HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration

Li M, Li Z, Chen X, Cui Y, Engelman AN, Craigie R. HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration. Viruses. 2024; 16(7):1166. https://doi.org/10.3390/v16071166

Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial

Gray GE, Mngadi K, Lavreys L, Nijs S, Gilbert PB, Hural J, Hyrien O, Juraska M, Luedtke A, Mann P, McElrath MJ, Odhiambo JA, Stieh DJ, van Duijn J, Takalani AN, Willems W, Tapley A, Tomaras GD, Van Hoof J, Schuitemaker H, Swann E, Barouch DH, Kublin JG, Corey L, Pau MG, Buchbinder S, Tomaka F; Imbokodo/HVTN 705/HPX2008 Study Group. Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Infect Dis. 2024 Jul 19:S1473-3099(24)00358-X. doi: 10.1016/S1473-3099(24)00358-X. Epub ahead of print. PMID: 39038477.

Covid on The Rise Again in Dozens of States

Health authorities say Covid cases are on the rise around the nation, with 15 states reporting high levels of the virus in wastewater. While the severity of the disease is lessening overall, the elderly and immunocompromised are still at higher risk. NBC News’ Erin McLaughlin reports.

Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans

Williams WB, Alam SM, Ofek G, Erdmann N, Montefiori DC, Seaman MS, Wagh K, Korber B, Edwards RJ, Mansouri K, Eaton A, Cain DW, Martin M, Hwang J, Arus-Altuz A, Lu X, Cai F, Jamieson N, Parks R, Barr M, Foulger A, Anasti K, Patel P, Sammour S, Parsons RJ, Huang X, Lindenberger J, Fetics S, Janowska K, Niyongabo A, Janus BM, Astavans A, Fox CB, Mohanty I, Evangelous T, Chen Y, Berry M, Kirshner H, Van Itallie E, Saunders KO, Wiehe K, Cohen KW, McElrath MJ, Corey L, Acharya P, Walsh SR, Baden LR, Haynes BF. Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans. Cell. 2024 Jun 6;187(12):2919-2934.e20. doi: 10.1016/j.cell.2024.04.033. Epub 2024 May 17. PMID: 38761800.

The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?

Woolley G, Kroll K, Hoffman K, Ward A, Corneli A, Mudrak SV, Qureshi MU, Okeke NL, Chan C, Jones AD, Tomaras GD, Reeves RK. The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk? AIDS Res Hum Retroviruses. 2024 May 27. doi: 10.1089/AID.2024.0050. Epub ahead of print. PMID: 38753709.

The potential of broadly neutralizing antibodies for HIV prevention

Gelderblom, H.C., Corey, L. and Barouch, D.H. (2024), The potential of broadly neutralizing antibodies for HIV prevention. J Int AIDS Soc., 27: e26257. https://doi.org/10.1002/jia2.26257

SARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated Individuals: A Secondary Cross-Protocol Analysis of 4 Randomized Trials

Fisher LHKee JJLiu A, et al. SARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated IndividualsA Secondary Cross-Protocol Analysis of 4 Randomized TrialsJAMA Netw Open. 2024;7(5):e2412835. doi:10.1001/jamanetworkopen.2024.12835

Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans

Williams WB, Alam SM, Ofek G, Erdmann N, Montefiori DC, Seaman MS, Wagh K, Korber B, Edwards RJ, Mansouri K, Eaton A, Cain DW, Martin M, Hwang J, Arus-Altuz A, Lu X, Cai F, Jamieson N, Parks R, Barr M, Foulger A, Anasti K, Patel P, Sammour S, Parsons RJ, Huang X, Lindenberger J, Fetics S, Janowska K, Niyongabo A, Janus BM, Astavans A, Fox CB, Mohanty I, Evangelous T, Chen Y, Berry M, Kirshner H, Van Itallie E, Saunders KO, Wiehe K, Cohen KW, McElrath MJ, Corey L, Acharya P, Walsh SR, Baden LR, Haynes BF. Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans. Cell. 2024 May 14:S0092-8674(24)00459-8. doi: 10.1016/j.cell.2024.04.033. Epub ahead of print. PMID: 38761800.

Natural killer like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques

Manickam C, Upadhyay AA, Woolley G, Kroll KW, Terry K, Broedlow CA, Klatt NR, Bosinger SE, Reeves RK. Natural killer like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques. PLoS Pathog. 2024 May 13;20(5):e1012223. doi: 10.1371/journal.ppat.1012223. Epub ahead of print. PMID: 38739675.

The potential of broadly neutralizing antibodies for HIV prevention

Gelderblom HC, Corey L, Barouch DH. The potential of broadly neutralizing antibodies for HIV prevention. J Int AIDS Soc. 2024 May;27(5):e26257. doi: 10.1002/jia2.26257. PMID: 38757844; PMCID: PMC11100278.