Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease

Zhang L, Cagle C, Nguyen DH, Gomes GS, Gromova B, Csizmadia E, Karimitar A, Lee GR, Chen G, Kokkotou E, Grossberg L, Jiang S, Cheifetz AS, Kota SK, Longhi MS. Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease. Cellular Molecular Immunology. 2025 Jul;22(7):730-742. doi: 10.1038/s41423-025-01295-6. Epub 2025 May 26.

CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data

Zhu B, Gao S, Chen S, Wang Y, Yeung J, Bai Y, Huang AY, Yeo YY, Liao G, Mao S, Jiang ZG, Rodig SJ, Wong KC, Shalek AK, Nolan GP, Jiang S, Ma Z. CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data. Nature Immunology. 2025 Jun;26(6):963-974. doi: 10.1038/s41590-025-02163-1. Epub 2025 May 22.

A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning

Kim, S., Radford, C. E., Xu, D., Zhong, J., Do, J., Pham, D. M., Travisano, K. A., Filsinger Interrante, M. V., Bruun, T. U. J., Rezek, V., Wilder, B., Palomares, M., Seaman, M. S., Kitchen, S. G., Bloom, J. D., & Kim, P. S. (2025). A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning. Nature communications16(1), 4617. https://doi.org/10.1038/s41467-025-60035-6

Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR

Chaubey, M., Gao, H., Lavine, C. L., Seaman, M. S., Chen, B., & Chou, J. J. (2025). Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR. Journal of the American Chemical Society147(21), 17561–17565. https://doi.org/10.1021/jacs.5c04597

Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas

Mahyari, E., Boggy, G. J., McElfresh, G. W., Kaza, M., Benjamin, S., Varco-Merth, B., Ojha, S., Feltham, S., Goodwin, W., Nkoy, C., Duell, D., Selseth, A., Bennett, T., Barber-Axthelm, A., Smedley, J. V., Labriola, C. S., Axthelm, M. K., Reeves, R. K., Okoye, A. A., Hansen, S. G., … Bimber, B. N. (2025). Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas. Cell genomics5(5), 100849. https://doi.org/10.1016/j.xgen.2025.100849

Computationally designed proteins mimic antibody immune evasion in viral evolution

Youssef N, Gurev S, Ghantous F, Brock KP, Jaimes JA, Thadani NN, Dauphin A, Sherman AC, Yurkovetskiy L, Soto D, Estanboulieh R, Kotzen B, Notin P, Kollasch AW, Cohen AA, Dross SE, Erasmus J, Fuller DH, Bjorkman PJ, Lemieux JE, Luban J, Seaman MS, Marks DS. Computationally designed proteins mimic antibody immune evasion in viral evolution. Immunity. 2025 Jun 10;58(6):1411-1421.e6. doi: 10.1016/j.immuni.2025.04.015. Epub 2025 May 8.

Next-Generation Coronavirus Disease 2019 Vaccines: Clinical Data and Future Directions

Stephenson K. E. (2025). Next-Generation Coronavirus Disease 2019 Vaccines: Clinical Data and Future Directions. Infectious disease clinics of North America39(2), 253–274. https://doi.org/10.1016/j.idc.2025.02.003

Fanzors, a family of eukaryotic RNA-guided DNA endonucleases

Jiang, K., Gootenberg, J. S., & Abudayyeh, O. O. (2025). Fanzors, a family of eukaryotic RNA-guided DNA endonucleases. FEBS letters599(8), 1089–1093. https://doi.org/10.1002/1873-3468.70038

Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir

Briganti, L., Annamalai, A. S., Bester, S. M., Wei, G., Andino-Moncada, J. R., Singh, S. P., Kleinpeter, A. B., Tripathi, M., Nguyen, B., Radhakrishnan, R., Singh, P. K., Greenwood, J., Schope, L. I., Haney, R., Huang, S.-W., Freed, E. O., Engelman, A. N., Francis, A. C., & Kvaratskhelia, M. (2025). Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir. mBio16(5), e0361324. https://doi.org/10.1128/mbio.03613-24

Reprogramming site-specific retrotransposon activity to new DNA sites

Fell CW, Villiger L, Lim J, Hiraizumi M, Tagliaferri D, Yarnall MTN, Lee A, Jiang K, Kayabolen A, Krajeski RN, Schmitt-Ulms C, Ramani H, Yousef SM, Roberts N, Vakulskas CA, Nishimasu H, Abudayyeh OO, Gootenberg JS. Reprogramming site-specific retrotransposon activity to new DNA sites. Nature. 2025 Jun;642(8069):1080-1089. doi: 10.1038/s41586-025-08877-4. Epub 2025 Apr 9.