Engineered hyperactive integrase for concerted HIV-1 DNA integration.

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Li M, Jurado KA, Lin S, Engelman A, Craigie R. Engineered hyperactive integrase for concerted HIV-1 DNA integration. PLoS One 2014 Aug 13;9(8):e105078. doi: 10.1371/journal.pone.0105078. eCollection 2014. PubMed PMID: 25119883; PubMed Central PMCID: PMC4132020.

Host and viral determinants for MxB restriction of HIV-1 infection.

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Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman A. Host and viral determinants for MxB restriction of HIV-1 infection. Retrovirology 2014 Oct 25;11:90. doi: 10.1186/s12977-014-0090-z. PubMed PMID: 25348155; PubMed Central PMCID: PMC4213484.

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: Implications for the mechanism of target DNA binding.

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Serrao E, Krishnan L, Shun MC, Li X, Cherepanov P, Engelman A, Maertens GN. Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: Implications for the mechanism of target DNA binding. Nucleic Acids Res 2014 Apr;42(8):5164-76. doi: 10.1093/nar/gku136. Epub 2014 Feb 11. PubMed PMID: 24520116; PubMed Central PMCID: PMC4005685.

Molecular mechanisms of retroviral integration site selection.

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Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res 2014;42(16):10209-25. doi: 10.1093/nar/gku769. Epub 2014 Aug 21. PubMed PMID: 25147212; PubMed Central PMCID: PMC4176367.

Retroviral Integrase Structure and DNA Recombination Mechanism

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Engelman A, Cherepanov P. Spectrum 2014 Dec;2(6):1-22. doi: 10.1128/microbiolspec.MDNA3-0024-2014. PubMed PMID: 25705574; PubMed Central PMCID: PMC4334468.

Structural basis for nuclear import of splicing factors by human Transportin 3.

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Maertens GN, Cook N, Wang W, Hare S, Gupta SS, Oztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov P. Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A 2014 Feb 18;111(7):2728-33. doi: 10.1073/pnas.1320755111. Epub 2014 Jan 21. PubMed PMID: 24449914; PubMed Central PMCID: PMC3932936.

Structural insight into HIV-1 restriction by MxB.

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Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y. Structural insight into HIV-1 restriction by MxB. Cell Host Microbe 2014 Nov 12;16(5):627-38. doi: 10.1016/j.chom.2014.09.021. Epub 2014 Oct 9. PubMed PMID: 25312384; PubMed Central PMCID: PMC4252739.

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.

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Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. PubMed PMID: 25421939; PubMed Central PMCID: PMC4251946.

Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses.

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Wang H, Shun MC, Li X, Di Nunzio F, Hare S, Cherepanov P, Engelman A. Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses. Mol Ther Methods Clin Dev 2014 Jan 8;1:2. doi: 10.1038/mtm.2013.2. PubMed PMID: 25383358; PubMed Central PMCID: PMC4222252.

Allosteric inhibition of HIV-1 integrase activity.

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Engelman A, Kessl JJ, Kvaratskhelia M. Allosteric inhibition of HIV-1 integrase activity. Curr Opin Chem Biol 2013 Jun;17(3):339-45. doi: 10.1016/j.cbpa.2013.04.010. Epub 2013 May 3. PubMed PMID: 23647983; PubMed Central PMCID: PMC3679204.