Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.

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Manuzak, J. A., Hensley-McBain, T., Zevin, A., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Brenchley, J.M., Estes, J.D., Langevin, S., Reeves, R.K., Haddad, E.K., and Klatt, N.R. 2016. Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function. J. Immunol. 196(5):2401-2409. PMID: 26826246. PMCID: PMC4761491

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection.

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The cleavage and polyadenylation specific factor 6 (CPSF6) subunit of the capsid-recruited pre-messenger RNA cleavage factor I (CFIm) complex mediates HIV-1 integration into genes.

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Rasheedi S, Shun M-C, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski J. The cleavage and polyadenylation specific factor 6 (CPSF6) subunit of the capsid-recruited pre-messenger RNA cleavage factor I (CFIm) complex mediates HIV-1 integration into genes. J Biol Chem 2016 May 27;291(22):11809-19. doi: 10.1074/jbc.M116.721647. Epub 2016 Mar 18. PubMed PMID: 26994143; PubMed Central PMCID: PMC4882448.

Anti-HIV-1 Antibody 3BNC117 Suppresses Rebound in Humans During Treatment Interruption.

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Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lorenzi JCC, Feldmann A, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen Y, Hadrigan S, Settler A, Witmer-Pack M, West, Jr AP, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Klein F, Schlesinger SJ, Walker B, Hahn BH, Nussenzweig MC, Caskey M. Anti-HIV-1 Antibody 3BNC117 Suppresses Rebound in Humans During Treatment Interruption. Nature. 2016, 535(7613): 556-60.

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.

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Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM. Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. 2016. Proc. Natl. Acad. Sci. USA. 113(24):E3413-3422.

Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.

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Lorenzi JC, Cohen YZ, Cohn LB, Kreider EF, Barton JP, Learn GH, Oliveira T, Lavine CL, Horwitz JA, Settler A, Jankovic M, Seaman MS, Chakraborty AK, Hahn BH, Caskey M, Nussenzweig MC. Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7908-E7916.

The competitive interplay between allosteric HIV-1 integrase inhibitor BI/D and LEDGF/p75 during the early stage of HIV-1 replication adversely affects inhibitor potency.

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Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The competitive interplay between allosteric HIV-1 integrase inhibitor BI/D and LEDGF/p75 during the early stage of HIV-1 replication adversely affects inhibitor potency. ACS Chem Biol 2016 Mar 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2. PubMed PMID: 26910179; PubMed Central PMCID: PMC4874862.

Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.

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Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski J. Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J Virol. 2016 May 15; 90(10):5031-46.

Establishment and reversal of HIV-1 latency in naïve and central memory CD4+ T cells in vitro.

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Persistent Low-Level Replication of SIV∆nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.

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Adnan, S. **, Reeves, R.K.**, Gillis, J., Wong, F.E., Yu, Y., Li, Q., Connole, M., Piatak, M., Lifson, J.D., Li, W., Keele, B.F., Kozlowski, P.A., Desrosiers, R. C., Haase, A.T., Johnson, R.P. 2016. Persistent Low-Level Replication of SIV∆nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection. PLoS Path. 12(12):e1006104. PMID: 27959961. PMCID: PMC5189958. **Co-First Authorship