The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Huang, S. W., Briganti, L., Annamalai, A. S., Greenwood, J., Shkriabai, N., Haney, R., Armstrong, M. L., Wempe, M. F., Singh, S. P., Francis, A. C., Engelman, A. N., & Kvaratskhelia, M. (2025). The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir. PLoS pathogens21(1), e1012862. https://doi.org/10.1371/journal.ppat.1012862

Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity

Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, Reeves RK, Wiehe KJ, Pollara J, Tomaras GD, Bradley T, Ferrari G. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity. Pathog Immun. 2025 Jan 23;10(1):49-79. doi: 10.20411/pai.v10i1.734.

Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity

Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, Reeves RK, Wiehe KJ, Pollara J, Tomaras GD, Bradley T, Ferrari G. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity. Pathog Immun. 2025 Jan 23;10(1):49-79. doi: 10.20411/pai.v10i1.734. PMID: 39911143; PMCID: PMC11792536.

Nonhuman primate antigenic cartography of SARS-CoV-2

Rössler A, Netzl A, Lasrado N, Chaudhari J, Mühlemann B, Wilks SH, Kimpel J, Smith DJ, Barouch DH. Nonhuman primate antigenic cartography of SARS-CoV-2. Cell Rep. 2025 Jan 28;44(1):115140. doi: 10.1016/j.celrep.2024.115140. Epub 2025 Jan 3. PMID: 39754717; PMCID: PMC11781863.

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

Rohlfes, N., Radhakrishnan, R., Singh, P. K., Bedwell, G. J., Engelman, A. N., Dharan, A., & Campbell, E. M. (2025). The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. PLoS pathogens21(1), e1012354. https://doi.org/10.1371/journal.ppat.1012354

Elephant in the room: natural killer cells don’t forget HIV either

Jost S, Reeves RK. Elephant in the room: natural killer cells don’t forget HIV either. Curr Opin HIV AIDS. 2025 Mar 1;20(2):109-116. doi: 10.1097/COH.0000000000000909. Epub 2025 Jan 17. PMID: 39773904; PMCID: PMC11802307.

Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

Edupuganti S, Hurt CB, Stephenson KE, Huang Y, Paez CA, Yu C, Yen C, Hanscom B, He Z, Miner MD, Gamble T, Heptinstall J, Seaton KE, Domin E, Lin BC, McKee K, Doria-Rose N, Regenold S, Spiegel H, Anderson M, McClosky N, Zhang L, Piwowar-Manning E, Ackerman ME, Pensiero M, Dye BJ, Landovitz RJ, Mayer K, Siegel M, Sobieszczyk M, Walsh SR, Gama L, Barouch DH, Montefiori DC, Tomaras GD; HVTN 136/HPTN 092 Study Team. Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial. Lancet HIV. 2025 Jan;12(1):e13-e25. doi: 10.1016/S2352-3018(24)00247-9. Epub 2024 Dec 10. PMID: 39667379; PMCID: PMC11795396.

Precise kilobase-scale genomic insertions in mammalian cells using PASTE

Fell CW, Schmitt-Ulms C, Tagliaferri DV, Gootenberg JS, Abudayyeh OO. Precise kilobase-scale genomic insertions in mammalian cells using PASTE. Nature Protocols. 2025 Jun;20(6):1546-1583. doi: 10.1038/s41596-024-01090-z. Epub 2024 Dec 15.

Identification of a novel neutralization epitope in rhesus AAVs

Dagotto, G., Fisher, J. L., Li, D., Li, Z., Jenni, S., Li, Z., Tartaglia, L. J., Abbink, P., & Barouch, D. H. (2024). Identification of a novel neutralization epitope in rhesus AAVs. Molecular therapy. Methods & clinical development32(4), 101350. https://doi.org/10.1016/j.omtm.2024.101350

Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial

Gray, G. E., Mngadi, K., Lavreys, L., Nijs, S., Gilbert, P. B., Hural, J., Hyrien, O., Juraska, M., Luedtke, A., Mann, P., McElrath, M. J., Odhiambo, J. A., Stieh, D. J., van Duijn, J., Takalani, A. N., Willems, W., Tapley, A., Tomaras, G. D., Van Hoof, J., Schuitemaker, H., … Imbokodo/HVTN 705/HPX2008 Study Group (2024). Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial. The Lancet. Infectious diseases24(11), 1201–1212. https://doi.org/10.1016/S1473-3099(24)00358-X