Sites of retroviral DNA integration: From basic research to clinical applications.

Serrao E, Engelman AN. Sites of retroviral DNA integration: From basic research to clinical applications. Crit Rev Biochem Mol Biol 2016;51(1):26-42. doi: 10.3109/10409238.2015.1102859. Epub 2015 Oct 28. PubMed PMID: 26508664; PubMed Central PMCID: PMC4866806.

Structural basis for retroviral integration into nucleosomes.

Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov P. Structural basis for retroviral integration into nucleosomes. Nature 2015 Jul 16;523(7560):366-9. doi: 10.1038/nature14495. Epub 2015 Jun 10. PubMed PMID: 26061770; PubMed Central PMCID: PMC4530500.

Engineered hyperactive integrase for concerted HIV-1 DNA integration.

Li M, Jurado KA, Lin S, Engelman A, Craigie R. Engineered hyperactive integrase for concerted HIV-1 DNA integration. PLoS One 2014 Aug 13;9(8):e105078. doi: 10.1371/journal.pone.0105078. eCollection 2014. PubMed PMID: 25119883; PubMed Central PMCID: PMC4132020.

Host and viral determinants for MxB restriction of HIV-1 infection.

Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman A. Host and viral determinants for MxB restriction of HIV-1 infection. Retrovirology 2014 Oct 25;11:90. doi: 10.1186/s12977-014-0090-z. PubMed PMID: 25348155; PubMed Central PMCID: PMC4213484.

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: Implications for the mechanism of target DNA binding.

Serrao E, Krishnan L, Shun MC, Li X, Cherepanov P, Engelman A, Maertens GN. Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: Implications for the mechanism of target DNA binding. Nucleic Acids Res 2014 Apr;42(8):5164-76. doi: 10.1093/nar/gku136. Epub 2014 Feb 11. PubMed PMID: 24520116; PubMed Central PMCID: PMC4005685.

Molecular mechanisms of retroviral integration site selection.

Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res 2014;42(16):10209-25. doi: 10.1093/nar/gku769. Epub 2014 Aug 21. PubMed PMID: 25147212; PubMed Central PMCID: PMC4176367.

Retroviral Integrase Structure and DNA Recombination Mechanism

Engelman A, Cherepanov P. Spectrum 2014 Dec;2(6):1-22. doi: 10.1128/microbiolspec.MDNA3-0024-2014. PubMed PMID: 25705574; PubMed Central PMCID: PMC4334468.

Structural basis for nuclear import of splicing factors by human Transportin 3.

Maertens GN, Cook N, Wang W, Hare S, Gupta SS, Oztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov P. Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A 2014 Feb 18;111(7):2728-33. doi: 10.1073/pnas.1320755111. Epub 2014 Jan 21. PubMed PMID: 24449914; PubMed Central PMCID: PMC3932936.

Structural insight into HIV-1 restriction by MxB.

Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y. Structural insight into HIV-1 restriction by MxB. Cell Host Microbe 2014 Nov 12;16(5):627-38. doi: 10.1016/j.chom.2014.09.021. Epub 2014 Oct 9. PubMed PMID: 25312384; PubMed Central PMCID: PMC4252739.

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.

Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. PubMed PMID: 25421939; PubMed Central PMCID: PMC4251946.