Knowns and unknowns of assaying antibody-dependent cell-mediated cytotoxicity against HIV-1. 2019.

/in

Lewis, G., Ackerman, M.E., Scarlatti, G, Moog, C, Robert-Guroff, M., Kent, S.J., Overbaugh, J., Reeves, R.K., Ferrari, G., and Thyagarajan, B. Knowns and unknowns of assaying antibody-dependent cell-mediated cytotoxicity against HIV-1. 2019. Front. Immunol. 10:1025. PMID: 31134085. PMCID: PMC6522882

A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.

/in

Ehrenberg PK, Shangguan S, Issac B, Alter G, Geretz A, Izumi T, Bryant C, Eller MA, Wegmann F, Apps R, Creegan M, Bolton DL, Sekaly RP, Robb ML, Gramzinski RA, Pau MG, Schuitemaker H, Barouch DH, Michael NL, Thomas R. A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials. Sci. Transl. Med. 2019; 11: eaaw4236.

Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques.

/in

Abbink P, Mercado NB, Nkolola JP, Peterson RL, Tuyishime H, McMahan K, Moseley ET, Borducchi EN, Chandrashekar A, Bondzie EA, Agarwal A, Belli AJ, Reimann KA, Keele BF, Geleziunas R, Lewis MG, Barouch DH. Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques. Science 2019; 365:1029-1033.

Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial.

/in

Mahomed S, Garrett N, Capparelli E, Baxter C, Zuma NY, Gengiah T, Archary D, Moore P, Samsunder N, Barouch DH, Mascola J, Ledgerwood J, Morris L, Abdool Karim S. Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial. BMJ Open 2019; 9:e030283.

Memory and antigen-specific NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?

/in

Ram, R., Manickam, C, Lucar, O., Shah, S., and Reeves, R.K. Memory and antigen-specific NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics? 2019. J. Leukoc. Bio. 105(6):1253-1259. PMID: 30730588. PMID: 30730588. PMCID: PMC6536345

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

/in ,

Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ. Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity. 2019 Jun 18;50(6):1513-1529.e9.

Monkeying around: Using nonhuman primate models to study NK cell biology in HIV infections.

/in

Manickam, C., Shah, S., Nohara, J., Ferrari, G., Reeves, R.K. ­­­­2019 Monkeying around: Using nonhuman primate models to study NK cell biology in HIV infections. Front. Immunol. 10:1124. PMID: 31191520. PMCID: PMC6540610.

Decreased JC virus-specific antibody-dependent cellular cytotoxicity in HIV-seropositive PML survivors

/in , ,

Tan CS., Ghofrani J., Geiger E., Koralnik IJ, Jost S., Decreased JC virus-specific antibody-dependent cellular cytotoxicity in HIV-seropositive PML survivors. JAIDS; 2019 (In Press)

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.

/in

Engelman, AN. Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition. J Biol Chem 2019 Oct 11;294(41):15137-57. doi: 10.1074/jbc.REV119.006901. Epub 2019 Aug 29. PubMed PMID: 31467082; PubMed Central PMCID: PMC6791320.

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.

/in

Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206. Epub 2019 Mar 27. PubMed PMID: 30916345; PubMed Central PMCID: PMC6511849.