Entries by Academic Web Pages

Studying Zika

By:  Matthew Disler
Harvard Magazine, May 8th, 2017

To understand the outbreak of a disease like Zika, and ultimately to fight it, researchers must work on multiple levels. There are questions of molecules and chemical processes: how does the virus infect a cell, and what components provoke an immune response that can be harnessed for treatments and vaccines? On a larger scale, there are questions about populations. How does a pathogen discovered in Uganda spread from French Polynesia to Brazil and the Caribbean? How do families and individuals cope with infants born with complications from the disease, like microcephaly (an abnormally small head size) and neurological damage, whose lasting effects still have not been fully determined? Harvard researchers have already made strides at all of these levels, and, as North America prepares for another outbreak this summer, now seek to answer further questions.

New therapeutic vaccine approach holds promise for HIV remission

A new study has demonstrated that combining an experimental vaccine with an innate immune stimulant may help lead to viral remission in people living with HIV. In animal trials, the combination decreased levels of viral DNA in peripheral blood and lymph nodes, and improved viral suppression and delayed viral rebound following discontinuation of anti-retroviral therapy (ART).

‘Striking’ Results from Early Zika Vaccine Trial

by Linda Carroll and Samuel Sarmiento, MD
NBC Health, August 4th, 2016

The race to develop a safe and effective vaccine against the Zika virus got one step closer Thursday, when a team of researchers reported positive results in the latest round of testing in monkeys.