CPSF6 promotes HIV-1 preintegration complex function

/in

Chaudhuri, E., Jang, S., Chakraborty, R., Radhakrishnan, R., Arnarson, B., Prakash, P., Cornish, D., Rohlfes, N., Singh, P. K., Shi, J., Aiken, C., Campbell, E., Hultquist, J., Balsubramaniam, M., Engelman, A. N., & Dash, C. (2025). CPSF6 promotes HIV-1 preintegration complex function. Journal of virology, 99(5), e0049025. https://doi.org/10.1128/jvi.00490-25

Early spatiotemporal evolution of the immune response elicited by adenovirus serotype 26 vector vaccination in mice

/in , ,

Blass, E., Colarusso, A., Aid, M., Larocca, R. A., Reeves, R. K., & Barouch, D. H. (2025). Early spatiotemporal evolution of the immune response elicited by adenovirus serotype 26 vector vaccination in mice. Journal of virology, 99(5), e0024725. https://doi.org/10.1128/jvi.00247-25

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

/in

Ingram, Z., Kline, C., Hughson, A. K., Singh, P. K., Fischer, H. L., Radhakrishnan, R., Sowd, G. A., Dos Santos, N. F. B., Ganser-Pornillos, B. K., Watkins, S. C., Kane, M., Engelman, A. N., & Ambrose, Z. (2025). Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration. mBio, 16(4), e0016925. https://doi.org/10.1128/mbio.00169-25

On-patient medical record and mRNA therapeutics using intradermal microneedles

/in

Han, J., Kanelli, M., Liu, Y., Daristotle, J. L., Pardeshi, A., Forster, T. A., Karchin, A., Folk, B., Murmann, L., Tostanoski, L. H., Carrasco, S. E., Alsaiari, S. K., Wang, E. Y., Tran, K., Zhang, L., Eshaghi, B., Levy, L., Pyon, S., Sloane, C., Lin, S. Q., … Jaklenec, A. (2025). On-patient medical record and mRNA therapeutics using intradermal microneedles. Nature materials, 24(5), 794–803. https://doi.org/10.1038/s41563-024-02115-4

Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV

/in ,

Chawana, T. D., Walsh, S. R., Stranix-Chibanda, L., Chirenje, Z. M., Yu, C., Zhang, L., Seaton, K. E., Heptinstall, J., Zhang, L., Paez, C. A., Gamble, T., Karuna, S. T., Andrew, P., Hanscom, B., Sobieszczyk, M. E., Edupuganti, S., Gay, C. L., Mannheimer, S. B., Hurt, C. B., Stephenson, K. E., … HVTN 127/HPTN 087, HVTN 130/HPTN 089 and HVTN 136/HPTN 092 Study Teams (2025). Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV. BMC immunology, 26(1), 8. https://doi.org/10.1186/s12865-025-00687-7

Computationally Selected Multivalent HIV-1 Subtype C Vaccine Protects Against Heterologous SHIV Challenge

/in

Mielke, D., Tuyishime, M., Kelkar, N. S., Wang, Y., Parks, R., Santra, S., Rountree, W., Williams, L. D., Peters, T., Eisel, N., Sawant, S., Zhang, L., Goodman, D., Jha, S., Zalaquett, A., Ramasubramanian, P., Stanfield-Oakley, S., Matyas, G., Beck, Z., … Ferrari, G. (2025). Computationally Selected Multivalent HIV-1 Subtype C Vaccine Protects Against Heterologous SHIV Challenge. Vaccines, 13(3), 231. https://doi.org/10.3390/vaccines13030231

Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes

/in

Hudson, A., Wu, P., Kroll, K. W., Hueber, B., Woolley, G., Shi, P., & Reeves, R. K. (2025). Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes. Journal of virology, 99(3), e0163424. https://doi.org/10.1128/jvi.01634-24

Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development

/in

Hahn, K., Amberg, B., Monné Rodriguez, J. M., Verslegers, M., Kang, B., Wils, H., Saravanan, C., Bangari, D. S., Long, S. Y., Youssef, S. A., Pesti, B., Schaffenrath, J., Valdeolivas, A., Kumpesa, N., Galván, J. A., Richardson, M., Giroud, N., Kunz, L., Veiga, I. B., Bscheider, M., … Jacobsen, B. (2025). Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development. Toxicologic pathology, 53(1), 107–129. doi: 10.1177/01926233241311258

Nonhuman primate antigenic cartography of SARS-CoV-2

/in

Annika Rössler, Antonia Netzl, Ninaad Lasrado, Jayeshbhai Chaudhari, Barbara Mühlemann, Samuel H. Wilks, Janine Kimpel, Derek J. Smith, Dan H. Barouch,
Nonhuman primate antigenic cartography of SARS-CoV-2, Cell Reports, Volume 44, Issue 1, 2025, 115140, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2024.115140

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment

/in

Zhu B, Bai Y, Yeo YY, Lu X, Rovira-Clavé X, Chen H, Yeung J, Nkosi D, Glickman J, Delgado-Gonzalez A, Gerber GK, Angelo M, Shalek AK, Nolan GP, Jiang S. A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment. Nat Commun. 2025 Jan 31;16(1):1230. doi: 10.1038/s41467-025-56237-7. PMID: 39890778; PMCID: PMC11785740.