Broadly neutralizing antibody-mediated protection against simian-HIV infection among macaques with vaginal sexually transmitted infections

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Garber, David A.a; Guenthner, Patriciaa; Zhao, Chunxiaa; Mitchell, Jamesa; Ellis, Shanona; Jia, Hongweia; Manganare, Marcosa; Gazumyan, Annab; Seaman, Michael S.c; Vishwanathan, Sundaram Ajaya; Heneine, Walida; McNicholl, Janet M.a. Broadly neutralizing antibody-mediated protection against simian-HIV infection among macaques with vaginal sexually transmitted infections. AIDS 37(5):p 723-731, April 1, 2023. | DOI: 10.1097/QAD.0000000000003472

The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores

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Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2202815120. doi: 10.1073/pnas.2202815120. Epub 2023 Mar 21. PMID: 36943880; PMCID: PMC10068764.

Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

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Nanishi E, Borriello F, Seo HS, O’Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Mar 3;8(1):30. doi: 10.1038/s41541-023-00634-w. Erratum for: NPJ Vaccines. 2023 Feb 14;8(1):18. PMID: 36869134; PMCID: PMC9982769.

COVID-19 Therapeutics and Considerations for Pregnancy

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Joseph NT, Collier AY. COVID-19 Therapeutics and Considerations for Pregnancy. Obstet Gynecol Clin North Am. 2023 Mar;50(1):163-182. doi: 10.1016/j.ogc.2022.10.018. Epub 2022 Oct 21. PMID: 36822701; PMCID: PMC9584862.

Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels

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Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nat Struct Mol Biol. 2023 Apr;30(4):425-435. doi: 10.1038/s41594-023-00925-9. Epub 2023 Feb 20. PMID: 36807645; PMCID: PMC10121901.

Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants

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Fray EJ, Wu F, Simonetti FR, Zitzmann C, Sambaturu N, Molina-Paris C, Bender AM, Liu PT, Ventura JD, Wiseman RW, O’Connor DH, Geleziunas R, Leitner T, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants. Cell Host Microbe. 2023 Mar 8;31(3):356-372.e5. doi: 10.1016/j.chom.2023.01.016. Epub 2023 Feb 20. PMID: 36809762; PMCID: PMC10583177.

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

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Nanishi E, Borriello F, Seo HS, O’Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Feb 14;8(1):18. doi: 10.1038/s41541-023-00610-4. Erratum in: NPJ Vaccines. 2023 Mar 3;8(1):30. PMID: 36788219; PMCID: PMC9927065.

The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function

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Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio. 2023 Feb 28;14(1):e0356022. doi: 10.1128/mbio.03560-22. Epub 2023 Feb 6. PMID: 36744954; PMCID: PMC9973045.

Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events

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Woolley G, Mosher M, Kroll K, Jones R, Hueber B, Sugawara S, Manickam C, Terry K, Varner V, Lifton M, Ram D, Fennessey CM, Keele BF, Reeves RK. Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events. J Virol. 2023 Jan 31;97(1):e0151922. doi: 10.1128/jvi.01519-22. Epub 2022 Dec 13. PMID: 36511699; PMCID: PMC9888193

Physiological and pathological influences

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Rascle P, Woolley G, Jost S, Manickam C, Reeves RK. NK cell education: Physiological and pathological influences. Front Immunol. 2023 Jan 20;14:1087155. doi: 10.3389/fimmu.2023.1087155. PMID: 36742337; PMCID: PMC9896005.