central PMCID: PMC3668738.

Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes.

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Matreyek KA, Engelman A. Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes. Viruses 2013 Oct 7;5(10):2483-511. doi: 10.3390/v5102483. PubMed PMID: 24103892; PubMed Central PMCID: PMC3814599.

Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.

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Li X, Koh Y, Engelman A. Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus. J Virol 2012 Apr;86(7):3861-79. doi: 10.1128/JVI.06386-11. Epub 2012 Jan 25. PubMed PMID: 22278243; PubMed Central PMCID: PMC3302524.

Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration.

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Koh Y, Wu X, Ferris AL, Matreyek KA, Smith SJ, Lee K, KewalRamani VN, Hughes SH, Engelman A. Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration. J Virol 2013 Jan;87(1):648-58. doi: 10.1128/JVI.01148-12. Epub 2012 Oct 24. PubMed PMID: 23097450; PubMed Central PMCID: PMC3536403.

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.

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Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res 2012 Dec;40(22):11518-30. doi: 10.1093/nar/gks913. Epub 2012 Oct 5. PubMed PMID: 23042676; PubMed Central PMCID: PMC3526291.