Structural Basis for Membrane Anchoring of HIV-1 Envelope Spike.

/in

Dev J, Park D, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chan W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ. Structural Basis for Membrane Anchoring of HIV-1 Envelope Spike. Science. 2016, 353(6295): 172-5.

Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function.

/in

Larocca RA, Provine NM, Aid M, Iampietro MJ, Borducchi EN, Badamchi-Zadeh A, Abbink P, Ng’ang’a D, Bricault CA, Blass E, Penaloza-MacMaster P, Stephenson KE, Barouch DH. Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function. Sci. Immunol. 2016; 1:eaaf7643.

Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity.

/in

Huang Y, Yu J, Lanzi A, Yao X, Andrews CD, Tsai L, Gajjar MR, Sun M, Seaman MS, Padte NN, Ho DD. Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity. Cell. 2016, 165(7): 1621-31.

New concepts in HIV-1 vaccine development.

/in

Stephenson KE, D’Couto HT, Barouch DH. New concepts in HIV-1 vaccine development. Curr Opin Immunol. 2016 Aug;41:39-46. doi: 10.1016/j.coi.2016.05.011. Epub 2016 Jun 3. Review. PubMed PMID: 27268856; PubMed Central PMCID: PMC4992607.

Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.

/in

Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Parks R, Eaton A, Foulger A, Nie X, Karim SS, Barnett S, Kelsoe G, Kepler TB, Alam SM, Montefiori DC, Moody MA, Liao HX, Morris L, Santra S, Harrison SC, Haynes BF. Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep. 2016 Jan 5; 14(1):43-54. PMID: 26725118.

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.

/in

Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Sci 2016 Nov;25(11):1911-1917. doi: 10.1002/pro.2997. Epub 2016 Aug 17. PubMed PMID: 27503276; PubMed Central PMCID: PMC5079246.

Engineered murine HSCs reconstitute multi-lineage hematopoiesis and adaptive immunity.

/in

Lu Y-F, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ. Engineered murine HSCs reconstitute multi-lineage hematopoiesis and adaptive immunity. Cell Rep 2016 Dec 20;17(12):3178-92. doi: 10.1016/j.celrep.2016.11.077. PubMed PMID: 28009288. PubMed Central PMCID: PMC5247798.

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.

/in

Garcia-Beltran WF, Holzemer A, Martrus G, Chung AW, Pacheco Y, Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M. Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. (2016) Nature immunology. 17(9):1067-74.

Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity.

/in

Zolla-Pazner S, Cohen SS, Boyd D, Kong XP, Seaman M, Nussenzweig M, Klein F, Overbaugh J, Totrov M. Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity. J. Virol. 2015, 90(2):636-49.

Rapid inflammasome activation following mucosal SIV infection of rhesus monkeys.

/in

Barouch DH, Ghneim K, Bosche WJ, Li Y, Berkemeier B, Hull M, Bhattacharyya S, Cameron M, Liu J, Smith K, Borducchi E, Cabral C, Peter L, Brinkman A, Shetty M, Li H, Gittens C, Baker C, Wagner W, Lewis MG, Colantonio A, Kang HJ, Li W, Lifson JD, Piatak M, Sekaly RP. Rapid inflammasome activation following mucosal SIV infection of rhesus monkeys. Cell 2016; 165:656-667.