Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection.

Manickam, C., Rajakumar, P., Wachtman, Kramer, J.A., Martinot, A.J., Varner, V., Giavedoni, L.D., and Reeves, R.K. 2016. Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection. J. Virol. 90(20):9153-62. PMID: 27489267. PMCID: PMC5044824

Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.

Hensley-McBain, T., Zevin, A., Langevin, S., Manuzak, J. A., Gile, J., Miller, C., Agricola, B., Reeves, R.K., Katze, M., Kraft, C.S., and Klatt, N.R. 2016. Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques. J. Virol. 90(10):4981-4989. PMID: 26937040. PMCID: PMC4859719

Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.

Manuzak, J. A., Hensley-McBain, T., Zevin, A., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Brenchley, J.M., Estes, J.D., Langevin, S., Reeves, R.K., Haddad, E.K., and Klatt, N.R. 2016. Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function. J. Immunol. 196(5):2401-2409. PMID: 26826246. PMCID: PMC4761491

Persistent Low-Level Replication of SIV∆nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.

Adnan, S. **, Reeves, R.K.**, Gillis, J., Wong, F.E., Yu, Y., Li, Q., Connole, M., Piatak, M., Lifson, J.D., Li, W., Keele, B.F., Kozlowski, P.A., Desrosiers, R. C., Haase, A.T., Johnson, R.P. 2016. Persistent Low-Level Replication of SIV∆nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection. PLoS Path. 12(12):e1006104. PMID: 27959961. PMCID: PMC5189958. **Co-First Authorship

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated with Liver Damage.

Evans, T.I., Li, H., Schafer, J.L., Klatt, N.R., Estes, J.D., Brenchley, J.M., and Reeves, R.K. 2016. SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated with Liver Damage. J. Infect. Dis. 213(3):361-369. PMID: 26238685. PMCID: PMC4704667

Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-infected Lymph Nodes Associated with in Situ Differentiation and Functional Anergy.

Schafer, J. L., Li, H., Evans, T. I., Estes, J. D., and Reeves, R. K. 2015. Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-infected Lymph Nodes Associated with in Situ Differentiation and Functional Anergy. J. Virol. 89(13):6887-6894. PMID: 25903330. PMCID: PMC4468491

Antigen-specific NK cell memory in rhesus macaques.

Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, Von Andrian UH, Barouch DH. Antigen-specific NK cell memory in rhesus macaques. Nat. Immunol. 2015; 16:927-932.

Bone marrow-imprinted gut-homing of plasmacytoid dendritic cells (pDCs) in acute simian immunodeficiency virus infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae.

Li, H., Evans, T. I., Gillis, J., Connole, M., and Reeves, R. K. 2015. Bone marrow-imprinted gut-homing of plasmacytoid dendritic cells (pDCs) in acute simian immunodeficiency virus infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae. J. Infect. Dis. 211(11):1717-1725. PMID: 25489000.

CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVDnef-induced protection.

Adnan, S., Colantonio, A. D., Yu, Y., Gillis, J., Wong, F. E., Becker, E. A., Piatak, M., Reeves, R. K., Lifson, J. D., O’Connor, S. L., and R. P. Johnson. 2015. CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVDnef-induced protection. PLoS Path. 11(2):e1004633. PMID: 25688559. PMCID: PMC4334552

Characterization of CD8+ T cell differentiation following SIVDnef vaccination by transcription factor expression profiling.

Billingsley, J. M., Rajakumar, P. A., Connole, M. A., Salisch, N. C., Kuzmichev, Y. V., Hong, H. S., Reeves, R. K., Kang, H.-J, Li, W., Haase, A. T., and Johnson, R. P. 2015. Characterization of CD8+ T cell differentiation following SIVDnef vaccination by transcription factor expression profiling. PLoS Pathog. 11(3):e1004740. PMID: 25768938. PMCID: PMC4358830