Researchers – Page 26 – Center for Virology and Vaccine Research (CVVR)

Structural basis of second-generation inhibitor action and viral resistance

2020-01-30/in Engelman

Cook NJ, Li W, Berta D, Badaoui D, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Structural basis of second-generation inhibitor action and viral resistance. Science 2020 Feb 14;367(6479):806-10. doi: 10.1126/science.aay4919. Epub 2020 Jan 30. PubMed PMID: 32001525.

Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia

2019-08-03/in Collier

Yonekura Collier AR, Zsengeller Z, Pernicone E, Salahuddin S, Khankin EV, Karumanchi SA. Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia. Hypertens Pregnancy. 2019 Aug;38(3):193-199. doi: 10.1080/10641955.2019.1640725. Epub 2019 Jul 10. PMID: 31291799; PMCID: PMC6707710.

Silent damage? Occult HCV replication and histological disease may occur following apparent HCV clearance

2019-07-23/in Reeves

Manickam C, Reeves RK. Silent damage? Occult HCV replication and histological disease may occur following apparent HCV clearance. EBioMedicine. 2019;47:12-13. doi:10.1016/j.ebiom.2019.08.029.

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

2019-05-21/in Engelman

Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res. 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206. PMID: 30916345; PMCID: PMC6511849.

Harvard HIV and aging workshop: Perspective and priorities from Claude D. Pepper Centers and Centers for AIDS Research.

2019-05-01/in Reeves

Montano, M., Bhasin, S., D’Aquila, R.T., Erlandson, K.M., Evans, W.J., Funderburg, N.T., Justice, A., Ndhlovu, L., Ojikutu, B., Pahor, M., Pahwa, S., Ryan, A.S., Schrack, J., Schultz, M.B., Sebatiani, P, Sinclair, D., Tripp, J., Walker, B., Womack, J.A., Yung, R., and Reeves, R.K. Harvard HIV and aging workshop: Perspective and priorities from Claude D. Pepper Centers and Centers for AIDS Research. AIDS Research and Human Retroviruses Epub. doi: 10.1089/AID.2019.0130. PMID: 31456412

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.

2019-05-01/in Seaman

Cohen YZ, Butler AL, Millard K, Witmer-Pack M, Levin R, et al. (2019) Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study. PLOS ONE 14(8): e0219142.

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

2019-05-01/in Engelman

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344. PubMed PMID: 31120420; PubMed Central PMCID: PMC6581505.

Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.

2019-05-01/in Jost, Reeves

Ghofrani J, Lucar O, Dugan H, Reeves RK, Jost S. Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells. (2019) European Journal of Immunology. 49(8):1153-1166.

A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection.

2019-05-01/in Researchers, Seaman

Silver ZA, Dickinson GM, Seaman MS, Desrosiers RC. A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection. J Virol. 2019 May 15;93(10). doi: 10.1128/JVI.00094-19.

HIV-1 neutralizing antibody signatures and application to epitope-targeted vaccine design.

2019-05-01/in Seaman, Stephenson

Bricault CA, Yusim K, Seaman MS, Yoon H, Theiler J, Giorgi EE, Wagh K, Theiler M, Hraber P, Macke JP, Kreider EF, Learn GH, Hahn BH, Scheid JF, Kovacs JM, Shields JL, Lavine CL, Ghantous F, Rist M, Bayne MG, Neubauer GH, McMahan K, Peng H, Chéneau C, Jones JJ, Zeng J, Ochsenbauer C, Nkolola JP, Stephenson KE, Chen B, Gnanakaran S, Bonsignori M, Williams LD, Haynes BF, Doria-Rose N, Mascola JR, Montefiori DC, Barouch DH*, Korber B*. HIV-1 neutralizing antibody signatures and application to epitope-targeted vaccine design. Cell Host Microbe 2019; 25:59-72.