Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques

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Tong X, Wang Q, Jung W, Chicz TM, Blanc R, Parker LJ, Barouch DH, McNamara RP. Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques. iScience. 2024 Jun 4;27(9):110174. doi: 10.1016/j.isci.2024.110174. PMID: 39224511; PMCID: PMC11367469.

Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial

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Julg B, Walker-Sperling VEK, Wagh K, Aid M, Stephenson KE, Zash R, Liu J, Nkolola JP, Hoyt A, Castro M, Serebryannyy L, Yanosick K, Speidel T, Borducchi EN, Murzda T, Maxfield L, Arduino R, McDermott AB, Gama L, Giorgi EE, Koup RA, Seaman MS, Rolle CP, DeJesus E, Li W, Korber B, Barouch DH. Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial. Nat Med. 2024 Sep 12. doi: 10.1038/s41591-024-03247-5. Epub ahead of print. PMID: 39266747.

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration

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Sooin Jang, Gregory J Bedwell, Satya P Singh, Hyun Jae Yu, Bjarki Arnarson, Parmit K Singh, Rajalingam Radhakrishnan, AidanDarian W Douglas, Zachary M Ingram, Christian Freniere, Onno Akkermans, Stefan G Sarafianos, Zandrea Ambrose, Yong Xiong, Praju V Anekal, Paula Montero Llopis, Vineet N KewalRamani, Ashwanth C Francis, Alan N Engelman, HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration, Nucleic Acids Research, 2024;, gkae769, https://doi.org/10.1093/nar/gkae769

Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience

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Rowe M, Collier AY, Barouch DH. Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience. Vaccine. 2024 Oct 24;42(24):126306. doi: 10.1016/j.vaccine.2024.126306. Epub 2024 Sep 5. PMID: 39241351; PMCID: PMC11401756.

Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study

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Kenny A, van Duijn J, Dintwe O, Heptinstall J, Burnham R, Sawant S, Zhang L, Mielke D, Khuzwayo S, Omar FL, Stanfield-Oakley S, Keyes T, Dunn B, Goodman D, Fong Y, Benkeser D, Zou R, Hural J, Hyrien O, Juraska M, Luedtke A, van der Laan L, Giorgi EE, Magaret C, Carpp LN, Pattacini L, van de Kerkhof T, Korber B, Willems W, Fisher LH, Schuitemaker H, Swann E, Kublin JG, Pau MG, Buchbinder S, Tomaka F, Nijs S, Lavreys L, Gelderblom HC, Corey L, Mngadi K, Gray GE, Borducchi E, Hendriks J, Seaton KE, Zolla-Pazner S, Barouch DH, Ferrari G, De Rosa SC, McElrath MJ, Andersen-Nissen E, Stieh DJ, Tomaras GD, Gilbert PB; Imbokodo Study and Correlates Group. Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study. EBioMedicine. 2024 Sep 4;108:105320. doi: 10.1016/j.ebiom.2024.105320. Epub ahead of print. PMID: 39236556.

Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site

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Caniels TG, Medina-Ramìrez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sánchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Sci Immunol. 2024 Aug 30;9(98):eadk9550. doi: 10.1126/sciimmunol.adk9550. Epub 2024 Aug 30. PMID: 39213338.

FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions

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Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug;17(4):692-699. doi: 10.1016/j.mucimm.2024.04.003. Epub 2024 Apr 25. PMID: 38677592; PMCID: PMC11323182.

Graph Fourier transform for spatial omics representation and analyses of complex organs

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Chang, Y., Liu, J., Jiang, Y., Ma, A., Yeo, Y. Y., Guo, Q., McNutt, M., Krull, J. E., Rodig, S. J., Barouch, D. H., Nolan, G. P., Xu, D., Jiang, S., Li, Z., Liu, B., & Ma, Q. (2024). Graph Fourier transform for spatial omics representation and analyses of complex organs. Nature communications, 15(1), 7467. https://doi.org/10.1038/s41467-024-51590-5

Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection

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Martinot, A. J., Cox, F., Abbink, P., Hecht, J. L., Bronson, R., Borducchi, E. N., Rinaldi, W. J., Ferguson, M. J., De La Barrera, R. A., Zahn, R., van der Fits, L., & Barouch, D. H. (2024). Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection. NPJ vaccines, 9(1), 157. https://doi.org/10.1038/s41541-024-00927-8

Patterns and predictors of COVID-19 vaccination among young adults at 44 US sites: Secondary analysis of a randomized, controlled, open-label trial, March – December 2021

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Vielot, N. A., Kelly, N. K., Ludema, C., Rosenberg, M., Brown, E. R., Janes, H. E., Kublin, J. G., Stephenson, K. E., Marcelin, J. R., & Pettifor, A. (2024). Patterns and predictors of COVID-19 vaccination among young adults at 44 US sites: Secondary analysis of a randomized, controlled, open-label trial, March – December 2021. Vaccine, 42(23), 126237. https://doi.org/10.1016/j.vaccine.2024.126237