Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial.

Mahomed S, Garrett N, Capparelli E, Baxter C, Zuma NY, Gengiah T, Archary D, Moore P, Samsunder N, Barouch DH, Mascola J, Ledgerwood J, Morris L, Abdool Karim S. Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial. BMJ Open 2019; 9:e030283.

Memory and antigen-specific NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?

Ram, R., Manickam, C, Lucar, O., Shah, S., and Reeves, R.K. Memory and antigen-specific NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics? 2019. J. Leukoc. Bio. 105(6):1253-1259. PMID: 30730588. PMID: 30730588. PMCID: PMC6536345

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ. Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity. 2019 Jun 18;50(6):1513-1529.e9.

Monkeying around: Using nonhuman primate models to study NK cell biology in HIV infections.

Manickam, C., Shah, S., Nohara, J., Ferrari, G., Reeves, R.K. ­­­­2019 Monkeying around: Using nonhuman primate models to study NK cell biology in HIV infections. Front. Immunol. 10:1124. PMID: 31191520. PMCID: PMC6540610.

Decreased JC virus-specific antibody-dependent cellular cytotoxicity in HIV-seropositive PML survivors

Tan CS., Ghofrani J., Geiger E., Koralnik IJ, Jost S., Decreased JC virus-specific antibody-dependent cellular cytotoxicity in HIV-seropositive PML survivors. JAIDS; 2019 (In Press)

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.

Engelman, AN. Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition. J Biol Chem 2019 Oct 11;294(41):15137-57. doi: 10.1074/jbc.REV119.006901. Epub 2019 Aug 29. PubMed PMID: 31467082; PubMed Central PMCID: PMC6791320.

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.

Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206. Epub 2019 Mar 27. PubMed PMID: 30916345; PubMed Central PMCID: PMC6511849.

NK Cells Contribute to the Immune Risk Profile in Kidney Transplant Candidates.

DeWolfe D, Aid M, McGann K, Ghofrani J, Geiger E, Helzer C, Malik S, Kleiboeker S, Jost S, Tan CS. NK Cells Contribute to the Immune Risk Profile in Kidney Transplant Candidates. (2019) Frontiers in Immunology. 10:1890.

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.

Han Q, Jones JA, Nicely NI, Reed RK, Shen X, Mansouri K, Louder M, Trama AM, Alam SM, Edwards RJ, Bonsignori M, Tomaras GD, Korber B, Montefiori DC, Mascola JR, Seaman MS, Haynes BF, Saunders KO. Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. Nat Commun. 2019 Jul 1;10(1):2898.

Non-linear multidimensional flow cytometry analyses delineate NK cell phenotypes in normal and HIV-infected chimpanzees.

Manickam, C., Li, H., Kroll, K., and Reeves, R.K. Non-linear multidimensional flow cytometry analyses delineate NK cell phenotypes in normal and HIV-infected chimpanzees. 2019. Int. Immunol. 5;31(3):175-180. PMID: 30418531. PMCID: PMC6400041