Stephenson – Page 5 – Center for Virology and Vaccine Research (CVVR)

New concepts in HIV-1 vaccine development.

2016-05-01/in Stephenson

Stephenson KE, D’Couto HT, Barouch DH. New concepts in HIV-1 vaccine development. Curr Opin Immunol. 2016 Aug;41:39-46. doi: 10.1016/j.coi.2016.05.011. Epub 2016 Jun 3. Review. PubMed PMID: 27268856; PubMed Central PMCID: PMC4992607.

Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys.

2016-05-01/in Barouch, Stephenson

Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng’ang’a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science 2016; 353:1129-1132.

Attenuation of replication-competent adenovirus serotype 26 vaccines by vectorization.

2015-05-01/in Barouch, Stephenson

Maxfield LF, Abbink P, Stephenson KE, Borducchi EN, Ng’ang’a D, Kirilova MM, Paulino N, Boyd M, Shabram P, Ruan Q, Patel M, Barouch DH. Attenuation of replication-competent adenovirus serotype 26 vaccines by vectorization. Clin. Vaccine Immunol. 2015; 22:1166-1175.

Quantification of the epitope diversity of HIV-1-specific binding antibodies by peptide microarrays for global HIV-1 vaccine development.

2015-05-01/in Barouch, Stephenson

Stephenson KE, Neubauer GH, Reimer U, Pawlowski N, Knaute T, Zerweck J, Korber BT, Barouch DH. Quantification of the epitope diversity of HIV-1-specific binding antibodies by peptide microarrays for global HIV-1 vaccine development. J. Immunol. Methods 2015; 416:105-123.

Common features of mucosal and peripheral antibody responses elicited by candidate HIV-1 vaccines in rhesus monkeys.

2014-05-01/in Barouch, Seaman, Stephenson

Li H, Stephenson KE, Kang ZH, Lavine CL, Seaman MS, Barouch DH. Common features of mucosal and peripheral antibody responses elicited by candidate HIV-1 vaccines in rhesus monkeys. J. Virol. 2014; 88:13510-13515.

A global approach to HIV-1 vaccine development.

2013-05-01/in Stephenson

Stephenson KE, Barouch DH. A global approach to HIV-1 vaccine development. Immunol Rev. 2013 Jul;254(1):295-304. doi: 10.1111/imr.12073. Review. PubMed PMID: 23772627; PubMed Central PMCID: PMC3693768.

Protective efficacy of a global HIV-1 mosaic vaccine against acquisition of heterologous SHIV challenges in rhesus monkeys.

2013-05-01/in Barouch, Seaman, Stephenson

Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, Liu J, Abbink P, Maxfield LF, Seaman MS, Dugast AS, Alter G, Ferguson M, Li W, Earl PL, Moss B, Giorgi EE, Szinger JJ, Eller LA, Billings EA, Rao M, Tovanabutra S, Sanders-Buell E, Weijtens M, Pau MG, Schuitemaker H, Robb ML, Kim JH, Korber BT, Michael NL. Protective efficacy of a global HIV-1 mosaic vaccine against acquisition of heterologous SHIV challenges in rhesus monkeys. Cell 2013; 155:531-539.

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.

2013-05-01/in Barouch, Seaman, Stephenson, Whitney

Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 2013; 503:224-228.

Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys.

2012-05-01/in Barouch, Stephenson

Stephenson KE, SanMiguel A, Simmons NL, Smith K, Lewis MG, Szinger JJ, Korber B, Barouch DH. Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys. J. Virol. 2012; 86:11434-11440.

Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeys.