Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

/in

McMahan K, Wegmann F, Aid M, Sciacca M, Liu J, Hachmann NP, Miller J, Jacob-Dolan C, Powers O, Hope D, Wu C, Pereira J, Murdza T, Mazurek CR, Hoyt A, Boon ACM, Davis-Gardner M, Suthar MS, Martinot AJ, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Tolboom J, Serroyen J, Solforosi L, Costes LMM, Zahn RC, Barouch DH. Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques. Nature. 2023 Dec 14. doi: 10.1038/s41586-023-06951-3. Epub ahead of print. PMID: 38096903.

Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses

/in

Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, Cui Z, Zhao D, Barouch DH, Yu J. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses. 2023 Dec 9;15(12):2401. doi: 10.3390/v15122401. PMID: 38140642; PMCID: PMC10747620.

Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis

/in

Jost S, Lucar O, Lee E, Yoder T, Kroll K, Sugawara S, Smith S, Jones R, Tweet G, Werner A, Tomezsko PJ, Dugan HL, Ghofrani J, Rascle P, Altfeld M, Müller-Trutwin M, Goepfert P, Reeves RK. Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis. Sci Immunol. 2023 Dec 8;8(90):eadi3974. doi: 10.1126/sciimmunol.adi3974. Epub 2023 Dec 8. PMID: 38064568.

Viral and host mediators of non-suppressible HIV-1 viremia

/in

Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Viral and host mediators of non-suppressible HIV-1 viremia. Nat Med. 2023 Dec;29(12):3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. PMID: 37957382; PMCID: PMC10719098.

Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86

/in ,

Lasrado N, Collier AY, Hachmann NP, Miller J, Rowe M, Schonberg ED, Rodrigues SL, LaPiana A, Patio RC, Anand T, Fisher J, Mazurek CR, Guan R, Wagh K, Theiler J, Korber BT, Barouch DH. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023 Nov 13;41(47):6904-6909. doi: 10.1016/j.vaccine.2023.10.051. Epub 2023 Oct 21. PMID: 37872011.

SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds

/in

Lasrado N, Barouch DH. SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds. J Infect Dis. 2023 Nov 11;228(10):1311-1313. doi: 10.1093/infdis/jiad353. PMID: 37592872.

Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection

/in

Huot N, Planchais C, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Rosenbaum P, Rey F, Reeves RK, Grand RL, Mouquet H, Müller-Trutwin M. Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection. Nat Immunol 24, 2068–2079 (2023). https://doi.org/10.1038/s41590-023-01661-4

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells

/in

Huot N, Planchais C, Rosenbaum P, Contreras V, Jacquelin B, Petitdemange C, Lazzerini M, Beaumont E, Orta-Resendiz A, Rey FA, Reeves RK, Le Grand R, Mouquet H, Müller-Trutwin M. SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells. Nat Immunol. 2023 Dec;24(12):2068-2079. doi: 10.1038/s41590-023-01661-4. Epub 2023 Nov 2. PMID: 37919524; PMCID: PMC10681903.

Efficacy of Messenger RNA–1273 Against Severe Acute Respiratory Syndrome Coronavirus 2 Acquisition in Young Adults From March to December 2021

/in

Stephenson KE, Marcelin JR, Pettifor AE, Janes H, Brown E, Neradilek M, Yen C, Andriesen J, Grunenberg N, Espy N, Trahey M, Fischer RSB, DeSouza CA, Shisler JL, Connick E, Houpt ER, Chu HY, McCulloh RJ, Becker-Dreps S, Vielot NA, Kalbaugh CA, Cherabuddi K, Krueger KM, Rosenberg M, Greenberg RN, Joaquin A, Immergluck LC, Corey L, Kublin JG. Efficacy of Messenger RNA-1273 Against Severe Acute Respiratory Syndrome Coronavirus 2 Acquisition in Young Adults From March to December 2021. Open Forum Infect Dis. 2023 Nov 2;10(11):ofad511. doi: 10.1093/ofid/ofad511. PMID: 38023544; PMCID: PMC10655942.

Mosaic HIV-1 vaccination induces anti-viral CD8+ T cell functionality in the phase 1/2a clinical trial APPROACH

/in

van Duijn J, Stieh D, Fernandez N, King D, Gilmour J, Tolboom J, Callewaert K, Willems W, Pau MG, De Rosa SC, McElrath MJ, Barouch DH, Hayes P. Mosaic HIV-1 vaccination induces anti-viral CD8+ T cell functionality in the phase 1/2a clinical trial APPROACH. J Virol. 2023 Oct 31;97(10):e0112623. doi: 10.1128/jvi.01126-23. Epub 2023 Oct 9. PMID: 37811993; PMCID: PMC10617392.