Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection

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Huot N, Planchais C, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Rosenbaum P, Rey F, Reeves RK, Grand RL, Mouquet H, Müller-Trutwin M. Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection. Nat Immunol 24, 2068–2079 (2023). https://doi.org/10.1038/s41590-023-01661-4

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells

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Huot N, Planchais C, Rosenbaum P, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Beaumont E, Orta-Resendiz A, Rey FA, Reeves RK, Le Grand R, Mouquet H, Müller-Trutwin M. SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells. Nat Immunol. 2023 Dec;24(12):2068-2079. doi: 10.1038/s41590-023-01661-4. Epub 2023 Nov 2. PMID: 37919524; PMCID: PMC10681903.

Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events

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Woolley G, Mosher M, Kroll K, Jones R, Hueber B, Sugawara S, Manickam C, Terry K, Varner V, Lifton M, Ram D, Fennessey CM, Keele BF, Reeves RK. Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events. J Virol. 2023 Jan 31;97(1):e0151922. doi: 10.1128/jvi.01519-22. Epub 2022 Dec 13. PMID: 36511699; PMCID: PMC9888193

Physiological and pathological influences

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Rascle P, Woolley G, Jost S, Manickam C, Reeves RK. NK cell education: Physiological and pathological influences. Front Immunol. 2023 Jan 20;14:1087155. doi: 10.3389/fimmu.2023.1087155. PMID: 36742337; PMCID: PMC9896005.

Protocol for identification and computational analysis of human natural killer cells using flow cytometry and R. STAR Protoc

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Kroll K, Reeves RK. Protocol for identification and computational analysis of human natural killer cells using flow cytometry and R. STAR Protoc. 2023 Jan 19;4(1):102044. doi: 10.1016/j.xpro.2023.102044. Epub ahead of print. PMID: 36853664; PMCID: PMC9871333.

A genetically engineered, stem-cell-derived cellular vaccine

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Cooper, A., Sidaway, A., Chandrashekar, A., Latta, E., Chakraborty, K., Yu, J., McMahan, K., Giffin, V., Manickam, C., Kroll, K., Mosher, M., Reeves, R. K., Gam, R., Arthofer, E., Choudhry, M., Henley, T., & Barouch, D. H. (2022). A genetically engineered, stem-cell-derived cellular vaccine. Cell reports. Medicine, 3(12), 100843. https://doi.org/10.1016/j.xcrm.2022.100843

 

A genetically engineered, stem-cell-derived cellular vaccine

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Cooper A, Sidaway A, Chandrashekar A, Latta E, Chakraborty K, Yu J, McMahan K, Giffin V, Manickam C, Kroll K, Mosher M, Reeves RK, Gam R, Arthofer E, Choudhry M, Henley T, Barouch DH. A genetically engineered, stem-cell-derived cellular vaccine. Cell Rep Med. 2022 Dec 20;3(12):100843. doi: 10.1016/j.xcrm.2022.100843. Epub 2022 Dec 7. PMID: 36480934; PMCID: PMC9727836.

Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection

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Gopalakrishnan RM, Aid M, Mercado NB, Davis C, Malik S, Geiger E, Varner V, Jones R, Bosinger SE, Piedra-Mora C, Martinot AJ, Barouch DH, Reeves RK, Tan CS. Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection. JCI Insight. 2021 Oct 22;6(20):e152013. doi: 10.1172/jci.insight.152013. PMID: 34676832; PMCID: PMC8564899.

Mucosal-homing natural killer cells are associated with aging in persons living with HIV

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Kroll KW, Shah SV, Lucar OA, Premeaux TA, Shikuma CM, Corley MJ, Mosher M, Woolley G, Bowler S, Ndhlovu LC, Reeves RK. Mucosal-homing natural killer cells are associated with aging in persons living with HIV. Cell Rep Med. 2022 Oct 18;3(10):100773. doi: 10.1016/j.xcrm.2022.100773. Epub 2022 Oct 7. PMID: 36208628; PMCID: PMC9589002.

The functional diversity of tissue-resident natural killer cells against infection

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Le T, Reeves RK, McKinnon LR. The functional diversity of tissue-resident natural killer cells against infection. Immunology. 2022 Sep;167(1):28-39. doi: 10.1111/imm.13523. Epub 2022 Jul 12. PMID: 35751452.