A Mouse Model for HCV Infection: Are We There Yet?

/in

Manickam, C. and Reeves, R. K. 2017. A Mouse Model for HCV Infection: Are We There Yet? Annals of Infection. 8:5 doi: 10.21037/aoi.2017.11.01. PMID: 30123888. PMCID: PMC6095674

Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection.

/in

Manickam, C., Rajakumar, P., Wachtman, Kramer, J.A., Martinot, A.J., Varner, V., Giavedoni, L.D., and Reeves, R.K. 2016. Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection. J. Virol. 90(20):9153-62. PMID: 27489267. PMCID: PMC5044824

Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.

/in

Hensley-McBain, T., Zevin, A., Langevin, S., Manuzak, J. A., Gile, J., Miller, C., Agricola, B., Reeves, R.K., Katze, M., Kraft, C.S., and Klatt, N.R. 2016. Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques. J. Virol. 90(10):4981-4989. PMID: 26937040. PMCID: PMC4859719

Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.

/in

Manuzak, J. A., Hensley-McBain, T., Zevin, A., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Brenchley, J.M., Estes, J.D., Langevin, S., Reeves, R.K., Haddad, E.K., and Klatt, N.R. 2016. Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function. J. Immunol. 196(5):2401-2409. PMID: 26826246. PMCID: PMC4761491

Persistent Low-Level Replication of SIV∆nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.

/in

Adnan, S. **, Reeves, R.K.**, Gillis, J., Wong, F.E., Yu, Y., Li, Q., Connole, M., Piatak, M., Lifson, J.D., Li, W., Keele, B.F., Kozlowski, P.A., Desrosiers, R. C., Haase, A.T., Johnson, R.P. 2016. Persistent Low-Level Replication of SIV∆nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection. PLoS Path. 12(12):e1006104. PMID: 27959961. PMCID: PMC5189958. **Co-First Authorship

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated with Liver Damage.

/in

Evans, T.I., Li, H., Schafer, J.L., Klatt, N.R., Estes, J.D., Brenchley, J.M., and Reeves, R.K. 2016. SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated with Liver Damage. J. Infect. Dis. 213(3):361-369. PMID: 26238685. PMCID: PMC4704667

Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-infected Lymph Nodes Associated with in Situ Differentiation and Functional Anergy.

/in

Schafer, J. L., Li, H., Evans, T. I., Estes, J. D., and Reeves, R. K. 2015. Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-infected Lymph Nodes Associated with in Situ Differentiation and Functional Anergy. J. Virol. 89(13):6887-6894. PMID: 25903330. PMCID: PMC4468491

Antigen-specific NK cell memory in rhesus macaques.

/in , ,

Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, Von Andrian UH, Barouch DH. Antigen-specific NK cell memory in rhesus macaques. Nat. Immunol. 2015; 16:927-932.

Bone marrow-imprinted gut-homing of plasmacytoid dendritic cells (pDCs) in acute simian immunodeficiency virus infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae.

/in

Li, H., Evans, T. I., Gillis, J., Connole, M., and Reeves, R. K. 2015. Bone marrow-imprinted gut-homing of plasmacytoid dendritic cells (pDCs) in acute simian immunodeficiency virus infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae. J. Infect. Dis. 211(11):1717-1725. PMID: 25489000.

CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVDnef-induced protection.

/in

Adnan, S., Colantonio, A. D., Yu, Y., Gillis, J., Wong, F. E., Becker, E. A., Piatak, M., Reeves, R. K., Lifson, J. D., O’Connor, S. L., and R. P. Johnson. 2015. CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVDnef-induced protection. PLoS Path. 11(2):e1004633. PMID: 25688559. PMCID: PMC4334552